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Gepubliceerd in: Journal of Autism and Developmental Disorders 11/2010

01-11-2010 | Brief Report

Brief Report: Acamprosate in Fragile X Syndrome

Auteurs: Craig A. Erickson, Jennifer E. Mullett, Christopher J. McDougle

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2010

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Abstract

Glutamatergic dysfunction is implicated in the pathophysiology of fragile X syndrome (FXS). We report on the first trial of acamprosate, a drug with putative mGluR5 antagonism, in three adults with FXS and autism. Medical records describing open-label treatment with acamprosate in 3 patients with FXS and a comorbid diagnosis of autistic disorder were reviewed. In all three patients, acamprosate was associated with improved linguistic communication. Three patients received acamprosate over a mean 21.3 weeks of treatment. All patients showed global clinical benefit as rated with the Clinical Global Impressions-Improvement scale. Marked communication improvement was unexpected and has potential implications for the treatment of FXS, as well as idiopathic autism.
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Metagegevens
Titel
Brief Report: Acamprosate in Fragile X Syndrome
Auteurs
Craig A. Erickson
Jennifer E. Mullett
Christopher J. McDougle
Publicatiedatum
01-11-2010
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 11/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-0988-9

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