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Journal of Autism and Developmental Disorders

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01-02-2008 | Brief Report

Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder

Auteurs: Antonio Y. Hardan, Ragy R. Girgis, Jason Adams, Andrew R. Gilbert, Nadine M. Melhem, Matcheri S. Keshavan, Nancy J. Minshew

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2008

Abstract

The objective of this study was to examine the relationship between thalamic volume and brain size in individuals with Asperger’s disorder (ASP). Volumetric measurements of the thalamus were performed on MRI scans obtained from 12 individuals with ASP (age range: 10–35 years) and 12 healthy controls (age range: 9–33 years). A positive correlation was found between total brain volume and thalamic size in controls, but not in ASP subjects. This occurred in the absence of differences in mean thalamic volumes between the study groups. Findings from this investigation point to an abnormal relationship between the thalamus and its projection areas in ASP and are consistent with similar studies in autism, supporting that these disorders are qualitatively similar and possibly quantitatively different.

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Titel: Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder
Auteurs: Antonio Y. Hardan
Ragy R. Girgis
Jason Adams
Andrew R. Gilbert
Nadine M. Melhem
Matcheri S. Keshavan
Nancy J. Minshew
Publicatiedatum: 01-02-2008
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-007-0385-1

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