Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2014

01-02-2014 | Brief Report

Brief Report: Antibodies Reacting to Brain Tissue in Basque Spanish Children with Autism Spectrum Disorder and Their Mothers

Auteurs: Christy C. Rossi, Joaquin Fuentes, Judy Van de Water, David G. Amaral

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2014

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Previous investigations found that a subset of children with autism spectrum disorder (ASD) in California possessed plasma autoantibodies that reacted intensely with brain interneurons or other neural profiles. Moreover, for several cohorts of American women, maternal autoantibody reactivity to specific fetal brain proteins was highly specific to mothers of children with ASD. We sought to determine whether children and their mothers from a regionally specific cohort from the Basque Country of Spain demonstrated similar reactivity. Some children’s plasma reacted to interneurons, beaded axons or other neural profiles with no difference in the occurrence of these antibodies in children with or without ASD. Findings on the maternal antibodies confirmed previous research; plasma reactivity to fetal brain a combination of proteins at 37 and 73 kDa or 39 and 73 kDa was found exclusively in mothers of children with ASD.
Literatuur
go back to reference ADDM. (2012). Prevalence of autism spectrum disorders–Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveillance Summaries, 61, 1–19. ADDM. (2012). Prevalence of autism spectrum disorders–Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveillance Summaries, 61, 1–19.
go back to reference Baron-Cohen, S., Scott, F. J., Allison, C., Williams, J., Bolton, P., Matthews, F. E., et al. (2009). Prevalence of autism-spectrum conditions: UK school-based population study. British Journal of Psychiatry, 194, 500–509. PubMedCrossRef Baron-Cohen, S., Scott, F. J., Allison, C., Williams, J., Bolton, P., Matthews, F. E., et al. (2009). Prevalence of autism-spectrum conditions: UK school-based population study. British Journal of Psychiatry, 194, 500–509. PubMedCrossRef
go back to reference Braunschweig, D., Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Croen, L. A., et al. (2008). Autism: Maternally derived antibodies specific for fetal brain proteins. Neurotoxicology, 29, 226–231. PubMedCentralPubMed Braunschweig, D., Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Croen, L. A., et al. (2008). Autism: Maternally derived antibodies specific for fetal brain proteins. Neurotoxicology, 29, 226–231. PubMedCentralPubMed
go back to reference Braunschweig, D., Duncanson, P., Boyce, R., Hansen, R., Ashwood, P., Pessah, I. N., et al. (2012). Behavioral correlates of maternal antibody status among children with autism. Journal of Autism and Development Disorders, 42(7), 1435–1445. Braunschweig, D., Duncanson, P., Boyce, R., Hansen, R., Ashwood, P., Pessah, I. N., et al. (2012). Behavioral correlates of maternal antibody status among children with autism. Journal of Autism and Development Disorders, 42(7), 1435–1445.
go back to reference Cabanlit, M., Wills, S., Goines, P., Ashwood, P., & Van de Water, J. (2007). Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Annals of the New York Academy of Sciences, 1107, 92–103. PubMedCrossRef Cabanlit, M., Wills, S., Goines, P., Ashwood, P., & Van de Water, J. (2007). Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Annals of the New York Academy of Sciences, 1107, 92–103. PubMedCrossRef
go back to reference Connolly, A. M., Chez, M. G., Pestronk, A., Arnold, S. T., Mehta, S., & Deuel, R. K. (1999). Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. Journal of Pediatrics, 134, 607–613. PubMedCrossRef Connolly, A. M., Chez, M. G., Pestronk, A., Arnold, S. T., Mehta, S., & Deuel, R. K. (1999). Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. Journal of Pediatrics, 134, 607–613. PubMedCrossRef
go back to reference Croen, L. A., Braunschweig, D., Haapanen, L., Yoshida, C. K., Fireman, B., Grether, J. K., et al. (2008). Maternal mid-pregnancy autoantibodies to fetal brain protein: The early markers for autism study. Biological Psychiatry, 64, 583–588. PubMedCentralPubMedCrossRef Croen, L. A., Braunschweig, D., Haapanen, L., Yoshida, C. K., Fireman, B., Grether, J. K., et al. (2008). Maternal mid-pregnancy autoantibodies to fetal brain protein: The early markers for autism study. Biological Psychiatry, 64, 583–588. PubMedCentralPubMedCrossRef
go back to reference Dalton, P., Deacon, R., Blamire, A., Pike, M., McKinlay, I., Stein, J., et al. (2003). Maternal neuronal antibodies associated with autism and a language disorder. Annals of Neurology, 53, 533–537. PubMedCrossRef Dalton, P., Deacon, R., Blamire, A., Pike, M., McKinlay, I., Stein, J., et al. (2003). Maternal neuronal antibodies associated with autism and a language disorder. Annals of Neurology, 53, 533–537. PubMedCrossRef
go back to reference D’Angelo, E. (2008). The critical role of Golgi cells in regulating spatio-temporal integration and plasticity at the cerebellum input stage. Frontiers in Neuroscience, 2, 35–46. PubMedCentralPubMedCrossRef D’Angelo, E. (2008). The critical role of Golgi cells in regulating spatio-temporal integration and plasticity at the cerebellum input stage. Frontiers in Neuroscience, 2, 35–46. PubMedCentralPubMedCrossRef
go back to reference García-Primo, P., Canal-Bedia, R., Martín Cilleros, M. V., Guisuraga Fernández, Z., Herráez-García, L., Herraez García, M. M., et al. (2011). Population-based autism screening program using the M-CHAT in Spain. In: International meeting for autism research. San Diego, California. García-Primo, P., Canal-Bedia, R., Martín Cilleros, M. V., Guisuraga Fernández, Z., Herráez-García, L., Herraez García, M. M., et al. (2011). Population-based autism screening program using the M-CHAT in Spain. In: International meeting for autism research. San Diego, California.
go back to reference Geschwind, D. H., & Levitt, P. (2007). Autism spectrum disorders: Developmental disconnection syndromes. Current Opinion in Neurobiology, 17, 103–111. PubMedCrossRef Geschwind, D. H., & Levitt, P. (2007). Autism spectrum disorders: Developmental disconnection syndromes. Current Opinion in Neurobiology, 17, 103–111. PubMedCrossRef
go back to reference Gillberg, C., Cederlund, M., Lamberg, K., & Zeijlon, L. (2006). Brief report: “The autism epidemic”. The registered prevalence of autism in a Swedish urban area. Journal of Autism and Developmental Disorders, 36, 429–435. PubMedCrossRef Gillberg, C., Cederlund, M., Lamberg, K., & Zeijlon, L. (2006). Brief report: “The autism epidemic”. The registered prevalence of autism in a Swedish urban area. Journal of Autism and Developmental Disorders, 36, 429–435. PubMedCrossRef
go back to reference Goines, P., Haapanen, L., Boyce, R., Duncanson, P., Braunschweig, D., Delwiche, L., et al. (2011). Autoantibodies to cerebellum in children with autism associate with behavior. Brain, Behavior, and Immunity, 25, 514–523. PubMedCentralPubMedCrossRef Goines, P., Haapanen, L., Boyce, R., Duncanson, P., Braunschweig, D., Delwiche, L., et al. (2011). Autoantibodies to cerebellum in children with autism associate with behavior. Brain, Behavior, and Immunity, 25, 514–523. PubMedCentralPubMedCrossRef
go back to reference Hickey, W. F. (2001). Basic principles of immunological surveillance of the normal central nervous system. Glia, 36, 118–124. PubMedCrossRef Hickey, W. F. (2001). Basic principles of immunological surveillance of the normal central nervous system. Glia, 36, 118–124. PubMedCrossRef
go back to reference Kadesjo, B., Gillberg, C., & Hagberg, B. (1999). Brief report: Autism and Asperger syndrome in seven-year-old children: A total population study. Journal of Autism and Developmental Disorders, 29, 327–331. PubMedCrossRef Kadesjo, B., Gillberg, C., & Hagberg, B. (1999). Brief report: Autism and Asperger syndrome in seven-year-old children: A total population study. Journal of Autism and Developmental Disorders, 29, 327–331. PubMedCrossRef
go back to reference Kowal, C., DeGiorgio, L. A., Nakaoka, T., Hetherington, H., Huerta, P. T., Diamond, B., et al. (2004). Cognition and immunity; antibody impairs memory. Immunity, 21, 179–188. PubMedCrossRef Kowal, C., DeGiorgio, L. A., Nakaoka, T., Hetherington, H., Huerta, P. T., Diamond, B., et al. (2004). Cognition and immunity; antibody impairs memory. Immunity, 21, 179–188. PubMedCrossRef
go back to reference Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X. M., et al. (2009). Elevated immune response in the brain of autistic patients. Journal of Neuroimmunology, 207, 111–116. PubMedCentralPubMedCrossRef Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X. M., et al. (2009). Elevated immune response in the brain of autistic patients. Journal of Neuroimmunology, 207, 111–116. PubMedCentralPubMedCrossRef
go back to reference Miller, D. W. (1999). Immunobiology of the blood-brain barrier. Journal of Neurovirology, 5, 570–578. PubMedCrossRef Miller, D. W. (1999). Immunobiology of the blood-brain barrier. Journal of Neurovirology, 5, 570–578. PubMedCrossRef
go back to reference Morgan, J. T., Chana, G., Pardo, C. A., Achim, C., Semendeferi, K., Buckwalter, J., et al. (2010). Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biological Psychiatry, 68, 368–376. PubMedCrossRef Morgan, J. T., Chana, G., Pardo, C. A., Achim, C., Semendeferi, K., Buckwalter, J., et al. (2010). Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biological Psychiatry, 68, 368–376. PubMedCrossRef
go back to reference Rossi, C. C., Van de Water, J., Rogers, S. J., & Amaral, D. G. (2011). Detection of plasma autoantibodies to brain tissue in young children with and without autism spectrum disorders. Brain, Behavior, and Immunity, 25, 1123–1135. PubMedCentralPubMedCrossRef Rossi, C. C., Van de Water, J., Rogers, S. J., & Amaral, D. G. (2011). Detection of plasma autoantibodies to brain tissue in young children with and without autism spectrum disorders. Brain, Behavior, and Immunity, 25, 1123–1135. PubMedCentralPubMedCrossRef
go back to reference Rout, U. K., Mungan, N. K., & Dhossche, D. M. (2012). Presence of GAD65 autoantibodies in the serum of children with autism or ADHD. European Child and Adolescent Psychiatry, 21(3), 141–147. Rout, U. K., Mungan, N. K., & Dhossche, D. M. (2012). Presence of GAD65 autoantibodies in the serum of children with autism or ADHD. European Child and Adolescent Psychiatry, 21(3), 141–147.
go back to reference Singer, H. S., Morris, C. M., Gause, C. D., Gillin, P. K., Crawford, S., & Zimmerman, A. W. (2008). Antibodies against fetal brain in sera of mothers with autistic children. Journal of Neuroimmunology, 194, 165–172. PubMedCrossRef Singer, H. S., Morris, C. M., Gause, C. D., Gillin, P. K., Crawford, S., & Zimmerman, A. W. (2008). Antibodies against fetal brain in sera of mothers with autistic children. Journal of Neuroimmunology, 194, 165–172. PubMedCrossRef
go back to reference Singer, H. S., Morris, C. M., Williams, P. N., Yoon, D. Y., Hong, J. J., & Zimmerman, A. W. (2006). Antibrain antibodies in children with autism and their unaffected siblings. Journal of Neuroimmunology, 178, 149–155. PubMedCrossRef Singer, H. S., Morris, C. M., Williams, P. N., Yoon, D. Y., Hong, J. J., & Zimmerman, A. W. (2006). Antibrain antibodies in children with autism and their unaffected siblings. Journal of Neuroimmunology, 178, 149–155. PubMedCrossRef
go back to reference Singh, V. K., Warren, R., Averett, R., & Ghaziuddin, M. (1997). Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatric Neurology, 17, 88–90. PubMedCrossRef Singh, V. K., Warren, R., Averett, R., & Ghaziuddin, M. (1997). Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatric Neurology, 17, 88–90. PubMedCrossRef
go back to reference Talja, I., Reimand, T., Uibo, O., Reimand, K., Aun, S., Talvik, T., et al. (2009). Antibodies to neurofilaments. Annals of the New York Academy of Sciences, 1173, 130–136. PubMedCrossRef Talja, I., Reimand, T., Uibo, O., Reimand, K., Aun, S., Talvik, T., et al. (2009). Antibodies to neurofilaments. Annals of the New York Academy of Sciences, 1173, 130–136. PubMedCrossRef
go back to reference Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67–81. PubMedCrossRef Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67–81. PubMedCrossRef
go back to reference Wills, S., Cabanlit, M., Bennett, J., Ashwood, P., Amaral, D. G., & Van de Water, J. (2009). Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain, Behavior, and Immunity, 23, 64–74. PubMedCentralPubMedCrossRef Wills, S., Cabanlit, M., Bennett, J., Ashwood, P., Amaral, D. G., & Van de Water, J. (2009). Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain, Behavior, and Immunity, 23, 64–74. PubMedCentralPubMedCrossRef
go back to reference Wills, S., Rossi, C. C., Bennett, J., Cerdeno, V. M., Ashwood, P., Amaral, D. G., et al. (2011). Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism. Molecular Autism, 2, 5. PubMedCentralPubMedCrossRef Wills, S., Rossi, C. C., Bennett, J., Cerdeno, V. M., Ashwood, P., Amaral, D. G., et al. (2011). Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism. Molecular Autism, 2, 5. PubMedCentralPubMedCrossRef
go back to reference Zimmerman, A. W., Connors, S. L., Matteson, K. J., Lee, L. C., Singer, H. S., Castaneda, J. A., et al. (2007). Maternal antibrain antibodies in autism. Brain, Behavior, and Immunity, 21, 351–357. PubMedCrossRef Zimmerman, A. W., Connors, S. L., Matteson, K. J., Lee, L. C., Singer, H. S., Castaneda, J. A., et al. (2007). Maternal antibrain antibodies in autism. Brain, Behavior, and Immunity, 21, 351–357. PubMedCrossRef
Metagegevens
Titel
Brief Report: Antibodies Reacting to Brain Tissue in Basque Spanish Children with Autism Spectrum Disorder and Their Mothers
Auteurs
Christy C. Rossi
Joaquin Fuentes
Judy Van de Water
David G. Amaral
Publicatiedatum
01-02-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1859-y

Andere artikelen Uitgave 2/2014

Journal of Autism and Developmental Disorders 2/2014 Naar de uitgave