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01-11-2013 | Original Paper | Uitgave 11/2013

Autism and Phthalate Metabolite Glucuronidation

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 11/2013

Auteurs:: T. Peter Stein, Margaret D. Schluter, Robert A. Steer, Xue Ming

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Abstract

Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD.

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Titel: Autism and Phthalate Metabolite Glucuronidation
Auteurs:: T. Peter Stein
Margaret D. Schluter
Robert A. Steer
Xue Ming
Publicatiedatum: 01-11-2013
DOI: https://doi.org/10.1007/s10803-013-1822-y
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 11/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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