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21-08-2018 | Brief Report | Uitgave 1/2019

Journal of Autism and Developmental Disorders 1/2019

Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children

Tijdschrift:
Journal of Autism and Developmental Disorders > Uitgave 1/2019
Auteurs:
Eric Rubenstein, Jessica C. Young, Lisa A. Croen, Carolyn DiGuiseppi, Nicole F. Dowling, Li-Ching Lee, Laura Schieve, Lisa D. Wiggins, Julie Daniels
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10803-018-3721-8) contains supplementary material, which is available to authorized users.
Since study completion, Dr. Dowling has moved to the Division of Cancer Prevention and Control within CDC's National Center for Chronic Disease Prevention and Health Promotion.

Abstract

Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child’s risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.

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Extra materiaal
Supplementary material 1 (DOCX 72 KB)
10803_2018_3721_MOESM1_ESM.docx
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