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Journal of Autism and Developmental Disorders

Gepubliceerd in:

24-02-2020 | S.I. : Suicidality and Self-harm in Autism

Brief Report: Genetic Links Between Autism and Suicidal Behavior—A Preliminary Investigation

Auteurs: Emily DiBlasi, Anne V. Kirby, Eoin Gaj, Anna R. Docherty, Brooks R. Keeshin, Amanda V. Bakian, Hilary Coon

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2020

Abstract

Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD.

vorige artikel What is the Prevalence of Self-harming and Suicidal Behaviour in Under 18s with ASD, With or Without an Intellectual Disability?

volgende artikel An Exploratory Analysis of Predictors of Youth Suicide-Related Behaviors in Autism Spectrum Disorder: Implications for Prevention Science

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Titel: Brief Report: Genetic Links Between Autism and Suicidal Behavior—A Preliminary Investigation
Auteurs: Emily DiBlasi
Anne V. Kirby
Eoin Gaj
Anna R. Docherty
Brooks R. Keeshin
Amanda V. Bakian
Hilary Coon
Publicatiedatum: 24-02-2020
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04419-1

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