Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in:

25-03-2017 | Original Paper

Bone Mass in Boys with Autism Spectrum Disorder

Auteurs: Chadi A. Calarge, Janet A. Schlechte

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2017

Abstract

To examine bone mass in children and adolescents with autism spectrum disorders (ASD). Risperidone-treated 5 to 17 year-old males underwent anthropometric and bone measurements, using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Multivariable linear regression analysis models examined whether skeletal outcomes differed among participants with (n = 30) versus without ASD (n = 156). After adjusting for potential covariates, having ASD was associated with significantly lower trabecular bone mineral density and bone strength at the radius, and with marginally lower total body less head bone mineral content (p < 0.09). No differences at the lumbar spine were observed. ASD are associated with lower bone mass. Future studies should investigate interventions to optimize skeletal health in ASD.

vorige artikel Symptom Recognition and Diagnosis of Cerebral Palsy in Nepal

volgende artikel Formal Thought Disorder and Executive Functioning in Children and Adolescents with Autism Spectrum Disorder: Old Leads and New Avenues

Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA school-age forms & profiles. Burlington, VT: Research Center for Children, Youth and Families.

Aman, M. G., Arnold, L. E., McDougle, C. J., Vitiello, B., Scahill, L., Davies, M., et al. (2005). Acute and long-term safety and tolerability of risperidone in children with autism. Journal of Child and Adolescent Psychopharmacology, 15(6), 869–884. doi: 10.1089/cap.2005.15.869. CrossRefPubMed

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, text revision (4th ed.). Washington, DC: American Psychiatric Association.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5) (5th ed.). Washington, DC: American Psychiatric Association. CrossRef

Bahr, S. M., Tyler, B. C., Wooldridge, N., Butcher, B. D., Burns, T. L., Teesch, L. M., et al. (2015). Use of the second-generation antipsychotic, risperidone, and secondary weight gain are associated with an altered gut microbiota in children. Translational Psychiatry, 5, e652. doi: 10.1038/tp.2015.135. CrossRefPubMedPubMedCentral

Baim, S., Leonard, M. B., Bianchi, M. L., Hans, D. B., Kalkwarf, H. J., Langman, C. B., et al. (2008). Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Pediatric Position Development Conference. Journal of Clinical Densitometry, 11(1), 6–21. CrossRefPubMed

Block, G., Murphy, M., Roullet, J. B., Wakimoto, P., Crawford, P. B., & Block, T. (2000, September 17–20). Pilot validation of a FFQ for children 8–10 years (Abstract). Paper presented at the 4th International Conference On Dietary Assessment Methods. Tucson, AZ.

Bonnick, S. L., Johnston, C. C. Jr., Kleerekoper, M., Lindsay, R., Miller, P., Sherwood, L., et al. (2001). Importance of precision in bone density measurements. Journal of Clinical Densitometry, 4(2), 105–110. CrossRefPubMed

Calarge, C. A., Ivins, S. D., Motyl, K. J., Shibli-Rahhal, A. A., Bliziotes, M. M., & Schlechte, J. A. (2013). Possible mechanisms for the skeletal effects of antipsychotics in children and adolescents. Therapeutic Advances in Psychopharmacology, 3(5), 278–293. doi: 10.1177/2045125313487548. CrossRefPubMedPubMedCentral

Calarge, C. A., Nicol, G., Schlechte, J. A., & Burns, T. L. (2014). Cardiometabolic outcomes in children and adolescents following discontinuation of long-term risperidone treatment. Journal of Child and Adolescent Psychopharmacology, 24(3), 120–129. doi: 10.1089/cap.2013.0126. CrossRefPubMedPubMedCentral

Calarge, C. A., Schlechte, J. A., Burns, T. L., & Zemel, B. S. (2015). The effect of psychostimulants on skeletal health in boys co-treated with risperidone. The Journal of Pediatrics, 166(6), 1449–1454 e1441. doi: 10.1016/j.jpeds.2015.03.005. CrossRefPubMedPubMedCentral

Calarge, C. A., Xie, D., Fiedorowicz, J. G., Burns, T. L., & Haynes, W. G. (2012). Rate of weight gain and cardiometabolic abnormalities in children and adolescents. The Journal of Pediatrics, 161(6), 1010–1015. doi: 10.1016/j.jpeds.2012.05.051. CrossRefPubMedPubMedCentral

Cashin, A., Buckley, T., Trollor, J. N., & Lennox, N. (2016). A scoping review of what is known of the physical health of adults with autism spectrum disorder. Journal of Intellectual Disabilities. doi: 10.1177/1744629516665242. PubMed

Hategan, A., Bourgeois, J. A., & Goldberg, J. (2016). Aging with autism spectrum disorder: an emerging public health problem. International Psychogeriatrics/IPA. doi: 10.1017/S1041610216001599.

Hediger, M. L., England, L. J., Molloy, C. A., Yu, K. F., Manning-Courtney, P., & Mills, J. L. (2008). Reduced bone cortical thickness in boys with autism or autism spectrum disorder. Journal of Autism and Developmental Disorders, 38(5), 848–856. doi: 10.1007/s10803-007-0453-6. CrossRefPubMed

Mouridsen, S. E., Rich, B., & Isager, T. (2012). Fractures in individuals with and without a history of infantile autism. A Danish register study based on hospital discharge diagnoses. Journal of Autism and Developmental Disorders, 42(4), 619–624. doi: 10.1007/s10803-011-1286-x. CrossRefPubMed

Neumeyer, A. M., Cano Sokoloff, N., McDonnell, E., Macklin, E. A., McDougle, C. J., & Misra, M. (2017). Bone microarchitecture in adolescent boys with autism spectrum disorder. Bone, 97, 139–146. doi: 10.1016/j.bone.2017.01.009. CrossRefPubMed

Neumeyer, A. M., Gates, A., Ferrone, C., Lee, H., & Misra, M. (2013). Bone density in peripubertal boys with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(7), 1623–1629. doi: 10.1007/s10803-012-1709-3. CrossRefPubMedPubMedCentral

Neumeyer, A. M., O’Rourke, J. A., Massa, A., Lee, H., Lawson, E. A., McDougle, C. J., & Misra, M. (2015). Brief report: Bone fractures in children and adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 45(3), 881–887. doi: 10.1007/s10803-014-2228-1. CrossRefPubMedPubMedCentral

Nilas, L., & Christiansen, C. (1988). Rates of bone loss in normal women: evidence of accelerated trabecular bone loss after the menopause. European Journal of Clinical Investigation, 18(5), 529–534. CrossRefPubMed

Ogden, C. L., Kuczmarski, R. J., Flegal, K. M., Mei, Z., Guo, S., Wei, R., et al. (2002). Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics, 109(1), 45–60. CrossRefPubMed

Osteoporosis prevention, diagnosis, and therapy. (2001). Jama, 285(6), 785–795. CrossRef

Pitukcheewanont, P., & Chen, P. (2005). Bone density measurements in children and adolescents. Quantitative computed tomography versus dual-energy X-ray absorptiometry. The Endocrinologist, 15(4), 232–239. CrossRef

Shaffer, D., Fisher, P., Lucas, C. P., Dulcan, M. K., & Schwab-Stone, M. E. (2000). NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. Journal of the American Academy of Child and Adolescent Psychiatry, 39(1), 28–38. CrossRefPubMed

Slemenda, C. W., Miller, J. Z., Hui, S. L., Reister, T. K., & Johnston, C. C. Jr. (1991). Role of physical activity in the development of skeletal mass in children. Journal of Bone and Mineral Res0earch, 6(11), 1227–1233. CrossRef

Specker, B. L., & Schoenau, E. (2005). Quantitative bone analysis in children: current methods and recommendations. The Journal of pediatrics, 146(6), 726–731. doi: 10.1016/j.jpeds.2005.02.002. CrossRefPubMed

Walter, S. D., Eliasziw, M., & Donner, A. (1998). Sample size and optimal designs for reliability studies. Statistics in Medicine, 17(1), 101–110. CrossRefPubMed

Zemel, B. S., Kalkwarf, H. J., Gilsanz, V., Lappe, J. M., Oberfield, S., Shepherd, J. A., et al. (2011). Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study. The Journal of Clinical Endocrinology and Metabolism, 96(10), 3160–3169. doi: 10.1210/jc.2011-1111. CrossRefPubMedPubMedCentral

Titel: Bone Mass in Boys with Autism Spectrum Disorder
Auteurs: Chadi A. Calarge
Janet A. Schlechte
Publicatiedatum: 25-03-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3097-1

Bohn Stafleu van Loghum

Tip

Swipe om te navigeren naar een ander artikel

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 6/2017

Social Attention, Joint Attention and Sustained Attention in Autism Spectrum Disorder and Williams Syndrome: Convergences and Divergences

Language ENvironment Analysis (LENA) in Phelan-McDermid Syndrome: Validity and Suggestions for Use in Minimally Verbal Children with Autism Spectrum Disorder

Expressive Incoherence and Alexithymia in Autism Spectrum Disorder

Hierarchical Letters in ASD: High Stimulus Variability Under Different Attentional Modes

A Pilot Study of a Behavioral Parent Training in the Republic of Macedonia

Attempting to “Increase Intake from the Input”: Attention and Word Learning in Children with Autism