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Child Psychiatry & Human Development
Gepubliceerd in: Child Psychiatry & Human Development 3/2016

01-09-2015 | Original Article

Attention and Working Memory in Adolescents with Autism Spectrum Disorder: A Functional MRI Study

Auteurs: Jukka S. Rahko, Virve A. Vuontela, Synnöve Carlson, Juha Nikkinen, Tuula M. Hurtig, Sanna Kuusikko-Gauffin, Marja-Leena Mattila, Katja K. Jussila, Jukka J. Remes, Eira M. Jansson-Verkasalo, Eeva T. Aronen, David L. Pauls, Hanna E. Ebeling, Osmo Tervonen, Irma K. Moilanen, Vesa J. Kiviniemi

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 3/2016

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Abstract

The present study examined attention and memory load-dependent differences in the brain activation and deactivation patterns between adolescents with autism spectrum disorders (ASDs) and typically developing (TD) controls using functional magnetic resonance imaging. Attentional (0-back) and working memory (WM; 2-back) processing and load differences (0 vs. 2-back) were analysed. WM-related areas activated and default mode network deactivated normally in ASDs as a function of task load. ASDs performed the attentional 0-back task similarly to TD controls but showed increased deactivation in cerebellum and right temporal cortical areas and weaker activation in other cerebellar areas. Increasing task load resulted in multiple responses in ASDs compared to TD and in inadequate modulation of brain activity in right insula, primary somatosensory, motor and auditory cortices. The changes during attentional task may reflect compensatory mechanisms enabling normal behavioral performance. The inadequate memory load-dependent modulation of activity suggests diminished compensatory potential in ASD.
vorige artikel Treatments and Services Provided to Children Diagnosed with Bipolar Disorder
volgende artikel Effect of Treating Anxiety Disorders on Cognitive Deficits and Behaviors Associated with Attention Deficit Hyperactivity Disorder: A Preliminary Study
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Metagegevens
Titel
Attention and Working Memory in Adolescents with Autism Spectrum Disorder: A Functional MRI Study
Auteurs
Jukka S. Rahko
Virve A. Vuontela
Synnöve Carlson
Juha Nikkinen
Tuula M. Hurtig
Sanna Kuusikko-Gauffin
Marja-Leena Mattila
Katja K. Jussila
Jukka J. Remes
Eira M. Jansson-Verkasalo
Eeva T. Aronen
David L. Pauls
Hanna E. Ebeling
Osmo Tervonen
Irma K. Moilanen
Vesa J. Kiviniemi
Publicatiedatum
01-09-2015
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 3/2016
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-015-0583-6

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