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Journal of Autism and Developmental Disorders

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26-04-2017 | Brief Report

Brief Report: Metformin for Antipsychotic-Induced Weight Gain in Youth with Autism Spectrum Disorder

Auteurs: Logan K. Wink, Ryan Adams, Ernest V. Pedapati, Kelli C. Dominick, Emma Fox, Catherine Buck, Craig A. Erickson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2017

Abstract

Antipsychotic treatment in youth with autism spectrum disorder (ASD) is becoming increasingly common, placing individuals at risk for antipsychotic-induced weight gain and associated complications. Metformin hydrochloride, a biguanide medication FDA-approved for treatment of type-2 diabetes in youth, may hold promise for treatment of antipsychotic-induced weight gain in youth with ASD. In this report we assess the long-term impact of metformin on antipsychotic-associated weight gain in a naturalistic sample of 53 youth with ASD. Results indicate that treatment with metformin stabilized BMI z-score over a nearly 2 year mean treatment period. Further work is indicated to determine the safety and efficacy of metformin treatment in youth with ASD, as well as predictors of response as a treatment for antipsychotic-induced weight gain.

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Titel: Brief Report: Metformin for Antipsychotic-Induced Weight Gain in Youth with Autism Spectrum Disorder
Auteurs: Logan K. Wink
Ryan Adams
Ernest V. Pedapati
Kelli C. Dominick
Emma Fox
Catherine Buck
Craig A. Erickson
Publicatiedatum: 26-04-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3132-2

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