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The online version of this article (https://doi.org/10.1007/s10803-018-3721-8) contains supplementary material, which is available to authorized users.
Since study completion, Dr. Dowling has moved to the Division of Cancer Prevention and Control within CDC's National Center for Chronic Disease Prevention and Health Promotion.
Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child’s risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.
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Supplementary material 1 (DOCX 72 KB)10803_2018_3721_MOESM1_ESM.docx
American Psychiatric Association. (2000). Diagnostic and statistcal manual of mental disoders ( 4). Arlington: American Psychiatric Publishing.
Broussard, C. S., Rasmussen, S. A., Reefhuis, J., Friedman, J. M., Jann, M. W., Riehle-Colarusso, T., et al. (2011). Maternal treatment with opioid analgesics and risk for birth defects. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/j.ajog.2010.12.039.
Constantino, J. N. (2011). The quantitative nature of autistic social impairment. Pediatric Research. 69(5 Pt 2), 55R–62R, https://doi.org/10.1203/PDR.0b013e318212ec6e. CrossRef
Desai, R. J., Hernandez-Diaz, S., Bateman, B. T., & Huybrechts, K. F. (2014). Increase in prescription opioid use during pregnancy among Medicaid-enrolled women. Obstetrics and Gynecology, 123(5), 997–1002. https://doi.org/10.1097/AOG.0000000000000208. CrossRef
DiGuiseppi, C. G., Daniels, J. L., Fallin, D. M., Rosenberg, S. A., Schieve, L. A., Thomas, K. C., et al. (2016). Demographic profile of families and children in the Study to Explore Early Development (SEED): Case–control study of autism spectrum disorder. Disability and Health Journal, 9(3), 544–551. https://doi.org/10.1016/j.dhjo.2016.01.005. CrossRef
Epstein, R. A., Bobo, W. V., Martin, P. R., Morrow, J. A., Wang, W., Chandrasekhar, R., et al. (2013). Increasing pregnancy-related use of prescribed opioid analgesics. Annals of Epidemiology, 23(8), 498–503. https://doi.org/10.1016/j.annepidem.2013.05.017. CrossRef
Kocek, M., Wilcox, R., Crank, C., & Patra, K. (2016). Evaluation of the relationship between opioid exposure in extremely low birth weight infants in the neonatal intensive care unit and neurodevelopmental outcome at 2 years. Early Human Development, 92, 29–32. https://doi.org/10.1016/j.earlhumdev.2015.11.001. CrossRef
Lind, J. N., Interrante, J. D., Ailes, E. C., Gilboa, S. M., Khan, S., Frey, M. T., et al. (2017). Maternal use of opioids during pregnancy and congenital malformations: A systematic review. Pediatrics. https://doi.org/10.1542/peds.2016-4131.
Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (2012). Autism diagnostic observation schedule. Journal of Autism and Developmental Disorders. 30, 205–223 CrossRef
Lyall, K., Croen, L., Daniels, J., Fallin, M. D., Ladd-Acosta, C., Lee, B. K., et al. (2017). The changing epidemiology of autism spectrum disorders. Annual Review of Public Health, 38, 81–102. https://doi.org/10.1146/annurev-publhealth-031816-044318. CrossRef
Norgaard, M., Nielsson, M. S., & Heide-Jorgensen, U. (2015). Birth and neonatal outcomes following opioid use in pregnancy: A Danish population-based study. Substance Abuse, 9(Suppl 2), 5–11. https://doi.org/10.4137/SART.S23547.
Reddy, U. M., Davis, J. M., Ren, Z., & Greene, M. F., Opioid Use in Pregnancy, N. A. S., & Childhood Outcomes Workshop Invited (2017). Opioid use in pregnancy, neonatal abstinence syndrome, and childhood outcomes: Executive summary of a joint workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, American Academy of Pediatrics, Society for Maternal-Fetal Medicine, Centers for Disease Control and Prevention, and the March of Dimes Foundation. Obstetrics and Gynecology, 130(1), 10–28. https://doi.org/10.1097/AOG.0000000000002054. S. CrossRef
Rutter, M., Bailey, A., & Lord, C. (2003a). SCQ: Social Communication Questionnaire. Los Angeles: Western Psychological Services.
Rutter, M., Le Couteur, A., & Lord, C. (2003b). ADI-R: Autism Diagnostic Interview-Revised.
Schendel, D. E., Diguiseppi, C., Croen, L. A., Fallin, M. D., Reed, P. L., Schieve, L. A., et al. (2012). The Study to Explore Early Development (SEED): A multisite epidemiologic study of autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) network. Journal of Autism and Developmental Disorders, 42(10), 2121–2140. https://doi.org/10.1007/s10803-012-1461-8. CrossRef
Whiteman, V. E., Salemi, J. L., Mogos, M. F., Cain, M. A., Aliyu, M. H., & Salihu, H. M. (2014). Maternal opioid drug use during pregnancy and its impact on perinatal morbidity, mortality, and the costs of medical care in the United States. J Pregnancy. 2014, 906723, https://doi.org/10.1155/2014/906723.
Wiggins, L. D., Reynolds, A., Rice, C. E., Moody, E. J., Bernal, P., Blaskey, L., et al. (2015). Using standardized diagnostic instruments to classify children with autism in the study to explore early development. Journal of Autism and Developmental Disorders, 45(5), 1271–1280. https://doi.org/10.1007/s10803-014-2287-3. CrossRef
Yazdy, M. M., Mitchell, A. A., Tinker, S. C., Parker, S. E., & Werler, M. M. (2013). Periconceptional use of opioids and the risk of neural tube defects. Obstetrics and Gynecology, 122(4), 838–844. https://doi.org/10.1097/AOG.0b013e3182a6643c. CrossRef
- Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children
Jessica C. Young
Lisa A. Croen
Nicole F. Dowling
Lisa D. Wiggins
- Springer US