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Journal of Autism and Developmental Disorders

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11-11-2020 | Brief Report

Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations

Auteurs: Evangeline C. Kurtz-Nelson, See Wan Tham, Kaitlyn Ahlers, Daniel Cho, Arianne S. Wallace, Evan E. Eichler, Raphael A. Bernier, Rachel K. Earl

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2021

Abstract

Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population.

vorige artikel Brief Report: Social Behavior and Special Interests in the Stigmatization of Autistic College Students

volgende artikel Brief Report: Using Cognitive Screeners in Autistic Adults

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American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596

Arron, K., Oliver, C., Moss, J., Berg, K., & Burbidge, C. (2011). The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes. Journal of Intellectual Disability Research, 55(2), 109–120.PubMedCrossRef

Beighley, J. S., Hudac, C. M., Arnett, A. B., Peterson, J. L., Gerdts, J., Wallace, A. S., et al. (2020). Clinical phenotypes of carriers of mutations in CHD8 or its conserved target genes. Biological Psychiatry, 87(2), 123–131.PubMedCrossRef

Bernier, R., Golzio, C., Xiong, B., Stessman, H. A., Coe, B. P., Penn, O., et al. (2014). Disruptive CHD8 mutations define a subtype of autism early in development. Cell, 158(2), 263–276.PubMedPubMedCentralCrossRef

Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000). Varieties of repetitive behavior in autism: Comparisons to mental retardation. Journal of Autism and Developmental Disorders, 30(3), 237–243. https://doi.org/10.1023/A:1005596502855CrossRefPubMed

Breau, L. M., Camfield, C. S., Symons, F. J., Bodfish, J. W., MacKay, A., Finley, G. A., & McGrath, P. J. (2003). Relation between pain and self-injurious behavior in nonverbal children with severe cognitive impairments. The Journal of pediatrics, 142(5), 498–503.PubMedCrossRef

Chaidez, V., Hansen, R. L., & Hertz-Picciotto, I. (2014). Gastrointestinal problems in children with autism, developmental delays or typical development. Journal of Autism and Developmental Disorders, 44(5), 1117–1127.PubMedPubMedCentralCrossRef

Chandler, S., Carcani-Rathwell, I., Charman, T., Pickles, A., Loucas, T., Meldrum, D., Simonoff, E., Sullivan, P., & Baird, G. (2013). Parent-reported gastro-intestinal symptoms in children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(12), 2737–2747.PubMedCrossRef

Chitkara, D. K., Rawat, D. J., & Talley, N. J. (2005). The epidemiology of childhood recurrent abdominal pain in Western countries: A systematic review. American Journal of Gastroenterology, 100(8), 1868–1875.CrossRefPubMed

Chen, H., Cohen, P., & Chen, S. (2010). How big is a big odds ratio? Interpreting the magnitudes of odds ratios in epidemiological studies. Communications in Statistics—Simulation and Computation, 39(4), 860–864.CrossRef

Constantino, J. N., & Gruber, C. P. (2012). Social responsiveness scale (2nd ed.). Torrance, CA: Western Psychological Services.

Coury, D. L., Ashwood, P., Fasano, A., Fuchs, G., Geraghty, M., Kaul, A., et al. (2012). Gastrointestinal conditions in children with autism spectrum disorder: Developing a research agenda. Pediatrics, 130(Supplement 2), S160–S168.PubMedCrossRef

Dempsey, J., Dempsey, A. G., Guffey, D., Minard, C. G., & Goin-Kochel, R. P. (2016). Brief report: Further examination of self-injurious behaviors in children and adolescents with autism spectrum disorders. Journal of Autism and Developmental Disorders, 46(5), 1872–1879.PubMedCrossRef

Derby, K. M., Hagopian, L., Fisher, W. W., Richman, D., Augustine, M., Fahs, A., & Thompson, R. (2000). Functional analysis of aberrant behavior through measurement of separate response topographies. Journal of Applied Behavior Analysis, 33(1), 113–117.PubMedPubMedCentralCrossRef

Dimian, A. F., Botteron, K. N., Dager, S. R., Elison, J. T., Estes, A. M., Pruett, J. R., et al. (2017). Potential risk factors for the development of self-injurious behavior among infants at risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 47(5), 1403–1415.PubMedPubMedCentralCrossRef

Duerden, E. G., Oatley, H. K., Mak-Fan, K. M., McGrath, P. A., Taylor, M. J., Szatmari, P., & Roberts, S. W. (2012). Risk factors associated with self-injurious behaviors in children and adolescents with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(11), 2460–2470.PubMedCrossRef

Earl, R. K., Turner, T. N., Mefford, H. C., Hudac, C. M., Gerdts, J., Eichler, E. E., & Bernier, R. A. (2017). Clinical phenotype of ASD-associated DYRK1A haploinsufficiency. Molecular Autism, 8(1), 54.PubMedPubMedCentralCrossRef

Elliott, C. D. (2007). Differential ability scales (2nd ed.). San Antonio, TX: Harcourt Assessment.

Ely, E., Chen-Lim, M. L., Carpenter, K. M., Wallhauser, E., & Friedlaender, E. (2016). Pain assessment of children with autism spectrum disorders. Journal of Developmental & Behavioral Pediatrics, 37(1), 53–61.CrossRef

Fischbach, G. D., & Lord, C. (2010). The Simons Simplex Collection: A resource for identification of autism genetic risk factors. Neuron, 68, 192–195.PubMedCrossRef

Fulceri, F., Morelli, M., Santocchi, E., Cena, H., Del Bianco, T., Narzisi, A., et al. (2016). Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder. Digestive and Liver Disease, 48(3), 248–254.PubMedCrossRef

Gulsrud, A., Lin, C. E., Park, M. N., Hellemann, G., & McCracken, J. (2018). Self-injurious behaviours in children and adults with autism spectrum disorder (ASD). Journal of Intellectual Disability Research, 62(12), 1030–1042.PubMedCrossRef

Huisman, S., Mulder, P., Kuijk, J., Kerstholt, M., van Eeghen, A., Leenders, A., et al. (2018). Self-injurious behavior. Neuroscience & Biobehavioral Reviews, 84, 483–491.CrossRef

Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., et al. (2014). The contribution of de novo coding mutations to autism spectrum disorder. Nature, 515(7526), 216.PubMedPubMedCentralCrossRef

Kalb, L. G., Stuart, E. A., Freedman, B., Zablotsky, B., & Vasa, R. (2012). Psychiatric-related emergency department visits among children with an autism spectrum disorder. Pediatric Emergency Care, 28(12), 1269–1276.PubMedCrossRef

Kanne, S. M., & Mazurek, M. O. (2011). Aggression in children and adolescents with ASD: Prevalence and risk factors. Journal of Autism and Developmental Disorders, 41(7), 926–937.PubMedCrossRef

Kong, X., Liu, J., Cetinbas, M., Sadreyev, R., Koh, M., Huang, H., et al. (2019). New and preliminary evidence on altered oral and gut microbiota in individuals with autism spectrum disorder (ASD): Implications for ASD diagnosis and subtyping based on microbial biomarkers. Nutrients, 11(9), 2128.PubMedCentralCrossRef

Kurtz-Nelson, E. C., Beighley, J. S., Hudac, C. M., Gerdts, J., Wallace, A. S., Hoekzema, K., et al. (2020). Co-occurring medical conditions among individuals with ASD-associated disruptive mutations. Children’s Health Care, 49(4), 361–384. https://doi.org/10.1080/02739615.2020.1741361CrossRefPubMedPubMedCentral

Lord, C., Rutter, M., DiLavore, P., Risi, S., Gotham, K., & Bishop, S. (2013). Autism diagnostic observation schedule—2nd edition (ADOS-2). Los Angeles: Western Psychological Services.

Luzzani, S., Macchini, F., Valade, A., Milani, D., & Selicorni, A. (2003). Gastroesophageal reflux and Cornelia de Lange syndrome: Typical and atypical symptoms. American Journal of Medical Genetics Part A, 119A(3), 283–287.PubMedCrossRef

Mazurek, M. O., Vasa, R. A., Kalb, L. G., Kanne, S. M., Rosenberg, D., Keefer, A., et al. (2013). Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders. Journal of Abnormal Child Psychology, 41(1), 165–176.PubMedCrossRef

Mazurek, M. O., Keefer, A., Shui, A., & Vasa, R. A. (2014). One-year course and predictors of abdominal pain in children with autism spectrum disorders: The role of anxiety and sensory over-responsivity. Research in Autism Spectrum Disorders, 8(11), 1508–1515.CrossRef

McClintock, K., Hall, S., & Oliver, C. (2003). Risk markers associated with challenging behaviours in people with intellectual disabilities: A meta-analytic study. Journal of Intellectual Disability Research, 47(6), 405–416.PubMedCrossRef

McElhanon, B. O., McCracken, C., Karpen, S., & Sharp, W. G. (2014). Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics, 133(5), 872–883.PubMedCrossRef

McGuire, B. E., Daly, P., & Smyth, F. (2010). Chronic pain in people with an intellectual disability: Under-recognised and under-treated? Journal of Intellectual Disability Research, 54(3), 240–245.PubMedCrossRef

Minshawi, N. F., Hurwitz, S., Morriss, D., & McDougle, C. J. (2015). Multidisciplinary assessment and treatment of self-injurious behavior in autism spectrum disorder and intellectual disability: Integration of psychological and biological theory and approach. Journal of Autism and Developmental Disorders, 45(6), 1541–1568.PubMedCrossRef

Molloy, C. A., & Manning-Courtney, P. (2003). Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism, 7(2), 165–171.PubMedCrossRef

Moss, J. F., Oliver, C., Berg, K., Kaur, G., Jephcott, L., & Cornish, K. (2008). Prevalence of autism spectrum phenomenology in Cornelia de Lange and Cri du Chat syndromes. American Journal on Mental Retardation, 113(4), 278–291.PubMedCrossRef

Mullen, E. M. (1995). Mullen scales of early learning (AGS). Circle Pines, MN: American Guidance Service Inc.

Neuhaus, E., Bernier, R. A., Tham, S. W., & Webb, S. J. (2018). Gastrointestinal and psychiatric symptoms among children and adolescents with autism spectrum disorder. Frontiers in Psychiatry, 9, 515.PubMedPubMedCentralCrossRef

Oliver, C., & Richards, C. (2015). Practitioner review: Self-injurious behaviour in children with developmental delay. Journal of Child Psychology and Psychiatry, 56(10), 1042–1054.PubMedCrossRef

O’Roak, B. J., Vives, L., Girirajan, S., Karakoc, E., Krumm, N., Coe, B. P., et al. (2012). Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature, 485(7397), 246.PubMedPubMedCentralCrossRef

Peebles, K. A., & Price, T. J. (2012). Self-injurious behaviour in intellectual disability syndromes: Evidence for aberrant pain signalling as a contributing factor. Journal of Intellectual Disability Research, 56(5), 441–452.PubMedCrossRef

Rattaz, C., Michelon, C., & Baghdadli, A. (2015). Symptom severity as a risk factor for self-injurious behaviours in adolescents with autism spectrum disorders. Journal of Intellectual Disability Research, 59(8), 730–741.PubMedCrossRef

Richman, D. M. (2008). Annotation: Early intervention and prevention of self-injurious behaviour exhibited by young children with developmental disabilities. Journal of Intellectual Disability Research, 52(1), 3–17.PubMedCrossRef

Rojahn, J., Barnard-Brak, L., Medeiros, K., & Schroeder, S. R. (2016). Stereotyped behaviours as precursors of self-injurious behaviours: A longitudinal study with infants and toddlers at risk for developmental delay. Journal of Intellectual Disability Research, 60(2), 156–166.PubMedCrossRef

Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview-revised (ADI-R). Los Angeles: Western Psychological Services.

Samsam, M., Ahangari, R., & Naser, S. A. (2014). Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance. World Journal of Gastroenterology: WJG, 20(29), 9942–9951.PubMedPubMedCentralCrossRef

Saps, M., Seshadri, R., Sztainberg, M., Schaffer, G., Marshall, B. M., & Di Lorenzo, C. (2009). A prospective school-based study of abdominal pain and other common somatic complaints in children. Journal of Pediatrics, 154(3), 322–326.CrossRefPubMed

Shirley, M. D., Frelin, L., López, J. S., Jedlicka, A., Dziedzic, A., Frank-Crawford, M. A., et al. (2016). Copy number variants associated with 14 cases of self-injurious behavior. PLoS One, 11(3), e0149646.PubMedPubMedCentralCrossRef

Smith, R. G., Iwata, B. A., Vollmer, T. R., & Zarcone, J. R. (1993). Experimental analysis and treatment of multiply controlled self-injury. Journal of Applied Behavior Analysis, 26(2), 183–196.PubMedPubMedCentralCrossRef

Soke, G. N., Rosenberg, S. A., Hamman, R. F., Fingerlin, T., Robinson, C., Carpenter, L., et al. (2016). Brief report: Prevalence of self-injurious behaviors among children with autism spectrum disorder—a population-based study. Journal of Autism and Developmental Disorders, 46(11), 3607–3614.PubMedPubMedCentralCrossRef

Soke, G. N., Rosenberg, S. A., Rosenberg, C. R., Vasa, R. A., Lee, L. C., & DiGuiseppi, C. (2018). Self-injurious behaviors in children with autism spectrum disorder enrolled in the Study to Explore Early Development. Autism, 22(5), 625–635.PubMedCrossRef

Siper, P. M., De Rubeis, S., del Pilar Trelles, M., Durkin, A., Di Marino, D., Muratet, F., et al. (2017). Prospective investigation of FOXP1 syndrome. Molecular Autism, 8(1), 57.PubMedPubMedCentralCrossRef

Sparrow, S. S., Balla, D. A., & Cicchetti, D. V. (2005). Vineland II: Vineland adaptive behavior scales. Circle Pines, MN: American Guidance Service.

Stessman, H. A., Xiong, B., Coe, B. P., Wang, T., Hoekzema, K., Fenckova, M., et al. (2017). Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases. Nature Genetics, 49(4), 515.PubMedPubMedCentralCrossRef

Symons, F. J. (2011). Self-injurious behavior in neurodevelopmental disorders: Relevance of nociceptive and immune mechanisms. Neuroscience & Biobehavioral Reviews, 35(5), 1266–1274.CrossRef

Symons, F. J., Clark, R. D., Hatton, D. D., Skinner, M., & Bailey, D. B., Jr. (2003). Self-injurious behavior in young boys with fragile X syndrome. American Journal of Medical Genetics Part A, 118A(2), 115–121.PubMedCrossRef

Van Dijck, A., Vulto-van Silfhout, A. T., Cappuyns, E., van der Werf, I. M., Mancini, G. M., Tzschach, A., et al. (2019). Clinical presentation of a complex neurodevelopmental disorder caused by mutations in ADNP. Biological Psychiatry, 85(4), 287–297.PubMedCrossRef

Wechsler, D. (2011). Wechsler abbreviated scales of intelligence—Second edition (WASI-II). San Antonio, TX: The Psychological Corporation.

Wolff, J. J., Bodfish, J. W., Hazlett, H. C., Lightbody, A. A., Reiss, A. L., & Piven, J. (2012). Evidence of a distinct behavioral phenotype in young boys with fragile X syndrome and autism. Journal of the American Academy of Child & Adolescent Psychiatry, 51(12), 1324–1332.CrossRef

Titel: Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations
Auteurs: Evangeline C. Kurtz-Nelson
See Wan Tham
Kaitlyn Ahlers
Daniel Cho
Arianne S. Wallace
Evan E. Eichler
Raphael A. Bernier
Rachel K. Earl
Publicatiedatum: 11-11-2020
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04774-z

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