Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

12-12-2018 | Brief Report

Brief Report: Challenging Behaviors in Toddlers and Preschoolers with Angelman, Prader–Willi, and Williams Syndromes

Auteurs: Wei Siong Neo, Bridgette L. Tonnsen

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2019

Abstract

Children with neurogenetic syndromes (NGS) experience comorbid challenging behaviors and psychopathology. We examined challenging behaviors in 86 toddlers and preschoolers across three NGS [Angelman syndrome (AS), Prader–Willi syndrome (PWS), and Williams syndrome (WS)] and 43 low-risk controls (LRC), using the Child Behavior Checklist for Ages 1½–5. Challenging behavior profiles differed across NGS, with generally elevated behaviors in AS and WS, but not PWS, relative to LRC. Withdrawn and autism spectrum symptoms were particularly elevated in AS. Although several profiles were similar to those previously reported in older children and adults, we also observed inconsistencies that suggest non-linear developmental patterns of challenging behaviors. These findings underscore the importance of characterizing early challenging behaviors to inform atypical phenotypic development and targeted intervention.

vorige artikel Brief Report: A Novel System to Evaluate Autism Spectrum Disorders Using Two Humanoid Robots

volgende artikel Brief Report: Pilot Study of a Novel Interactive Digital Treatment to Improve Cognitive Control in Children with Autism Spectrum Disorder and Co-occurring ADHD Symptoms

Abel, E. A., & Tonnsen, B. L. (2017). Sleep phenotypes in infants and toddlers with neurogenetic syndromes. Sleep Medicine, 38, 130–134.PubMedCrossRef

Achenbach, T. M., & Rescorla, L. A. (2000). Manual for the ASEBA preschool forms and profiles. Burlington: University of Vermont Research Center for Children, Youth, and Families.

Åkefeldt, A., & Gillberg, C. (1999). Behavior and personality characteristics of children and young adults with Prader–Willi syndrome: A controlled study. Journal of the American Academy of Child and Adolescent Psychiatry, 38(6), 761–769.PubMedCrossRef

Alexander, R. C. (2016). Prader–Willi syndrome. In I. L. Rubin, J. Merrick, D. E. Greydanus & D. R. Patel (Eds.), Health care for people with intellectual and developmental disabilities across the lifespan (pp. 779–798). Switzerland: Springer International Publishing.CrossRef

Annaz, D., Hill, C. M., Ashworth, A., Holley, S., & Karmiloff-Smith, A. (2011). Characterisation of sleep problems in children with Williams syndrome. Research in Developmental Disabilities, 32(1), 164–169.PubMedCrossRef

Baranek, G. T., Roberts, J. E., David, F. J., Sideris, J., Mirrett, P. L., Hatton, D. D., & Bailey, D. B. (2008). Developmental trajectories and correlates of sensory processing in young boys with fragile X syndrome. Physical and Occupational Therapy in Pediatrics, 28(1), 79–98.PubMedCrossRef

Berry, R. J., Leitner, R. P., Clarke, A. R., & Einfeld, S. L. (2005). Behavioral aspects of Angelman syndrome: A case control study. American Journal of Medical Genetics Part A, 132A(1), 8–12.PubMedCrossRef

Betancur, C. (2011). Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting. Brain Research, 1380, 42–77.PubMedCrossRef

Bonati, M. T., Russo, S., Finelli, P., Valsecchi, M. R., Cogliati, F., Cavalleri, F., et al. (2007). Evaluation of autism traits in Angelman syndrome: A resource to unfold autism genes. Neurogenetics, 8(3), 169–178.PubMedCrossRef

Borsboom, D. (2006). When does measurement invariance matter? Medical Care, 44(11), S176–S181.PubMedCrossRef

Clarke, D. J., & Marston, G. (2000). Problem behaviors associated with 15q- Angelman syndrome. American Journal on Mental Retardation, 105(1), 25–31.PubMedCrossRef

Cohen, J. (1992). A power primer. Psychological Bulletin, 112(1), 155–159.PubMedCrossRef

de Lijster, J. M., Dierckx, B., Utens, E. M. W. J., Verhulst, F. C., Zieldorff, C., Dieleman, G. C., & Legerstee, J. S. (2017). The age of onset of anxiety disorders: A meta-analysis. The Canadian Journal of Psychiatry, 62(4), 237–246.PubMedCrossRef

Dimitropoulos, A., Blackford, J., Walden, T., & Thompson, T. (2006). Compulsive behavior in Prader–Willi syndrome: Examining severity in early childhood. Research in Developmental Disabilities, 27(2), 190–202.PubMedCrossRef

Dimitropoulos, A., Feurer, I. D., Butler, M. G., & Thompson, T. (2001). Emergence of compulsive behavior and tantrums in children with Prader–Willi syndrome. American Journal on Mental Retardation, 106(1), 39–51.PubMedCrossRef

Dykens, E. M., Roof, E., Hunt-Hawkins, H., Dankner, N., Lee, E. B., Shivers, C. M., et al. (2017). Diagnoses and characteristics of autism spectrum disorders in children with Prader–Willi syndrome. Journal of Neurodevelopmental Disorders, 9, 1–12.CrossRef

Fidler, D. J., Most, D. E., Booth-LaForce, C., & Kelly, J. F. (2006). Temperament and behaviour problems in young children with Down syndrome at 12, 30, and 45 months. Down Syndrome Research and Practice, 10(1), 23–29.CrossRef

Fritz, C. O., Morris, P. E., & Richler, J. J. (2012). Effect size estimates: Current use, calculations, and interpretation. Journal of Experimental Psychology: General, 141(1), 2–18.CrossRef

Glascoe, F. P., & Dworkin, P. H. (1995). The role of parents in the detection of developmental and behavioral problems. Pediatrics, 95(6), 829–836.PubMed

Glenn, S., & Cunningham, C. (2007). Typical or pathological? Routinized and compulsive-like behaviors in children and young people with Down syndrome. Intellectual and Developmental Disabilities, 45(4), 246–256.PubMedCrossRef

Green, J., Pickles, A., Pasco, G., Bedford, R., Wan, M. W., Elsabbagh, M., et al. (2017). Randomised trial of a parent-mediated intervention for infants at high risk for autism: Longitudinal outcomes to age 3 years. Journal of Child Psychology and Psychiatry, 58(12), 1330–1340.PubMedCrossRef

Greydanus, D. E., Pratt, H. D., & Pryson, M. (2016). Angelman syndrome. In I. L. Rubin, J. Merrick, D. E. Greydanus & D. R. Patel (Eds.), Health care for people with intellectual and developmental disabilities across the lifespan (pp. 815–819). Cham: Springer International Publishing.CrossRef

Hahn, L. J., Fidler, D. J., & Hepburn, S. L. (2014). Adaptive behavior and problem behavior in young children with Williams syndrome. American Journal on Intellectual and Developmental Disabilities, 119(1), 49–63.PubMedCrossRef

Hinshaw, S. P., Han, S. S., Erhardt, D., & Huber, A. (1992). Internalizing and externalizing behavior problems in preschool children: Correspondence among parent and teacher ratings and behavior observations. Journal of Clinical Child Psychology, 21(2), 143–150.CrossRef

Hodapp, R. M., DesJardin, J. L., & Ricci, L. A. (2003). Genetic syndromes of mental retardation: Should they matter for the early interventionist? Infants and Young Children, 16(2), 152–160.CrossRef

Hodapp, R. M., & Dykens, E. M. (2007). Behavioral effects of genetic mental retardation disorders. In J. W. Jacobson, J. A. Mulick & J. Rojahn (Eds.), Handbook of intellectual and developmental disabilities (pp. 115–131). New York: Springer.CrossRef

Hustyi, K. M., Hammond, J. L., Rezvani, A. B., & Hall, S. S. (2013). An analysis of the topography, severity, potential sources of reinforcement, and treatments utilized for skin picking in Prader–Willi syndrome. Research in Developmental Disabilities, 34(9), 2890–2899.PubMedCrossRef

Karmiloff-Smith, A. (2009). Nativism versus neuroconstructivism: Rethinking the study of developmental disorders. Developmental Psychology, 45(1), 56–63.PubMedCrossRef

Kessler, R. C., Amminger, G. P., Aguilar-Gaxiola, S., Alonso, J., Lee, S., & Üstün, T. B. (2007). Age of onset of mental disorders: A review of recent literature. Current Opinion in Psychiatry, 20(4), 359–364.PubMedPubMedCentralCrossRef

Klaassen, P., Duijff, S., Swanenburg de Veye, H., Vorstman, J., Beemer, F., & Sinnema, G. (2013). Behavior in preschool children with the 22q11.2 deletion syndrome. American Journal of Medical Genetics Part A, 161A(1), 94–101.PubMedCrossRef

Klein-Tasman, B. P., & Lee, K. (2017). Problem behaviour and psychosocial functioning in young children with Williams syndrome: Parent and teacher perspectives. Journal of Intellectual Disability Research, 61(9), 853–865.PubMedCrossRef

Klein-Tasman, B. P., Phillips, K. D., Lord, C. E., Mervis, C. B., & Gallo, F. (2009). Overlap with the autism spectrum in young children with Williams syndrome. Journal of Developmental and Behavioral Pediatrics, 30(4), 289–299.PubMedPubMedCentralCrossRef

Larson, A. M., Shinnick, J. E., Shaaya, E. A., Thiele, E. A., & Thibert, R. L. (2015). Angelman syndrome in adulthood. American Journal of Medical Genetics Part A, 167A(2), 331–344.PubMedCrossRef

Leyfer, O. T., Woodruff-Borden, J., Klein-Tasman, B. P., Fricke, J. S., & Mervis, C. B. (2006). Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B(6), 615–622.CrossRef

Low Kapalu, C. M., & Gartstein, M. A. (2016). Boys with fragile X syndrome: Investigating temperament in early childhood. Journal of Intellectual Disability Research, 60(9), 891–900.PubMedCrossRef

Maas, A. P. H. M., Sinnema, M., Didden, R., Maaskant, M. A., Smits, M. G., Schrander-Stumpel, C. T., R. M., et al. (2010). Sleep disturbances and behavioural problems in adults with Prader–Willi syndrome. Journal of Intellectual Disability Research, 54(10), 906–917.PubMedCrossRef

Medeiros, K., Mazurek, M. O., & Kanne, S. (2017). Investigating the factor structure of the Child Behavior Checklist in a large sample of children with autism spectrum disorder. Research in Autism Spectrum Disorders, 40, 24–40.CrossRef

Morris, C. A. (2010). The behavioral phenotype of Williams syndrome: A recognizable pattern of neurodevelopment. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 154C(4), 427–431.CrossRef

Pandolfi, V., Magyar, C. I., & Dill, C. A. (2009). Confirmatory factor analysis of the Child Behavior Checklist 1.5-5 in a sample of children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(7), 986–995.PubMedPubMedCentralCrossRef

Pereira, E. M., Marion, R. W., & Pober, B. R. (2016). Williams syndrome. In I. L. Rubin, J. Merrick, D. E. Greydanus & D. R. Patel (Eds.), Health care for people with intellectual and developmental disabilities across the lifespan (pp. 799–814). Cham: Springer International Publishing.CrossRef

Rapee, R. M., Kennedy, S. J., Ingram, M., Edwards, S. L., & Sweeney, L. (2010). Altering the trajectory of anxiety in at-risk young children. American Journal of Psychiatry, 167(12), 1518–1525.PubMedCrossRef

Reilly, C., Murtagh, L., & Senior, J. (2015). The impact on the family of four neurogenetic syndromes: A comparative study of parental views. Journal of Genetic Counseling, 24(5), 851–861.PubMedCrossRef

Rescorla, L. A. (2005). Assessment of young children using the Achenbach System of Empirically Based Assessment (ASEBA). Mental Retardation and Developmental Disabilities Research Reviews, 11(3), 226–237.PubMedCrossRef

Rhodes, S. M., Riby, D. M., Matthews, K., & Coghill, D. R. (2011). Attention-deficit/hyperactivity disorder and Williams syndrome: Shared behavioral and neuropsychological profiles. Journal of Clinical and Experimental Neuropsychology, 33(1), 147–156.PubMedCrossRef

Roberts, J. E., Tonnsen, B., Robinson, A., & Shinkareva, S. V. (2012). Heart activity and autistic behavior in infants and toddlers with fragile X syndrome. American Journal on Intellectual and Developmental Disabilities, 117(2), 90–102.PubMedPubMedCentralCrossRef

Royston, R., Howlin, P., Waite, J., & Oliver, C. (2017). Anxiety disorders in Williams syndrome contrasted with intellectual disability and the general population: A systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 47(12), 3765–3777.PubMedCrossRef

Shriki-Tal, L., Avrahamy, H., Pollak, Y., Gross-Tsur, V., Genstil, L., Hirsch, H. J., & Benarroch, F. (2017). Psychiatric disorders in a cohort of individuals with Prader–Willi syndrome. European Psychiatry, 44, 47–52.PubMedCrossRef

Soorya, L., Leon, J., Trelles, M. P., & Thurm, A. (2018). Framework for assessing individuals with rare genetic disorders associated with profound intellectual and multiple disabilities (PIMD): The example of Phelan McDermid syndrome. The Clinical Neuropsychologist, 32(7), 1226–1255.PubMedCrossRef

Spruyt, K., Braam, W., & Curfs, L. M. G. (2018). Sleep in Angelman syndrome: A review of evidence. Sleep Medicine Reviews, 37, 69–84.PubMedCrossRef

Tonnsen, B. L., Grefer, M. L., Hatton, D. D., & Roberts, J. E. (2015). Developmental trajectories of attentional control in preschool males with fragile X syndrome. Research in Developmental Disabilities, 36, 62–71.CrossRef

Tunnicliffe, P., Woodcock, K., Bull, L., Oliver, C., & Penhallow, J. (2014). Temper outbursts in Prader–Willi syndrome: Causes, behavioural and emotional sequence and responses by carers. Journal of Intellectual Disability Research, 58(2), 134–150.PubMedCrossRef

Waite, J., Rose, J., Wilde, L., Eden, K., Stinton, C., Moss, J., & Oliver, C. (2017). Associations between behaviours that challenge in adults with intellectual disability, parental perceptions and parental mental health. British Journal of Clinical Psychology, 56(4), 408–430.PubMedCrossRef

Welham, A., Lau, J. K. L., Moss, J., Cullen, J., Higgs, S., Warren, G., et al. (2015). Are Angelman and Prader–Willi syndromes more similar than we thought? Food-related behavior problems in Angelman, Cornelia de Lange, fragile X, Prader–Willi and 1p36 deletion syndromes. American Journal of Medical Genetics Part A, 167A(3), 572–578.PubMedCrossRef

Whitcomb, S. A. (2018). Behavioral, social, and emotional assessment of children and adolescents (5th edn.). New York: Routledge.

Whittington, J., & Holland, A. (2010). Neurobehavioral phenotype in Prader–Willi syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 154C(4), 438–447.CrossRef

Williams, C. A. (2010). The behavioral phenotype of the Angelman syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 154C(4), 432–437.CrossRef

Yang, L., Zhan, G.-D., Ding, J.-J., Wang, H.-J., Ma, D., Huang, G.-Y., et al. (2013). Psychiatric illness and intellectual disability in the Prader–Willi syndrome with different molecular defects: A meta analysis. PLoS ONE, 8(8), 1–11.CrossRef

Zafeiriou, D. I., Ververi, A., Dafoulis, V., Kalyva, E., & Vargiami, E. (2013). Autism spectrum disorders: The quest for genetic syndromes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162B(4), 327–366.CrossRef

Titel: Brief Report: Challenging Behaviors in Toddlers and Preschoolers with Angelman, Prader–Willi, and Williams Syndromes
Auteurs: Wei Siong Neo
Bridgette L. Tonnsen
Publicatiedatum: 12-12-2018
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-018-3853-x

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 4/2019

Brief Report: Evaluating the Utility of Varied Technological Agents to Elicit Social Attention from Children with Autism Spectrum Disorders

Editorial: 2018 in Review

Autism Spectrum Disorder: Incidence and Time Trends Over Two Decades in a Population-Based Birth Cohort

Predictors of Pragmatic Communication in School-Age Siblings of Children with ASD and Low-Risk Controls

An International Survey of Parental Attitudes to Technology Use by Their Autistic Children at Home

Brief Report: A Novel System to Evaluate Autism Spectrum Disorders Using Two Humanoid Robots