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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2012

01-06-2012 | Brief Report

Brief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children with and without Autism Spectrum Disorder

Auteurs: Laura C. Erickson, Ashley A. Scott-Van Zeeland, Gavin Hamilton, Alan Lincoln, Beatrice A. Golomb

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2012

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Abstract

We piloted a suite of approaches aimed to facilitate a successful series of up to four brain and muscle 31Phosphorus-Magnetic Resonance Spectroscopy (31P-MRS) scans performed in one session in 12 awake, non-sedated subjects (ages 6–18), 6 with autism spectrum disorders (ASD) and 6 controls. We targeted advanced preparation, parental input, physical comfort, short scan protocols, allocation of extra time, and subject emotional support. 100% of subjects completed at least one brain scan and one leg muscle scan: 42 of 46 attempted scans were completed (91%), with failures dominated by exercise muscle scans (completed in 6/6 controls but 3/6 cases). One completed scan lacked usable data unrelated to subject/scan procedure (orthodonture affected a frontal brain scan). As a group, these methods provide a foundation for conduct and enhancement of future MR studies in pediatric subjects with ASD.
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Metagegevens
Titel
Brief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children with and without Autism Spectrum Disorder
Auteurs
Laura C. Erickson
Ashley A. Scott-Van Zeeland
Gavin Hamilton
Alan Lincoln
Beatrice A. Golomb
Publicatiedatum
01-06-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-011-1359-x