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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-07-2009 | Brief Report

Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder

Auteurs: Natalia M. Kleinhans, Todd Richards, Kurt E. Weaver, Olivia Liang, Geraldine Dawson, Elizabeth Aylward

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2009

Abstract

Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger’s disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD.

vorige artikel Brief Report: The Vineland Adaptive Behavior Scales in Young Children with Autism Spectrum Disorders at Different Cognitive Levels

volgende artikel Breif Report: Sensory Abnormalities as Distinguishing Symptoms of Autism Spectrum Disorders in Young Children

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Titel: Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder
Auteurs: Natalia M. Kleinhans
Todd Richards
Kurt E. Weaver
Olivia Liang
Geraldine Dawson
Elizabeth Aylward
Publicatiedatum: 01-07-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-009-0707-6

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