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01-08-2013 | Review

Biological pathways and genetic mechanisms involved in social functioning

Auteurs: Juan R. Ordoñana, Meike Bartels, Dorret I. Boomsma, David Cella, Miriam Mosing, Joao R. Oliveira, Donald L. Patrick, Ruut Veenhoven, Gert G. Wagner, Mirjam A.G. Sprangers, The GENEQOL Consortium

Gepubliceerd in: Quality of Life Research | Uitgave 6/2013

Abstract

Purpose

Methods

A search of Web of Science and PubMed databases was conducted using combinations of the following keywords: genetics, twins, heritability, social functioning, social adjustment, social interaction, and social dysfunction.

Results

Variability in the definitions and measures of social functioning was extensive. Moderate to high heritability was reported for social functioning and related concepts, including prosocial behavior, loneliness, and extraversion. Disorders characterized by impairments in social functioning also show substantial heritability. Genetic variants hypothesized to be involved in social functioning are related to the network of brain structures and processes that are known to affect social cognition and behavior.

Conclusions

Better knowledge and understanding about the impact of genetic factors on social functioning is needed to help us to attain a more comprehensive view of health-related quality-of-life (HRQOL) and will ultimately enhance our ability to identify those patients who are vulnerable to poor social functioning.

vorige artikel Measuring the health-related quality of life (HRQoL) of young children in resource-limited settings: a review of existing measures

volgende artikel Monitoring population health for Healthy People 2020: evaluation of the NIH PROMIS® Global Health, CDC Healthy Days, and satisfaction with life instruments

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Titel: Biological pathways and genetic mechanisms involved in social functioning
Auteurs: Juan R. Ordoñana
Meike Bartels
Dorret I. Boomsma
David Cella
Miriam Mosing
Joao R. Oliveira
Donald L. Patrick
Ruut Veenhoven
Gert G. Wagner
Mirjam A.G. Sprangers
The GENEQOL Consortium
Publicatiedatum: 01-08-2013
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 6/2013
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-012-0277-5

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