Swipe om te navigeren naar een ander artikel
Individuals with a history of poor interpersonal relationships are more likely to demonstrate negative health outcomes than those who have had high quality relationships. We sought to evaluate how attachment orientations, stress-induced respiratory sinus arrhythmia (RSA), and self-reported stress were associated with length of telomeres measured from peripheral blood mononuclear cells. Participants (N = 213) completed self-report measures of attachment and stress. Measurement of RSA was conducted before and after a stressful task and a blood draw was completed for analysis of telomere length. Attachment orientations were not directly associated with telomere length; however, we found that high attachment anxiety was associated with shorter length of telomeres via high self-reported stress. Attachment avoidance was also associated with telomere length via self-reported stress, but only among those with high stress-induced RSA. Exploratory analyses of T cell subsets indicated that stress was most strongly associated with telomeres from CD8CD28+ cells in comparison to CD8CD28− and CD4 cells. Study findings indicate that attachment orientations are associated with telomere length via stress, providing novel insights into the mechanisms through which close relationships can impact health and aging.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Baumeister, R. F., & Heatherton, T. F. (1996). Self-regulation failure: An overview. Psychological Inquiry, 7, 1–15. CrossRef
Bentler, P. M. (2004). EQS (Version 6.1). Encino, CA: Multivariate Software.
Brennan, K. A., Clark, C. L., & Shaver, P. R. (1998). Self-reported measurement of adult attachment: An integrative overview. In J. A. Simpson & W. S. Rholes (Eds.), Attachment theory and close relationships (pp. 46–76). New York: Guilford Press.
Chen, W., Kimura, M., Kim, S., Cao, X., Srinivasan, S. R., Berenson, G. S., et al. (2011). Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: Age-dependent telomere shortening is the rule. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 66a, 312–319. doi: 10.1093/gerona/glq223 CrossRefPubMedCentral
Cohen, S., Janicki-Deverts, D., Turner, R. B., Casselbrant, M. L., Li-Korotky, H. S., Epel, E. S., et al. (2013). Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults. JAMA, 309, 699–705. doi: 10.1001/jama.2013.613 CrossRefPubMedPubMedCentral
Ditzen, B., Schmidt, S., Strauss, B., Nater, U. M., Ehlert, U., & Heinrichs, M. (2008). Adult attachment and social support interact to reduce psychological but not cortisol responses to stress. Journal of Psychosomatic Research, 64, 479–486. doi: 10.1016/j.jpsychores.2007.11.011 CrossRefPubMed
Effros, R. B., Allsopp, R., Chiu, C. P., Hausner, M. A., Hirji, K., Wang, L., et al. (1996). Shortened telomeres in the expanded CD28–CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS, 10, 17–22. CrossRef
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., et al. (2004). Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences of the United States of America, 101, 17312–17315. doi: 10.1073/pnas.0407162101 CrossRefPubMedPubMedCentral
IBM. (2012). IBM SPSS statistics for Windows, Version 21.0. Armonk, NY: IBM Corp.
Laboratory for the Study of Stress, Immunity, and Disease. (2016). Common Cold Project. Retrieved from http://www.commoncoldproject.com
Lo, C., Walsh, A., Mikulincer, M., Gagliese, L., Zimmermann, C., & Rodin, G. (2009). Measuring attachment security in patients with advanced cancer: Psychometric properties of a modified and brief Experiences in close Relationships scale. Psycho-Oncology, 18, 490–499. doi: 10.1002/pon.1417 CrossRefPubMed
Malik, M. (1996). Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Task force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation, 93, 1043–1065. doi: 10.1161/01.CIR.93.5.1043 CrossRef
Mathur, M. B., Epel, E., Kind, S., Desai, M., Parks, C. G., Sandler, D. P., et al. (2016). Perceived stress and telomere length: A systematic review, meta-analysis, and methodologic considerations for advancing the field. Brain, Behavior, and Immunity, 54, 158–169. doi: 10.1016/j.bbi.2016.02.002 CrossRefPubMedPubMedCentral
Mikulincer, M., & Shaver, P. R. (2007). Attachment in adulthood: Structure, dynamics, and change. New York, NY, US: Guilford Press.
Murdock, K. W., & Fagundes, C. P. (2017). Attachment orientations, respiratory sinus arrhythmia, and stress are important for understanding the link between childhood socioeconomic status and adult self-reported health. Annals of Behavioral Medicine, 51, 189–198. doi: 10.1007/s12160-016-9842-4 CrossRefPubMedPubMedCentral
Schaefer, C., Sciortino, S., Kvale, M., Lapham, K., Ranatunga, D., Rowell, S., et al. (2013). Demographic and behavioral influence on telomere length and relationship with all-cause mortality: Early results from the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH). Clinical Medicine & Research, 11, 145. doi: 10.3121/cmr.2013.1176.b4-3
Tyrka, A. R., Price, L. H., Kao, H. T., Porton, B., Marsella, S. A., & Carpenter, L. L. (2010). Childhood maltreatment and telomere shortening: Preliminary support for an effect of early stress on cellular aging. Biological Psychiatry, 67, 531–534. doi: 10.1016/j.biopsych.2009.08.014 CrossRefPubMed
Uchino, B. N., Cacioppo, J. T., & Kiecolt-Glaser, J. K. (1996). The relationship between social support and physiological processes: A review with emphasis on underlying mechanisms and implications for health. Psychological Bulletin, 119, 488–531. doi: 10.1037/0033-2909.119.3.488 CrossRefPubMed
Uchino, B. N., Cawthon, R. M., Smith, T. W., Light, C. K., Mckenzie, J., Carlisle, M., et al. (2012). Social relationships and health: Is feeling positive, negative, or both (ambivalent) about your social ties related to telomeres. Health Psychology, 31, 789–796. doi: 10.1037/a0026836 CrossRefPubMedPubMedCentral
Uchino, B. N., Smith, T. W., & Berg, C. A. (2014). Spousal relationship quality and cardiovascular risk: Dyadic perceptions of relationship ambivalence are associated with coronary-artery calcification. Psychological Science, 25, 1037–1042. doi: 10.1177/0956797613520015 CrossRefPubMedPubMedCentral
Wagner, D. D., & Heatherton, T. F. (2014). Emotion and self-regulation failure. In J. J. Gross (Ed.), Handbook of emotion regulation (2nd ed., pp. 613–628). New York, NY: The Guilford Press.
- Attachment and telomere length: more evidence for psychobiological connections between close relationships, health, and aging
Kyle W. Murdock
Cobi J. Heijnen
Christopher P. Fagundes
- Springer US