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05-12-2018 | Original Paper

Autism Spectrum Disorder: Incidence and Time Trends Over Two Decades in a Population-Based Birth Cohort

Journal of Autism and Developmental Disorders
Scott M. Myers, Robert G. Voigt, Robert C. Colligan, Amy L. Weaver, Curtis B. Storlie, Ruth E. Stoeckel, John D. Port, Slavica K. Katusic
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10803-018-3834-0) contains supplementary material, which is available to authorized users.
Robert C. Colligan is Deceased.

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We retrospectively identified autism spectrum disorder (ASD) incident cases among 31,220 individuals in a population-based birth cohort based on signs and symptoms uniformly abstracted from medical and educational records. Inclusive and narrow research definitions of ASD (ASD-RI and ASD-RN, respectively) were explored, along with clinical diagnoses of ASD (ASD-C) obtained from the records. The incidence of ASD-RI, ASD-RN, and ASD-C increased significantly from 1985 to 1998, then ASD-RI and ASD-RN plateaued while the rate of ASD-C continued to increase during 1998–2004. The rising incidence of research-defined ASD may reflect improved recognition and documentation of ASD signs and symptoms. Although the frequency of threshold ASD symptoms stabilized, the rate of ASD-C continued to increase, narrowing the gap between clinical ascertainment and symptom documentation.

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Supplementary material 1 (DOCX 23 KB)
Supplementary material 2 (DOCX 12 KB)
Supplementary material 3 (XLSX 137 KB)
Supplementary material 4 (DOCX 35 KB)
Supplementary material 5 (DOCX 211 KB)
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