Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-02-2009 | Original Paper

Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Auteurs: Aisling Mulligan, Richard J. L. Anney, Myra O’Regan, Wai Chen, Louise Butler, Michael Fitzgerald, Jan Buitelaar, Hans-Christoph Steinhausen, Aribert Rothenberger, Ruud Minderaa, Judith Nijmeijer, Pieter J. Hoekstra, Robert D. Oades, Herbert Roeyers, Cathelijne Buschgens, Hanna Christiansen, Barbara Franke, Isabel Gabriels, Catharina Hartman, Jonna Kuntsi, Rafaela Marco, Sheera Meidad, Ueli Mueller, Lamprini Psychogiou, Nanda Rommelse, Margaret Thompson, Henrik Uebel, Tobias Banaschewski, Richard Ebstein, Jacques Eisenberg, Iris Manor, Ana Miranda, Fernando Mulas, Joseph Sergeant, Edmund Sonuga-Barke, Phil Asherson, Stephen V. Faraone, Michael Gill

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2009

Abstract

It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.

volgende artikel Autism Symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial Trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Alleen toegankelijk voor geautoriseerde gebruikers

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., Text revision). Washington DC: American Psychiatric Association.

Andreou, P., Neale, B. M., Chen, W., Christiansen, H., Gabriels, I., Heise, A., et al. (2007). Reaction time performance in ADHD: Improvement under fast-incentive condition and familial effects. Psychological Medicine, 31, 1–13. doi:10.1007/s11013-006-9042-y.CrossRef

Arnold, L. E., Vitello, B., McDougle, C., Scahill, L., Shah, B., Conazalez, N., et al. (2003). Parent-defined target symptoms respond to risperidone in rupp autism study: Customer approach to clinical trials. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 1443–1450. doi:10.1097/00004583-200312000-00011.PubMedCrossRef

Berument, S. K., Rutter, M., Lord, C., Pickles, A., & Bailey, A. (1999). Autism screening questionnaire: Diagnostic validity. The British Journal of Psychiatry, 175, 444–451.PubMedCrossRef

Bishop, D. V. M., & Baird, G. (2001). Parent and teacher report of pragmatic aspects of communication: Use of the children’s communication checklist in a clinical setting. Developmental Medicine and Child Neurology, 43, 809–818. doi:10.1017/S0012162201001475.PubMedCrossRef

Bishop, D. V. M., & Norbury, C. F. (2002). Exploring the borderlands of autistic disorder and specific language impairment: A study using standardized diagnostic instruments. Journal of Child Psychology and Psychiatry and Allied Disciplines, 43, 917–929. doi:10.1111/1469-7610.00114.CrossRef

Bölte, S., Holtmann, M., & Poustka, F. (2008). The social communication questionnaire (SCQ) as a screener for autism spectrum disorders: Additional evidence and cross-cultural validity. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 719–720.PubMedCrossRef

Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., et al. (2006). The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: Association signals in DRD4, DAT1 and 16 other genes. Molecular Psychiatry, 11, 934–953. doi:10.1038/sj.mp. 4001869.PubMedCrossRef

Buitelaar, J. K., van der Wees, W. M., Swaab-Barneveld, H., & van der Gaag, R. J. (1999). Theory of mind and emotion-recognition functioning in autism spectrum disorders and in psychiatric control and normal children. Development and Psychopathology, 11, 39–58. doi:10.1017/S0954579499001947.PubMedCrossRef

Caron, C., & Rutter, M. (1991). Comorbidity in child psychopathology concepts, issues and research strategies. Journal of Child Psychology and Psychiatry and Allied Disciplines, 32, 1063–1080. doi:10.1111/j.1469-7610.1991.tb00350.x.CrossRef

Chandler, S., Charman, T., Baird, G., Simonoff, E., Loucas, T., Meldrum, D., et al. (2007). Validation of the social communication questionnaire in a population cohort of children with autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 1324–1332. doi:10.1097/chi.0b013e31812f7d8d.PubMedCrossRef

Clarke, T., Feehan, C., Tinline, C., & Vostanis, P. (1999). Autism symptoms in children with attention deficit-hyperactivity disorder. European Child and Adolescent Psychiatry, 8, 50–55. doi:10.1007/s007870050083.CrossRef

Conners, C. K. (2001). Conners’ rating scales- revised (CRS-R) technical manual. Toronto: Multi-Health Systems Inc.

Constantino, J. N., & Todd, R. D. (2003). Autistic traits in the general population: A twin study. Archives of General Psychiatry, 60, 524–530. doi:10.1001/archpsyc.60.5.524.PubMedCrossRef

Constantino, J. N., & Todd, R. D. (2005). Intergenerational transmission of subthreshold autism trains in the general population. Biological Psychiatry, 57, 655–660. doi:10.1016/j.biopsych.2004.12.014.PubMedCrossRef

Corsello, C., Hus, V., Pickles, A., Risi, S., Cook, E. H., Leventhal, B. L., Jr., et al. (2007). Between a ROC and a hard place: Decision making and making decisions about using the SCQ. Journal of Child Psychology and Psychiatry and Allied Disciplines, 48, 932–940. doi:10.1111/j.1469-7610.2007.01762.x.CrossRef

Curran, S., Newman, S., Taylor, E., & Asherson, P. (2000). Hypescheme: An operational criteria checklist and minimum data set for molecular genetic studies of attention deficit and hyperactivity disorders. American Journal of Medical Genetics, 96, 244–250. doi:10.1002/1096-8628(20000612)96:3<244::AID-AJMG2>3.0.CO;2-L.PubMedCrossRef

DeFries, J. C., & Fulker, D. W. (1985). Multiple regression analysis of twin data. Behavior Genetics, 15, 467–473. doi:10.1007/BF01066239.PubMedCrossRef

Dyck, M. J., Ferguson, K., & Shochet, I. M. (2001). Do autism spectrum disorders differ from each other and from non-spectrum disorders on emotion recognition tests? European Child and Adolescent Psychiatry, 10, 105–116. doi:10.1007/s007870170033.

Faraone, S. V., Biederman, J., Weber, W., & Russell, R. L. (1998). Psychiatric, neuropsychological, and psychosocial features of DSM-IV subtypes of attention-deficit/hyperactivity disorder: Results from a clinically referred sample. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 185–193.PubMedCrossRef

Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., et al. (2005). Advancing the neuroscience of ADHD––molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry, 57, 1313–1323. doi:10.1016/j.biopsych.2004.11.024.PubMedCrossRef

Farzin, F., Perry, H., Hessl, D., Loesch, D., Cohen, J., Bacalman, S., et al. (2006). Autism spectrum disorders and attention-deficit/hyperactivity disorder in boys with the fragile × permutation. Developmental and Behavioural Pediatrics, 27, S137–S144. doi:10.1097/00004703-200604002-00012.CrossRef

Gadow, K. D., DeVincent, C. J., & Pomeroy, J. (2006). ADHD symptom subtypes in children with pervaisive developmental disorder. Journal of Autism and Developmental Disorders, 36, 271–283. doi:10.1007/s10803-005-0060-3.PubMedCrossRef

Geurts, H. M., Verte, S., Oosterlaan, J., Roeyers, H., Hartman, C. A., Mulder, E. J., et al. (2004). Can the children’s communication checklist differentiate between children with autism, children with ADHD, and normal controls? Journal of Child Psychology and Psychiatry and Allied Disciplines, 45, 1437–1453. doi:10.1111/j.1469-7610.2004.00326.x.

Gillberg, C. (1983). Perceptual, motor and attentional deficits in Swedish primary school children. Some child psychiatric aspects. Journal of Child Psychology and Psychiatry and Allied Disciplines, 24, 377–403. doi:10.1111/j.1469-7610.1983.tb00116.x.CrossRef

Gillberg, C. (2003). Deficits in attention, motor control, and perception: A brief review. Archives of Disease in Childhood, 88, 904–910. doi:10.1136/adc.88.10.904.PubMedCrossRef

Gillberg, C., Rasmussen, P., Carlström, G., Svenson, B., & Waldenström, E. (1982). Perceptual, motor and attentional deficits in six-year-old children. Epidemiological aspects. Journal of Child Psychology and Psychiatry and Allied Disciplines, 23, 131–144. doi:10.1111/j.1469-7610.1982.tb00058.x.CrossRef

Goldstein, S., & Schwebach, A. (2004). The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: Results of a retrospective chart review. Journal of Autism and Developmental Disorders, 34, 329–339. doi:10.1023/B:JADD.0000029554.46570.68.PubMedCrossRef

Goodman, R., Ford, T., Corbin, T., & Meltzer, H. (2004). Using the strengths and difficulties questionnaire (SDQ) multi-informant algorithm to screen looked-after children for psychiatric disorders. European Child and Adolescent Psychiatry, 13(Suppl 2), 11/25–11/31.

Greene, R. W., Biederman, J., Faraone, S. V., Ouellette, C. A., Penn, C., & Griffin, S. M. (1996). Toward a new psychometric definition of social disability in children with attention-deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 571–578. doi:10.1097/00004583-199605000-00011.PubMedCrossRef

Greene, R. W., Biederman, J., Faraone, S. V., Sienna, M., & Garcia-Jetton, J. (1997). Adolescent outcome of boys with attention deficit/hyperactivity disorder and social disability: Results from a 4-year longitudinal follow-up study. Journal of Consulting and Clinical Psychology, 65, 758–767. doi:10.1037/0022-006X.65.5.758.PubMedCrossRef

Hattori, J., Ogino, T., Abiru, K., Nakano, K., Oka, M., & Ohtsuka, Y. (2006). Are pervasive developmental disorder and attention deficit/hyperactivity disorder distinct disorders? Brain and Development, 28, 371–374. doi:10.1016/j.braindev.2005.11.009.PubMedCrossRef

Hoza, B. (2007). Peer functioning in children with ADHD. Journal of Pediatric Psychology, 32, 655–663. doi:10.1093/jpepsy/jsm024.PubMedCrossRef

Hoza, B., Gerdes, A. C., Murg, S., Hinshaw, S. P., Bukowski, W. M., Gold, J. A., et al. (2005). Peer assessed outcomes in the multimodal treatment study of children with attention deficit hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 34, 74–86. doi:10.1207/s15374424jccp3401_7.PubMedCrossRef

Kadesjo, B., & Gillberg, C. (2001). The comorbidity of ADHD in the general population of Swedish school-age children. Journal of Child Psychology and Psychiatry and Allied Disciplines, 42, 487–492. doi:10.1017/S0021963001007090.CrossRef

Lee, L.-C., David, A. B., Rusyniak, J., Landa, R., & Newschaffer, C. J. (2007). Performance of the social communication questionnaire in children receiving preschool special education services. Research in Autism Spectrum Disorders, 1, 126–138. doi:10.1016/j.rasd.2006.08.004.CrossRef

Lord, C., Cook, E. H., Leventhal, B. L., & Amaral, D. G. (2000). Autism spectrum disorders. Neuron, 28, 355–363. doi:10.1016/S0896-6273(00)00115-X.

Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview––revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. doi:10.1007/BF02172145.PubMedCrossRef

Luteijn, E. F., Serra, M., Jackson, S., Seenhuis, M. P., Althaus, M., Volkmar, F., et al. (2000). How unspecified are disorders of children with a pervasive developmental disorder not otherwise specified? A study of social problems in children with PDD-NOS and ADHD. European Child and Adolescent Psychiatry, 9, 168–179. doi:10.1007/s007870070040.PubMedCrossRef

Mulligan, A., Richardson, T., Anney, R. J. L., & Gill, M. (2008). The Social communication questionnaire in a sample of the general population of school-going children. Irish Journal of Medical Science, in press.

Neale, M. C., & Kendler, K. S. (1995). Models of comorbidity for multifactorial disorders. American Journal of Human Genetics, 57, 935–953.PubMed

Nijmeijer, J. S., Minderaa, R. B., Buitelaar, J. K., Mulligan, A., Hartman, C. A., & Hoekstra, P. J. (2008). Attention-deficit/hyperactivity disorder and social dysfunctioning. Clinical Psychology Review, 28, 692–708. doi:10.1016/j.cpr.2007.10.003.

Pelham, W. E., & Bender, M. E. (1982). Peer relationships in hyperactive children: Description and treatment. In K. D. Gadow & I. Bialer (Eds.), Advances in learning and behavioural disabilities (Vol. 1, pp. 365–436). Greenwich, Conn: JA1 Press.

Purcell, S., & Sham, P. C. (2003). A model fitting implementation of the DeFries-Fulker model for selected twin data. Behavior Genetics, 33, 271–278. doi:10.1023/A:1023494408079.PubMedCrossRef

Rabe-Hesketh, S., & Skrondal, A. (2005). Multilevel and longitudinal modeling using stata. Texas: Stata Press Publication.

Reiersen, A. M., Constantino, J. N., & Todd, R. D. (2008). Co-occurrence of motor problems and autistic symptoms in attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 662–672. doi:10.1097/CHI.0b013e31816bff88.PubMedCrossRef

Reiersen, A. M., Constantino, J. N., Volk, H. E., & Todd, R. D. (2007). Autism symptoms in a population-based ADHD twin sample. Journal of Child Psychology and Psychiatry and Allied Disciplines, 48, 464–472. doi:10.1111/j.1469-7610.2006.01720.x.CrossRef

Reiersen, A. M., & Todd, R. D. (2008). Co-occurrence of ADHD and autism spectrum disorders: Phenomenology and treatment. Expert Review of Neurotherapeutics, 8, 657–669. doi:10.1586/14737175.8.4.657. review.PubMedCrossRef

Ronald, A., Happe, F., Bolton, P., Butcher, L. M., Price, T. S., Wheelwright, S., et al. (2006). Genetic heterogeneity between the three components of the autism spectrum: A twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 691–699. doi:10.1097/01.chi.0000215325.13058.9d.PubMedCrossRef

Ronald, A., Simonoff, E., Kuntsi, J., Asherson, P., & Plomin, R. (2008). Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. Journal of Child Psychology and Psychiatry and Allied Disciplines, 49, 535–542. doi:10.1111/j.1469-7610.2007.01857.x.CrossRef

Rutter, M., Anderson-Wood, L., Beckett, C., Bredenkamp, D., Castle, J., Groothues, C., et al. (1999). Quasi-autism patterns following severe early global privation. Journal of Child Psychology and Psychiatry and Allied Disciplines, 40, 537–549. doi:10.1017/S0021963099003935.CrossRef

Rutter, M., Bailey, A., & Lord, C. (2003). The social communication questionnaire manual. Los Angeles: Western Psychological Services.

Santosh, P., & Mijovic, A. (2004). Social impairment in hyperkinetic disorder, relationship to psychopathology and environmental stressors. European Child and Adolescent Psychiatry, 13, 141–150. doi:10.1007/s00787-004-0372-4.PubMed

Sattler, J. M. (1992). Assessment of children: WISC-III and WPPSI-R supplement. San Diego, CA.

Scott, S., Spender, Q., Doolan, M., Jacobs, B., & Aspland, H. (2001). Multicentre controlled trial of parenting groups for childhood antisocial behaviour in clinical practice. British Medical Journal, 323, 194–197. doi:10.1136/bmj.323.7306.194.PubMedCrossRef

Taylor, E., Schachar, R., Thorley, G., & Wieselberg, M. (1986). Conduct disorder and hyperactivity: I. Separation of hyperactivity and antisocial conduct in British child psychiatric patients. The British Journal of Psychiatry, 149, 760–767.PubMedCrossRef

Vermunt, J. K., & Magidson, J. (2000). Latent gold 2.00 user’s guide. Belmont, M.A.: Statistical Innovations.

Webster-Stratton, C., & Hancock, L. (1998). Training for parents of young children with conduct problems: Content, methods, and therapeutic processes. In J. M. Briesmeister & C. E. Schaefer (Eds.), Handbook of parent training (2nd ed ed.). New York: Wiley.

Wechsler, D. (1981). Wechsler adult intelligence scale-revised. San Antonio: Psychological Corporation.

Wechsler, D. (1991). Wechsler intelligence scale for children-revised. San Antonio: The Psychological Corporation.

World Health Organization. (1992). The ICD-10 classification of mental and behavioural disorders––clinical descriptions and diagnostic guidelines. Geneva, World Health Organization.

Yoshida, Y., & Uchiyama, T. (2004). The clinical necessity for assessing attention deficit/hyperactivity disorder (AD/HD) symptoms in children with high-functioning pervasive developmental disorder (PDD). European Child and Adolescent Psychiatry, 13, 307–314. doi:10.1007/s00787-004-0391-1.PubMedCrossRef

Titel: Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders
Auteurs: Aisling Mulligan
Richard J. L. Anney
Myra O’Regan
Wai Chen
Louise Butler
Michael Fitzgerald
Jan Buitelaar
Hans-Christoph Steinhausen
Aribert Rothenberger
Ruud Minderaa
Judith Nijmeijer
Pieter J. Hoekstra
Robert D. Oades
Herbert Roeyers
Cathelijne Buschgens
Hanna Christiansen
Barbara Franke
Isabel Gabriels
Catharina Hartman
Jonna Kuntsi
Rafaela Marco
Sheera Meidad
Ueli Mueller
Lamprini Psychogiou
Nanda Rommelse
Margaret Thompson
Henrik Uebel
Tobias Banaschewski
Richard Ebstein
Jacques Eisenberg
Iris Manor
Ana Miranda
Fernando Mulas
Joseph Sergeant
Edmund Sonuga-Barke
Phil Asherson
Stephen V. Faraone
Michael Gill
Publicatiedatum: 01-02-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-008-0621-3

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 2/2009

Does Nutritional Intake Differ Between Children with Autism Spectrum Disorders and Children with Typical Development?

GABAA Receptor Downregulation in Brains of Subjects with Autism

A Novel 6.14 Mb Duplication of Chromosome 8p21 in a Patient with Autism and Self Mutilation

The Effect of Stimulus Salience on Over-selectivity

Brief Report: Eye-Movement Patterns During an Embedded Figures Test in Children with ASD

A Specific Autistic Trait that Modulates Visuospatial Illusion Susceptibility