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Children with neurogenetic syndromes (NGS) experience comorbid challenging behaviors and psychopathology. We examined challenging behaviors in 86 toddlers and preschoolers across three NGS [Angelman syndrome (AS), Prader–Willi syndrome (PWS), and Williams syndrome (WS)] and 43 low-risk controls (LRC), using the Child Behavior Checklist for Ages 1½–5. Challenging behavior profiles differed across NGS, with generally elevated behaviors in AS and WS, but not PWS, relative to LRC. Withdrawn and autism spectrum symptoms were particularly elevated in AS. Although several profiles were similar to those previously reported in older children and adults, we also observed inconsistencies that suggest non-linear developmental patterns of challenging behaviors. These findings underscore the importance of characterizing early challenging behaviors to inform atypical phenotypic development and targeted intervention.
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Achenbach, T. M., & Rescorla, L. A. (2000). Manual for the ASEBA preschool forms and profiles. Burlington: University of Vermont Research Center for Children, Youth, and Families.
Alexander, R. C. (2016). Prader–Willi syndrome. In I. L. Rubin, J. Merrick, D. E. Greydanus & D. R. Patel (Eds.), Health care for people with intellectual and developmental disabilities across the lifespan (pp. 779–798). Switzerland: Springer International Publishing. CrossRef
Dykens, E. M., Roof, E., Hunt-Hawkins, H., Dankner, N., Lee, E. B., Shivers, C. M., et al. (2017). Diagnoses and characteristics of autism spectrum disorders in children with Prader–Willi syndrome. Journal of Neurodevelopmental Disorders, 9, 1–12. CrossRef
Fidler, D. J., Most, D. E., Booth-LaForce, C., & Kelly, J. F. (2006). Temperament and behaviour problems in young children with Down syndrome at 12, 30, and 45 months. Down Syndrome Research and Practice, 10(1), 23–29. CrossRef
Fritz, C. O., Morris, P. E., & Richler, J. J. (2012). Effect size estimates: Current use, calculations, and interpretation. Journal of Experimental Psychology: General, 141(1), 2–18. CrossRef
Glascoe, F. P., & Dworkin, P. H. (1995). The role of parents in the detection of developmental and behavioral problems. Pediatrics, 95(6), 829–836. PubMed
Greydanus, D. E., Pratt, H. D., & Pryson, M. (2016). Angelman syndrome. In I. L. Rubin, J. Merrick, D. E. Greydanus & D. R. Patel (Eds.), Health care for people with intellectual and developmental disabilities across the lifespan (pp. 815–819). Cham: Springer International Publishing. CrossRef
Hinshaw, S. P., Han, S. S., Erhardt, D., & Huber, A. (1992). Internalizing and externalizing behavior problems in preschool children: Correspondence among parent and teacher ratings and behavior observations. Journal of Clinical Child Psychology, 21(2), 143–150. CrossRef
Hodapp, R. M., DesJardin, J. L., & Ricci, L. A. (2003). Genetic syndromes of mental retardation: Should they matter for the early interventionist? Infants and Young Children, 16(2), 152–160. CrossRef
Hodapp, R. M., & Dykens, E. M. (2007). Behavioral effects of genetic mental retardation disorders. In J. W. Jacobson, J. A. Mulick & J. Rojahn (Eds.), Handbook of intellectual and developmental disabilities (pp. 115–131). New York: Springer. CrossRef
Leyfer, O. T., Woodruff-Borden, J., Klein-Tasman, B. P., Fricke, J. S., & Mervis, C. B. (2006). Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B(6), 615–622. CrossRef
Medeiros, K., Mazurek, M. O., & Kanne, S. (2017). Investigating the factor structure of the Child Behavior Checklist in a large sample of children with autism spectrum disorder. Research in Autism Spectrum Disorders, 40, 24–40. CrossRef
Morris, C. A. (2010). The behavioral phenotype of Williams syndrome: A recognizable pattern of neurodevelopment. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 154C(4), 427–431. CrossRef
Pereira, E. M., Marion, R. W., & Pober, B. R. (2016). Williams syndrome. In I. L. Rubin, J. Merrick, D. E. Greydanus & D. R. Patel (Eds.), Health care for people with intellectual and developmental disabilities across the lifespan (pp. 799–814). Cham: Springer International Publishing. CrossRef
Tonnsen, B. L., Grefer, M. L., Hatton, D. D., & Roberts, J. E. (2015). Developmental trajectories of attentional control in preschool males with fragile X syndrome. Research in Developmental Disabilities, 36, 62–71. CrossRef
Welham, A., Lau, J. K. L., Moss, J., Cullen, J., Higgs, S., Warren, G., et al. (2015). Are Angelman and Prader–Willi syndromes more similar than we thought? Food-related behavior problems in Angelman, Cornelia de Lange, fragile X, Prader–Willi and 1p36 deletion syndromes. American Journal of Medical Genetics Part A, 167A(3), 572–578. PubMedCrossRef
Whitcomb, S. A. (2018). Behavioral, social, and emotional assessment of children and adolescents (5th edn.). New York: Routledge.
Whittington, J., & Holland, A. (2010). Neurobehavioral phenotype in Prader–Willi syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 154C(4), 438–447. CrossRef
Williams, C. A. (2010). The behavioral phenotype of the Angelman syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 154C(4), 432–437. CrossRef
Yang, L., Zhan, G.-D., Ding, J.-J., Wang, H.-J., Ma, D., Huang, G.-Y., et al. (2013). Psychiatric illness and intellectual disability in the Prader–Willi syndrome with different molecular defects: A meta analysis. PLoS ONE, 8(8), 1–11. CrossRef
Zafeiriou, D. I., Ververi, A., Dafoulis, V., Kalyva, E., & Vargiami, E. (2013). Autism spectrum disorders: The quest for genetic syndromes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162B(4), 327–366. CrossRef
- Brief Report: Challenging Behaviors in Toddlers and Preschoolers with Angelman, Prader–Willi, and Williams Syndromes
Wei Siong Neo
Bridgette L. Tonnsen
- Springer US