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Research on Child and Adolescent Psychopathology

Gepubliceerd in:

01-10-2008

Biological Implications of Gene–Environment Interaction

Auteur: Michael Rutter

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 7/2008

Abstract

Gene–environment interaction (G × E) has been treated as both a statistical phenomenon and a biological reality. It is argued that, although there are important statistical issues that need to be considered, the focus has to be on the biological implications of G × E. Four reports of G × E deriving from the Dunedin longitudinal study are used as exemplars of the biological considerations that should lead to an hypothesis-driven choice of the specific genetic polymorphisms and the specific environmental influence to be investigated. The same four studies are used to discuss how the assessment of internal and external validity can be undertaken and how experimental approaches in humans and with animal models may be informative in the elucidation of the relevant operative biological mechanisms.

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Academy of Medical Sciences (2007). Identifying the environmental causes of disease: how should we decide what to believe and when to take action?. London: Academy of Medical Sciences.

Adamo, K. B., & Tesson, F. (2008). Gene–environment interaction and the metabolic syndrome. In M. Rutter (Ed.), Gene effects on environmental vulnerability to disease (pp. 103–127). Chichester: Wiley.

Battaglia, M., Marino, C., Maziade, M., Molteni, M., & D’Amato, F. (2008). Gene–environment interaction and behavioral disorders: a developmental perspective based on endophenotypes. In M. Rutter (Ed.), Gene effects on environmental vulnerability to disease (pp. 31–47). Chichester: Wiley.

Bird, A. (2007). Perceptions of epigenetics. Nature, 447, 396–398.PubMedCrossRef

Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.PubMedCrossRef

Caspi, A., & Moffitt, T. E. (2006). Gene–environment interactions in psychiatry: joining forces with neuroscience. Nature Reviews Neuroscience, 7, 583–590.PubMedCrossRef

Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., et al. (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biological Psychiatry, 57, 1117–1127.PubMedCrossRef

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.PubMedCrossRef

Caspi, A., Williams, B., Kim-Cohen, J., Craig, I. W., Milne, B. J., Poulton, R., et al. (2007). Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proceedings of the National Academy of Science U S A, 104, 18860–18865.CrossRef

Eaves, L. J. (2006). Genotype x Environment interaction in psychopathology: fact or artifact? Twin Research and Human Genetics, 9, 1–8.PubMedCrossRef

Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry, 62, 146–152.PubMedCrossRef

Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400–403.PubMedCrossRef

Henquet, C., Rosa, A., Krabbendam, L., Papiol, S., Fananás, L., Drukker, M., et al. (2006). An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition. Neuropsychopharmacology, 31, 2748–2757.PubMedCrossRef

Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., et al. (2006). MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: New evidence and a meta-analysis. Molecular Psychiatry, 11, 903–913.PubMedCrossRef

Meaney, M. J., & Szyf, M. (2005). Environmental programming of stress responses through DNA methylation: Life at the interface between a dynamic environment and a fixed genome. Dialogues in Clinical Neuroscience, 7, 103–123.PubMed

Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B. R., Hariri, A., Pezawas, L., Blasi, G., et al. (2006). Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences U S A, 103, 6269–6274.CrossRef

Mill, J., & Petronis, A. (2007). Molecular studies of major depressive disorder: the epigenetic perspective. Molecular Psychiatry, 12, 799–814.PubMedCrossRef

Moffitt, T. E., Caspi, A., Rutter, M., & Silva, P. A. (2001). Sex differences in antisocial behavior: conduct disorder, delinquency, and violence in the Dunedin longitudinal study. Cambridge, UK: Cambridge University Press.

Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., et al. (2005). 5-HTTLPR polymorphism impacts human cingulated–amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828–834.PubMedCrossRef

Rutter, M. (2006a). Genes and behavior: nature–nurture interplay explained. Oxford: Blackwell.

Rutter, M. (2006b). Implications of resilience concepts for scientific understanding. Annals of the New York Academy of Sciences, 1094, 1–12.PubMedCrossRef

Rutter, M. (2006c). The psychological effects of early institutional rearing. In P. Marshall, & N. Fox (Eds.), The development of social engagement: neurobiological perspectives (pp. 355–391). New York & Oxford: Oxford University Press.

Rutter, M. (2007). Gene–environment interdependence. Developmental Science, 10, 12–18.PubMedCrossRef

Rutter, M. (Ed.) (2008a). Introduction: whither gene–environment interactions? In Genetic effects on environmental vulnerability (pp. 1–12). Chichester, Wiley.

Rutter, M. (Ed.) (2008b). Conclusions: taking stock and looking ahead. In Gene effects on environmental vulnerability to disease (pp. 198–205). Chichester: Wiley.

Rutter, M., Beckett, C., Castle, J., Colvert, E., Kreppner, J., Mehta, M., et al. (2007). Effects of profound early institutional deprivation: an overview of findings from a UK longitudinal study of Romanian adoptees. European Journal of Developmental Psychology, 4, 332–350.CrossRef

Rutter, M., Caspi, A., & Moffitt, T. E. (2003). Using sex differences in psychopathology to study causal mechanisms: unifying issues and research strategies. Journal of Child Psychology and Psychiatry, 44, 1092–1115.PubMedCrossRef

Rutter, M., Hagel, A., & Giller, H. (1998). Anti-social behaviour and young people. Cambridge: Cambridge University Press.

Rutter, M., & Pickles, A. (1991). Person–environment interactions; concepts, mechanisms, and implications for data analysis. In T. D. Wachs, & R. Plomin (Eds.), Conceptualization and measurement of organism–environment interaction (pp. 105–141). Washington DC: APA.CrossRef

Snieder, H., Wang, X., Lagou, V., Penninx, B. W. J. H., Riese, H., & Hartman, C. A. (2008). Role of gene–stress interactions in gene finding studies. In M. Rutter (Ed.), Gene effects on environmental vulnerability to disease (pp. 71–86). Chichester: Wiley.

Sonuga-Barke, E. J. S., Beckett, C., Kreppner, J., Castle, J., Colvert, E., Stevens, S., et al. (2008). Is subnutrition necessary for a poor outcome following severe and pervasive early institutional deprivation? Brain growth, cognition and mental health. Developmental Medicine and Child Neurology, in press.

Tabery, J. (2007). Biometric and developmental gene–environment interactions: looking back, moving forward. Development and Psychopathology, 19, 961–976.PubMedCrossRef

Taylor, A., & Kim-Cohen, J. (2007). Meta-analysis of gene–environment interactions in developmental psychopathology. Development and Psychopathology, 19, 1029–1037.PubMedCrossRef

Uher, R. (2008). Gene–environment interaction: Overcoming methodological challenges. In M. Rutter (Ed.), Gene effects on environmental vulnerability to disease (pp. 13–30). Chichester: Wiley.

Wray, N. R., Coventry, W. L., James, M. R., Montgomery, G. W., Eaves, L. J., & Martin, N. G. (2008). Use of monozygotic twins to investigate the relationship between 5-HTTLPR genotype, depression and stressful life events: an application of Item Response Theory. In M. Rutter (Ed.),Gene effects on environmental vulnerability to disease (pp. 48–67). Chichester: Wiley.

Titel: Biological Implications of Gene–Environment Interaction
Auteur: Michael Rutter
Publicatiedatum: 01-10-2008
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 7/2008
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-008-9256-2

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