Skip to main content
Top
Gepubliceerd in: Research on Child and Adolescent Psychopathology 4/2022

06-10-2021

Blunted Flanker P300 Demonstrates Specificity to Depressive Symptoms in Females during Adolescence

Auteurs: Nicholas J. Santopetro, Alexander M. Kallen, Austin Hunter Threadgill, Nader Amir, Greg Hajcak

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 4/2022

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Recent research suggests that depressive disorders in adults are characterized by reductions in flanker P300 amplitude, and that a reduced flanker P300 may also predict worst depressive trajectories over time. The current study extended this work to adolescence—and to evaluate the specificity of the relationship between flanker P300 to depressive symptoms versus anxiety symptoms, and whether the association between flanker P300 and depressive symptoms was moderated by biological sex. To this end, P300 amplitude, depression, anxiety, and sex were assessed in a large sample of 619 adolescents aged 11 to 14. Participants completed a speeded response flanker task while EEG was recorded, as well as self-reported measures of current depression and anxiety symptoms. Reduced P300 amplitude was related to both heightened depression and anxiety symptoms in zero-order correlations. Regression-based analyses suggest that reduced P300 was uniquely related to depressive symptoms. Furthermore, this negative association between P300 and depression was apparent in female adolescents, but not male adolescents. In sum, the current study suggests that flanker P300 amplitude may potentially serve as a neural marker specific to depression in females during adolescence.
Voetnoten
1
A total of 23 participants did not answer their ethnicity or race (n = 596).
 
2
A total of 59 participants did not answer questions related to psychotropic medication status (n = 560).
 
3
Results from the multiple regression remain unchanged when adding correct reaction time, error rate, psychotropic medication status and N200 amplitude as additional predictors into the model. The overall model remains significant, F(7, 552) = 14.56, p < .001, and CDI total score (b =-.15, t(560) = -2.55, p = .011, sr = -.10, 95% CI [-0.26, -0.03]) and age (b =-1.81, t(560) = -6.64, p < .001, sr = -.26, 95% CI [-2.34, -1.27]) still emerge as significant predictors. Additionally, N200 amplitude is also a significant predictor of P300 amplitude in this model, b = .21, t(560) = 3.90, p < .001, sr = .15, 95% CI [0.11, 0.32], such that participants with reduced N200 amplitude exhibited larger P300.
 
4
Results do not change when predicting P300 amplitude on congruent trials compared to P300 amplitude on incongruent trials. Current depressive symptoms, not anxiety symptoms, are a significant predictor of P300 amplitude while controlling for age.
 
5
N200 amplitude (b = .05, SE = .02, OR = 1.05, p = .004), P300 amplitude (b = .03, SE = .01, OR = 1.03, p = .031), and current depressive symptoms (b = -.06, SE = .01, OR = 0.94, p < .001) are all independent predictors of sex. The overall model is significant as well, X2(3) = 45.44, p < .001. Sex is coded female = 0 and male = 1 in the model.
 
6
Including N200 amplitude and current psychotropic medication status as additional independent variables into the regression does not affect the current results. The overall model remains significant, F(6,553) = 14.60, p < .001, and the P300 x sex interaction term is still significant, b = .35, t(590) = 4.23, p < .001, sr = .17, 95% CI [0.19, 0.51].
 
7
The multiple linear regression from the previous section (i.e. Table 2) was conducted again only in female participants (n = 292) in order to avoid the confounding sex main effect involving P300 amplitude. This overall model remains significant, F(3,288) = 22.68, p < .001. Consistent with our original model involving the entire sample, current depressive symptoms (b = -.29, t(292) = -3.88, p < .001, sr = -.21, 95% CI [-0.41, -0.13]) and age (b = -1.68, t(292) = -5.26, p < .001, sr = -.28, 95% CI [-2.31, -1.05]) are the only significant predictors of P300 amplitude such that female participants with lower levels of depression and younger female participants exhibit heightened P300 amplitude. Current anxiety symptoms were not a significant independent variable in the model, b = .04, t(292) = 1.04, p = .301, sr = .06, 95% CI [-0.04, 0.11].
 
Literatuur
go back to reference Albert, P. R. (2015). Why is depression more prevalent in women? Journal of Psychiatry & Neuroscience: JPN, 40(4), 219. Albert, P. R. (2015). Why is depression more prevalent in women? Journal of Psychiatry & Neuroscience: JPN, 40(4), 219.
go back to reference Altemus, M., Sarvaiya, N., & Epperson, C. N. (2014). Sex differences in anxiety and depression clinical perspectives. Frontiers in Neuroendocrinology, 35(3), 320–330.PubMedPubMedCentral Altemus, M., Sarvaiya, N., & Epperson, C. N. (2014). Sex differences in anxiety and depression clinical perspectives. Frontiers in Neuroendocrinology, 35(3), 320–330.PubMedPubMedCentral
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub.
go back to reference Anderer, P., Semlitsch, H. V., Saletu, B., Saletu-Zyhlarz, G., Gruber, D., Metka, M., & Oettel, M. (2003). Effects of hormone replacement therapy on perceptual and cognitive event-related potentials in menopausal insomnia. Psychoneuroendocrinology, 28(3), 419–445.PubMed Anderer, P., Semlitsch, H. V., Saletu, B., Saletu-Zyhlarz, G., Gruber, D., Metka, M., & Oettel, M. (2003). Effects of hormone replacement therapy on perceptual and cognitive event-related potentials in menopausal insomnia. Psychoneuroendocrinology, 28(3), 419–445.PubMed
go back to reference Bardone, A. M., Moffitt, T. E., Caspi, A., Dickson, N., & Silva, P. A. (1996). Adult mental health and social outcomes of adolescent girls with depression and conduct disorder. Development and Psychopathology, 8(4), 811–829. Bardone, A. M., Moffitt, T. E., Caspi, A., Dickson, N., & Silva, P. A. (1996). Adult mental health and social outcomes of adolescent girls with depression and conduct disorder. Development and Psychopathology, 8(4), 811–829.
go back to reference Baving, L., Rellum, T., Laucht, M., & Schmidt, M. H. (2004). Attentional enhancement to NoGo stimuli in anxious children. Journal of Neural Transmission, 111(7), 985–999.PubMed Baving, L., Rellum, T., Laucht, M., & Schmidt, M. H. (2004). Attentional enhancement to NoGo stimuli in anxious children. Journal of Neural Transmission, 111(7), 985–999.PubMed
go back to reference Beesdo, K., Knappe, S., & Pine, D. S. (2009). Anxiety and anxiety disorders in children and adolescents: Developmental issues and implications for DSM-V. Psychiatric Clinics, 32(3), 483–524.PubMed Beesdo, K., Knappe, S., & Pine, D. S. (2009). Anxiety and anxiety disorders in children and adolescents: Developmental issues and implications for DSM-V. Psychiatric Clinics, 32(3), 483–524.PubMed
go back to reference Birmaher, B., Khetarpal, S., Brent, D., Cully, M., Balach, L., Kaufman, J., & Neer, S. M. (1997). The screen for child anxiety related emotional disorders (SCARED): Scale construction and psychometric characteristics. Journal of the American Academy of Child & Adolescent Psychiatry, 36(4), 545–553. Birmaher, B., Khetarpal, S., Brent, D., Cully, M., Balach, L., Kaufman, J., & Neer, S. M. (1997). The screen for child anxiety related emotional disorders (SCARED): Scale construction and psychometric characteristics. Journal of the American Academy of Child & Adolescent Psychiatry, 36(4), 545–553.
go back to reference Birmaher, B., Williamson, D. E., Dahl, R. E., Axelson, D. A., Kaufman, J., Dorn, L. D., & Ryan, N. D. (2004). Clinical presentation and course of depression in youth: Does onset in childhood differ from onset in adolescence? Journal of the American Academy of Child & Adolescent Psychiatry, 43(1), 63–70. Birmaher, B., Williamson, D. E., Dahl, R. E., Axelson, D. A., Kaufman, J., Dorn, L. D., & Ryan, N. D. (2004). Clinical presentation and course of depression in youth: Does onset in childhood differ from onset in adolescence? Journal of the American Academy of Child & Adolescent Psychiatry, 43(1), 63–70.
go back to reference Bonnewyn, A., Bruffaerts, R., Vilagut, G., Almansa, J., & Demyttenaere, K. (2007). Lifetime risk and age-of-onset of mental disorders in the Belgian general population. Social Psychiatry and Psychiatric Epidemiology, 42(7), 522–529.PubMed Bonnewyn, A., Bruffaerts, R., Vilagut, G., Almansa, J., & Demyttenaere, K. (2007). Lifetime risk and age-of-onset of mental disorders in the Belgian general population. Social Psychiatry and Psychiatric Epidemiology, 42(7), 522–529.PubMed
go back to reference Bruder, G. E., Kayser, J., & Tenke, C. E. (2012). Event-related brain potentials in depression: Clinical, cognitive and neurophysiologic implications. The Oxford Handbook of Event-Related Potential Components, 2012, 563–592. Bruder, G. E., Kayser, J., & Tenke, C. E. (2012). Event-related brain potentials in depression: Clinical, cognitive and neurophysiologic implications. The Oxford Handbook of Event-Related Potential Components, 2012, 563–592.
go back to reference Bruder, G. E., Tenke, C. E., Towey, J. P., Leite, P., Fong, R., Stewart, J. E., & Quitkin, F. M. (1998). Brain ERPs of depressed patients to complex tones in an oddball task: Relation of reduced P3 asymmetry to physical anhedonia. Psychophysiology, 35(1), 54–63.PubMed Bruder, G. E., Tenke, C. E., Towey, J. P., Leite, P., Fong, R., Stewart, J. E., & Quitkin, F. M. (1998). Brain ERPs of depressed patients to complex tones in an oddball task: Relation of reduced P3 asymmetry to physical anhedonia. Psychophysiology, 35(1), 54–63.PubMed
go back to reference Carle, A. C., Millsap, R. E., & Cole, D. A. (2008). Measurement bias across gender on the Children’s Depression Inventory: Evidence for invariance from two latent variable models. Educational and Psychological Measurement, 68(2), 281–303. Carle, A. C., Millsap, R. E., & Cole, D. A. (2008). Measurement bias across gender on the Children’s Depression Inventory: Evidence for invariance from two latent variable models. Educational and Psychological Measurement, 68(2), 281–303.
go back to reference Cía, A. H., Stagnaro, J. C., Gaxiola, S. A., Vommaro, H., Loera, G., Medina-Mora, M. E., & Kessler, R. C. (2018). Lifetime prevalence and age-of-onset of mental disorders in adults from the Argentinean Study of Mental Health Epidemiology. Social Psychiatry and Psychiatric Epidemiology, 53(4), 341–350.PubMed Cía, A. H., Stagnaro, J. C., Gaxiola, S. A., Vommaro, H., Loera, G., Medina-Mora, M. E., & Kessler, R. C. (2018). Lifetime prevalence and age-of-onset of mental disorders in adults from the Argentinean Study of Mental Health Epidemiology. Social Psychiatry and Psychiatric Epidemiology, 53(4), 341–350.PubMed
go back to reference Clark, L., Chamberlain, S. R., & Sahakian, B. J. (2009). Neurocognitive mechanisms in depression: Implications for treatment. Annual Review of Neuroscience, 32(1), 57–74.PubMed Clark, L., Chamberlain, S. R., & Sahakian, B. J. (2009). Neurocognitive mechanisms in depression: Implications for treatment. Annual Review of Neuroscience, 32(1), 57–74.PubMed
go back to reference Costello, E. J., Copeland, W., & Angold, A. (2011). Trends in psychopathology across the adolescent years: What changes when children become adolescents, and when adolescents become adults? Journal of Child Psychology and Psychiatry, 52(10), 1015–1025.PubMed Costello, E. J., Copeland, W., & Angold, A. (2011). Trends in psychopathology across the adolescent years: What changes when children become adolescents, and when adolescents become adults? Journal of Child Psychology and Psychiatry, 52(10), 1015–1025.PubMed
go back to reference Crocetti, E., Hale, W. W., III., Fermani, A., Raaijmakers, Q., & Meeus, W. (2009). Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED) in the general Italian adolescent population: A validation and a comparison between Italy and The Netherlands. Journal of Anxiety Disorders, 23(6), 824–829.PubMed Crocetti, E., Hale, W. W., III., Fermani, A., Raaijmakers, Q., & Meeus, W. (2009). Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED) in the general Italian adolescent population: A validation and a comparison between Italy and The Netherlands. Journal of Anxiety Disorders, 23(6), 824–829.PubMed
go back to reference Cummings, C. M., Caporino, N. E., & Kendall, P. C. (2014). Comorbidity of anxiety and depression in children and adolescents: 20 years after. Psychological Bulletin, 140(3), 816.PubMed Cummings, C. M., Caporino, N. E., & Kendall, P. C. (2014). Comorbidity of anxiety and depression in children and adolescents: 20 years after. Psychological Bulletin, 140(3), 816.PubMed
go back to reference de Lijster, J. M., Dierckx, B., Utens, E. M., Verhulst, F. C., Zieldorff, C., Dieleman, G. C., & Legerstee, J. S. (2017). The age of onset of anxiety disorders: a meta-analysis. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 62(4), 237. de Lijster, J. M., Dierckx, B., Utens, E. M., Verhulst, F. C., Zieldorff, C., Dieleman, G. C., & Legerstee, J. S. (2017). The age of onset of anxiety disorders: a meta-analysis. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie62(4), 237.
go back to reference Deldin, P. J., Keller, J., Gergen, J. A., & Miller, G. A. (2000). Right-posterior face processing anomaly in depression. Journal of Abnormal Psychology, 109(1), 116.PubMed Deldin, P. J., Keller, J., Gergen, J. A., & Miller, G. A. (2000). Right-posterior face processing anomaly in depression. Journal of Abnormal Psychology, 109(1), 116.PubMed
go back to reference Éismont, E. V., Lutsyuk, N. V., & Pavlenko, V. B. (2009). Reflection of anxiety in the characteristics of evoked EEG potentials in 10-to 11-year-old children. Neurophysiology, 41(6), 435–442. Éismont, E. V., Lutsyuk, N. V., & Pavlenko, V. B. (2009). Reflection of anxiety in the characteristics of evoked EEG potentials in 10-to 11-year-old children. Neurophysiology, 41(6), 435–442.
go back to reference El Massioui, F., Everett, J., Martin, M. T., Jouvent, R., & Widlöcher, D. (1996). Attention deficits in depression: An electrophysiological marker. NeuroReport, 7(15–17), 2483–2486.PubMed El Massioui, F., Everett, J., Martin, M. T., Jouvent, R., & Widlöcher, D. (1996). Attention deficits in depression: An electrophysiological marker. NeuroReport, 7(15–17), 2483–2486.PubMed
go back to reference Eriksen, B. A., & Eriksen, C. W. (1974). Effects of noise letters upon the identification of a target letter in a nonsearch task. Perception & psychophysics, 16(1), 143–149.M. Kovacs, The Children’s Depression Inventory, Multi-Health Systems, North Tonawanda, NY, USA, 1992. Eriksen, B. A., & Eriksen, C. W. (1974). Effects of noise letters upon the identification of a target letter in a nonsearch task. Perception & psychophysics16(1), 143–149.M. Kovacs, The Children’s Depression Inventory, Multi-Health Systems, North Tonawanda, NY, USA, 1992.
go back to reference Feldmann, L., Piechaczek, C. E., Pehl, V., Bartling, J., Bakos, S., Schulte-Körne, G., & Greimel, E. (2018). State or trait? Auditory event-related potentials in adolescents with current and remitted major depression. Neuropsychologia, 113, 95–103.PubMed Feldmann, L., Piechaczek, C. E., Pehl, V., Bartling, J., Bakos, S., Schulte-Körne, G., & Greimel, E. (2018). State or trait? Auditory event-related potentials in adolescents with current and remitted major depression. Neuropsychologia, 113, 95–103.PubMed
go back to reference Fergusson, D. M., & Woodward, L. J. (2002). Mental health, educational, and social role outcomes of adolescents with depression. Archives of General Psychiatry, 59(3), 225–231.PubMed Fergusson, D. M., & Woodward, L. J. (2002). Mental health, educational, and social role outcomes of adolescents with depression. Archives of General Psychiatry, 59(3), 225–231.PubMed
go back to reference Ferreri, F., Lapp, L. K., & Peretti, C. S. (2011). Current research on cognitive aspects of anxiety disorders. Current Opinion in Psychiatry, 24(1), 49–54.PubMed Ferreri, F., Lapp, L. K., & Peretti, C. S. (2011). Current research on cognitive aspects of anxiety disorders. Current Opinion in Psychiatry, 24(1), 49–54.PubMed
go back to reference GIESE-DAVIS, J. E., Miller, G. A., & Knight, R. A. (1993). Memory template comparison processes in anhedonia and dysthymia. Psychophysiology, 30(6), 646–656. GIESE-DAVIS, J. E., Miller, G. A., & Knight, R. A. (1993). Memory template comparison processes in anhedonia and dysthymia. Psychophysiology, 30(6), 646–656.
go back to reference Gratton, G., Coles, M. G., & Donchin, E. (1983). A new method for off-line removal of ocular artifact. Electroencephalography and Clinical Neurophysiology, 55(4), 468–484.PubMed Gratton, G., Coles, M. G., & Donchin, E. (1983). A new method for off-line removal of ocular artifact. Electroencephalography and Clinical Neurophysiology, 55(4), 468–484.PubMed
go back to reference Greden, J. F. (2001). The burden of recurrent depression: Causes, consequences, and future prospects. Journal of Clinical Psychiatry, 62, 5–9. Greden, J. F. (2001). The burden of recurrent depression: Causes, consequences, and future prospects. Journal of Clinical Psychiatry, 62, 5–9.
go back to reference Greimel, E., Trinkl, M., Bartling, J., Bakos, S., Grossheinrich, N., & Schulte-Körne, G. (2015). Auditory selective attention in adolescents with major depression: An event-related potential study. Journal of Affective Disorders, 172, 445–452.PubMed Greimel, E., Trinkl, M., Bartling, J., Bakos, S., Grossheinrich, N., & Schulte-Körne, G. (2015). Auditory selective attention in adolescents with major depression: An event-related potential study. Journal of Affective Disorders, 172, 445–452.PubMed
go back to reference Hajcak, G., & Foti, D. (2020). Significance?... Significance! Empirical, methodological, and theoretical connections between the late positive potential and P300 as neural responses to stimulus significance: An integrative review. Psychophysiology, e13570. Hajcak, G., & Foti, D. (2020). Significance?... Significance! Empirical, methodological, and theoretical connections between the late positive potential and P300 as neural responses to stimulus significance: An integrative review. Psychophysiology, e13570.
go back to reference Hajcak, G., Klawohn, J., & Meyer, A. (2019). The utility of event-related potentials in clinical psychology. Annual review of clinical psychology. Hajcak, G., Klawohn, J., & Meyer, A. (2019). The utility of event-related potentials in clinical psychology. Annual review of clinical psychology.
go back to reference Hogan, A. M., Butterfield, E. L., Phillips, L., & Hadwin, J. A. (2007). Brain response to unexpected novel noises in children with low and high trait anxiety. Journal of Cognitive Neuroscience, 19(1), 25–31.PubMed Hogan, A. M., Butterfield, E. L., Phillips, L., & Hadwin, J. A. (2007). Brain response to unexpected novel noises in children with low and high trait anxiety. Journal of Cognitive Neuroscience, 19(1), 25–31.PubMed
go back to reference Houston, R. J., Bauer, L. O., & Hesselbrock, V. M. (2003). Depression and familial risk for substance dependence: A P300 study of young women. Psychiatry Research: Neuroimaging, 124(1), 49–62.PubMed Houston, R. J., Bauer, L. O., & Hesselbrock, V. M. (2003). Depression and familial risk for substance dependence: A P300 study of young women. Psychiatry Research: Neuroimaging, 124(1), 49–62.PubMed
go back to reference Houston, R. J., Bauer, L. O., & Hesselbrock, V. M. (2004). P300 evidence of cognitive inflexibility in female adolescents at risk for recurrent depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 28, 529–536. Houston, R. J., Bauer, L. O., & Hesselbrock, V. M. (2004). P300 evidence of cognitive inflexibility in female adolescents at risk for recurrent depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 28, 529–536.
go back to reference Iannaccone, R., Hauser, T. U., Staempfli, P., Walitza, S., Brandeis, D., & Brem, S. (2015). Conflict monitoring and error processing: New insights from simultaneous EEG–fMRI. NeuroImage, 105, 395–407.PubMed Iannaccone, R., Hauser, T. U., Staempfli, P., Walitza, S., Brandeis, D., & Brem, S. (2015). Conflict monitoring and error processing: New insights from simultaneous EEG–fMRI. NeuroImage, 105, 395–407.PubMed
go back to reference Imburgio, M. J., Banica, I., Hill, K. E., Weinberg, A., Foti, D., & MacNamara, A. (2020). Establishing norms for error-related brain activity during the arrow Flanker task among young adults. NeuroImage, 213, 116694. Imburgio, M. J., Banica, I., Hill, K. E., Weinberg, A., Foti, D., & MacNamara, A. (2020). Establishing norms for error-related brain activity during the arrow Flanker task among young adults. NeuroImage213, 116694.
go back to reference Ivarsson, T., Svalander, P., & Litlere, O. (2006). The Children's Depression Inventory (CDI) as measure of depression in Swedish adolescents. A normative study. Nordic Journal of Psychiatry, 60(3), 220–226. Ivarsson, T., Svalander, P., & Litlere, O. (2006). The Children's Depression Inventory (CDI) as measure of depression in Swedish adolescents. A normative study. Nordic Journal of Psychiatry60(3), 220–226.
go back to reference Jelínek, M., Květon, P., Burešová, I., & Klimusová, H. (2021). Measuring depression in adolescence: Evaluation of a hierarchical factor model of the Children’s Depression Inventory and measurement invariance across boys and girls. Plos one, 16(4), e0249943. Jelínek, M., Květon, P., Burešová, I., & Klimusová, H. (2021). Measuring depression in adolescence: Evaluation of a hierarchical factor model of the Children’s Depression Inventory and measurement invariance across boys and girls. Plos one16(4), e0249943.
go back to reference Kelly, E. V., Newton, N. C., Stapinski, L. A., Slade, T., Barrett, E. L., Conrod, P. J., & Teesson, M. (2015). Suicidality, internalizing problems and externalizing problems among adolescent bullies, victims and bully-victims. Preventive Medicine, 73, 100–105.PubMed Kelly, E. V., Newton, N. C., Stapinski, L. A., Slade, T., Barrett, E. L., Conrod, P. J., & Teesson, M. (2015). Suicidality, internalizing problems and externalizing problems among adolescent bullies, victims and bully-victims. Preventive Medicine, 73, 100–105.PubMed
go back to reference Klawohn, J., Santopetro, N. J., Meyer, A., & Hajcak, G. (2020). Reduced P300 in depression: Evidence from a flanker task and impact on ERN, CRN, and Pe. Psychophysiology, 57(4), e13520. Klawohn, J., Santopetro, N. J., Meyer, A., & Hajcak, G. (2020). Reduced P300 in depression: Evidence from a flanker task and impact on ERN, CRN, and Pe. Psychophysiology57(4), e13520.
go back to reference Schleider, L., & J., D Krause, E., & E Gillham, J. (2014). Sequential comorbidity of anxiety and depression in youth: Present knowledge and future directions. Current Psychiatry Reviews, 10(1), 75–87. Schleider, L., & J., D Krause, E., & E Gillham, J. (2014). Sequential comorbidity of anxiety and depression in youth: Present knowledge and future directions. Current Psychiatry Reviews, 10(1), 75–87.
go back to reference Lawrence, D., Johnson, S., Hafekost, J., Boterhoven de Haan, K., Sawyer, M., Ainley, J., & Zubrick, S. R. (2015). The mental health of children and adolescents: Report on the second Australian child and adolescent survey of mental health and wellbeing. Lawrence, D., Johnson, S., Hafekost, J., Boterhoven de Haan, K., Sawyer, M., Ainley, J., & Zubrick, S. R. (2015). The mental health of children and adolescents: Report on the second Australian child and adolescent survey of mental health and wellbeing.
go back to reference Kovacs, M. (1992) The Children’s Depression Inventory, Multi-Health Systems, North Tonawanda, NY, USA. Kovacs, M. (1992) The Children’s Depression Inventory, Multi-Health Systems, North Tonawanda, NY, USA.
go back to reference McNaughton, N. (1997). Cognitive dysfunction resulting from hippocampal hyperactivity—a possible cause of anxiety disorder? Pharmacology Biochemistry and Behavior, 56(4), 603–611. McNaughton, N. (1997). Cognitive dysfunction resulting from hippocampal hyperactivity—a possible cause of anxiety disorder? Pharmacology Biochemistry and Behavior, 56(4), 603–611.
go back to reference Melton, T. H., Croarkin, P. E., Strawn, J. R., & Mcclintock, S. M. (2016). Comorbid anxiety and depressive symptoms in children and adolescents: A systematic review and analysis. Journal of Psychiatric Practice, 22(2), 84.PubMedPubMedCentral Melton, T. H., Croarkin, P. E., Strawn, J. R., & Mcclintock, S. M. (2016). Comorbid anxiety and depressive symptoms in children and adolescents: A systematic review and analysis. Journal of Psychiatric Practice, 22(2), 84.PubMedPubMedCentral
go back to reference Nunnally, J. C., Bernstein, I. H., & Berge, J. M. T. (1967). Psychometric theory (Vol. 226). McGraw-Hill. Nunnally, J. C., Bernstein, I. H., & Berge, J. M. T. (1967). Psychometric theory (Vol. 226). McGraw-Hill.
go back to reference Ogura, C., Nageishi, Y., Omura, F., Fukao, K., Ohta, H., Kishimoto, A., & Matsubayashi, M. (1993). N200 component of event-related potentials in depression. Biological Psychiatry, 33(10), 720–726.PubMed Ogura, C., Nageishi, Y., Omura, F., Fukao, K., Ohta, H., Kishimoto, A., & Matsubayashi, M. (1993). N200 component of event-related potentials in depression. Biological Psychiatry, 33(10), 720–726.PubMed
go back to reference Palmwood, E. N., Krompinger, J. W., & Simons, R. F. (2017). Electrophysiological indicators of inhibitory control deficits in depression. Biological Psychology, 130, 1–10.PubMed Palmwood, E. N., Krompinger, J. W., & Simons, R. F. (2017). Electrophysiological indicators of inhibitory control deficits in depression. Biological Psychology, 130, 1–10.PubMed
go back to reference Patrick, C. J., Iacono, W. G., & Venables, N. C. (2019). Incorporating neurophysiological measures into clinical assessments: Fundamental challenges and a strategy for addressing them. Psychological Assessment, 31(12), 1512.PubMedPubMedCentral Patrick, C. J., Iacono, W. G., & Venables, N. C. (2019). Incorporating neurophysiological measures into clinical assessments: Fundamental challenges and a strategy for addressing them. Psychological Assessment, 31(12), 1512.PubMedPubMedCentral
go back to reference Pfabigan, D. M., Seidel, E. M., Sladky, R., Hahn, A., Paul, K., Grahl, A., & Lamm, C. (2014). P300 amplitude variation is related to ventral striatum BOLD response during gain and loss anticipation: An EEG and fMRI experiment. NeuroImage, 96, 12–21.PubMed Pfabigan, D. M., Seidel, E. M., Sladky, R., Hahn, A., Paul, K., Grahl, A., & Lamm, C. (2014). P300 amplitude variation is related to ventral striatum BOLD response during gain and loss anticipation: An EEG and fMRI experiment. NeuroImage, 96, 12–21.PubMed
go back to reference Pogarell, O., Padberg, F., Karch, S., Segmiller, F., Juckel, G., Mulert, C., & Koch, W. (2011). Dopaminergic mechanisms of target detection—P300 event related potential and striatal dopamine. Psychiatry Research: Neuroimaging, 194(3), 212–218.PubMed Pogarell, O., Padberg, F., Karch, S., Segmiller, F., Juckel, G., Mulert, C., & Koch, W. (2011). Dopaminergic mechanisms of target detection—P300 event related potential and striatal dopamine. Psychiatry Research: Neuroimaging, 194(3), 212–218.PubMed
go back to reference Polich, J. (2012). Neuropsychology of P300. Oxford Handbook of Event-Related Potential Components, 159, 88. Polich, J. (2012). Neuropsychology of P300. Oxford Handbook of Event-Related Potential Components, 159, 88.
go back to reference Pompili, A., Arnone, B., D’Amico, M., Federico, P., & Gasbarri, A. (2016). Evidence of estrogen modulation on memory processes for emotional content in healthy young women. Psychoneuroendocrinology, 65, 94–101.PubMed Pompili, A., Arnone, B., D’Amico, M., Federico, P., & Gasbarri, A. (2016). Evidence of estrogen modulation on memory processes for emotional content in healthy young women. Psychoneuroendocrinology, 65, 94–101.PubMed
go back to reference Powers, A., & Casey, B. J. (2015). The adolescent brain and the emergence and peak of psychopathology. Journal of Infant, Child, and Adolescent Psychotherapy, 14(1), 3–15. Powers, A., & Casey, B. J. (2015). The adolescent brain and the emergence and peak of psychopathology. Journal of Infant, Child, and Adolescent Psychotherapy, 14(1), 3–15.
go back to reference Rapee, R. M., Oar, E. L., Johnco, C. J., Forbes, M. K., Fardouly, J., Magson, N. R., & Richardson, C. E. (2019). Adolescent development and risk for the onset of social-emotional disorders: A review and conceptual model. Behaviour research and therapy, 123, 103501. Rapee, R. M., Oar, E. L., Johnco, C. J., Forbes, M. K., Fardouly, J., Magson, N. R., & Richardson, C. E. (2019). Adolescent development and risk for the onset of social-emotional disorders: A review and conceptual model. Behaviour research and therapy123, 103501.
go back to reference Reeb-Sutherland, B. C., Vanderwert, R. E., Degnan, K. A., Marshall, P. J., Pérez-Edgar, K., Chronis-Tuscano, A., & Fox, N. A. (2009). Attention to novelty in behaviorally inhibited adolescents moderates risk for anxiety. Journal of Child Psychology and Psychiatry, 50(11), 1365–1372.PubMed Reeb-Sutherland, B. C., Vanderwert, R. E., Degnan, K. A., Marshall, P. J., Pérez-Edgar, K., Chronis-Tuscano, A., & Fox, N. A. (2009). Attention to novelty in behaviorally inhibited adolescents moderates risk for anxiety. Journal of Child Psychology and Psychiatry, 50(11), 1365–1372.PubMed
go back to reference Rivera, C. L., Bernal, G., & Rosselló, J. (2005). The Children Depression Inventory (CDI) and the Beck Depression Inventory (BDI): Their validity as screening measures for major depression in a group of Puerto Rican adolescents. International Journal of Clinical and Health Psychology, 5(3), 485–498. Rivera, C. L., Bernal, G., & Rosselló, J. (2005). The Children Depression Inventory (CDI) and the Beck Depression Inventory (BDI): Their validity as screening measures for major depression in a group of Puerto Rican adolescents. International Journal of Clinical and Health Psychology, 5(3), 485–498.
go back to reference Roiser, J. P., Rubinsztein, J. S., & Sahakian, B. J. (2009). Neuropsychology of affective disorders. Psychiatry, 8(3), 91–96. Roiser, J. P., Rubinsztein, J. S., & Sahakian, B. J. (2009). Neuropsychology of affective disorders. Psychiatry, 8(3), 91–96.
go back to reference Roza, S. J., Hofstra, M. B., Van Der Ende, J., & Verhulst, F. C. (2003). Stable prediction of mood and anxiety disorders based on behavioral and emotional problems in childhood: A 14-year follow-up during childhood, adolescence, and young adulthood. American Journal of Psychiatry, 160(12), 2116–2121. Roza, S. J., Hofstra, M. B., Van Der Ende, J., & Verhulst, F. C. (2003). Stable prediction of mood and anxiety disorders based on behavioral and emotional problems in childhood: A 14-year follow-up during childhood, adolescence, and young adulthood. American Journal of Psychiatry, 160(12), 2116–2121.
go back to reference Santopetro, N. J., Brush, C. J., Bruchnak, A., Klawohn, J., & Hajcak, G. (2021a). A reduced P300 prospectively predicts increased depressive severity in adults with clinical depression. Psychophysiology, e13767. Santopetro, N. J., Brush, C. J., Bruchnak, A., Klawohn, J., & Hajcak, G. (2021a). A reduced P300 prospectively predicts increased depressive severity in adults with clinical depression. Psychophysiology, e13767.
go back to reference Santopetro, N. J., Brush, C. J., Burani, K., Bruchnak, A., & Hajcak, G. (2021b). Doors P300 moderates the relationship between reward positivity and current depression status in adults. Journal of Affective Disorders, 294, 776–785.PubMed Santopetro, N. J., Brush, C. J., Burani, K., Bruchnak, A., & Hajcak, G. (2021b). Doors P300 moderates the relationship between reward positivity and current depression status in adults. Journal of Affective Disorders, 294, 776–785.PubMed
go back to reference Santopetro, N. J., Kallen, A. M., Threadgill, A. H., & Hajcak, G. (2020). Reduced Flanker P300 Prospectively Predicts Increases in Depression in Female Adolescents. Biological Psychology, 107967. Santopetro, N. J., Kallen, A. M., Threadgill, A. H., & Hajcak, G. (2020). Reduced Flanker P300 Prospectively Predicts Increases in Depression in Female Adolescents. Biological Psychology, 107967.
go back to reference Sara, G., Gordon, E., Kraiuhin, C., Coyle, S., Howson, A., & Meares, R. (1994). The P300 ERP component: An index of cognitive dysfunction xin depression? Journal of Affective Disorders, 31(1), 29–38.PubMed Sara, G., Gordon, E., Kraiuhin, C., Coyle, S., Howson, A., & Meares, R. (1994). The P300 ERP component: An index of cognitive dysfunction xin depression? Journal of Affective Disorders, 31(1), 29–38.PubMed
go back to reference Snyder, H. R. (2013). Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: A meta-analysis and review. Psychological Bulletin, 139(1), 81.PubMed Snyder, H. R. (2013). Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: A meta-analysis and review. Psychological Bulletin, 139(1), 81.PubMed
go back to reference Spear, L. P. (2000). The adolescent brain and age-related behavioral manifestations. Neuroscience & Biobehavioral Reviews, 24(4), 417–463. Spear, L. P. (2000). The adolescent brain and age-related behavioral manifestations. Neuroscience & Biobehavioral Reviews, 24(4), 417–463.
go back to reference Thapar, A., Collishaw, S., Pine, D. S., & Thapar, A. K. (2012). Depression in adolescence. The Lancet, 379(9820), 1056–1067. Thapar, A., Collishaw, S., Pine, D. S., & Thapar, A. K. (2012). Depression in adolescence. The Lancet, 379(9820), 1056–1067.
go back to reference Ullsperger, J. M., & Nikolas, M. A. (2017). A meta-analytic review of the association between pubertal timing and psychopathology in adolescence: Are there sex differences in risk? Psychological Bulletin, 143(9), 903.PubMed Ullsperger, J. M., & Nikolas, M. A. (2017). A meta-analytic review of the association between pubertal timing and psychopathology in adolescence: Are there sex differences in risk? Psychological Bulletin, 143(9), 903.PubMed
go back to reference Wittchen, H. U., Kessler, R. C., Pfister, H., Höfler, M., & Lieb, R. (2000). Why do people with anxiety disorders become depressed? A prospective-longitudinal community study. Acta Psychiatrica Scandinavica, 102, 14–23. Wittchen, H. U., Kessler, R. C., Pfister, H., Höfler, M., & Lieb, R. (2000). Why do people with anxiety disorders become depressed? A prospective-longitudinal community study. Acta Psychiatrica Scandinavica, 102, 14–23.
go back to reference Xie, H., Jiang, D., & Zhang, D. (2018). Individuals with depressive tendencies experience difficulty in forgetting negative material: Two mechanisms revealed by ERP data in the directed forgetting paradigm. Scientific Reports, 8(1), 1–14. Xie, H., Jiang, D., & Zhang, D. (2018). Individuals with depressive tendencies experience difficulty in forgetting negative material: Two mechanisms revealed by ERP data in the directed forgetting paradigm. Scientific Reports, 8(1), 1–14.
go back to reference Youniss, J. (1982). Changes in functions of three relations during adolescence. Developmental Psychology, 18(6), 806–811. Youniss, J. (1982). Changes in functions of three relations during adolescence. Developmental Psychology, 18(6), 806–811.
go back to reference Zhou, L., Wang, G., Nan, C., Wang, H., Liu, Z., & Bai, H. (2019). Abnormalities in P300 components in depression: An ERP-sLORETA study. Nordic Journal of Psychiatry, 73(1), 1–8.PubMed Zhou, L., Wang, G., Nan, C., Wang, H., Liu, Z., & Bai, H. (2019). Abnormalities in P300 components in depression: An ERP-sLORETA study. Nordic Journal of Psychiatry, 73(1), 1–8.PubMed
Metagegevens
Titel
Blunted Flanker P300 Demonstrates Specificity to Depressive Symptoms in Females during Adolescence
Auteurs
Nicholas J. Santopetro
Alexander M. Kallen
Austin Hunter Threadgill
Nader Amir
Greg Hajcak
Publicatiedatum
06-10-2021
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 4/2022
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-021-00876-z

Andere artikelen Uitgave 4/2022

Research on Child and Adolescent Psychopathology 4/2022 Naar de uitgave