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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-11-2013 | Original Paper

Autism and Phthalate Metabolite Glucuronidation

Auteurs: T. Peter Stein, Margaret D. Schluter, Robert A. Steer, Xue Ming

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2013

Abstract

Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD.

vorige artikel A Critical Review of the Research on the Extreme Male Brain Theory and Digit Ratio (2D:4D)

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Alberti, A., Pirrone, P., Elia, M., Waring, R. H., & Romano, C. (1999). Sulphation deficit in “low-functioning” autistic children: A pilot study. Biological Psychiatry, 46, 420–424.PubMedCrossRef

Argikar, U. A., Iwuchukwu, O. F., & Nagar, S. (2008). Update on tools for evaluation of uridine diphosphoglucuronosyltransferase polymorphisms. Expert Opinion On Drug Metabolism & Toxicology, 4, 879–894.CrossRef

Armstrong, R. N. (1997). Structure, catalytic mechanism and evolution of the glutathione transferase. Chemical Research in Toxicology, 10, 2–18.PubMedCrossRef

Baio, J., et al. (2012). Prevalence of autism spectrum disorders—autism and developmental disabilities monitoring network, 14 sites, United States, 2008 Surveillance summaries. Morbidity and Mortality Weekly Report (MMWR), 61, 1–19.

Buyske, S., Williams, T. A., Mars, A. E., Stenroos, E. S., Ming, S. X., Wang, R., et al. (2006). Analysis of case-parent trios at a locus with a deletion allele: Association of GSTM1 with autism. BMC Genetics, 7, 8.PubMedCrossRef

Calafat, A. M., Ye, X., Wong, L. Y., Reidy, J. A., & Needham, L. L. (2008). Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004. Environmental Health Perspectives, 116, 39–44.PubMedCrossRef

Cohen, J. (1993). A power primer. Psychological Bulletin, 112, 155–159.CrossRef

Cohen, J., & Cohen, P. (1983). Applied multiple regression/correlation analysis for the behavioral sciences (2nd ed., pp. 265–266). Hillsdale, NJ: Lawrence Erlbaum.

de Cock, M., Maas, Y. G., & van de Bor, M. (2012). Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review. Acta Paediatrica, 101, 811–818.PubMedCrossRef

Edelson, S. B., & Cantor, D. S. (2000). The neurotoxic etiology of the autistic spectrum disorder: A replicative study. Toxicology and Industrial Health, 16, 239–247.

Engel, S. M., Miodovnik, A., Canfield, R. L., Zhu, C., Silva, M. J., Calafat, A. M., et al. (2010). Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environmental Health Perspectives, 118, 565–571.PubMedCrossRef

Hauser, R., Meeker, J. D., Duty, S., Silva, M. J., & Calafat, A. M. (2006). Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology, 17, 682–691.PubMedCrossRef

Herbert, M. R. (2010). Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Current Opinion in Neurology, 23, 103–110.PubMedCrossRef

Herr, C., Zur Nieden, A., Koch, H. M., Schuppe, H. C., Fieber, C., Angerer, J., et al. (2009). Urinary di(2-ethylhexyl)phthalate (DEHP)—metabolites and male human markers of reproductive function. International Journal of Hygiene and Environmental Health, 212, 648–653.PubMedCrossRef

Hwang, H. M., Park, E. K., Young, T. M., & Hammock, B. D. (2008). Occurrence of endocrine-disrupting chemicals in indoor dust. Science of the Total Environment, 404, 26–35.PubMedCrossRef

James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., et al. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. American Journal of Clinical Nutrition, 80, 1611–1617.PubMed

James, S. J., Melnyk, S., Jernigan, S., Hubamks, A., Rose, S., & Gaylor, D. W. (2008). Abnormam methyllation-transulfuration metabolism and DNA hypomethylation among parents of children with autism. Journal of Autism and Developmental Disorders, 38, 1966–1975.PubMedCrossRef

Kalkbrenner, A. E., Daniels, J. L., Chen, J. C., Poole, C., Emch, M., & Morrissey, J. (2010). Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8. Epidemiology, 21, 631–641.PubMedCrossRef

Koch, H. M. (2010). Exposure assessment to phthalates by human biomonitoring. In: PVC plasticizers 2010. Brussels: Crain Communications, 15, 11–17.

Koch, H. M., Bolt, H. M., Preuss, R., & Angerer, J. (2005). New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP. Archives of Toxicology, 79, 367–376.PubMedCrossRef

Koch, H. M., Preuss, R., & Angerer, J. (2006). Di(2-ethylhexyl)phthalate (DEHP): Human metabolism and internal exposure—an update and latest results. International Journal of Andrology, 29, 155–165.PubMedCrossRef

Landrigan, P. J. (2010). What causes autism? Exploring the environmental contribution. Current Opinion in Pediatrics, 22, 219–225.PubMedCrossRef

Larsson, M., Weiss, B., Janson, S., Sundell, J., & Bornehag, C. G. (2009). Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6–8 years of age. Neurotoxicology, 30, 822–831.PubMedCrossRef

Ming, X., Brimacombe, M., Zimmerman-Bier, B., Chaaban, J., & Wagner, G. C. (2008). Autism spectrum disorders: Concurrent disorders. Journal of Child Neurology, 23, 6–13.CrossRef

Ming, X., Johnson, W. G., Stenroos, E. S., Mars, A., Lambert, G. H., & Buyske, S. (2010). Genetic variant of glutathione peroxidase 1 in autism. Brain and Development, 32, 105–109.PubMedCrossRef

Muhle, R., Trentacoste, S. V., & Rapin, I. (2004). The genetics of autism. Pediatrics, 113, 472–486.CrossRef

NIEHS. (2011). Report on carcinogens (12th ed, pp. 156–158). Research Triangle Park, North Carolina: U.S. Department of Health and Human Services Public Health Service National Toxicology Program.

NTP-CERHR. (2005). NTP-CERHR expert panel update on the reproductive and developmental toxicity of Di)2-ethylhexyl) phthalate. NIEHS, Research Triangle Park, NC: National Toxicology Program—US Dept. of Health and Human Services.

O’Reilly, B., & Waring, R. H. (2003). Enzyme and sulphur oxidation deficiencies in autistic children with known food and chemical intolerances. Journal of Orthomolecular Medicine, 4, 198–200.

Pessah, I. N., Seegal, R. F., Lein, P. J., LaSalle, J., Yee, B. K., Van De Water, J., et al. (2008). Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology, 29, 532–545.PubMedCrossRef

Rudel, R. A., Gray, J. M., Engel, C. L., Rawsthorne, T. W., Dodson, R. E., Ackerman, J. M., et al. (2012). Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: Findings from a dietary intervention. Environmental Health Perspectives, 119, 914–920.CrossRef

Silva, M. J., Malek, N. A., Hodge, C. C., Reidy, J. A., Kato, K., Barr, D. B., et al. (2003). Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 789, 393–404.PubMedCrossRef

Silva, M. J., Reidy, J. A., Samander, E., Herbert, A., Needham, L. L., & Calafat, A. M. (2005). Detection of phthalate metabolites in human saliva. Archives of Toxicology, 79, 647–652.PubMedCrossRef

Teitelbaum, S. L., Britton, J. A., Calafat, A. M., Ye, X., Silva, M. J., Reidy, J. A., et al. (2008). Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environmental Research, 106, 257–269.PubMedCrossRef

Tukey, R. H., & Strassburg, C. P. (2000). Human UDP-glucuronosyltransferases: Metabolism, expression, and disease. Annual Review of Pharmacology and Toxicology, 40, 581–616.PubMedCrossRef

Waring, R. H., & Klovrza, L. (2000). Sulphur metabolism in autism. Journal of Nutritional & Environmental Medicine, 10, 25–32.CrossRef

Wells, P. G., Mackenzie, P. I., Chowdhury, J. R., Guillemette, C., Gregory, P. A., Ishii, Y., et al. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. Drug Metabolism and Disposition, 32, 281–290.PubMedCrossRef

Whiteley, P., Waring, R., Williams, L., Klovrza, L., Nolan, F., Smith, S., et al. (2006). Spot urinary creatinine excretion in pervasive developmental disorders. Pediatrics International, 48, 292–297.PubMedCrossRef

Williams, T. A., Mars, A. E., Buyske, S. G., Stenroos, E. S., Wang, R., Factura-Santiago, M. F., et al. (2007). Risk of autistic disorder in affected offspring of mothers with a glutathione S-transferase P1 haplotype. Archives of Pediatrics and Adolescent Medicine, 16, 356–361.

Windham, G. C., Zhang, L., Gunier, R., Croen, L. A., & Grether, J. K. (2006). Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco bay area. Environmental Health Perspectives, 114, 1438–1444.PubMedCrossRef

Wittassek, M., Heger, W., Koch, H. M., Becker, K., Angerer, J., & Kolossa-Gehring, M. (2007). Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children—A comparison of two estimation models based on urinary DEHP metabolite levels. Int. Journal of Hygiene and Environmental Health, 210, 35–42.CrossRef

Wolff, M. S., Teitelbaum, S. L., Windham, G., Pinney, S. M., Britton, J. A., Chelimo, C., et al. (2007). Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environmental Health Perspectives, 115, 116–121.PubMedCrossRef

Ye, X., Pierik, F. H., Hauser, R., Duty, S., Angerer, J., Park, M. M., et al. (2008). Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: The Generation R study. Environmental Research, 108, 260–267.PubMedCrossRef

Titel: Autism and Phthalate Metabolite Glucuronidation
Auteurs: T. Peter Stein
Margaret D. Schluter
Robert A. Steer
Xue Ming
Publicatiedatum: 01-11-2013
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-013-1822-y

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