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Journal of Autism and Developmental Disorders

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04-08-2016 | Original Paper

Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders

Auteurs: Laya Ekhlaspour, Charumathi Baskaran, Karen Joanie Campoverde, Natalia Cano Sokoloff, Ann M. Neumeyer, Madhusmita Misra

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2016

Abstract

Patients with autism spectrum disorder (ASD) are at increased risk for fracture, and peri-pubertal boys with ASD have lower bone mineral density (BMD) than controls. Data are lacking regarding BMD in older adolescents with ASD. We compared BMD using dual-energy X-ray absorptiometry in 9 adolescents/young adults with ASD against 9 typically developing matched controls. Patients with ASD and controls were excluded if they had other underlying conditions that may affect bone. Compared to controls, patients with ASD had (i) lower femoral neck and hip BMD Z-scores, and (ii) lower spine, femoral neck and hip height adjusted BMD Z-scores even after controlling for BMI. Understanding the underlying pathophysiology will be key to developing therapies to improve BMD and reduce fracture risk.

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Titel: Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders
Auteurs: Laya Ekhlaspour
Charumathi Baskaran
Karen Joanie Campoverde
Natalia Cano Sokoloff
Ann M. Neumeyer
Madhusmita Misra
Publicatiedatum: 04-08-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-016-2871-9

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