Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

25-03-2021 | Brief Report

Brief Report: Linguistic Mazes and Perseverations in School-Age Boys with Fragile X Syndrome and Autism Spectrum Disorder and Relationships with Maternal Maze Use

Auteurs: Nell Maltman, Laura Friedman, Emily Lorang, Audra Sterling

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2022

Abstract

Autism spectrum disorder (ASD) and fragile X syndrome (FXS) are neurodevelopmental disorders with overlapping pragmatic language impairments. Prior work suggests pragmatic language differences may run in families. This study examined specific pragmatic difficulties (i.e., linguistic mazes and perseverations) in boys (9–18 years) with idiopathic ASD (n = 26) and FXS+ASD (n = 29), and relationships with maternal maze use. Language samples were obtained separately for boys and mothers. Nonparametric analyses suggested that boys largely did not differ in their rates of mazes, but that boys with FXS+ASD exhibited more perseverations. Mazes were correlated between fragile X dyads. Maternal mazes were correlated with child perseverations among idiopathic ASD dyads. These findings have implications for the etiological significance of ASD-related language phenotypes.

vorige artikel Brief Report: The Benefits of an Employer-Based Work-Experience Program for Participants with ASD

volgende artikel Brief Report: Sources of Sexuality and Relationship Education for Autistic and Neurotypical Adults in the U.S. and a Call to Action

Abbeduto, L., Berry-Kravis, E., Sterling, A., Sherman, S., Edgin, J. O., McDuffie, A., Hoffmann, A., Hamilton, D., Nelson, M., Aschkenasy, J., & Thurman, A. J. (2020). Expressive language sampling as a source of outcome measures for treatment studies in fragile X syndrome: Feasibility, practice effects, test-retest reliability, and construct validity. Journal of Neurodevelopmental Disorders, 12(1), 10. https://doi.org/10.1186/s11689-020-09313-6.CrossRefPubMedPubMedCentral

Abbeduto, L., Thurman, A. J., McDuffie, A., Klusek, J., Feigles, R. T., Ted Brown, W., Harvey, D. J., Adayev, T., LaFauci, G., Dobkins, C., & Roberts, J. E. (2019). ASD comorbidity in fragile X syndrome: Symptom profile and predictors of symptom severity in adolescent and young adult males. Journal of Autism and Developmental Disorders, 49(3), 960–977. https://doi.org/10.1007/s10803-018-3796-2.CrossRefPubMedPubMedCentral

Bangert, K. J., & Finestack, L. H. (2020). Linguistic maze production by children and adolescents with attention-deficit/hyperactivity disorder. Journal of Speech, Language, and Hearing Research, 63(1), 274–285. https://doi.org/10.1044/2019_JSLHR-19-00187.CrossRefPubMedPubMedCentral

Barnlund, D. C. (1970). Transactional model of communication. In K. K. Sereno & C. D. Mortensen (Eds.), Foundations of communication theory. (p. 99). Harper.

Belser, R. C., & Sudhalter, V. (2001). Conversational characteristics of children with fragile X syndrome: Repetitive speech. American Journal of Mental Retardation, 106(1), 28–38. https://doi.org/10.1352/0895-8017(2001)106%3c0028:CCOCWF%3e2.0.CO;2.CrossRefPubMed

Berry-Kravis, E., Doll, E., Sterling, A., Kover, S. T., Schroeder, S. M., Mathur, S., & Abbeduto, L. (2013). Development of an expressive language sampling procedure in fragile X syndrome: A pilot study. Journal of Developmental and Behavioral Pediatrics, 34(4), 245–251. https://doi.org/10.1097/DBP.0b013e31828742fc.CrossRefPubMedPubMedCentral

Bortfeld, H., Leon, S. D., Bloom, J., Schober, M., & Brennan, S. (2001). Disfluency rates in conversation: Effects of age, relationship, topic, role, and gender. Language and Speech, 44, 123–147.CrossRef

Buckingham, H. W., & Christman, S. S. (2004). Perseveration in neurogenic communication disorders. Seminars in Speech and Language, 25(4), 291–293. https://doi.org/10.1055/s-2004-837242.CrossRefPubMed

Byom, L., & Turkstra, L. S. (2017). Cognitive task demands and discourse performance after traumatic brain injury. International Journal of Language & Communication Disorders, 52(4), 501–513. https://doi.org/10.1111/1460-6984.12289.CrossRef

Chaste, P., Roeder, K., & Devlin, B. (2017). The Yin and Yang of autism genetics: How rare de novo and common variations affect liability. Annual Review of Genomics and Human Genetics. https://doi.org/10.1146/annurev-genom-083115-022647.CrossRefPubMed

Christman, S. S., Boutsen, F. R., & Buckingham, H. W. (2004). Perseveration and other repetitive verbal behaviors: Functional dissociations. Seminars in Speech and Language, 25(4), 295–307. https://doi.org/10.1055/s-2004-837243.CrossRefPubMed

Clifford, S., Dissanayake, C., Bui, Q. M., Huggins, R., Taylor, A. K., & Loesch, D. Z. (2007). Autism spectrum phenotype in males and females with fragile X full mutation and premutation. Journal of Autism and Developmental Disorders, 37(4), 738–747. https://doi.org/10.1007/s10803-006-0205-z.CrossRefPubMed

Cohen, J. (1988). Statistical power analysis for the behavioral sciences. . Routledge.

Coleman, C. (2013). How can you tell if childhood stuttering is the real deal? Retrieved from https://leader.pubs.asha.org/do/https://doi.org/10.1044/how-can-you-tell-if-childhood-stuttering-is-the-real-deal/full/

Couper-Kuhlen, E. (2018). Interactional linguistics: Studying language in social interaction. . Cambridge University Press.

Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., Licatalosi, D. D., Richter, J. D., & Darnell, R. B. (2011). FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell, 146(2), 247–261. https://doi.org/10.1016/j.cell.2011.06.013.CrossRefPubMedPubMedCentral

Del Hoyo Soriano, L., Thurman, A. J., Harvey, D., Kover, S. T., & Abbeduto, L. (2020). Expressive language development in adolescents with Down syndrome and fragile X syndrome: Change over time and the role of family-related factors. Journal of Neurodevelopmental Disorders, 12(1), 18. https://doi.org/10.1186/s11689-020-09320-7.CrossRefPubMedPubMedCentral

Dennis, M., Francis, D. J., Cirino, P. T., Schachar, R., Barnes, M. A., & Fletcher, J. M. (2009). Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. Journal of the International Neuropsychological Society, 15(3), 331–343. https://doi.org/10.1017/S1355617709090481.CrossRefPubMedPubMedCentral

Dollaghan, C. A., & Campbell, T. F. (1992). A procedure for classifying disruptions in spontaneous language samples. Topics in Language Disorders, 12, 56–68.CrossRef

Engelhardt, P., Alfridijanta, O., McMullon, M. E. G., & Corley, M. (2017). Speaker-versus listener-oriented disfluency: A re-examination of arguments and assumptions from autism spectrum disorder. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-017-3215-0.CrossRefPubMedPubMedCentral

Engelhardt, P., Corley, M., Nigg, J., & Ferreira, F. (2010). The role of inhibition in the production of disfluencies. Memory & Cognition, 38(5), 617–628. https://doi.org/10.3758/MC.38.5.617.CrossRef

Engelhardt, P. E., Ferreira, F., & Nigg, J. T. (2011). Language production strategies and disfluencies in multi-clause network descriptions: A study of adult attention-deficit/hyperactivity disorder. Neuropsychology, 25(4), 442–453. https://doi.org/10.1037/a0022436.CrossRefPubMedPubMedCentral

Engelhardt, P. E., Nigg, J. T., & Ferreira, F. (2013). Is the fluency of language outputs related to individual differences in intelligence and executive function? Acta Psychologica, 144(2), 424–432. https://doi.org/10.1016/j.actpsy.2013.08.002.CrossRefPubMedPubMedCentral

Field, A. (2013). Discovering statistics using IBM SPSS statistics. (4th ed.). SAGE Publications Ltd.

Friedman, L., Sterling, A., & Barton-Hulsey, A. (2018). Gaze avoidance and perseverative language in fragile X syndrome and autism spectrum disorder: Brief report. Developmental Neurorehabilitation, 21(2), 137–140. https://doi.org/10.1080/17518423.2018.1424264.CrossRefPubMedPubMedCentral

Gaetano, J. (2013). Holm-Bonferroni Sequential Correction: An EXCEL Calculator.

Gotham, K., Pickles, A., & Lord, C. (2009). Standardizing ADOS scores for a measure of severity in autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(5), 693–705. https://doi.org/10.1007/s10803-008-0674-3.CrossRefPubMed

Guitar, B. (2014). Stuttering: An integrated approach to its nature and treatment. (4th ed.). Lippincott Williams & Wilkins.

Hilvert, E., Sterling, A., Haebig, E., & Friedman, L. (2020). Expressive language abilities of boys with idiopathic autism spectrum disorder and boys with fragile X syndrome + autism spectrum disorder: Cross-context comparisons. Autism & Developmental Language Impairments, 5, 1–16.CrossRef

Iossifov, I., Ronemus, M., Levy, D., Wang, Z., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y. H., Narzisi, G., Leotta, A., Kendall, J., Grabowska, E., Ma, B., Marks, S., Rodgers, L., Stepansky, A., Troge, J., Andrews, P., Bekritsky, M., … Wigler, M. (2012). De novo gene disruptions in children on the autistic spectrum. Neuron, 74(2), 285–299. https://doi.org/10.1016/j.neuron.2012.04.009.CrossRefPubMedPubMedCentral

Irvine, C. A., Eigsti, I. M., & Fein, D. A. (2015). Uh, um, and autism: Filler disfluencies as pragmatic markers in adolescents with optimal outcomes from autism spectrum disorder. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-015-2651-y.CrossRef

Klusek, J., Martin, G. E., & Losh, M. (2014). A comparison of pragmatic language in boys with autism and fragile X syndrome. Journal of Speech, Language, and Hearing Research, 57(5), 1692–1707. https://doi.org/10.1044/2014_JSLHR-L-13-0064.CrossRefPubMed

Klusek, J., Porter, A., Abbeduto, L., Adayev, T., Tassone, F., Mailick, M. R., Glicksman, A., Tonnsen, B. L., & Roberts, J. E. (2018). Curvilinear association between language disfluency and FMR1 CGG repeat size across the normal, intermediate, and premutation range. Frontiers in Genetics, 9, 344. https://doi.org/10.3389/fgene.2018.00344.CrossRefPubMedPubMedCentral

Kover, S. T., & Abbeduto, L. (2010). Expressive language in male adolescents with fragile X syndrome with and without comorbid autism. Journal of Intellectual Disability Research, 54(3), 246–265. https://doi.org/10.1111/j.1365-2788.2010.01255.x.CrossRefPubMed

Kover, S. T., & Atwoo, A. K. (2013). Establishing equivalence: Methodological progress in group-matching design and analysis. American Journal on Intellectual and Developmental Disabilities, 118(1), 3–15. https://doi.org/10.1352/1944-7558-118.1.3.CrossRefPubMedPubMedCentral

Kover, S. T., McDuffie, A., Abbeduto, L., & Brown, W. T. (2012). Effects of sampling context on spontaneous expressive language in males with fragile X syndrome or Down syndrome. Journal of Speech, Language, and Hearing Research, 55(4), 1022–1038. https://doi.org/10.1044/1092-4388(2011/11-0075).CrossRefPubMed

Lake, J. K., Humphreys, K. R., & Cardy, S. (2011). Listener vs. speaker-oriented aspects of speech: Studying the disfluencies of individuals with autism spectrum disorders. Psychonomic Bulletin & Review, 18(1), 135–140.CrossRef

Landa, R., Piven, J., Wzorek, M. M., Gayle, J. O., Chase, G. A., & Folstein, S. E. (1992). Social language use in parents of autistic individuals. Psychological Medicine, 22(1), 245–254.CrossRef

Lee, M., Martin, G. E., Berry-Kravis, E., & Losh, M. (2016). A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome. Journal of Neurodevelopmental Disorders, 8, 47. https://doi.org/10.1186/s11689-016-9179-0.CrossRefPubMedPubMedCentral

Lord, C., Rutter, M., Di Lavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule: Manual. . Western Psychological Services.

Lord, C., Rutter, M., Di Lavore, P. C., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule. (2nd ed.). Western Psychological Services.

Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. American Journal of Medical Genetics, 147B(4), 424–433. https://doi.org/10.1002/ajmg.b.30612.CrossRefPubMedPubMedCentral

Losh, M., Klusek, J., Martin, G. E., Sideris, J., Parlier, M., & Piven, J. (2012). Defining genetically meaningful language and personality traits in relatives of individuals with fragile X syndrome and relatives of individuals with autism. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 159B(6), 660–668. https://doi.org/10.1002/ajmg.b.32070.CrossRef

Losh, M., Martin, G. E., Klusek, J., & Hogan-Brown, A. L. (2012a). Pragmatic language in autism and fragile X syndrome: Genetic and clinical applications. Perspectives on Language Learning and Education, 19, 48–55. https://doi.org/10.1044/lle19.2.48.CrossRefPubMedPubMedCentral

Losh, M., Martin, G. E., Klusek, J., Hogan-Brown, A. L., & Sideris, J. (2012b). Social communication and theory of mind in boys with autism and fragile X syndrome. Frontiers in Psychology, 3, 266. https://doi.org/10.3389/fpsyg.2012.00266.CrossRefPubMedPubMedCentral

MacFarlane, H., Gorman, K., Ingham, R., Presmanes Hill, A., Papadakis, K., Kiss, G., & van Santen, J. (2017). Quantitative analysis of disfluency in children with autism spectrum disorder or language impairment. PLoS ONE, 12(3), e0173936. https://doi.org/10.1371/journal.pone.0173936.CrossRefPubMedPubMedCentral

Magana, A. B., Goldstein, J. M., Karno, M., Miklowitz, D. J., Jenkins, J., & Falloon, I. R. (1986). A brief method for assessing expressed emotion in relatives of psychiatric patients. Psychiatry Research, 17(3), 203–212. https://doi.org/10.1016/0165-1781(86)90049-1.CrossRefPubMed

Maltman, N. (2019). Discourse marker use as a pragmatic language endophenotype of ASD: Links to cognitive domains and the FMR1 gene. ProQuest. Dissertation, Northwestern University

Martin, G. E., Bush, L., Klusek, J., Patel, S., & Losh, M. (2018). A multimethod analysis of pragmatic skills in children and adolescents with fragile X syndrome, autism spectrum disorder, and down syndrome. Journal of Speech, Language, and Hearing Research, 61(12), 3023–3037. https://doi.org/10.1044/2018_JSLHR-L-18-0008.CrossRefPubMedPubMedCentral

Martin, G. E., Roberts, J. E., Helm-Estabrooks, N., Sideris, J., Vanderbilt, J., & Moskowitz, L. (2012). Perseveration in the connected speech of boys with fragile X syndrome with and without autism spectrum disorder. American Journal on Intellectual and Developmental Disabilities, 117(5), 384–399. https://doi.org/10.1352/1944-7558-117.5.384.CrossRefPubMedPubMedCentral

Miller, J. F., Andriacchi, K., & Nockerts, A. (2019). A clinician’s guide to language sample analysis. In K. Andriacchi, J. F. Miller, & A. Nockerts (Eds.), Assessing language production using SALT software. (3rd ed.). SALT Software LLC.

Miller, J. F., & Chapman, R. S. (2008). Systematic Analysis of Language Transcripts (SALT).

Movaghar, A., Mailick, M., Sterling, A., Greenberg, J., & Saha, K. (2017). Automated screening for Fragile X premutation carriers based on linguistic and cognitive computational phenotypes. Science and Reports, 7(1), 2674. https://doi.org/10.1038/s41598-017-02682-4.CrossRef

Niu, M., Han, Y., Dy, A. B. C., Du, J., Jin, H., Qin, J., Zhang, J., Li, Q., & Hagerman, R. J. (2017). Autism symptoms in fragile X syndrome. Journal of Child Neurology, 32(10), 903–909. https://doi.org/10.1177/0883073817712875.CrossRefPubMed

Piven, J., Palmer, P., Landa, R., Santangelo, S., Jacobi, D., & Childress, D. (1997). Personality and language characteristics in parents from multiple-incidence autism families. American Journal of Medical Genetics, 74(4), 398–411.CrossRef

Postma, A., Kolk, H., & Povel, D. J. (1990). On the relation among speech errors, disfluencies, and self-repairs. Language and Speech, 33(Pt 1), 19–29. https://doi.org/10.1177/002383099003300102.CrossRefPubMed

Roberts, J., Martin, G. E., Moskowitz, L., Harris, A. A., Foreman, J., & Nelson, L. (2007). Discourse skills of boys with fragile X syndrome in comparison to boys with Down syndrome. Journal of Speech, Language, and Hearing Research, 50(2), 475–492. https://doi.org/10.1044/1092-4388(2007/033).CrossRefPubMed

Roid, G. H., & Miller, L. J. (1997). Leiter-R: Leiter international performance scale. . Stoelting.

Sterling, A. (2018). Grammar in boys with idiopathic autism spectrum disorder and boys with fragile X syndrome plus autism spectrum disorder. Journal of Speech, Language, and Hearing Research, 61(4), 857–869. https://doi.org/10.1044/2017_JSLHR-L-17-0248.CrossRefPubMedPubMedCentral

Sterling, A., Mailick, M., Greenberg, J., Warren, S. F., & Brady, N. (2013). Language dysfluencies in females with the FMR1 premutation. Brain and Cognition, 82(1), 84–89. https://doi.org/10.1016/j.bandc.2013.02.009.CrossRefPubMedPubMedCentral

Sudhalter, V., Cohen, I. L., Silverman, W., & Wolf-Schein, E. G. (1990). Conversational analyses of males with fragile X, Down syndrome, and autism: Comparison of the emergence of deviant language. American Journal of Mental Retardation, 94(4), 431–441.PubMed

Suh, J., Eigsti, I. M., Naigles, L., Barton, M., Kelley, E., & Fein, D. (2014). Narrative performance of optimal outcome children and adolescents with a history of an autism spectrum disorder (ASD). Journal of Autism and Developmental Disorders, 44(7), 1681–1694. https://doi.org/10.1007/s10803-014-2042-9.CrossRefPubMedPubMedCentral

Thordardottir, E. T., & Ellis Weismer, S. (2002). Content mazes and filled pauses in narrative language samples of children with specific language impairment. Brain and Cognition, 48(2–3), 587–592. https://doi.org/10.1006/brcg.2001.1422.CrossRefPubMed

Turkstra, L. S., Fuller, T., Youngstrom, E., Green, K., & Kuegeler, E. (2004). Conversational fluency and executive function in adolescents with conduct disorder. Acta Neuropsychologica, 2(1), 70–85.PubMedPubMedCentral

Van Borsel, J., Dor, O., & Rondal, J. (2008). Speech fluency in fragile X syndrome. Clinical Linguistics & Phonetics, 22(1), 1–11. https://doi.org/10.1080/02699200701601997.CrossRef

Titel: Brief Report: Linguistic Mazes and Perseverations in School-Age Boys with Fragile X Syndrome and Autism Spectrum Disorder and Relationships with Maternal Maze Use
Auteurs: Nell Maltman
Laura Friedman
Emily Lorang
Audra Sterling
Publicatiedatum: 25-03-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-04981-2

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 2/2022

Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression

What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism?

Understanding Camouflaging as a Response to Autism-Related Stigma: A Social Identity Theory Approach

Emergency Department Utilization of Adolescents and Young Adults with Autism Spectrum Disorder

Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome

Alexithymia and Autistic Traits as Contributing Factors to Empathy Difficulties in Preadolescent Children