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Journal of Autism and Developmental Disorders

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15-02-2018 | Original Paper

Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development

Auteurs: Laura A. Schieve, Lin Tian, Nicole Dowling, Lisa Croen, Julie Hoover-Fong, Aimee Alexander, Stuart K. Shapira

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2018

Abstract

The ratio of the index (2nd) finger to ring (4th) finger lengths (2D:4D) is a proxy for fetal testosterone and estradiol. Studies suggesting 2D:4D is inversely associated with autism spectrum disorder (ASD) in males were limited by lack of confounder and subgroup assessments. Studies of females are sparse. We examined associations between ASD and 2D:4D among children in the Study to Explore Early Development; we considered case subgroups and numerous potential demographic and maternal-perinatal health confounders. We observed a modest inverse association between ASD and right-hand 2D:4D in males; subgroup analyses indicated associations were limited to ASD cases with birth defects/genetic syndromes or dysmorphic features. We observed a positive association between ASD and left-hand 2D:4D in females, overall and within most case subgroups.

vorige artikel Family Experiences with the Diagnosis of Autism Spectrum Disorder: System Barriers and Facilitators of Efficient Diagnosis

volgende artikel Characterizing Health Disparities in the Age of Autism Diagnosis in a Study of 8-Year-Old Children

Abbott, A. D., Colman, R. J., Tiefenthaler, R., Dumesic, D. A., & Abbott, D. H. (2012). Early-to-mid gestation fetal testosterone increases right hand 2D:4D finger length ratio in polycystic ovary syndrome-like monkeys. PLoS ONE, 7(8), e42372. https://doi.org/10.1371/journal.pone.0042372.CrossRefPubMedPubMedCentral

Al-Zaid, F. S., Alhader, A. A., & Al-Ayadhi, L. Y. (2015). The second to fourth digit ratio (2D:4D) in Saudi boys with autism: A potential screening tool. Early Human Development, 91(7), 413–415.CrossRefPubMed

Arndt, T. L., Stodgell, C. J., & Rodier, P. M. (2005). The teratology of autism. International Journal of Developmental Neuroscience, 23(2–3), 189–199.CrossRefPubMed

Barona, M., Kothari, R., Skuse, D., & Micali, N. (2015). Social communication and emotion difficulties and second to fourth digit ratio in a large community-based sample. Molecular Autism, 6, 68. https://doi.org/10.1186/s13229-015-0063-7.CrossRefPubMedPubMedCentral

Baron-Cohen, S., Auyeung, B., Nørgaard-Pedersen, B., et al. (2015). Elevated fetal steroidogenic activity in autism. Molecular Psychiatry, 20(3), 369–376.CrossRefPubMed

Baron-Cohen, S., Lombardo, M. V., Auyeung, B., Ashwin, E., Chakrabarti, B., & Knickmeyer, R. (2011). Why are autism spectrum conditions more prevalent in males? PLoS Biology, 9(6), e1001081. https://doi.org/10.1371/journal.pbio.1001081.CrossRefPubMedPubMedCentral

Bejerot, S., Eriksson, J. M., Bonde, S., Carlström, K., Humble, M. B., & Eriksson, E. (2012). The extreme male brain revisited: Gender coherence in adults with autism spectrum disorder. British Journal of Psychiatry, 201, 116–123.CrossRefPubMed

Blumberg, S. J., Bramlett, M. D., Kogan, M. D., Schieve, L. A., Jones, J. R., & Lu, M. C. (2013). Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children: 2007 to 2011-2012. National Health Statistics Report, 65, 1–11.

Chapman, E., Baron-Cohen, S., Auyeung, B., Knickmeyer, R., Taylor, K., & Hackett, G. (2006). Fetal testosterone and empathy: evidence from the empathy quotient (EQ) and the “reading the mind in the eyes” test. Social Neuroscience, 1(2), 136–148.CrossRef

Christensen, D. L., Baio, J., Braun, K. V., et al. (2016) Prevalence and characteristics of autism spectrum disorder among children aged 8 years—Autism and developmental disabilities monitoring network, 11 sites, United States, 2012. Morbidly and Mortality Weekly Report Surveillance Summary, 65(SS-3), pp. 1–23.

de Bruin, E. I., Verheij, F., Wiegman, T., & Ferdinand, R. F. (2006). Differences in finger length ratio between males with autism, pervasive developmental disorder-not otherwise specified, ADHD, and anxiety disorders. Developmental Medicine and Child Neurology, 48(12), 962–965.CrossRefPubMed

Dela Cruz, C., & Pereira, O. C. (2012). Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats. The Journal of Physiological Sciences, 62(2), 123–131.CrossRefPubMed

Dumesic, D. A., Goodarzi, M. O., Chazenbalk, G. D., & Abbott, D. H. (2014). Intrauterine environment and polycystic ovary syndrome. Seminars in Reproductive Medicine, 32(3), 159–165.CrossRefPubMedPubMedCentral

Falter, C. M., Plaisted, K. C., & Davis, G. (2008). Visuo-spatial processing in autism—Testing the predictions of extreme male brain theory. Journal of Autism and Developmental Disorders, 38(3), 507–515.CrossRefPubMed

Hu, M., Richard, J. E., Maliqueo, M., et al. (2015) Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring. Proceedings of the National Academy of Sciences USA, 112(46), 14348–1453.CrossRef

Jacome, L. F., Barateli, K., Buitrago, D., Lema, F., Frankfurt, M., & Luine, V. N. (2016). Gonadal hormones rapidly enhance spatial memory and increase hippocampal spine density in male rats. Endocrinology, 157(4), 1357–1362.CrossRefPubMedPubMedCentral

Järvelä, I. Y., Pelkonen, S., Uimari, O., Mäkikallio, K., Puukka, K., Ruokonen, A., et al. (2014). Controlled ovarian hyperstimulation leads to high progesterone and estradiol levels during early pregnancy. Human Reproduction, 29(11), 2393–2401.CrossRefPubMed

Kim, Y. S., & Leventhal, B. L. (2015). Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders. Biological Psychiatry, 77(1), 66–74.CrossRefPubMed

Knickmeyer, R., Baron-Cohen, S., Raggatt, P., & Taylor, K. (2005). Foetal testosterone, social relationships, and restricted interests in children. Journal of Child Psychology and Psychiatry, 46(2), 198–210.CrossRefPubMed

Knickmeyer, R., Baron-Cohen, S., Raggatt, P., Taylor, K., & Hackett, G. (2006). Fetal testosterone and empathy. Hormones and Behavior, 49(3), 282–292.CrossRefPubMed

Knickmeyer, R. C., Woolson, S., Hamer, R. M., Konneker, T., & Gilmore, J. H. (2011). 2D:4D ratios in the first 2 years of life: Stability and relation to testosterone exposure and sensitivity. Hormones and Behavior, 60(3), 256–263.CrossRefPubMedPubMedCentral

Kondo, T., Zákány, J., Innis, J. W., & Duboule, D. (1997). Of fingers, toes and penises. Nature, 390(6655), 29.CrossRefPubMed

Krajmer, P., Spajdel, M., Kubranska, A., & Ostatnikova, D. (2011). 2D:4D finger ratio in Slovak autism spectrum population. Bratisl Lek Listy, 112(7), 377–379.PubMed

Kuijper, E. A., Twisk, J. W., Korsen, T., et al. (2015). Mid-pregnancy, perinatal, and neonatal reproductive endocrinology: A prospective cohort study in twins and singleton control subjects. Fertility and Sterility, 104(6), 1527–1534.e1-9.CrossRefPubMed

Lutchmaya, S., Baron-Cohen, S., & Raggatt, P. (2002a). Foetal testosterone and eye contact in 12 month old infants. Infant Behavior and Development, 25, 327–335.CrossRef

Lutchmaya, S., Baron-Cohen, S., & Raggatt, P. (2002b). Foetal testosterone and vocabulary size in 18- and 24-month-old infants. Infant Behavior and Development, 24, 418–424.CrossRef

Lutchmaya, S., Baron-Cohen, S., Raggatt, P., Knickmeyer, R., & Manning, J. T. (2004). 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Human Development, 77(1–2), 23–28.CrossRefPubMed

Makieva, S., Saunders, P. T., & Norman, J. E. (2014). Androgens in pregnancy: Roles in parturition. Human Reproduction Update, 20(4), 542–559.CrossRefPubMedPubMedCentral

Manning, J. T., Baron-Cohen, S., Wheelwright, S., & Sanders, G. (2001). The 2nd to 4th digit ratio and autism. Developmental Medicine & Child Neurology, 43(3), 160–164.CrossRef

Manning, J. T., & Bundred, P. E. (2000). The ratio of 2nd to 4th digit length: a new predictor of disease predisposition? Medical Hypotheses, 54(5), 855–857.CrossRefPubMed

Manning, J. T., Scutt, D., Wilson, J., & Lewis-Jones, D. I. (1998). The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Human Reproduction, 13(11), 3000–3004.CrossRefPubMed

Masuya, Y., Okamoto, Y., Inohara, K., Matsumura, Y., Fujioka, T., Wada, Y., & Kosaka, H. (2015). Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders. Molecular Autism, 6, 34. https://doi.org/10.1186/s13229-015-0028-x.CrossRefPubMedPubMedCentral

McIntyre MH (2006) The use of digit ratios as markers for perinatal androgen action. Reproductive Biology and Endocrinology, 4, 10.CrossRefPubMedPubMedCentral

Miles, J. H. (2011). Autism spectrum disorders—A genetics review. Genetic in Medicine, 13(4), 278–294.CrossRef

Milne, E., White, S., Campbell, R., Swettenham, J., Hansen, P., & Ramus, F. (2006). Motion and form coherence detection in autistic spectrum disorder: Relationship to motor control and 2:4 digit ratio. Journal of Autism & Developmental Disorders, 36(2), 225–237.CrossRef

Noipayak, P. (2009). The ratio of 2nd and 4th digit length in autistic children. Journal of the Medical Association of Thailand, 92(8), 1040–1045.PubMed

Ornoy, A., Weinstein-Fudim, L., & Ergaz, Z. (2016). Genetic syndromes, maternal diseases and antenatal factors associated with autism spectrum disorders (ASD). Frontiers in Neuroscience, 10, 316. https://doi.org/10.3389/fnins.2016.00316.CrossRefPubMedPubMedCentral

Pointis, G., Latreille, M. T., Richard, M. O., D’Athis, P., & Cedard, L. (1987). Effect of natural progesterone treatment during pregnancy on fetal testosterone and sexual behavior of the male offspring in the mouse. Developmental Pharmacology and Therapeutics, 10(5), 385–392.CrossRefPubMed

Quinonez, S. C., & Innis, J. W. (2014). Human HOX gene disorders. Molecular Genetics and Metabolism, 111(1), 4–15.CrossRefPubMed

Ribeiro, E., Neave, N., Morals, R. N., & Manning, J. T. (2016) Direct versus indirect measurement of digit ratio (2DL:4D): A critical review of the literature and new data. Evolutionary Psychology, 1–8.

Rizwan, S., Manning, J. T., & Brabin, B. J. (2007). Maternal smoking during pregnancy and possible effects of in utero testosterone: evidence from the 2D:4D finger length ratio. Early Human Development, 83(2), 87–90.CrossRefPubMed

Saenz, J., & Alexander, G. M. (2013). Digit ratios (2D:4D), postnatal testosterone and eye contact in toddlers. Biological Psychology, 94(1), 106–108.CrossRefPubMed

Schendel, D. E., DiGuiseppi, C., Croen, L. A., et al. (2012). The study to explore early development (SEED): A multisite epidemiologic study of autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) network. Journal of Autism & Developmental Disorders, 42, 2121–2140.CrossRef

Schug, T. T., Blawas, A. M., Gray, K., Heindel, J. J., & Lawler, C. P. (2015). Elucidating the links between endocrine disruptors and neurodevelopment. Endocrinology, 156(6), 1941–1951.CrossRefPubMedPubMedCentral

Shapira, S. K., Tian, L. H., Aylsworth, A. S., et al. (2015). Development of a novel protocol for characterizing dysmorphology to enhance the phenotypic classification of autism spectrum disorder. Presented at the 2015 International Meeting for Autism Research, Atlanta, GA.

Sugie, Y., Sugie, H., Fukuda, T., & Osawa, J. (2010). Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length. Brain & Development, 32(5), 356–361.CrossRef

Taylor, G. T., Manzella, F. M., Huffman, J., Cabrera, O. H., & Hoffman, J. (2017) Cognition in female rats after blocking conversion of androgens to estrogens. Hormones and Behavior. https://doi.org/10.1016/j.yhbeh.2017.02.011.PubMed

Teatero, M. L., & Netley, C. (2013). A critical review of the research on the extreme male brain theory and digit ratio (2D:4D). Journal of Autism & Developmental Disorders, 43(11), 2664–2676.CrossRef

Thornton, J., Zehr, J. L., & Loose, M. D. (2009). Effects of prenatal androgens on rhesus monkeys: A model system to explore the organizational hypothesis in primates. Hormones and Behavior, 55(5), 633–645.CrossRefPubMedPubMedCentral

Toriola, A. T., Vääräsmäki, M., Lehtinen, M., et al. (2011). Determinants of maternal sex steroids during the first half of pregnancy. Obstetrics & Gynecology, 118(5), 1029–1036.CrossRef

Trivers, R., Manning, J., & Jacobson, A. (2006). A longitudinal study of digit ratio (2D:4D) and other finger ratios in Jamaican children. Hormones and Behavior, 49(2), 150–156.CrossRefPubMed

van de Beek, C., Thijssen, J. H., Cohen-Kettenis, P. T., van Goozen, S. H., & Buitelaar, J. K. (2004). Relationships between sex hormones assessed in amniotic fluid, and maternal and umbilical cord serum: what is the best source of information to investigate the effects of fetal hormonal exposure? Hormones and Behavior, 46(5), 663–669.CrossRefPubMed

Velez, M. P., Arbuckle, T. E., Monnier, P., & Fraser, W. D. (2017). Is maternal periconceptional smoking associated with 2D:4D digit ratio in their children? Journal of Developmental Origins of Health and Disease, 8(5), 597–603.CrossRefPubMed

Ventura, T., Gomes, M. C., Pita, A., Neto, M. T., & Taylor, A. (2013). Digit ratio (2D:4D) in newborns: influences of prenatal testosterone and maternal environment. Early Human Development, 89(2), 107–112.CrossRefPubMed

Wiggins, L. D., Levy, S. E., Daniels, J., et al. (2015b). Autism spectrum disorder symptoms among children enrolled in the Study to Explore Early Development (SEED). Journal of Autism & Developmental Disorders, 45(10), 3183–3194.CrossRef

Wiggins, L. D., Reynolds, A., Rice, C. E., et al. (2015a). Using standardized diagnostic instruments to classify children with autism in the study to explore early development. Journal of Autism & Developmental Disorders, 45(5), 1271–1280.CrossRef

Zheng, Z., & Cohn, M. J. (2011). Developmental basis of sexually dimorphic digit ratios. Proceedings of the National Academy of Sciences of the United States of America, 108(39), 16289–16294.CrossRefPubMedPubMedCentral

Titel: Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development
Auteurs: Laura A. Schieve
Lin Tian
Nicole Dowling
Lisa Croen
Julie Hoover-Fong
Aimee Alexander
Stuart K. Shapira
Publicatiedatum: 15-02-2018
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-018-3495-z

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