Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Research on Child and Adolescent Psychopathology 10/2019

27-04-2019

Association of OXTR rs53576 with the Developmental Trajectories of Callous-Unemotional Traits and Stressful Life Events in 3- to 9-Year-Old Community Children

Auteurs: Lourdes Ezpeleta, Eva Penelo, Núria de la Osa, J. Blas Navarro, Lourdes Fañanás, Mar Fatjó-Vilas

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 10/2019

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The objective was to obtain developmental trajectories combining callous-unemotional traits and the number of stressful life-events between ages 3 and 9 years and to ascertain their association with the polymorphism rs53576 at the Oxytocin Receptor gene (OXTR). A total of 377 children were assessed yearly from ages 3 to 9 years. Latent class growth analysis for parallel processes was used to identify distinct trajectories for callous-unemotional traits (assessed using the Inventory of Callous-Unemotional Traits, ICU) and number of stressful life-events, and then the influence of being an A allele carrier on class membership was included with OXTR genotypes as a binary time-invariant predictor, following a 3-step approach. A 3-class model showed the highest entropy (.859) and adequate posterior probabilities of class membership (≥.884). Class 1 (n = 226, 59.9%) included children with low and stable ICU scores and low and descending stressful life-events; class 2 (n = 127, 33.7%) included children with high and ascending ICU scores and low and slightly descending stressful life-events; and class 3 (n = 24, 6.4%) included children with persistently high profiles both for ICU scores and stressful life-events. Carrying an A allele (genotypes GA/AA) increased the odds of pertaining to class 3 (high and persistent ICU scores and stressful life-events) as opposed to class 2 (OR = 4.27, p = 0.034) or class 1 (OR = 3.81, p = 0.042). The results suggest the importance of considering callous-unemotional traits and stressful life-events in conjunction. In addition, the genetic variability of OXTR (rs53576) may help to understand individual differences in early development.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington: American Psychiatric Association. CrossRef American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington: American Psychiatric Association. CrossRef
go back to reference Hicks, B. M., Carlson, M. D., Blonigen, D. M., Patrick, C. J., Iacono, W. G., & MGue, M. (2012). Psychopathic personality traits and environmental contexts: Differential correlates, gender differences, and genetic mediation. Personality Disorders, Theory, Research, and Treatment, 33, 209–227. https://​doi.​org/​10.​1037/​a0025084. CrossRef Hicks, B. M., Carlson, M. D., Blonigen, D. M., Patrick, C. J., Iacono, W. G., & MGue, M. (2012). Psychopathic personality traits and environmental contexts: Differential correlates, gender differences, and genetic mediation. Personality Disorders, Theory, Research, and Treatment, 33, 209–227. https://​doi.​org/​10.​1037/​a0025084. CrossRef
go back to reference Hollingshead, A. B. (1975). Four factor index of social status. New Haven: Unpublished manuscript, Yale University, Department of Sociology. Hollingshead, A. B. (1975). Four factor index of social status. New Haven: Unpublished manuscript, Yale University, Department of Sociology.
go back to reference Johnson, J. H. (1982). Life events as stressors in childhood and adolescence. In B. Lahey & A. Kazdin (Eds.), Advances in clinical child psychology. Vol 5 (pp. 220–253). New York: Plenum Press. Johnson, J. H. (1982). Life events as stressors in childhood and adolescence. In B. Lahey & A. Kazdin (Eds.), Advances in clinical child psychology. Vol 5 (pp. 220–253). New York: Plenum Press.
go back to reference Johnson, J. H., & McCutcheon, S. M. (1980). Assessing life stress in older children and adolescents: Preliminary findings with the life events checklist. In I. Saranson & C. D. Spielberger (Eds.), Stress and anxiety (pp. 111–125). Washington, DC: Hemisphere. Johnson, J. H., & McCutcheon, S. M. (1980). Assessing life stress in older children and adolescents: Preliminary findings with the life events checklist. In I. Saranson & C. D. Spielberger (Eds.), Stress and anxiety (pp. 111–125). Washington, DC: Hemisphere.
go back to reference Jones, C., Barrera, I., Brothers, S., Ring, R., & Wahlestedt, C. (2017). Oxytocin and social functioning. Dialogues in Clinical Neuroscience, 19(2), 193–202. PubMedPubMedCentral Jones, C., Barrera, I., Brothers, S., Ring, R., & Wahlestedt, C. (2017). Oxytocin and social functioning. Dialogues in Clinical Neuroscience, 19(2), 193–202. PubMedPubMedCentral
go back to reference Kimonis, E., Fanti, K. A., & Singh, A. L. (2014a). Establishing cut-off scores for parent-reported inventory of callous-unemotional traits. Archives of Forensic Psychology, 1, 27–48. Kimonis, E., Fanti, K. A., & Singh, A. L. (2014a). Establishing cut-off scores for parent-reported inventory of callous-unemotional traits. Archives of Forensic Psychology, 1, 27–48.
go back to reference Parker, K. J., Garner, J. P., Libove, R. A., Hyde, S. A., Hornbeak, K. B., Carson, D. S., Liao, C. P., Phillips, J. M., Hallmayer, J. F., & Hardan, A. Y. (2014). Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. Proceedings of the National Academy of Sciences of the United States of America, 111(33), 12258–12263. https://​doi.​org/​10.​1073/​pnas.​1402236111. CrossRefPubMedPubMedCentral Parker, K. J., Garner, J. P., Libove, R. A., Hyde, S. A., Hornbeak, K. B., Carson, D. S., Liao, C. P., Phillips, J. M., Hallmayer, J. F., & Hardan, A. Y. (2014). Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. Proceedings of the National Academy of Sciences of the United States of America, 111(33), 12258–12263. https://​doi.​org/​10.​1073/​pnas.​1402236111. CrossRefPubMedPubMedCentral
go back to reference Patrick, C. J. (2010). Conceptualizing the psychopathic personality. In R. T. Salekin & D. R. Lynam (Eds.), Handbook of child & adolescent psychopathy (pp. 15–48). New York: Guilford Press. Patrick, C. J. (2010). Conceptualizing the psychopathic personality. In R. T. Salekin & D. R. Lynam (Eds.), Handbook of child & adolescent psychopathy (pp. 15–48). New York: Guilford Press.
go back to reference Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer-Lindenberg, A. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of the National Academy of Sciences of the United States of America, 107(31), 13936–13941. https://​doi.​org/​10.​1073/​pnas.​1003296107. CrossRefPubMedPubMedCentral Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer-Lindenberg, A. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of the National Academy of Sciences of the United States of America, 107(31), 13936–13941. https://​doi.​org/​10.​1073/​pnas.​1003296107. CrossRefPubMedPubMedCentral
go back to reference Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament. (2009). Protocolo de Factores de Riesgo. Versión para preescolares. Universitat Autònoma de Barcelona, Departament de Psicologia Clínica i de la Salut, Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament. (2009). Protocolo de Factores de Riesgo. Versión para preescolares. Universitat Autònoma de Barcelona, Departament de Psicologia Clínica i de la Salut, Barcelona.
go back to reference World Health Organization. (2018). The ICD-11 classification of mental and behavioural disorders. Geneva: Author. World Health Organization. (2018). The ICD-11 classification of mental and behavioural disorders. Geneva: Author.
Metagegevens
Titel
Association of OXTR rs53576 with the Developmental Trajectories of Callous-Unemotional Traits and Stressful Life Events in 3- to 9-Year-Old Community Children
Auteurs
Lourdes Ezpeleta
Eva Penelo
Núria de la Osa
J. Blas Navarro
Lourdes Fañanás
Mar Fatjó-Vilas
Publicatiedatum
27-04-2019
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 10/2019
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-019-00548-z