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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2013

01-07-2013 | Original Paper

Bone Density in Peripubertal Boys with Autism Spectrum Disorders

Auteurs: Ann M. Neumeyer, Amy Gates, Christine Ferrone, Hang Lee, Madhusmita Misra

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2013

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Abstract

We determined whether bone mineral density (BMD) is lower in boys with autism spectrum disorders (ASD) than controls, and also assessed variables that may affect BMD in ASD. BMD was measured using dual energy X-ray absorptiometry (DXA) in 18 boys with ASD and 19 controls 8–14 years old. Boys with ASD had lower BMD Z-scores at the spine, hip and femoral neck, and differences at the hip and femoral neck persisted after controlling for maturity and BMI. Vitamin D intake from food and in serum were lower in ASD subjects, as was exercise activity. We conclude that BMD is lower in peripubertal boys with ASD and may be associated with impaired vitamin D status and lower exercise activity.
Literatuur
go back to reference American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition – Text Revision (DSM-IV-TR). Washington, DC: American Psychiatric Publishing, Inc. American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition – Text Revision (DSM-IV-TR). Washington, DC: American Psychiatric Publishing, Inc.
go back to reference Bostwick, J. R., Guthrie, S. K., & Ellingrod, V. L. (2009). Antipsychotic-induced hyperprolactinemia. Pharmacotherapy, 29(1), 64–73. PubMedCrossRef Bostwick, J. R., Guthrie, S. K., & Ellingrod, V. L. (2009). Antipsychotic-induced hyperprolactinemia. Pharmacotherapy, 29(1), 64–73. PubMedCrossRef
go back to reference Carter, D. R., Bouxsein, M. L., & Marcus, R. (1992). New approaches for interpreting projected bone densitometry data. Journal of Bone and Mineral Research, 7(2), 137–145. PubMedCrossRef Carter, D. R., Bouxsein, M. L., & Marcus, R. (1992). New approaches for interpreting projected bone densitometry data. Journal of Bone and Mineral Research, 7(2), 137–145. PubMedCrossRef
go back to reference CDC. (2009). Prevalence of autism spectrum disorders—autism and developmental disabilities monitoring network, United States, 2006. MMWR Surveillance Summary, 58(10), 1–20. CDC. (2009). Prevalence of autism spectrum disorders—autism and developmental disabilities monitoring network, United States, 2006. MMWR Surveillance Summary, 58(10), 1–20.
go back to reference Chou, I. J., Lin, K. L., Wang, H. S., & Wang, C. J. (2007). Evaluation of bone mineral density in children receiving carbamazepine or valproate monotherapy. Acta Paediatrics of Taiwan, 48(6), 317–322. Chou, I. J., Lin, K. L., Wang, H. S., & Wang, C. J. (2007). Evaluation of bone mineral density in children receiving carbamazepine or valproate monotherapy. Acta Paediatrics of Taiwan, 48(6), 317–322.
go back to reference Davies, J. H., Evans, B. A., & Gregory, J. W. (2005). Bone mass acquisition in healthy children. Archives of Disease in Childhood, 90(4), 373–378. PubMedCrossRef Davies, J. H., Evans, B. A., & Gregory, J. W. (2005). Bone mass acquisition in healthy children. Archives of Disease in Childhood, 90(4), 373–378. PubMedCrossRef
go back to reference Foo, L. H., Zhang, Q., Zhu, K., Ma, G., Hu, X., Greenfield, H., et al. (2009). Low vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in Chinese adolescent girls. Journal of Nutrition, 139(5), 1002–1007. PubMedCrossRef Foo, L. H., Zhang, Q., Zhu, K., Ma, G., Hu, X., Greenfield, H., et al. (2009). Low vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in Chinese adolescent girls. Journal of Nutrition, 139(5), 1002–1007. PubMedCrossRef
go back to reference Greaves-Lord, K., Huizink, A. C., Oldehinkel, A. J., Ormel, J., Verhulst, F. C., & Ferdinand, R. F. (2009). Baseline cortisol measures and developmental pathways of anxiety in early adolescence. Acta Paediatrica Scandinavia, 120(3), 178–186. CrossRef Greaves-Lord, K., Huizink, A. C., Oldehinkel, A. J., Ormel, J., Verhulst, F. C., & Ferdinand, R. F. (2009). Baseline cortisol measures and developmental pathways of anxiety in early adolescence. Acta Paediatrica Scandinavia, 120(3), 178–186. CrossRef
go back to reference Greulich, W., & Pyle, S. (1959). Radiographic atlas of skeletal development of the hand and wrist (2nd ed.). Stanford: Stanford University Press. Greulich, W., & Pyle, S. (1959). Radiographic atlas of skeletal development of the hand and wrist (2nd ed.). Stanford: Stanford University Press.
go back to reference Grey, V., Atkinson, S., Drury, D., Casey, L., Ferland, G., Gundberg, C., et al. (2008). Prevalence of low bone mass and deficiencies of vitamins D and K in pediatric patients with cystic fibrosis from 3 Canadian centers. Pediatrics, 122(5), 1014–1020. PubMedCrossRef Grey, V., Atkinson, S., Drury, D., Casey, L., Ferland, G., Gundberg, C., et al. (2008). Prevalence of low bone mass and deficiencies of vitamins D and K in pediatric patients with cystic fibrosis from 3 Canadian centers. Pediatrics, 122(5), 1014–1020. PubMedCrossRef
go back to reference Hediger, M. L., England, L. J., Molloy, C. A., Yu, K. F., Manning-Courtney, P., & Mills, J. L. (2008). Reduced bone cortical thickness in boys with autism or autism spectrum disorder. Journal of Autism and Developmental Disorders, 38(5), 848–856. PubMedCrossRef Hediger, M. L., England, L. J., Molloy, C. A., Yu, K. F., Manning-Courtney, P., & Mills, J. L. (2008). Reduced bone cortical thickness in boys with autism or autism spectrum disorder. Journal of Autism and Developmental Disorders, 38(5), 848–856. PubMedCrossRef
go back to reference Heyman, R., Guggenbuhl, P., Corbel, A., Bridoux-Henno, L., Tourtelier, Y., Balencon-Morival, M., et al. (2009). Effect of a gluten-free diet on bone mineral density in children with celiac disease. Gastroenterologie Clinique et Biologique, 33(2), 109–114. PubMedCrossRef Heyman, R., Guggenbuhl, P., Corbel, A., Bridoux-Henno, L., Tourtelier, Y., Balencon-Morival, M., et al. (2009). Effect of a gluten-free diet on bone mineral density in children with celiac disease. Gastroenterologie Clinique et Biologique, 33(2), 109–114. PubMedCrossRef
go back to reference Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., et al. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 96(7), 1911–1930. PubMedCrossRef Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., et al. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 96(7), 1911–1930. PubMedCrossRef
go back to reference Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tildon, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics, 135(5), 559–563. PubMedCrossRef Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tildon, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics, 135(5), 559–563. PubMedCrossRef
go back to reference Kushak, R. I., Lauwers, G. Y., Winter, H. S., & Buie, T. M. (2011). Intestinal disaccharidase activity in patients with autism: Effect of age, gender, and intestinal inflammation. Autism, 15(3), 285–294. PubMedCrossRef Kushak, R. I., Lauwers, G. Y., Winter, H. S., & Buie, T. M. (2011). Intestinal disaccharidase activity in patients with autism: Effect of age, gender, and intestinal inflammation. Autism, 15(3), 285–294. PubMedCrossRef
go back to reference Leder, B. Z., LeBlanc, K. M., Schoenfeld, D. A., Eastell, R., & Finkelstein, J. S. (2003). Differential effects of androgens and estrogens on bone turnover in normal men. Journal of Clinical Endocrinology and Metabolism, 88(1), 204–210. PubMedCrossRef Leder, B. Z., LeBlanc, K. M., Schoenfeld, D. A., Eastell, R., & Finkelstein, J. S. (2003). Differential effects of androgens and estrogens on bone turnover in normal men. Journal of Clinical Endocrinology and Metabolism, 88(1), 204–210. PubMedCrossRef
go back to reference Lehtonen-Veromaa, M. K., Mottonen, T. T., Nuotio, I. O., Irjala, K. M., Leino, A. E., & Viikari, J. S. (2002). Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: A 3-y prospective study. American Journal of Clinical Nutrition, 76(6), 1446–1453. PubMed Lehtonen-Veromaa, M. K., Mottonen, T. T., Nuotio, I. O., Irjala, K. M., Leino, A. E., & Viikari, J. S. (2002). Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: A 3-y prospective study. American Journal of Clinical Nutrition, 76(6), 1446–1453. PubMed
go back to reference Lopez-Duran, N. L., Kovacs, M., & George, C. J. (2009). Hypothalamic-pituitary-adrenal axis dysregulation in depressed children and adolescents: A meta-analysis. Psychoneuroendocrinology, 34(9), 1272–1283. PubMedCrossRef Lopez-Duran, N. L., Kovacs, M., & George, C. J. (2009). Hypothalamic-pituitary-adrenal axis dysregulation in depressed children and adolescents: A meta-analysis. Psychoneuroendocrinology, 34(9), 1272–1283. PubMedCrossRef
go back to reference Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. PubMedCrossRef Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. PubMedCrossRef
go back to reference Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685. PubMedCrossRef Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685. PubMedCrossRef
go back to reference Michael, H., Harkonen, P. L., Vaananen, H. K., & Hentunen, T. A. (2005). Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption. Journal of Bone and Mineral Research, 20(12), 2224–2232. PubMedCrossRef Michael, H., Harkonen, P. L., Vaananen, H. K., & Hentunen, T. A. (2005). Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption. Journal of Bone and Mineral Research, 20(12), 2224–2232. PubMedCrossRef
go back to reference Ming, X., Brimacombe, M., & Wagner, G. C. (2007). Prevalence of motor impairment in autism spectrum disorders. Brain Dev, 29(9), 565–570. PubMedCrossRef Ming, X., Brimacombe, M., & Wagner, G. C. (2007). Prevalence of motor impairment in autism spectrum disorders. Brain Dev, 29(9), 565–570. PubMedCrossRef
go back to reference Misra, M., Aggarwal, A., Miller, K. K., Almazan, C., Worley, M., Soyka, L. A., et al. (2004). Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics, 114(6), 1574–1583. PubMedCrossRef Misra, M., Aggarwal, A., Miller, K. K., Almazan, C., Worley, M., Soyka, L. A., et al. (2004). Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics, 114(6), 1574–1583. PubMedCrossRef
go back to reference Misra, M., Pacaud, D., Petryk, A., Collett-Solberg, P. F., & Kappy, M. (2008). Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics, 122(2), 398–417. PubMedCrossRef Misra, M., Pacaud, D., Petryk, A., Collett-Solberg, P. F., & Kappy, M. (2008). Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics, 122(2), 398–417. PubMedCrossRef
go back to reference Ogden, C., Kuczmarski, R., Flegal, K., Mei, Z., Guo, S., Wei, R., et al. (2002). Centers for Diseases Control and Prevention 2000 growth charts for the United States: Improvements to the 1997 National Center for health Statistics version. Pediatrics, 109, 45–60. PubMedCrossRef Ogden, C., Kuczmarski, R., Flegal, K., Mei, Z., Guo, S., Wei, R., et al. (2002). Centers for Diseases Control and Prevention 2000 growth charts for the United States: Improvements to the 1997 National Center for health Statistics version. Pediatrics, 109, 45–60. PubMedCrossRef
go back to reference Pack, A. M., Morrell, M. J., Randall, A., McMahon, D. J., & Shane, E. (2008). Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. Neurology, 70(18), 1586–1593. PubMedCrossRef Pack, A. M., Morrell, M. J., Randall, A., McMahon, D. J., & Shane, E. (2008). Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. Neurology, 70(18), 1586–1593. PubMedCrossRef
go back to reference Pan, C. Y. (2008). Objectively measured physical activity between children with autism spectrum disorders and children without disabilities during inclusive recess settings in Taiwan. Journal of Autism and Developmental Disorders, 38(7), 1292–1301. PubMedCrossRef Pan, C. Y. (2008). Objectively measured physical activity between children with autism spectrum disorders and children without disabilities during inclusive recess settings in Taiwan. Journal of Autism and Developmental Disorders, 38(7), 1292–1301. PubMedCrossRef
go back to reference Ragusa, L., Elia, M., & Scifo, R. (1993). Growth hormone deficit in autism. Journal of Autism and Developmental Disorders, 23(2), 421–422. PubMedCrossRef Ragusa, L., Elia, M., & Scifo, R. (1993). Growth hormone deficit in autism. Journal of Autism and Developmental Disorders, 23(2), 421–422. PubMedCrossRef
go back to reference Russell, M., Breggia, A., Mendes, N., Klibanski, A., & Misra, M. (2011). Growth hormone is positively associated with surrogate markers of bone turnover during puberty. Clinical Endocrinology (Oxford), 75(4), 482–488. CrossRef Russell, M., Breggia, A., Mendes, N., Klibanski, A., & Misra, M. (2011). Growth hormone is positively associated with surrogate markers of bone turnover during puberty. Clinical Endocrinology (Oxford), 75(4), 482–488. CrossRef
go back to reference Schmidt, S., Mellstrom, D., Norjavaara, E., Sundh, S. V., & Saalman, R. (2009). Low bone mineral density in children and adolescents with inflammatory bowel disease: A population-based study from Western Sweden. Inflammatory Bowel Diseases, 15(12), 1844–1850. PubMedCrossRef Schmidt, S., Mellstrom, D., Norjavaara, E., Sundh, S. V., & Saalman, R. (2009). Low bone mineral density in children and adolescents with inflammatory bowel disease: A population-based study from Western Sweden. Inflammatory Bowel Diseases, 15(12), 1844–1850. PubMedCrossRef
go back to reference Sheth, R. D., Binkley, N., & Hermann, B. P. (2008). Progressive bone deficit in epilepsy. Neurology, 70(3), 170–176. PubMedCrossRef Sheth, R. D., Binkley, N., & Hermann, B. P. (2008). Progressive bone deficit in epilepsy. Neurology, 70(3), 170–176. PubMedCrossRef
go back to reference Slomski, A. (2011). IOM endorses vitamin D, calcium only for bone health, dispels deficiency claims. JAMA, 305(5), 453–454, 456. Slomski, A. (2011). IOM endorses vitamin D, calcium only for bone health, dispels deficiency claims. JAMA, 305(5), 453–454, 456.
go back to reference Soyka, L. A., Grinspoon, S., Levitsky, L. L., Herzog, D. B., & Klibanski, A. (1999). The effects of anorexia nervosa on bone metabolism in female adolescents. Journal of Clinical Endocrinology and Metabolism, 84(12), 4489–4496. PubMedCrossRef Soyka, L. A., Grinspoon, S., Levitsky, L. L., Herzog, D. B., & Klibanski, A. (1999). The effects of anorexia nervosa on bone metabolism in female adolescents. Journal of Clinical Endocrinology and Metabolism, 84(12), 4489–4496. PubMedCrossRef
go back to reference Valicenti-McDermott, M. D., McVicar, K., Cohen, H. J., Wershil, B. K., & Shinnar, S. (2008). Gastrointestinal symptoms in children with an autism spectrum disorder and language regression. Pediatric Neurology, 39(6), 392–398. PubMedCrossRef Valicenti-McDermott, M. D., McVicar, K., Cohen, H. J., Wershil, B. K., & Shinnar, S. (2008). Gastrointestinal symptoms in children with an autism spectrum disorder and language regression. Pediatric Neurology, 39(6), 392–398. PubMedCrossRef
go back to reference Wren, T. A., Liu, X., Pitukcheewanont, P., & Gilsanz, V. (2005). Bone acquisition in healthy children and adolescents: Comparisons of dual-energy X-ray absorptiometry and computed tomography measures. Journal of Clinical Endocrinology and Metabolism, 90(4), 1925–1928. PubMedCrossRef Wren, T. A., Liu, X., Pitukcheewanont, P., & Gilsanz, V. (2005). Bone acquisition in healthy children and adolescents: Comparisons of dual-energy X-ray absorptiometry and computed tomography measures. Journal of Clinical Endocrinology and Metabolism, 90(4), 1925–1928. PubMedCrossRef
go back to reference Zemel, B. S., Kalkwarf, H. J., Gilsanz, V., Lappe, J. M., Oberfield, S., Shepherd, J. A., et al. (2011). Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: Results of the bone mineral density in childhood study. Journal of Clinical Endocrinology and Metabolism, 96(10), 3160–3169. PubMedCrossRef Zemel, B. S., Kalkwarf, H. J., Gilsanz, V., Lappe, J. M., Oberfield, S., Shepherd, J. A., et al. (2011). Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: Results of the bone mineral density in childhood study. Journal of Clinical Endocrinology and Metabolism, 96(10), 3160–3169. PubMedCrossRef
Metagegevens
Titel
Bone Density in Peripubertal Boys with Autism Spectrum Disorders
Auteurs
Ann M. Neumeyer
Amy Gates
Christine Ferrone
Hang Lee
Madhusmita Misra
Publicatiedatum
01-07-2013
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-012-1709-3