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Gepubliceerd in: Journal of Autism and Developmental Disorders 11/2016

04-08-2016 | Original Paper

Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders

Auteurs: Laya Ekhlaspour, Charumathi Baskaran, Karen Joanie Campoverde, Natalia Cano Sokoloff, Ann M. Neumeyer, Madhusmita Misra

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2016

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Abstract

Patients with autism spectrum disorder (ASD) are at increased risk for fracture, and peri-pubertal boys with ASD have lower bone mineral density (BMD) than controls. Data are lacking regarding BMD in older adolescents with ASD. We compared BMD using dual-energy X-ray absorptiometry in 9 adolescents/young adults with ASD against 9 typically developing matched controls. Patients with ASD and controls were excluded if they had other underlying conditions that may affect bone. Compared to controls, patients with ASD had (i) lower femoral neck and hip BMD Z-scores, and (ii) lower spine, femoral neck and hip height adjusted BMD Z-scores even after controlling for BMI. Understanding the underlying pathophysiology will be key to developing therapies to improve BMD and reduce fracture risk.

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Literatuur
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual disorders (5th ed.). VA: American Psychiatric Association. CrossRef American Psychiatric Association. (2013). Diagnostic and statistical manual disorders (5th ed.). VA: American Psychiatric Association. CrossRef
go back to reference Calarge, C. A., Burns, T. L., Schlechte, J. A., & Zemel, B. S. (2015). Longitudinal examination of the skeletal effects of selective serotonin reuptake inhibitors and risperidone in boys. Journal of Clinical Psychiatry, 76(5), 607–613. doi: 10.​4088/​JCP.​14m09195. CrossRefPubMed Calarge, C. A., Burns, T. L., Schlechte, J. A., & Zemel, B. S. (2015). Longitudinal examination of the skeletal effects of selective serotonin reuptake inhibitors and risperidone in boys. Journal of Clinical Psychiatry, 76(5), 607–613. doi: 10.​4088/​JCP.​14m09195. CrossRefPubMed
go back to reference Chou, I. J., Lin, K. L., Wang, H. S., & Wang, C. J. (2007). Evaluation of bone mineral density in children receiving carbamazepine or valproate monotherapy. Acta Paediatrica Taiwanica, 48(6), 317–322. PubMed Chou, I. J., Lin, K. L., Wang, H. S., & Wang, C. J. (2007). Evaluation of bone mineral density in children receiving carbamazepine or valproate monotherapy. Acta Paediatrica Taiwanica, 48(6), 317–322. PubMed
go back to reference Emin, O., Fatih, M., Emre, D., & Nedim, S. (2011). Lack of bone metabolism side effects after 3 years of nasal topical steroids in children with allergic rhinitis. Journal of Bone and Mineral Metabolism, 29(5), 582–587. doi: 10.​1007/​s00774-010-0255-3. CrossRefPubMed Emin, O., Fatih, M., Emre, D., & Nedim, S. (2011). Lack of bone metabolism side effects after 3 years of nasal topical steroids in children with allergic rhinitis. Journal of Bone and Mineral Metabolism, 29(5), 582–587. doi: 10.​1007/​s00774-010-0255-3. CrossRefPubMed
go back to reference Estrada, K., Styrkarsdottir, U., Evangelou, E., Hsu, Y. H., Duncan, E. L., Ntzani, E. E., et al. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491–501. doi: 10.​1038/​ng.​2249. CrossRefPubMedPubMedCentral Estrada, K., Styrkarsdottir, U., Evangelou, E., Hsu, Y. H., Duncan, E. L., Ntzani, E. E., et al. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491–501. doi: 10.​1038/​ng.​2249. CrossRefPubMedPubMedCentral
go back to reference Hediger, M. L., England, L. J., Molloy, C. A., Yu, K. F., Manning-Courtney, P., & Mills, J. L. (2008). Reduced bone cortical thickness in boys with autism or autism spectrum disorder. Journal of Autism and Developmental Disorders, 38(5), 848–856. doi: 10.​1007/​s10803-007-0453-6. CrossRefPubMed Hediger, M. L., England, L. J., Molloy, C. A., Yu, K. F., Manning-Courtney, P., & Mills, J. L. (2008). Reduced bone cortical thickness in boys with autism or autism spectrum disorder. Journal of Autism and Developmental Disorders, 38(5), 848–856. doi: 10.​1007/​s10803-007-0453-6. CrossRefPubMed
go back to reference Lehtonen-Veromaa, M. K., Mottonen, T. T., Nuotio, I. O., Irjala, K. M., Leino, A. E., & Viikari, J. S. (2002). Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: A 3-y prospective study. American Journal of Clinical Nutrition, 76(6), 1446–1453. PubMed Lehtonen-Veromaa, M. K., Mottonen, T. T., Nuotio, I. O., Irjala, K. M., Leino, A. E., & Viikari, J. S. (2002). Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: A 3-y prospective study. American Journal of Clinical Nutrition, 76(6), 1446–1453. PubMed
go back to reference Nishiyama, K. K., Macdonald, H. M., Moore, S. A., Fung, T., Boyd, S. K., & McKay, H. A. (2012). Cortical porosity is higher in boys compared with girls at the distal radius and distal tibia during pubertal growth: An HR-pQCT study. Journal of Bone and Mineral Research, 27(2), 273–282. doi: 10.​1002/​jbmr.​552. CrossRefPubMed Nishiyama, K. K., Macdonald, H. M., Moore, S. A., Fung, T., Boyd, S. K., & McKay, H. A. (2012). Cortical porosity is higher in boys compared with girls at the distal radius and distal tibia during pubertal growth: An HR-pQCT study. Journal of Bone and Mineral Research, 27(2), 273–282. doi: 10.​1002/​jbmr.​552. CrossRefPubMed
go back to reference Pan, C. Y. (2008). Objectively measured physical activity between children with autism spectrum disorders and children without disabilities during inclusive recess settings in Taiwan. Journal of Autism and Developmental Disorders, 38(7), 1292–1301. doi: 10.​1007/​s10803-007-0518-6. CrossRefPubMed Pan, C. Y. (2008). Objectively measured physical activity between children with autism spectrum disorders and children without disabilities during inclusive recess settings in Taiwan. Journal of Autism and Developmental Disorders, 38(7), 1292–1301. doi: 10.​1007/​s10803-007-0518-6. CrossRefPubMed
go back to reference Rieger-Wettengl, G., Tutlewski, B., Stabrey, A., Rauch, F., Herkenrath, P., Schauseil-Zipf, U., et al. (2001). Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine. Pediatrics, 108(6), E107. CrossRefPubMed Rieger-Wettengl, G., Tutlewski, B., Stabrey, A., Rauch, F., Herkenrath, P., Schauseil-Zipf, U., et al. (2001). Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine. Pediatrics, 108(6), E107. CrossRefPubMed
go back to reference Roke, Y., van Harten, P. N., Buitelaar, J. K., Tenback, D. E., Quekel, L. G., de Rijke, Y. B., et al. (2012). Bone mineral density in male adolescents with autism spectrum disorders and disruptive behavior disorder with or without antipsychotic treatment. European Journal of Endocrinology, 167(6), 855–863. doi: 10.​1530/​EJE-12-0521. CrossRefPubMed Roke, Y., van Harten, P. N., Buitelaar, J. K., Tenback, D. E., Quekel, L. G., de Rijke, Y. B., et al. (2012). Bone mineral density in male adolescents with autism spectrum disorders and disruptive behavior disorder with or without antipsychotic treatment. European Journal of Endocrinology, 167(6), 855–863. doi: 10.​1530/​EJE-12-0521. CrossRefPubMed
go back to reference Schoenau, E. (2005). From mechanostat theory to development of the “functional muscle-bone-unit”. Journal of Musculoskeletal and Neuronal Interactions, 5(3), 232–238. PubMed Schoenau, E. (2005). From mechanostat theory to development of the “functional muscle-bone-unit”. Journal of Musculoskeletal and Neuronal Interactions, 5(3), 232–238. PubMed
go back to reference Tan, V. P., Macdonald, H. M., Kim, S., Nettlefold, L., Gabel, L., Ashe, M. C., et al. (2014). Influence of physical activity on bone strength in children and adolescents: A systematic review and narrative synthesis. Journal of Bone and Mineral Research, 29(10), 2161–2181. doi: 10.​1002/​jbmr.​2254. CrossRefPubMed Tan, V. P., Macdonald, H. M., Kim, S., Nettlefold, L., Gabel, L., Ashe, M. C., et al. (2014). Influence of physical activity on bone strength in children and adolescents: A systematic review and narrative synthesis. Journal of Bone and Mineral Research, 29(10), 2161–2181. doi: 10.​1002/​jbmr.​2254. CrossRefPubMed
go back to reference Tekgul, H., Serdaroglu, G., Huseyinov, A., & Gokben, S. (2006). Bone mineral status in pediatric outpatients on antiepileptic drug monotherapy. Journal of Child Neurology, 21(5), 411–414. PubMed Tekgul, H., Serdaroglu, G., Huseyinov, A., & Gokben, S. (2006). Bone mineral status in pediatric outpatients on antiepileptic drug monotherapy. Journal of Child Neurology, 21(5), 411–414. PubMed
go back to reference Theintz, G., Buchs, B., Rizzoli, R., Slosman, D., Clavien, H., Sizonenko, P. C., et al. (1992). Longitudinal monitoring of bone mass accumulation in healthy adolescents: Evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. Journal of Clinical Endocrinology and Metabolism, 75(4), 1060–1065. doi: 10.​1210/​jcem.​75.​4.​1400871. PubMed Theintz, G., Buchs, B., Rizzoli, R., Slosman, D., Clavien, H., Sizonenko, P. C., et al. (1992). Longitudinal monitoring of bone mass accumulation in healthy adolescents: Evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. Journal of Clinical Endocrinology and Metabolism, 75(4), 1060–1065. doi: 10.​1210/​jcem.​75.​4.​1400871. PubMed
go back to reference Warden, S. J., Burr, D. B., & Brukner, P. D. (2006). Stress fractures: Pathophysiology, epidemiology, and risk factors. Curr Osteoporos Rep, 4(3), 103–109. CrossRefPubMed Warden, S. J., Burr, D. B., & Brukner, P. D. (2006). Stress fractures: Pathophysiology, epidemiology, and risk factors. Curr Osteoporos Rep, 4(3), 103–109. CrossRefPubMed
go back to reference Yaghini, O., Tonekaboni, S. H., Amir Shahkarami, S. M., Ahmad Abadi, F., Shariat, F., & Abdollah Gorji, F. (2015). Bone mineral density in ambulatory children with epilepsy. Indian Journal of Pediatrics, 82(3), 225–229. doi: 10.​1007/​s12098-014-1518-0. CrossRefPubMed Yaghini, O., Tonekaboni, S. H., Amir Shahkarami, S. M., Ahmad Abadi, F., Shariat, F., & Abdollah Gorji, F. (2015). Bone mineral density in ambulatory children with epilepsy. Indian Journal of Pediatrics, 82(3), 225–229. doi: 10.​1007/​s12098-014-1518-0. CrossRefPubMed
Metagegevens
Titel
Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders
Auteurs
Laya Ekhlaspour
Charumathi Baskaran
Karen Joanie Campoverde
Natalia Cano Sokoloff
Ann M. Neumeyer
Madhusmita Misra
Publicatiedatum
04-08-2016
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 11/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-016-2871-9