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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2018

06-01-2018 | Original Paper

Autism Spectrum Symptomatology Among Children with Duplication 7q11.23 Syndrome

Auteurs: Bonita P. Klein-Tasman, Carolyn B. Mervis

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2018

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Abstract

Gold-standard diagnostic assessments of autism spectrum disorder (ASD) symptomatology were conducted on 63 children (mean CA: 8.81 years) with 7q11.23 duplication syndrome, one of the copy number variants identified by Sanders et al. (Neuron 70:863–885, 2011a) as associated with ASD. ASD classification rate was 39.6% for the Autism Diagnostic Interview-Revised and 25.4% for the Autism Diagnostic Observation Schedule-2 (ADOS-2). Based on these assessments combined with clinical judgment, 19.0% of children were diagnosed with ASD. Reasons for these discrepancies are discussed, as are differences in rate of diagnosis as a function of sex, age, and ADOS-2 module administered and differences in intellectual and adaptive behavior abilities as a function of presence or absence of ASD diagnosis and ADOS-2 module administered. Implications are addressed.
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Metagegevens
Titel
Autism Spectrum Symptomatology Among Children with Duplication 7q11.23 Syndrome
Auteurs
Bonita P. Klein-Tasman
Carolyn B. Mervis
Publicatiedatum
06-01-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3439-z

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