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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2012

01-02-2012 | Brief Report

Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ

Auteurs: Marco Pagani, Irina Manouilenko, Sharon Stone-Elander, Richard Odh, Dario Salmaso, Robert Hatherly, Fredrik Brolin, Hans Jacobsson, Stig A. Larsson, Susanne Bejerot

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2012

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Abstract

Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal “social” brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-11C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD.
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Metagegevens
Titel
Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ
Auteurs
Marco Pagani
Irina Manouilenko
Sharon Stone-Elander
Richard Odh
Dario Salmaso
Robert Hatherly
Fredrik Brolin
Hans Jacobsson
Stig A. Larsson
Susanne Bejerot
Publicatiedatum
01-02-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-011-1240-y