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01-11-2008 | Brief Report | Uitgave 10/2008

Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 10/2008

Auteurs:: Frederike Schirmbeck, Alexander Georgi, Jana Strohmaier, Christine Schmael, Katja V. Boesshenz, Thomas W. Mühleisen, Stefan Herms, Per Hoffmann, Rami Abou Jamra, Johannes Schumacher, Wolfgang Maier, Peter Propping, Markus M. Nöthen, Sven Cichon, Marcella Rietschel, Thomas G. Schulze

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Abstract

Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831–838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.

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Titel: Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin
Auteurs:: Frederike Schirmbeck
Alexander Georgi
Jana Strohmaier
Christine Schmael
Katja V. Boesshenz
Thomas W. Mühleisen
Stefan Herms
Per Hoffmann
Rami Abou Jamra
Johannes Schumacher
Wolfgang Maier
Peter Propping
Markus M. Nöthen
Sven Cichon
Marcella Rietschel
Thomas G. Schulze
Publicatiedatum: 01-11-2008
DOI: https://doi.org/10.1007/s10803-008-0582-6
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 10/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin

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