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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2007

01-02-2007 | Original paper

Brief Report: Identical Male Twins Concordant for Asperger’s Disorder

Auteurs: Michiko Ishijima, Hiroshi Kurita

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2007

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Abstract

The first case study of identical male twins concordant for DSM-IV Asperger’s disorder (ASD) was presented. Their monozygocity was confirmed by short tandem repeat analyses with a probability of 99.999963%. Despite sharing the same DNA and environment, the twins are different in comorbidity (i.e., major depressive disorder in the elder and absence seizure in the younger) and in IQs and motor performance (i.e., the elder was lower in IQs and clumsier). Both of them were normal in computed tomographic scanning and magnetic resonance imaging discordant with some previous reports of brain imaging abnormalities in ASD. Further studies are needed to clarify inherited/acquired epigenetic defects and brain imaging abnormalities relating to behavioral phenotypes in ASD twins.
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Metagegevens
Titel
Brief Report: Identical Male Twins Concordant for Asperger’s Disorder
Auteurs
Michiko Ishijima
Hiroshi Kurita
Publicatiedatum
01-02-2007
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0150-x