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Gepubliceerd in: Quality of Life Research 6/2013

01-08-2013 | Review

Biological pathways and genetic mechanisms involved in social functioning

Auteurs: Juan R. Ordoñana, Meike Bartels, Dorret I. Boomsma, David Cella, Miriam Mosing, Joao R. Oliveira, Donald L. Patrick, Ruut Veenhoven, Gert G. Wagner, Mirjam A.G. Sprangers, The GENEQOL Consortium

Gepubliceerd in: Quality of Life Research | Uitgave 6/2013

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Abstract

Purpose

Methods

A search of Web of Science and PubMed databases was conducted using combinations of the following keywords: genetics, twins, heritability, social functioning, social adjustment, social interaction, and social dysfunction.

Results

Variability in the definitions and measures of social functioning was extensive. Moderate to high heritability was reported for social functioning and related concepts, including prosocial behavior, loneliness, and extraversion. Disorders characterized by impairments in social functioning also show substantial heritability. Genetic variants hypothesized to be involved in social functioning are related to the network of brain structures and processes that are known to affect social cognition and behavior.

Conclusions

Better knowledge and understanding about the impact of genetic factors on social functioning is needed to help us to attain a more comprehensive view of health-related quality-of-life (HRQOL) and will ultimately enhance our ability to identify those patients who are vulnerable to poor social functioning.
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Literatuur
1.
go back to reference Adolphs, R. (2003). Cognitive neuroscience of human social behaviour. Nature Reviews Neuroscience, 4(3), 165–178. PubMedCrossRef Adolphs, R. (2003). Cognitive neuroscience of human social behaviour. Nature Reviews Neuroscience, 4(3), 165–178. PubMedCrossRef
2.
go back to reference Brothers, L. (1990). The social brain: A project for integrating primate behavior and neurophysiology in a new domain. Concepts in Neuroscience, 1, 27–51. Brothers, L. (1990). The social brain: A project for integrating primate behavior and neurophysiology in a new domain. Concepts in Neuroscience, 1, 27–51.
3.
go back to reference Robinson, G. E., Fernald, R. D., & Clayton, D. F. (2008). Genes and social behavior. Science, 322(5903), 896–900. PubMedCrossRef Robinson, G. E., Fernald, R. D., & Clayton, D. F. (2008). Genes and social behavior. Science, 322(5903), 896–900. PubMedCrossRef
4.
go back to reference Cortina, S. D., Drotar, D., Ericksen, M., Lindsey, M., Patterson, T. L., Myers, J. M., et al. (2011). Genetic biomarkers of health-related quality of life in pediatric asthma. The Journal of Pediatric, 159(1), 21–26 e21. Cortina, S. D., Drotar, D., Ericksen, M., Lindsey, M., Patterson, T. L., Myers, J. M., et al. (2011). Genetic biomarkers of health-related quality of life in pediatric asthma. The Journal of Pediatric, 159(1), 21–26 e21.
5.
go back to reference Zou, Y. F., Wang, Y., Liu, P., Feng, X. L., Wang, B. Y., Zang, T. H., et al. (2010). Association of BDNF Val66Met polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine. Human Psychopharmacology, 25(2), 145–152. PubMedCrossRef Zou, Y. F., Wang, Y., Liu, P., Feng, X. L., Wang, B. Y., Zang, T. H., et al. (2010). Association of BDNF Val66Met polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine. Human Psychopharmacology, 25(2), 145–152. PubMedCrossRef
6.
go back to reference Sprangers, M. A., Sloan, J. A., Barsevick, A., Chauhan, C., Dueck, A. C., Raat, H., et al. (2010). Scientific imperatives, clinical implications, and theoretical underpinnings for the investigation of the relationship between genetic variables and patient-reported quality-of-life outcomes. Quality of Life Research, 19(10), 1395–1403. PubMedCrossRef Sprangers, M. A., Sloan, J. A., Barsevick, A., Chauhan, C., Dueck, A. C., Raat, H., et al. (2010). Scientific imperatives, clinical implications, and theoretical underpinnings for the investigation of the relationship between genetic variables and patient-reported quality-of-life outcomes. Quality of Life Research, 19(10), 1395–1403. PubMedCrossRef
7.
go back to reference Romeis, J. C., Heath, A. C., Xian, H., Eisen, S. A., Scherrer, J. F., Pedersen, N. L., et al. (2005). Heritability of SF-36 among middle-age, middle-class, male-male twins. Medical Care, 43(11), 1147–1154. PubMedCrossRef Romeis, J. C., Heath, A. C., Xian, H., Eisen, S. A., Scherrer, J. F., Pedersen, N. L., et al. (2005). Heritability of SF-36 among middle-age, middle-class, male-male twins. Medical Care, 43(11), 1147–1154. PubMedCrossRef
8.
go back to reference Sprangers, M. A., & Schwartz, C. E. (2008). Reflections on changeability versus stability of health-related quality of life: Distinguishing between its environmental and genetic components. Health Qualification of Life Outcomes, 6, 89. CrossRef Sprangers, M. A., & Schwartz, C. E. (2008). Reflections on changeability versus stability of health-related quality of life: Distinguishing between its environmental and genetic components. Health Qualification of Life Outcomes, 6, 89. CrossRef
9.
go back to reference Sprangers, M. A., Sloan, J. A., Veenhoven, R., Cleeland, C. S., Halyard, M. Y., Abertnethy, A. P., et al. (2009). The establishment of the GENEQOL consortium to investigate the genetic disposition of patient-reported quality-of-life outcomes. Twin Research and Human Genetics, 12(3), 301–311. PubMedCrossRef Sprangers, M. A., Sloan, J. A., Veenhoven, R., Cleeland, C. S., Halyard, M. Y., Abertnethy, A. P., et al. (2009). The establishment of the GENEQOL consortium to investigate the genetic disposition of patient-reported quality-of-life outcomes. Twin Research and Human Genetics, 12(3), 301–311. PubMedCrossRef
10.
go back to reference Barsevick, A., Frost, M., Zwinderman, A., Hall, P., & Halyard, M. (2010). I’m so tired: Biological and genetic mechanisms of cancer-related fatigue. Quality of Life Research, 19(10), 1419–1427. PubMedCrossRef Barsevick, A., Frost, M., Zwinderman, A., Hall, P., & Halyard, M. (2010). I’m so tired: Biological and genetic mechanisms of cancer-related fatigue. Quality of Life Research, 19(10), 1419–1427. PubMedCrossRef
11.
go back to reference Shi, Q., Cleeland, C. S., Klepstad, P., Miaskowski, C., & Pedersen, N. L. (2010). Biological pathways and genetic variables involved in pain. Quality of Life Research, 19(10), 1407–1417. PubMedCrossRef Shi, Q., Cleeland, C. S., Klepstad, P., Miaskowski, C., & Pedersen, N. L. (2010). Biological pathways and genetic variables involved in pain. Quality of Life Research, 19(10), 1407–1417. PubMedCrossRef
12.
go back to reference Sprangers, M. A., Bartels, M., Veenhoven, R., Baas, F., Martin, N. G., Mosing, M., et al. (2010). Which patient will feel down, which will be happy? The need to study the genetic disposition of emotional states. Quality of Life Research, 19(10), 1429–1437. PubMedCrossRef Sprangers, M. A., Bartels, M., Veenhoven, R., Baas, F., Martin, N. G., Mosing, M., et al. (2010). Which patient will feel down, which will be happy? The need to study the genetic disposition of emotional states. Quality of Life Research, 19(10), 1429–1437. PubMedCrossRef
13.
go back to reference WHO. (2002). Towards a common language for functioning, disability and health: ICF. Geneva: World Health Organization. WHO. (2002). Towards a common language for functioning, disability and health: ICF. Geneva: World Health Organization.
14.
go back to reference Sullivan, P. F., Daly, M. J., & O’Donovan, M. (2012). Genetic architectures of psychiatric disorders: The emerging picture and its implications. Nature Reviews Genetics, 13(8), 537–551. PubMedCrossRef Sullivan, P. F., Daly, M. J., & O’Donovan, M. (2012). Genetic architectures of psychiatric disorders: The emerging picture and its implications. Nature Reviews Genetics, 13(8), 537–551. PubMedCrossRef
15.
go back to reference Ware, J. E., Jr., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30(6), 473–483. PubMedCrossRef Ware, J. E., Jr., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30(6), 473–483. PubMedCrossRef
16.
go back to reference EuroQol Group. (1990). EuroQol–a new facility for the measurement of health-related quality of life. The EuroQol group. Health Policy, 16(3), 199–208. CrossRef EuroQol Group. (1990). EuroQol–a new facility for the measurement of health-related quality of life. The EuroQol group. Health Policy, 16(3), 199–208. CrossRef
17.
go back to reference Burns, T., & Patrick, D. (2007). Social functioning as an outcome measure in schizophrenia studies. Acta Psychiatrica Scandinavica, 116(6), 403–418. PubMedCrossRef Burns, T., & Patrick, D. (2007). Social functioning as an outcome measure in schizophrenia studies. Acta Psychiatrica Scandinavica, 116(6), 403–418. PubMedCrossRef
18.
go back to reference van der Mei, S. F., Krol, B., van Son, W. J., de Jong, P. E., Groothoff, J. W., & van den Heuvel, W. J. (2006). Social participation and employment status after kidney transplantation: A systematic review. Quality of Life Research, 15(6), 979–994. PubMedCrossRef van der Mei, S. F., Krol, B., van Son, W. J., de Jong, P. E., Groothoff, J. W., & van den Heuvel, W. J. (2006). Social participation and employment status after kidney transplantation: A systematic review. Quality of Life Research, 15(6), 979–994. PubMedCrossRef
19.
go back to reference Bonner, M. J., Hardy, K. K., Willard, V. W., Anthony, K. K., Hood, M., & Gururangan, S. (2008). Social functioning and facial expression recognition in survivors of pediatric brain tumors. Journal of Pediatric Psychology, 33(10), 1142–1152. PubMedCrossRef Bonner, M. J., Hardy, K. K., Willard, V. W., Anthony, K. K., Hood, M., & Gururangan, S. (2008). Social functioning and facial expression recognition in survivors of pediatric brain tumors. Journal of Pediatric Psychology, 33(10), 1142–1152. PubMedCrossRef
20.
go back to reference Avis, N. E., Smith, K. W., Hambleton, R. K., Feldman, H. A., Selwyn, A., & Jacobs, A. (1996). Development of the multidimensional index of life quality. A quality of life measure for cardiovascular disease. Medical Care, 34(11), 1102–1120. PubMedCrossRef Avis, N. E., Smith, K. W., Hambleton, R. K., Feldman, H. A., Selwyn, A., & Jacobs, A. (1996). Development of the multidimensional index of life quality. A quality of life measure for cardiovascular disease. Medical Care, 34(11), 1102–1120. PubMedCrossRef
21.
go back to reference The WHOQOL Group. (1998). Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL group. Psychological Medicine, 28(3), 551–558. CrossRef The WHOQOL Group. (1998). Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL group. Psychological Medicine, 28(3), 551–558. CrossRef
22.
go back to reference Becker, M., Diamond, R., & Sainfort, F. (1993). A new patient focused index for measuring quality of life in persons with severe and persistent mental illness. Quality of Life Research, 2(4), 239–251. PubMedCrossRef Becker, M., Diamond, R., & Sainfort, F. (1993). A new patient focused index for measuring quality of life in persons with severe and persistent mental illness. Quality of Life Research, 2(4), 239–251. PubMedCrossRef
23.
go back to reference Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376. PubMedCrossRef Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376. PubMedCrossRef
24.
go back to reference Cella, D. F., Tulsky, D. S., Gray, G., Sarafian, B., Linn, E., Bonomi, A., et al. (1993). The Functional Assessment of Cancer Therapy scale: Development and validation of the general measure. Journal of Clinical Oncology, 11(3), 570–579. PubMed Cella, D. F., Tulsky, D. S., Gray, G., Sarafian, B., Linn, E., Bonomi, A., et al. (1993). The Functional Assessment of Cancer Therapy scale: Development and validation of the general measure. Journal of Clinical Oncology, 11(3), 570–579. PubMed
25.
go back to reference Fayers, P. M., & Machin, D. (2007). Quality of life: The assessment, analysis and interpretation of patient-reported outcomes. Chichester: John Wiley & Sons Ltd. Fayers, P. M., & Machin, D. (2007). Quality of life: The assessment, analysis and interpretation of patient-reported outcomes. Chichester: John Wiley & Sons Ltd.
26.
go back to reference Herzog, A. R., Ofstedal, M. B., & Wheeler, L. M. (2002). Social engagement and its relationship to health. Clinics in Geriatric Medicine, 18(3), 593–609, ix. Herzog, A. R., Ofstedal, M. B., & Wheeler, L. M. (2002). Social engagement and its relationship to health. Clinics in Geriatric Medicine, 18(3), 593–609, ix.
27.
go back to reference Rasulo, D., Christensen, K., & Tomassini, C. (2005). The influence of social relations on mortality in later life: A study on elderly Danish twins. Gerontologist, 45(5), 601–608. PubMedCrossRef Rasulo, D., Christensen, K., & Tomassini, C. (2005). The influence of social relations on mortality in later life: A study on elderly Danish twins. Gerontologist, 45(5), 601–608. PubMedCrossRef
28.
go back to reference Tse, W. S., Rochelle, T. L., & Cheung, J. C. (2011). The relationship between personality, social functioning, and depression: A structural equation modeling analysis. International Journal of Psychology, 46(3), 234–240. PubMedCrossRef Tse, W. S., Rochelle, T. L., & Cheung, J. C. (2011). The relationship between personality, social functioning, and depression: A structural equation modeling analysis. International Journal of Psychology, 46(3), 234–240. PubMedCrossRef
29.
go back to reference Lyyra, T. M., & Heikkinen, R. L. (2006). Perceived social support and mortality in older people. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 61(3), S147–S152. CrossRef Lyyra, T. M., & Heikkinen, R. L. (2006). Perceived social support and mortality in older people. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 61(3), S147–S152. CrossRef
30.
go back to reference Neuhaus, E., Beauchaine, T. P., & Bernier, R. (2010). Neurobiological correlates of social functioning in autism. Clinical Psychology Review, 30(6), 733–748. PubMedCrossRef Neuhaus, E., Beauchaine, T. P., & Bernier, R. (2010). Neurobiological correlates of social functioning in autism. Clinical Psychology Review, 30(6), 733–748. PubMedCrossRef
31.
go back to reference Bouchard, T. J., Jr., & Loehlin, J. C. (2001). Genes, evolution, and personality. Behavior Genetics, 31(3), 243–273. PubMedCrossRef Bouchard, T. J., Jr., & Loehlin, J. C. (2001). Genes, evolution, and personality. Behavior Genetics, 31(3), 243–273. PubMedCrossRef
32.
go back to reference McGue, M., Osler, M., & Christensen, K. (2010). Causal inference and observational research: The utility of twins. Perspective on Psychological Science, 5(5), 546–556. CrossRef McGue, M., Osler, M., & Christensen, K. (2010). Causal inference and observational research: The utility of twins. Perspective on Psychological Science, 5(5), 546–556. CrossRef
33.
go back to reference Boyce, C. J., & Wood, A. M. (2011). Personality prior to disability determines adaptation: Agreeable individuals recover lost life satisfaction faster and more completely. Psychological Science, 22(11), 1397–1402. PubMedCrossRef Boyce, C. J., & Wood, A. M. (2011). Personality prior to disability determines adaptation: Agreeable individuals recover lost life satisfaction faster and more completely. Psychological Science, 22(11), 1397–1402. PubMedCrossRef
34.
go back to reference Wilson, I. B., & Cleary, P. D. (1995). Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA, 273(1), 59–65. PubMedCrossRef Wilson, I. B., & Cleary, P. D. (1995). Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA, 273(1), 59–65. PubMedCrossRef
35.
go back to reference Singh-Manoux, A. (2005). Commentary: Modelling multiple pathways to explain social inequalities in health and mortality. International Journal of Epidemiology, 34(3), 638–639. PubMedCrossRef Singh-Manoux, A. (2005). Commentary: Modelling multiple pathways to explain social inequalities in health and mortality. International Journal of Epidemiology, 34(3), 638–639. PubMedCrossRef
36.
go back to reference Johnson, W., Kyvik, K. O., Mortensen, E. L., Skytthe, A., Batty, G. D., & Deary, I. J. (2010). Education reduces the effects of genetic susceptibilities to poor physical health. International Journal of Epidemiology, 39(2), 406–414. PubMedCrossRef Johnson, W., Kyvik, K. O., Mortensen, E. L., Skytthe, A., Batty, G. D., & Deary, I. J. (2010). Education reduces the effects of genetic susceptibilities to poor physical health. International Journal of Epidemiology, 39(2), 406–414. PubMedCrossRef
37.
go back to reference Ordoñana, J. R., Bartels, M., Rebollo-Mesa, I., Monteagudo, O., & Perez-Riquelme, F. (2010). Causes of individual differences in quality of life dimensions of the EQ- 5D questionnaire. Paper presented at the 40th annual meeting of the behavior genetics association, Seoul. Ordoñana, J. R., Bartels, M., Rebollo-Mesa, I., Monteagudo, O., & Perez-Riquelme, F. (2010). Causes of individual differences in quality of life dimensions of the EQ- 5D questionnaire. Paper presented at the 40th annual meeting of the behavior genetics association, Seoul.
38.
go back to reference McGue, M., & Christensen, K. (2007). Social activity and healthy aging: A study of aging Danish twins. Twin Research and Human Genetics, 10(2), 255–265. PubMedCrossRef McGue, M., & Christensen, K. (2007). Social activity and healthy aging: A study of aging Danish twins. Twin Research and Human Genetics, 10(2), 255–265. PubMedCrossRef
39.
go back to reference Harris, J. R. (2007). Genetics, social behaviors, social environments and aging. Twin Research and Human Genetics, 10(2), 235–240. PubMedCrossRef Harris, J. R. (2007). Genetics, social behaviors, social environments and aging. Twin Research and Human Genetics, 10(2), 235–240. PubMedCrossRef
40.
go back to reference Gregory, A. M., Light-Hausermann, J. H., Rijsdijk, F., & Eley, T. C. (2009). Behavioral genetic analyses of prosocial behavior in adolescents. Developmental in Science, 12(1), 165–174. CrossRef Gregory, A. M., Light-Hausermann, J. H., Rijsdijk, F., & Eley, T. C. (2009). Behavioral genetic analyses of prosocial behavior in adolescents. Developmental in Science, 12(1), 165–174. CrossRef
41.
go back to reference Knafo, A., & Plomin, R. (2006). Prosocial behavior from early to middle childhood: Genetic and environmental influences on stability and change. Developmental Psychology, 42(5), 771–786. PubMedCrossRef Knafo, A., & Plomin, R. (2006). Prosocial behavior from early to middle childhood: Genetic and environmental influences on stability and change. Developmental Psychology, 42(5), 771–786. PubMedCrossRef
42.
go back to reference Kendler, K. S. (1997). Social support: A genetic-epidemiologic analysis. American Journal of Psychiatry, 154(10), 1398–1404. PubMed Kendler, K. S. (1997). Social support: A genetic-epidemiologic analysis. American Journal of Psychiatry, 154(10), 1398–1404. PubMed
43.
go back to reference Boomsma, D. I., Cacioppo, J. T., Muthen, B., Asparouhov, T., & Clark, S. (2007). Longitudinal genetic analysis for loneliness in Dutch twins. Twin Research and Human Genetics, 10(2), 267–273. PubMedCrossRef Boomsma, D. I., Cacioppo, J. T., Muthen, B., Asparouhov, T., & Clark, S. (2007). Longitudinal genetic analysis for loneliness in Dutch twins. Twin Research and Human Genetics, 10(2), 267–273. PubMedCrossRef
44.
go back to reference Bartels, M., Cacioppo, J. T., Hudziak, J. J., & Boomsma, D. I. (2008). Genetic and environmental contributions to stability in loneliness throughout childhood. American Journal of Medical Genetic B Neuropsychiatry Genetics, 147(3), 385–391. CrossRef Bartels, M., Cacioppo, J. T., Hudziak, J. J., & Boomsma, D. I. (2008). Genetic and environmental contributions to stability in loneliness throughout childhood. American Journal of Medical Genetic B Neuropsychiatry Genetics, 147(3), 385–391. CrossRef
45.
go back to reference Boomsma, D. I., Willemsen, G., Dolan, C. V., Hawkley, L. C., & Cacioppo, J. T. (2005). Genetic and environmental contributions to loneliness in adults: The Netherlands twin register study. Behavior Genetics, 35(6), 745–752. PubMedCrossRef Boomsma, D. I., Willemsen, G., Dolan, C. V., Hawkley, L. C., & Cacioppo, J. T. (2005). Genetic and environmental contributions to loneliness in adults: The Netherlands twin register study. Behavior Genetics, 35(6), 745–752. PubMedCrossRef
46.
go back to reference Waaktaar, T., & Torgersen, S. (2012). Genetic and environmental causes of variation in perceived loneliness in young people. American Journal of Medical Genetic B Neuropsychiatry Genetics, 159(5), 580–588. CrossRef Waaktaar, T., & Torgersen, S. (2012). Genetic and environmental causes of variation in perceived loneliness in young people. American Journal of Medical Genetic B Neuropsychiatry Genetics, 159(5), 580–588. CrossRef
47.
go back to reference Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2008). Behavioral genetics (5th ed.). New York: Worth Publishers. Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2008). Behavioral genetics (5th ed.). New York: Worth Publishers.
48.
go back to reference Keller, M. C., Coventry, W. L., Heath, A. C., & Martin, N. G. (2005). Widespread evidence for non-additive genetic variation in Cloninger’s and Eysenck’s personality dimensions using a twin plus sibling design. Behavior Genetics, 35(6), 707–721. PubMedCrossRef Keller, M. C., Coventry, W. L., Heath, A. C., & Martin, N. G. (2005). Widespread evidence for non-additive genetic variation in Cloninger’s and Eysenck’s personality dimensions using a twin plus sibling design. Behavior Genetics, 35(6), 707–721. PubMedCrossRef
49.
go back to reference Bratko, D., & Butkovic, A. (2007). Stability of genetic and environmental effects from adolescence to young adulthood: Results of Croatian longitudinal twin study of personality. Twin Research and Human Genetics, 10(1), 151–157. PubMedCrossRef Bratko, D., & Butkovic, A. (2007). Stability of genetic and environmental effects from adolescence to young adulthood: Results of Croatian longitudinal twin study of personality. Twin Research and Human Genetics, 10(1), 151–157. PubMedCrossRef
50.
go back to reference Kandler, C., Riemann, R., & Kampfe, N. (2009). Genetic and environmental mediation between measures of personality and family environment in twins reared together. Behavior Genetics, 39(1), 24–35. PubMedCrossRef Kandler, C., Riemann, R., & Kampfe, N. (2009). Genetic and environmental mediation between measures of personality and family environment in twins reared together. Behavior Genetics, 39(1), 24–35. PubMedCrossRef
51.
go back to reference Flint, J., Greenspan, R. J., & Kendler, K. S. (2010). How genes influence behavior. Oxford: Oxford University Press. Flint, J., Greenspan, R. J., & Kendler, K. S. (2010). How genes influence behavior. Oxford: Oxford University Press.
52.
go back to reference McGrath, J. A., Avramopoulos, D., Lasseter, V. K., Wolyniec, P. S., Fallin, M. D., Liang, K. Y., et al. (2009). Familiality of novel factorial dimensions of schizophrenia. Archives of General Psychiatry, 66(6), 591–600. PubMedCrossRef McGrath, J. A., Avramopoulos, D., Lasseter, V. K., Wolyniec, P. S., Fallin, M. D., Liang, K. Y., et al. (2009). Familiality of novel factorial dimensions of schizophrenia. Archives of General Psychiatry, 66(6), 591–600. PubMedCrossRef
53.
go back to reference Ronald, A., Happe, F., & Plomin, R. (2005). The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autism. Developmental Science, 8(5), 444–458. PubMedCrossRef Ronald, A., Happe, F., & Plomin, R. (2005). The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autism. Developmental Science, 8(5), 444–458. PubMedCrossRef
54.
go back to reference Anokhin, A. P., Golosheykin, S., & Heath, A. C. (2010). Heritability of individual differences in cortical processing of facial affect. Behavior Genetics, 40(2), 178–185. PubMedCrossRef Anokhin, A. P., Golosheykin, S., & Heath, A. C. (2010). Heritability of individual differences in cortical processing of facial affect. Behavior Genetics, 40(2), 178–185. PubMedCrossRef
55.
go back to reference Meyer-Lindenberg, A., Hariri, A. R., Munoz, K. E., Mervis, C. B., Mattay, V. S., Morris, C. A., et al. (2005). Neural correlates of genetically abnormal social cognition in Williams syndrome. Nature Neuroscience, 8(8), 991–993. PubMedCrossRef Meyer-Lindenberg, A., Hariri, A. R., Munoz, K. E., Mervis, C. B., Mattay, V. S., Morris, C. A., et al. (2005). Neural correlates of genetically abnormal social cognition in Williams syndrome. Nature Neuroscience, 8(8), 991–993. PubMedCrossRef
56.
go back to reference Stein, M. B., Goldin, P. R., Sareen, J., Zorrilla, L. T., & Brown, G. G. (2002). Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Archives of General Psychiatry, 59(11), 1027–1034. PubMedCrossRef Stein, M. B., Goldin, P. R., Sareen, J., Zorrilla, L. T., & Brown, G. G. (2002). Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Archives of General Psychiatry, 59(11), 1027–1034. PubMedCrossRef
57.
go back to reference Amaral, D. G. (2003). The amygdala, social behavior, and danger detection. Annals of the New York Academy of Sciences, 1000, 337–347. PubMedCrossRef Amaral, D. G. (2003). The amygdala, social behavior, and danger detection. Annals of the New York Academy of Sciences, 1000, 337–347. PubMedCrossRef
58.
go back to reference Donaldson, Z. R., & Young, L. J. (2008). Oxytocin, vasopressin, and the neurogenetics of sociality. Science, 322(5903), 900–904. PubMedCrossRef Donaldson, Z. R., & Young, L. J. (2008). Oxytocin, vasopressin, and the neurogenetics of sociality. Science, 322(5903), 900–904. PubMedCrossRef
59.
go back to reference Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nature Reviews Neuroscience, 12(9), 524–538. PubMedCrossRef Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nature Reviews Neuroscience, 12(9), 524–538. PubMedCrossRef
60.
go back to reference Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of Neuroscience, 25(49), 11489–11493. PubMedCrossRef Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of Neuroscience, 25(49), 11489–11493. PubMedCrossRef
61.
go back to reference Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., et al. (2007). Oxytocin increases retention of social cognition in autism. Biological Psychiatry, 61(4), 498–503. PubMedCrossRef Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., et al. (2007). Oxytocin increases retention of social cognition in autism. Biological Psychiatry, 61(4), 498–503. PubMedCrossRef
62.
go back to reference Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54(12), 1389–1398. PubMedCrossRef Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54(12), 1389–1398. PubMedCrossRef
63.
go back to reference Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435(7042), 673–676. PubMedCrossRef Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435(7042), 673–676. PubMedCrossRef
64.
go back to reference Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of Natural Academy of Science USA, 106(50), 21437–21441. CrossRef Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of Natural Academy of Science USA, 106(50), 21437–21441. CrossRef
65.
go back to reference Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., et al. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of Natural Academy of Science USA, 107(31), 13936–13941. CrossRef Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., et al. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of Natural Academy of Science USA, 107(31), 13936–13941. CrossRef
66.
go back to reference Thompson, R. J., Parker, K. J., Hallmayer, J. F., Waugh, C. E., & Gotlib, I. H. (2011). Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology, 36(1), 144–147. PubMedCrossRef Thompson, R. J., Parker, K. J., Hallmayer, J. F., Waugh, C. E., & Gotlib, I. H. (2011). Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology, 36(1), 144–147. PubMedCrossRef
67.
go back to reference Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affection in Neuroscience, 3(2), 128–134. CrossRef Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affection in Neuroscience, 3(2), 128–134. CrossRef
68.
go back to reference Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., et al. (2010). Association between the oxytocin receptor gene and amygdalar volume in healthy adults. Biological Psychiatry, 68(11), 1066–1072. PubMedCrossRef Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., et al. (2010). Association between the oxytocin receptor gene and amygdalar volume in healthy adults. Biological Psychiatry, 68(11), 1066–1072. PubMedCrossRef
69.
go back to reference Kim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, C., et al. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of Natural Academy of Science USA, 107(36), 15717–15721. CrossRef Kim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, C., et al. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of Natural Academy of Science USA, 107(36), 15717–15721. CrossRef
70.
go back to reference Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., et al. (2008). Genes controlling affiliative behavior as candidate genes for autism. Biological Psychiatry, 63(10), 911–916. PubMedCrossRef Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., et al. (2008). Genes controlling affiliative behavior as candidate genes for autism. Biological Psychiatry, 63(10), 911–916. PubMedCrossRef
71.
go back to reference Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008). Association between the oxytocin receptor (OXTR) gene and autism: Relationship to Vineland Adaptive Behavior scales and cognition. Molecular Psychiatry, 13(10), 980–988. PubMedCrossRef Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008). Association between the oxytocin receptor (OXTR) gene and autism: Relationship to Vineland Adaptive Behavior scales and cognition. Molecular Psychiatry, 13(10), 980–988. PubMedCrossRef
72.
go back to reference Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., et al. (2004). Examination of AVPR1a as an autism susceptibility gene. Molecular Psychiatry, 9(10), 968–972. PubMedCrossRef Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., et al. (2004). Examination of AVPR1a as an autism susceptibility gene. Molecular Psychiatry, 9(10), 968–972. PubMedCrossRef
73.
go back to reference Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J. M., Reiss, D., Igl, W., et al. (2008). Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proceedings of Natural Academy of Science USA, 105(37), 14153–14156. CrossRef Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J. M., Reiss, D., Igl, W., et al. (2008). Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proceedings of Natural Academy of Science USA, 105(37), 14153–14156. CrossRef
74.
go back to reference Meyer-Lindenberg, A., Kolachana, B., Gold, B., Olsh, A., Nicodemus, K. K., Mattay, V., et al. (2009). Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans. Molecular Psychiatry, 14(10), 968–975. PubMedCrossRef Meyer-Lindenberg, A., Kolachana, B., Gold, B., Olsh, A., Nicodemus, K. K., Mattay, V., et al. (2009). Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans. Molecular Psychiatry, 14(10), 968–975. PubMedCrossRef
75.
go back to reference Munafo, M. R., Yalcin, B., Willis-Owen, S. A., & Flint, J. (2008). Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: Meta-analysis and new data. Biological Psychiatry, 63(2), 197–206. PubMedCrossRef Munafo, M. R., Yalcin, B., Willis-Owen, S. A., & Flint, J. (2008). Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: Meta-analysis and new data. Biological Psychiatry, 63(2), 197–206. PubMedCrossRef
76.
go back to reference Lawford, B. R., Young, R., Noble, E. P., Kann, B., & Ritchie, T. (2006). The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. European Psychiatry, 21(3), 180–185. PubMedCrossRef Lawford, B. R., Young, R., Noble, E. P., Kann, B., & Ritchie, T. (2006). The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. European Psychiatry, 21(3), 180–185. PubMedCrossRef
77.
go back to reference Marino, C., Vanzin, L., Giorda, R., Frigerio, A., Lorusso, M. L., Nobile, M., et al. (2004). An assessment of transmission disequilibrium between quantitative measures of childhood problem behaviors and DRD2/Taql and DRD4/48 bp-repeat polymorphisms. Behavior Genetics, 34(5), 495–502. PubMedCrossRef Marino, C., Vanzin, L., Giorda, R., Frigerio, A., Lorusso, M. L., Nobile, M., et al. (2004). An assessment of transmission disequilibrium between quantitative measures of childhood problem behaviors and DRD2/Taql and DRD4/48 bp-repeat polymorphisms. Behavior Genetics, 34(5), 495–502. PubMedCrossRef
78.
go back to reference Godlewska, B. R., Olajossy-Hilkesberger, O., Limon, J., & Landowski, J. (2010). Ser9Gly polymorphism of the DRD3 gene is associated with worse premorbid social functioning and an earlier age of onset in female but not male schizophrenic patients. Psychiatry Research, 177(1–2), 266–267. PubMedCrossRef Godlewska, B. R., Olajossy-Hilkesberger, O., Limon, J., & Landowski, J. (2010). Ser9Gly polymorphism of the DRD3 gene is associated with worse premorbid social functioning and an earlier age of onset in female but not male schizophrenic patients. Psychiatry Research, 177(1–2), 266–267. PubMedCrossRef
79.
go back to reference Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297(5580), 400–403. PubMedCrossRef Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297(5580), 400–403. PubMedCrossRef
80.
go back to reference Munafo, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63(9), 852–857. PubMedCrossRef Munafo, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63(9), 852–857. PubMedCrossRef
81.
go back to reference Tse, W. S., & Bond, A. J. (2003). Reboxetine promotes social bonding in healthy volunteers. Journal of Psychopharmacolgy, 17(2), 189–195. CrossRef Tse, W. S., & Bond, A. J. (2003). Reboxetine promotes social bonding in healthy volunteers. Journal of Psychopharmacolgy, 17(2), 189–195. CrossRef
82.
go back to reference James, B. D., Wilson, R. S., Barnes, L. L., & Bennett, D. A. (2011). Late-life social activity and cognitive decline in old age. Journal of the International Neuropsychology Society, 17(6), 998–1005. CrossRef James, B. D., Wilson, R. S., Barnes, L. L., & Bennett, D. A. (2011). Late-life social activity and cognitive decline in old age. Journal of the International Neuropsychology Society, 17(6), 998–1005. CrossRef
83.
go back to reference Small, B. J., Dixon, R. A., McArdle, J. J., & Grimm, K. J. (2012). Do changes in lifestyle engagement moderate cognitive decline in normal aging? Evidence from the Victoria Longitudinal Study. Neuropsychology, 26(2), 144–155. Small, B. J., Dixon, R. A., McArdle, J. J., & Grimm, K. J. (2012). Do changes in lifestyle engagement moderate cognitive decline in normal aging? Evidence from the Victoria Longitudinal Study. Neuropsychology, 26(2), 144–155.
84.
go back to reference Harris, S. E., & Deary, I. J. (2011). The genetics of cognitive ability and cognitive ageing in healthy older people. Trends in Cognitive Sciences, 15(9), 388–394. PubMed Harris, S. E., & Deary, I. J. (2011). The genetics of cognitive ability and cognitive ageing in healthy older people. Trends in Cognitive Sciences, 15(9), 388–394. PubMed
85.
go back to reference Lee, T., Henry, J. D., Trollor, J. N., & Sachdev, P. S. (2010). Genetic influences on cognitive functions in the elderly: A selective review of twin studies. Brain Research Reviews, 64(1), 1–13. PubMedCrossRef Lee, T., Henry, J. D., Trollor, J. N., & Sachdev, P. S. (2010). Genetic influences on cognitive functions in the elderly: A selective review of twin studies. Brain Research Reviews, 64(1), 1–13. PubMedCrossRef
86.
go back to reference DiLalla, L. F., Elam, K. K., & Smolen, A. (2009). Genetic and gene-environment interaction effects on preschoolers’ social behaviors. Developmental Psychobiology, 51(6), 451–464. PubMedCrossRef DiLalla, L. F., Elam, K. K., & Smolen, A. (2009). Genetic and gene-environment interaction effects on preschoolers’ social behaviors. Developmental Psychobiology, 51(6), 451–464. PubMedCrossRef
87.
go back to reference Creswell, K. G., Sayette, M. A., Manuck, S. B., Ferrell, R. E., Hill, S. Y., & Dimoff, J. D. (2012). DRD4 polymorphism moderates the effect of alcohol consumption on social bonding. PLoS ONE, 7(2), e28914. PubMedCrossRef Creswell, K. G., Sayette, M. A., Manuck, S. B., Ferrell, R. E., Hill, S. Y., & Dimoff, J. D. (2012). DRD4 polymorphism moderates the effect of alcohol consumption on social bonding. PLoS ONE, 7(2), e28914. PubMedCrossRef
88.
go back to reference Kiser, D., Steemers, B., Branchi, I., & Homberg, J. R. (2012). The reciprocal interaction between serotonin and social behaviour. Neuroscience and Biobehavioral Reviews, 36(2), 786–798. PubMedCrossRef Kiser, D., Steemers, B., Branchi, I., & Homberg, J. R. (2012). The reciprocal interaction between serotonin and social behaviour. Neuroscience and Biobehavioral Reviews, 36(2), 786–798. PubMedCrossRef
89.
go back to reference Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168(10), 1041–1049. PubMedCrossRef Duncan, L. E., & Keller, M. C. (2011). A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry, 168(10), 1041–1049. PubMedCrossRef
90.
go back to reference McCrae, R. R., Scally, M., Terracciano, A., Abecasis, G. R., & Costa, P. T., Jr. (2010). An alternative to the search for single polymorphisms: Toward molecular personality scales for the five-factor model. Journal of Personality and Social Psychology, 99(6), 1014–1024. PubMedCrossRef McCrae, R. R., Scally, M., Terracciano, A., Abecasis, G. R., & Costa, P. T., Jr. (2010). An alternative to the search for single polymorphisms: Toward molecular personality scales for the five-factor model. Journal of Personality and Social Psychology, 99(6), 1014–1024. PubMedCrossRef
91.
go back to reference Hewitt, J. K. (2012). Editorial policy on candidate gene association and candidate gene-by-environment interaction studies of complex traits. Behavior Genetics, 42(1), 1–2. PubMedCrossRef Hewitt, J. K. (2012). Editorial policy on candidate gene association and candidate gene-by-environment interaction studies of complex traits. Behavior Genetics, 42(1), 1–2. PubMedCrossRef
92.
go back to reference Pearson, T. A., & Manolio, T. A. (2008). How to interpret a genome-wide association study. JAMA, 299(11), 1335–1344. PubMedCrossRef Pearson, T. A., & Manolio, T. A. (2008). How to interpret a genome-wide association study. JAMA, 299(11), 1335–1344. PubMedCrossRef
93.
go back to reference Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F., et al. (2010). Genome-wide association scan for five major dimensions of personality. Molecular Psychiatry, 15(6), 647–656. PubMedCrossRef Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F., et al. (2010). Genome-wide association scan for five major dimensions of personality. Molecular Psychiatry, 15(6), 647–656. PubMedCrossRef
94.
go back to reference de Moor, M. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J., Toshiko, T., et al. (2012). Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry, 17(3), 337–349. de Moor, M. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J., Toshiko, T., et al. (2012). Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry, 17(3), 337–349.
95.
go back to reference Gillespie, N. A., Zhu, G., Evans, D. M., Medland, S. E., Wright, M. J., & Martin, N. G. (2008). A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: Psychoticism, extraversion, neuroticism, and lie. Journal of Personality, 76(6), 1415–1446. PubMed Gillespie, N. A., Zhu, G., Evans, D. M., Medland, S. E., Wright, M. J., & Martin, N. G. (2008). A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: Psychoticism, extraversion, neuroticism, and lie. Journal of Personality, 76(6), 1415–1446. PubMed
96.
go back to reference Bosker, F. J., Hartman, C. A., Nolte, I. M., Prins, B. P., Terpstra, P., Posthuma, D., et al. (2011). Poor replication of candidate genes for major depressive disorder using genome-wide association data. Molecular Psychiatry, 16(5), 516–532. PubMedCrossRef Bosker, F. J., Hartman, C. A., Nolte, I. M., Prins, B. P., Terpstra, P., Posthuma, D., et al. (2011). Poor replication of candidate genes for major depressive disorder using genome-wide association data. Molecular Psychiatry, 16(5), 516–532. PubMedCrossRef
97.
go back to reference Attia, J., Ioannidis, J. P., Thakkinstian, A., McEvoy, M., Scott, R. J., Minelli, C., et al. (2009). How to use an article about genetic association: A: Background concepts. JAMA, 301(1), 74–81. PubMedCrossRef Attia, J., Ioannidis, J. P., Thakkinstian, A., McEvoy, M., Scott, R. J., Minelli, C., et al. (2009). How to use an article about genetic association: A: Background concepts. JAMA, 301(1), 74–81. PubMedCrossRef
98.
go back to reference John, O. P., Robins, R. W., & Pervin, L. A. (2008). Handbook of personality: Theory and research (3rd ed.). New York: Guilford Press. John, O. P., Robins, R. W., & Pervin, L. A. (2008). Handbook of personality: Theory and research (3rd ed.). New York: Guilford Press.
Metagegevens
Titel
Biological pathways and genetic mechanisms involved in social functioning
Auteurs
Juan R. Ordoñana
Meike Bartels
Dorret I. Boomsma
David Cella
Miriam Mosing
Joao R. Oliveira
Donald L. Patrick
Ruut Veenhoven
Gert G. Wagner
Mirjam A.G. Sprangers
The GENEQOL Consortium
Publicatiedatum
01-08-2013
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 6/2013
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-012-0277-5