Skip to main content
Top
Gepubliceerd in:

01-05-2008 | Brief Report

Brief Report: An Autistic Spectrum Subtype Revealed Through Familial Psychopathology Coupled with Cognition in ASD

Auteurs: Renée Lajiness-O’Neill, Philip Menard

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2008

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

This study identified a possible autistic spectrum subtype expressed through family psychopathology coupled with autistic probands’ cognitive functioning (i.e., an endophenotypic profile). Participants included 24 children with Autism Spectrum Disorder (ASD) and 49 children with Learning Disorder (LD). There were significantly higher rates of Mood and Anxiety Disorder in first degree maternal relatives and of LD and Attention-Deficit Hyperactivity Disorder in first degree paternal relatives of ASD probands. Significantly higher visuospatial functioning was noted in all ASD probands for which there were higher rates of Mood Disorder on the maternal side suggesting a possible marker for an ASD subtype and indicating that maternal psychopathology may have a neuroprotective effect on visuospatial functioning.
Literatuur
go back to reference American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.-text revised). Washington, DC: Author. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.-text revised). Washington, DC: Author.
go back to reference Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., Barta, P. E., & Pearlson, G. D. (1999). MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53, 2145–2150.PubMed Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., Barta, P. E., & Pearlson, G. D. (1999). MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53, 2145–2150.PubMed
go back to reference Baron-Cohen, S., & Hammer, J. (1997). Parents of children with asperger syndrome: What is the cognitive phenotype? Journal of Cognitive Neuroscience, 9, 548–555.CrossRef Baron-Cohen, S., & Hammer, J. (1997). Parents of children with asperger syndrome: What is the cognitive phenotype? Journal of Cognitive Neuroscience, 9, 548–555.CrossRef
go back to reference Barry, J. G., Yasin, I., & Bishop, D. V. (2007). Heritable risk factors associated with language Impairments. Genes, Brain, and Behavior, 6, 66–76.PubMedCrossRef Barry, J. G., Yasin, I., & Bishop, D. V. (2007). Heritable risk factors associated with language Impairments. Genes, Brain, and Behavior, 6, 66–76.PubMedCrossRef
go back to reference Briskman, J., Happe, F., & Frith, U. (2001). Exploring the cognitive phenotype of autism: Weak “Central Coherence” in parents and siblings of children with Autism: II. Real-life skills and preferences. Journal of Child Psychology and Psychiatry, 42, 309–316.PubMedCrossRef Briskman, J., Happe, F., & Frith, U. (2001). Exploring the cognitive phenotype of autism: Weak “Central Coherence” in parents and siblings of children with Autism: II. Real-life skills and preferences. Journal of Child Psychology and Psychiatry, 42, 309–316.PubMedCrossRef
go back to reference Carey, J., & McMahon, W. (1999). Neurobehavioral disorders and medical genetics. In S. Goldstein & C. R. Reynolds (Eds.), Handbook of neurodevelopmental and genetic disorders in children (pp. 38–60). New York, NY: The Guilford Press. Carey, J., & McMahon, W. (1999). Neurobehavioral disorders and medical genetics. In S. Goldstein & C. R. Reynolds (Eds.), Handbook of neurodevelopmental and genetic disorders in children (pp. 38–60). New York, NY: The Guilford Press.
go back to reference Caron, M. J., Mottron, L., Berthiaume, C., & Dawson, M. (2006). Cognitive mechanisms, Specificity and neural underpinnings of visuospatial peaks in autism. Brain, 129, 1789–1802.PubMedCrossRef Caron, M. J., Mottron, L., Berthiaume, C., & Dawson, M. (2006). Cognitive mechanisms, Specificity and neural underpinnings of visuospatial peaks in autism. Brain, 129, 1789–1802.PubMedCrossRef
go back to reference Caron, M. J., Mottron, L., Rainville, C., & Chouinard, S. (2004). Do high functioning persons with autism present superior spatial abilities? Neuropsychologia, 42, 467–481.PubMedCrossRef Caron, M. J., Mottron, L., Rainville, C., & Chouinard, S. (2004). Do high functioning persons with autism present superior spatial abilities? Neuropsychologia, 42, 467–481.PubMedCrossRef
go back to reference Cohen, I. L., & Tsiouris, J. A. (2006). Maternal recurrent mood disorder in high functioning autism. Journal of Autism and Developmental Disorders, 36, 1077–1088.PubMedCrossRef Cohen, I. L., & Tsiouris, J. A. (2006). Maternal recurrent mood disorder in high functioning autism. Journal of Autism and Developmental Disorders, 36, 1077–1088.PubMedCrossRef
go back to reference Courchesne, E., Townsend, J., Akshoomoff, N., et al. (1994). Impairments in shifting attention in autistic and cerebellar patients. Behavioral Neuroscience, 108, 848–865.PubMedCrossRef Courchesne, E., Townsend, J., Akshoomoff, N., et al. (1994). Impairments in shifting attention in autistic and cerebellar patients. Behavioral Neuroscience, 108, 848–865.PubMedCrossRef
go back to reference Courchesne, E., Townsend, J., & Saitoh, O. (1994). The brain in infantile autism: Posterior fossa structures are abnormal. Neurology, 44, 214–223.PubMed Courchesne, E., Townsend, J., & Saitoh, O. (1994). The brain in infantile autism: Posterior fossa structures are abnormal. Neurology, 44, 214–223.PubMed
go back to reference Courchesne, E., Press, G. A., & Yeung-Courchesne, R. (1993). Parietal lobe abnormalities detected with MRI in patients with infantile autism. American Journal of Radiology, 160, 387–393. Courchesne, E., Press, G. A., & Yeung-Courchesne, R. (1993). Parietal lobe abnormalities detected with MRI in patients with infantile autism. American Journal of Radiology, 160, 387–393.
go back to reference DeLong, R. (2004). Autism and familial major mood disorder: Are they related? Journal of Neuropsychiatry and Clinical Neurosciences, 16, 199–213.PubMed DeLong, R. (2004). Autism and familial major mood disorder: Are they related? Journal of Neuropsychiatry and Clinical Neurosciences, 16, 199–213.PubMed
go back to reference Edgin J. O., & Pennington, B. F. (2005). Spatial cognition in autistic spectrum disorders: Superior, impaired, or just intact. Journal of Autism and Developmental Disorders, 35, 729–745.PubMedCrossRef Edgin J. O., & Pennington, B. F. (2005). Spatial cognition in autistic spectrum disorders: Superior, impaired, or just intact. Journal of Autism and Developmental Disorders, 35, 729–745.PubMedCrossRef
go back to reference Gayan, J., Smith, S. D., Cherny, S. S., Cardon, L. R., Fulker, D. W., Brower, A. M., Olson, R. K., Pennington, B. F., & DeFries, J. C. (1999). Quantitative-trait locus for specific language and reading deficits on chromosome 6p. American Journal of Human Genetics, 64, 157–64.PubMedCrossRef Gayan, J., Smith, S. D., Cherny, S. S., Cardon, L. R., Fulker, D. W., Brower, A. M., Olson, R. K., Pennington, B. F., & DeFries, J. C. (1999). Quantitative-trait locus for specific language and reading deficits on chromosome 6p. American Journal of Human Genetics, 64, 157–64.PubMedCrossRef
go back to reference Glahn, D. C., Thompson, P. M., & Blanghero, J. (2007). Neuroimaging phenotypes: Strategies for finding genes influencing brain structure and function. Human Brain Mapping, 28, 488–501.PubMedCrossRef Glahn, D. C., Thompson, P. M., & Blanghero, J. (2007). Neuroimaging phenotypes: Strategies for finding genes influencing brain structure and function. Human Brain Mapping, 28, 488–501.PubMedCrossRef
go back to reference Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636–645.PubMedCrossRef Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636–645.PubMedCrossRef
go back to reference Happe, F., Briskman, J., & Frith, U. (2001). Exploring the cognitive phenotype of autism: Weak “Central Coherence” in parents and siblings of children with autism: I. Experimental Tests. Journal of Child Psychology and Psychiatry, 42, 299–307.PubMedCrossRef Happe, F., Briskman, J., & Frith, U. (2001). Exploring the cognitive phenotype of autism: Weak “Central Coherence” in parents and siblings of children with autism: I. Experimental Tests. Journal of Child Psychology and Psychiatry, 42, 299–307.PubMedCrossRef
go back to reference Hughes, C., Leboyer, M., & Bouvard, M. (1997). Executive functioning of children with autism. Psychological Medicine, 27, 209–220.PubMedCrossRef Hughes, C., Leboyer, M., & Bouvard, M. (1997). Executive functioning of children with autism. Psychological Medicine, 27, 209–220.PubMedCrossRef
go back to reference Hughes, C., Plumet, M., & Leboyer, M. (1999). Towards a cognitive phenotype for autism: Increased prevalence of executive dysfunction and superior spatial span amongst sibling of children with autism. Journal of Child Psychology and Psychiatry. 40, 705–718.PubMedCrossRef Hughes, C., Plumet, M., & Leboyer, M. (1999). Towards a cognitive phenotype for autism: Increased prevalence of executive dysfunction and superior spatial span amongst sibling of children with autism. Journal of Child Psychology and Psychiatry. 40, 705–718.PubMedCrossRef
go back to reference Klin, A., Volkmar, F. R., Sparrow, S. S., Cicchetti, D. V., & Rourke, B. P. (1995). Validity and Neuropsychological characterization of Asperger syndrome: convergence with nonverbal Learning disabilities syndrome. Journal of Child Psychology and Psychiatry, 36, 1127–1140.PubMedCrossRef Klin, A., Volkmar, F. R., Sparrow, S. S., Cicchetti, D. V., & Rourke, B. P. (1995). Validity and Neuropsychological characterization of Asperger syndrome: convergence with nonverbal Learning disabilities syndrome. Journal of Child Psychology and Psychiatry, 36, 1127–1140.PubMedCrossRef
go back to reference Koczat, D., Rogers, S., Pennington, B., & Ross, R. (2002). Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands. Journal of Autism and Developmental Disorders, 32, 513–518.PubMedCrossRef Koczat, D., Rogers, S., Pennington, B., & Ross, R. (2002). Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands. Journal of Autism and Developmental Disorders, 32, 513–518.PubMedCrossRef
go back to reference Korkman, M., Kirk, U., & Kemp, S. (1998). NEPSY: A neurodevelopmental neuropsychological assessment. The Psychological Corporation, San Antonio, TX. Korkman, M., Kirk, U., & Kemp, S. (1998). NEPSY: A neurodevelopmental neuropsychological assessment. The Psychological Corporation, San Antonio, TX.
go back to reference Lainhart, J. (1999). Psychiatric problems in individuals with autism, their parents and siblings. International Review of Psychiatry, 11, 278–298.CrossRef Lainhart, J. (1999). Psychiatric problems in individuals with autism, their parents and siblings. International Review of Psychiatry, 11, 278–298.CrossRef
go back to reference Lauritsen, M., Pedersen, C., & Mortensen, P. (2005). Effects of familial risk factors and place of birth on the risk of autism: A nationwide register-based study. Journal of Child Psychology and Psychiatry, 46, 963–971.PubMedCrossRef Lauritsen, M., Pedersen, C., & Mortensen, P. (2005). Effects of familial risk factors and place of birth on the risk of autism: A nationwide register-based study. Journal of Child Psychology and Psychiatry, 46, 963–971.PubMedCrossRef
go back to reference Lord C., Rutter M., & LeCouteur A (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.PubMedCrossRef Lord C., Rutter M., & LeCouteur A (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.PubMedCrossRef
go back to reference McDougle, C. J., Erickson, C. A., Stigler, K. A., & Posey, D. J. (2005). Neurochemistry in the pathophysiology of autism. Journal of Clinical Psychiatry, 66(Suppl 10), 9–18.PubMed McDougle, C. J., Erickson, C. A., Stigler, K. A., & Posey, D. J. (2005). Neurochemistry in the pathophysiology of autism. Journal of Clinical Psychiatry, 66(Suppl 10), 9–18.PubMed
go back to reference Micali, N., Chakrabarti, S., & Frombonne, E. (2004). The broad autism phenotype: Findings from an epidemiological survey. Autism, 1, 21–37.CrossRef Micali, N., Chakrabarti, S., & Frombonne, E. (2004). The broad autism phenotype: Findings from an epidemiological survey. Autism, 1, 21–37.CrossRef
go back to reference Autism, Developmental Disabilities Monitoring Network Surveillance Year. 2000 Principal Investigators; Centers for Disease Control and Prevention. (2007). Prevalence of autism spectrum disorders—autism and developmental disabilities monitoring, six sites, United States, 2000. MMWR Surveillance Summary, 56, 1–11. Autism, Developmental Disabilities Monitoring Network Surveillance Year. 2000 Principal Investigators; Centers for Disease Control and Prevention. (2007). Prevalence of autism spectrum disorders—autism and developmental disabilities monitoring, six sites, United States, 2000. MMWR Surveillance Summary, 56, 1–11.
go back to reference Murphy, M., Bolton, P., Pickles, A., Fombonne, E., Piven, J., Rutter, M. (2000). Personality traits of the relatives of autistic probands. Psychological Medicine, 30, 1411–1424.PubMedCrossRef Murphy, M., Bolton, P., Pickles, A., Fombonne, E., Piven, J., Rutter, M. (2000). Personality traits of the relatives of autistic probands. Psychological Medicine, 30, 1411–1424.PubMedCrossRef
go back to reference Ozonoff, S., Coon H., Dawson, G., Joseph, R., Klin, A., & McMahon, W., et al. (2004). Performance on CANTAB subtests sensitive to frontal lobe function in people with autistic disorder: Evidence from the CPEA Network. Journal of Autism and Developmental Disorders, 34, 139–150.PubMedCrossRef Ozonoff, S., Coon H., Dawson, G., Joseph, R., Klin, A., & McMahon, W., et al. (2004). Performance on CANTAB subtests sensitive to frontal lobe function in people with autistic disorder: Evidence from the CPEA Network. Journal of Autism and Developmental Disorders, 34, 139–150.PubMedCrossRef
go back to reference Ozonoff, S. & Strayer, D. L. (1997). Inhibitory function in nonretarded children with autism. Journal of Autism and Developmental Disorders, 27, 59–77.PubMedCrossRef Ozonoff, S. & Strayer, D. L. (1997). Inhibitory function in nonretarded children with autism. Journal of Autism and Developmental Disorders, 27, 59–77.PubMedCrossRef
go back to reference Piven, J., & Palmer, P. (1999). Psychiatric disorder and the broad autism phenotype: Evidence from a family study of multiple-incidence autism families. American Journal of Psychiatry, 156, 557–563.PubMed Piven, J., & Palmer, P. (1999). Psychiatric disorder and the broad autism phenotype: Evidence from a family study of multiple-incidence autism families. American Journal of Psychiatry, 156, 557–563.PubMed
go back to reference Schopler, E., Reichler, R. J., & Renner, B. R. (1988). The childhood autism rating scale (CARS). Los Angeles: Western Psychological Services. Schopler, E., Reichler, R. J., & Renner, B. R. (1988). The childhood autism rating scale (CARS). Los Angeles: Western Psychological Services.
go back to reference Shah, A., & Frith, U. (1993). Do autistic individuals show superior performance on the Block Design task? Journal of Child Psychology and Psychiatry, 24, 612–620. Shah, A., & Frith, U. (1993). Do autistic individuals show superior performance on the Block Design task? Journal of Child Psychology and Psychiatry, 24, 612–620.
go back to reference Simos, P. G., Breier, J. I., Fletcher, J. M., Foorman, B. R., Castillo, E. M., & Papanicolaou, A. C., 2000). Cerebral mechanisms involved in word reading in dyslexic children: A magnetic source imaging study. Cerebral Cortex, 10, 809–816.PubMedCrossRef Simos, P. G., Breier, J. I., Fletcher, J. M., Foorman, B. R., Castillo, E. M., & Papanicolaou, A. C., 2000). Cerebral mechanisms involved in word reading in dyslexic children: A magnetic source imaging study. Cerebral Cortex, 10, 809–816.PubMedCrossRef
go back to reference Wheelwright, S., & Baron-Cohen, S. (2001). The link between autism and skills such as engineering, math, physics, and computing. Autism, 5, 223–227.PubMedCrossRef Wheelwright, S., & Baron-Cohen, S. (2001). The link between autism and skills such as engineering, math, physics, and computing. Autism, 5, 223–227.PubMedCrossRef
go back to reference Wong, D., Maybery, M., Bishop, D. V., Maley, A., & Hallmayer, J (2006). Profiles of executive function in parents and siblings of individuals with autism spectrum disorders. Genes, Brain, and Behavior, 5, 561–576.PubMedCrossRef Wong, D., Maybery, M., Bishop, D. V., Maley, A., & Hallmayer, J (2006). Profiles of executive function in parents and siblings of individuals with autism spectrum disorders. Genes, Brain, and Behavior, 5, 561–576.PubMedCrossRef
Metagegevens
Titel
Brief Report: An Autistic Spectrum Subtype Revealed Through Familial Psychopathology Coupled with Cognition in ASD
Auteurs
Renée Lajiness-O’Neill
Philip Menard
Publicatiedatum
01-05-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0464-3