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11-10-2020 | Original Paper

Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD

Auteurs: Kate Stephens, Timothy J. Silk, Vicki Anderson, Philip Hazell, Peter G. Enticott, Emma Sciberras

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2021

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Abstract

Children with attention deficit/hyperactivity disorder (ADHD) combined with autism spectrum disorder (ASD) symptoms (ADHD + ASD) have poorer social and emotional functioning than those with ADHD alone. However, no studies have specifically examined the associations between ASD symptoms, measures of social and emotional functioning and limbic system white matter microstructure. Tractography on the cingulum, uncinate fasciculus and fornix were performed for 151 children with (N = 78) and without (N = 73) ADHD. Participants in the ADHD group who scored 11 or above on the Social Communication Questionnaire were classified as the ADHD + ASD group (N = 16). Significant differences in mean cingulum FA were present between the control group and the ADHD (all) group, however, no significant differences were seen between the ADHD and ADHD + ASD groups. Despite this, significant associations were seen between mean FA of the left cingulum and emotional problems for the ADHD + ASD group. Results give greater insights into the specific biological basis of emotional problems in the ADHD + ASD group, indicating that the cingulum may play a role.
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Metagegevens
Titel
Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD
Auteurs
Kate Stephens
Timothy J. Silk
Vicki Anderson
Philip Hazell
Peter G. Enticott
Emma Sciberras
Publicatiedatum
11-10-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04738-3

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