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01-06-2013 | Brief Report | Uitgave 6/2013

Brief Report: CANTAB Performance and Brain Structure in Pediatric Patients with Asperger Syndrome

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 6/2013

Auteurs:: Liane Kaufmann, Sibylle Zotter, Silvia Pixner, Marc Starke, Edda Haberlandt, Maria Steinmayr-Gensluckner, Karl Egger, Michael Schocke, Elisabeth M. Weiss, Josef Marksteiner

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Abstract

By merging neuropsychological (CANTAB/Cambridge Neuropsychological Test Automated Battery) and structural brain imaging data (voxel-based-morphometry) the present study sought to identify the neurocognitive correlates of executive functions in individuals with Asperger syndrome (AS) compared to healthy controls. Results disclosed subtle group differences regarding response speed on only one CANTAB subtest that is thought to tap fronto-executive network functions (SWM/spatial working memory). Across all participants, SWM performance was significantly associated with two brain regions (precentral gyrus white matter, precuneus grey matter), thus suggesting a close link between fronto-executive functions (SWM) and circumscribed fronto-parietal brain structures. Finally, symptom severity (ADOS total score) was best predicted by response speed on a set-shifting task (IES) thought to tap fronto-striatal functions (corrected R² 56 %).

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Titel: Brief Report: CANTAB Performance and Brain Structure in Pediatric Patients with Asperger Syndrome
Auteurs:: Liane Kaufmann
Sibylle Zotter
Silvia Pixner
Marc Starke
Edda Haberlandt
Maria Steinmayr-Gensluckner
Karl Egger
Michael Schocke
Elisabeth M. Weiss
Josef Marksteiner
Publicatiedatum: 01-06-2013
DOI: https://doi.org/10.1007/s10803-012-1686-6
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 6/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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Brief Report: CANTAB Performance and Brain Structure in Pediatric Patients with Asperger Syndrome

Abstract

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