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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2007

01-03-2007 | Original Paper

Autism Post-Mortem Neuroinformatic Resource: The Autism Tissue Program (ATP) Informatics Portal

Auteurs: Michael B. Brimacombe, Richard Pickett, Jane Pickett

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2007

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Abstract

The Autism Tissue Program (ATP) was established to oversee and manage brain donations related to neurological research in autism. The ATP Informatics Portal (www.atpportal.org) is an integrated data access system based on Oracle technology, developed to provide access for researchers to information on this rare tissue resource. It also permits sorting of existing cases based on donor ante-mortem history as well as agonal states and post-mortem tissue conditions. Phase II of development established administrative tracking of registrants intending to donate, as well as management of tissue requests and the awarding and tracking of tissue. Phase III is the ongoing assimilation of data sets derived from research on a core group of donors with searchable access by investigators.
Literatuur
go back to reference American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed. , text revision), Washington, D.C.: American Psychiatric Association. American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed. , text revision), Washington, D.C.: American Psychiatric Association.
go back to reference Bauman, M. L., & Kemper, T. L. (1994). Neuro-anatomic observations of the brain in Autism. In M. L. Bauman, & T. L. Kemper (Eds.), The neurobiology of autism (pp 119–145). Baltimore: Johns Hopkins University Press. Bauman, M. L., & Kemper, T. L. (1994). Neuro-anatomic observations of the brain in Autism. In M. L. Bauman, & T. L. Kemper (Eds.), The neurobiology of autism (pp 119–145). Baltimore: Johns Hopkins University Press.
go back to reference Bobinski, M, de Leon, M. J., & Wegiel, J. (2000) The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer’s disease. Neuroscience, 95, 721–725. PubMedCrossRef Bobinski, M, de Leon, M. J., & Wegiel, J. (2000) The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer’s disease. Neuroscience, 95, 721–725. PubMedCrossRef
go back to reference Brinkley, J. F., & Rosse, C (2002). Imaging and the human brain project: A review. Methods of Information in Medicine, 41(4), 245–260. PubMed Brinkley, J. F., & Rosse, C (2002). Imaging and the human brain project: A review. Methods of Information in Medicine, 41(4), 245–260. PubMed
go back to reference Casanova, M. F., Buxhoeveden, D., Switala, A., & Roy, E. (2002). Neuronal density and architecture (gray level index) in the brains of autistic patients. Journal of Child Neurology, 17(7), 515–521. PubMed Casanova, M. F., Buxhoeveden, D., Switala, A., & Roy, E. (2002). Neuronal density and architecture (gray level index) in the brains of autistic patients. Journal of Child Neurology, 17(7), 515–521. PubMed
go back to reference Courchesne, E. (2004). Brain development in autism: Early overgrowth followed by premature arrest of growth. Mental Retardation and Developmental Disabilities Research Reviews, 10(2), 106–111. PubMedCrossRef Courchesne, E. (2004). Brain development in autism: Early overgrowth followed by premature arrest of growth. Mental Retardation and Developmental Disabilities Research Reviews, 10(2), 106–111. PubMedCrossRef
go back to reference Eberhart, C. G., Copeland, J., & Abel, T. W. (2006). S6 ribosomal protein phosphorylation in autistic frontal cortex and cerebellum: A tissue array analysis. Journal of Autism and Developmental Disorders (in press). Eberhart, C. G., Copeland, J., & Abel, T. W. (2006). S6 ribosomal protein phosphorylation in autistic frontal cortex and cerebellum: A tissue array analysis. Journal of Autism and Developmental Disorders (in press).
go back to reference Gupta, A., Ludascher, B., Grethe, J. S., & Martone, M. E. (2003). Towards a formalization of disease-specific ontologies for neuroinformatics. Neural Networks, 16(9), 1277–92. PubMedCrossRef Gupta, A., Ludascher, B., Grethe, J. S., & Martone, M. E. (2003). Towards a formalization of disease-specific ontologies for neuroinformatics. Neural Networks, 16(9), 1277–92. PubMedCrossRef
go back to reference Kielinen, M., Rantala, H., Timonen, E., Linna, S. L., & Moilanen, I. (2004). Associated medical disorders and disabilities in children with autistic disorder: a population-based study. Autism, 8(1), 49–60. PubMedCrossRef Kielinen, M., Rantala, H., Timonen, E., Linna, S. L., & Moilanen, I. (2004). Associated medical disorders and disabilities in children with autistic disorder: a population-based study. Autism, 8(1), 49–60. PubMedCrossRef
go back to reference Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–230. PubMedCrossRef Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–230. PubMedCrossRef
go back to reference Palmen, S. J., van Engeland, H., Hof, P. R., & Schmitz, C. (2004). Neuropathological findings in autism. Brain, 127, 2572–2583. PubMedCrossRef Palmen, S. J., van Engeland, H., Hof, P. R., & Schmitz, C. (2004). Neuropathological findings in autism. Brain, 127, 2572–2583. PubMedCrossRef
go back to reference Perry, E. K., Lee, M. L., Martin-Ruiz, C. M., Court, J. A., Volsen, S. G., Merrit, J., Folly, E., Iversen, P. E., Bauman, M. L., Perry, R. H., & Wenk, G. L. (2001) Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain. American Journal of Psychiatry, 158(7), 1058–1066. PubMedCrossRef Perry, E. K., Lee, M. L., Martin-Ruiz, C. M., Court, J. A., Volsen, S. G., Merrit, J., Folly, E., Iversen, P. E., Bauman, M. L., Perry, R. H., & Wenk, G. L. (2001) Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain. American Journal of Psychiatry, 158(7), 1058–1066. PubMedCrossRef
go back to reference Samaco, R. C., Nagarajan, R. P., Braunschweig, D., & LaSalle, J. M. (2004) Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Human Molecular Genetics, 13(6), 629–639. Samaco, R. C., Nagarajan, R. P., Braunschweig, D., & LaSalle, J. M. (2004) Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Human Molecular Genetics, 13(6), 629–639.
go back to reference Schmitz, C., & Hof, P. (2005). Design-based stereology in neuroscience. Neuroscience, 130(4), 813–831. PubMedCrossRef Schmitz, C., & Hof, P. (2005). Design-based stereology in neuroscience. Neuroscience, 130(4), 813–831. PubMedCrossRef
go back to reference Schumann, C. M., Buonocore, M. H., & Amaral, D. G. (2001). MRI of the post-mortem autistic brain. Journal of Autism and Developmental Disorders, 31, 561–569. PubMedCrossRef Schumann, C. M., Buonocore, M. H., & Amaral, D. G. (2001). MRI of the post-mortem autistic brain. Journal of Autism and Developmental Disorders, 31, 561–569. PubMedCrossRef
go back to reference Schumann, C. M., Hamstra, J., Goodlin-Jones, B. L., Lotspeich, L. J., Kwon, H., Buonocore, M. H., Lammers, C. R., Reiss, A. L., Amaral, D. G. (2004). The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. Journal of Neuroscience, 24(28), 6392–6401. Schumann, C. M., Hamstra, J., Goodlin-Jones, B. L., Lotspeich, L. J., Kwon, H., Buonocore, M. H., Lammers, C. R., Reiss, A. L., Amaral, D. G. (2004). The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. Journal of Neuroscience, 24(28), 6392–6401.
go back to reference Shavelle, R. M., Straus, D. J., & Pickett, J. (2001). Causes of death in autism. Journal of Autism and Developmental Disorders, 31(6), 569–576. PubMedCrossRef Shavelle, R. M., Straus, D. J., & Pickett, J. (2001). Causes of death in autism. Journal of Autism and Developmental Disorders, 31(6), 569–576. PubMedCrossRef
go back to reference Toga, A. 2002. Neuroimage databases, the good, the bad and the ugly. Nature Reviews Neuroscience, 3, 302–309. PubMedCrossRef Toga, A. 2002. Neuroimage databases, the good, the bad and the ugly. Nature Reviews Neuroscience, 3, 302–309. PubMedCrossRef
go back to reference Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Increased neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57(1), 67–81. PubMedCrossRef Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Increased neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57(1), 67–81. PubMedCrossRef
go back to reference Weimer, J., Schubert, F., Granzow, M., Ragg, T., Fieres, J., & Mattes, R. (2003). Informatics united: exemplary studies combining medical informatics, neuroinformatics and bioinformatics. Methods of Information in Medicine, 42(2), 126–133. Weimer, J., Schubert, F., Granzow, M., Ragg, T., Fieres, J., & Mattes, R. (2003). Informatics united: exemplary studies combining medical informatics, neuroinformatics and bioinformatics. Methods of Information in Medicine, 42(2), 126–133.
go back to reference Wong, S. T., Hoo, K. S. Jr., Cao, X., Tjandra, D., Fu, J. C., & Dillon, W. P. (2004). A neuroinformatics database system for disease-oriented neuroimaging research. Academic Radiology, 11(3), 345–358. PubMedCrossRef Wong, S. T., Hoo, K. S. Jr., Cao, X., Tjandra, D., Fu, J. C., & Dillon, W. P. (2004). A neuroinformatics database system for disease-oriented neuroimaging research. Academic Radiology, 11(3), 345–358. PubMedCrossRef
go back to reference Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. JAMA, 289(1), 87–89. Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. JAMA, 289(1), 87–89.
Metagegevens
Titel
Autism Post-Mortem Neuroinformatic Resource: The Autism Tissue Program (ATP) Informatics Portal
Auteurs
Michael B. Brimacombe
Richard Pickett
Jane Pickett
Publicatiedatum
01-03-2007
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0188-9