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The online version of this article (https://doi.org/10.1007/s11136-017-1763-6) contains supplementary material, which is available to authorized users.
Among patients with lung disease, decreased lung function is associated with lower health-related quality of life. However, whether this association is detectable within the physiological variability of respiratory function in lung-healthy populations is unknown. We analyzed the association of each EQ-5D-3L dimension (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) and self-reported physical inactivity with spirometric indices in lung-healthy adults. Modulating effects between inactivity and EQ-5D dimensions were considered.
1132 non-smoking, apparently lung-healthy participants (48% male, aged 64 ± 12 years) from the population-based KORA F4L and Age surveys in Southern Germany were analyzed. Associations of each EQ-5D dimension and inactivity with spirometric indices serving as outcomes (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and mid-expiratory flow) were examined by linear regression, considering possible confounders. Interactions between EQ-5D dimensions (no problems/any problems) and inactivity (four categories of time spent engaging in exercise: inactive to most active) were assessed.
Among all participants 42% reported no problems in any EQ-5D dimension, 24% were inactive and 32% exercised > 2 h/week. After adjustment, FEV1 was − 99 ml (95% CI − 166; − 32) and FVC was − 109 ml (95% CI − 195; − 24) lower among subjects with mobility problems. Comparable estimates were observed for usual activities. Inactivity was negatively associated with FVC (β-coefficient: − 83 ml, 95% CI − 166; 0), but showed no interactions with EQ-5D.
Problems with mobility or usual activities, and inactivity were associated with slightly lower spirometric parameters in lung-healthy adults, suggesting a relationship between perceived physical functioning and volumetric lung function.
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Wacker, M. E., Jörres, R. A., Karch, A., Koch, A., Heinrich, J., Karrasch, S., et al. (2016). Relative impact of COPD and comorbidities on generic health-related quality of life: A pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies. Respiratory Research, 17(1), 81. CrossRefPubMedPubMedCentral
König, H. H., Heider, D., Lehnert, T., Riedel-Heller, S. G., Angermeyer, M. C., Matschinger, H., et al. (2010). Health status of the advanced elderly in six European countries: Results from a representative survey using EQ-5D and SF-12. Health and Quality of Life Outcomes, 8, 143. CrossRefPubMedPubMedCentral
Wacker, M. E., Hunger, M., Karrasch, S., Heinrich, J., Peters, A., Schulz, H., et al. (2014). Health-related quality of life and chronic obstructive pulmonary disease in early stages - longitudinal results from the population-based KORA cohort in a working age population. BMC Pulmonary Medicine, 14, 134. CrossRefPubMedPubMedCentral
Jakes, R. W., Day, N. E., Patel, B., Khaw, K.-T., Oakes, S., Luben, R., et al. (2002). Physical inactivity is associated with lower forced expiratory volume in 1 s: European Prospective Investigation into Cancer-Norfolk Prospective Population Study. American Journal of Epidemiology, 156(2), 139–147. CrossRefPubMed
Nystad, W., Samuelsen, S. O., Nafstad, P., & Langhammer, A. (2006). Association between level of physical activity and lung function among Norwegian men and women: The HUNT study. The International Journal of Tuberculosis and Lung Disease, 10(12), 1399–1405. PubMed
Report (2017) From the global strategy for the diagnosis, management and prevention of COPD, global initiative for chronic obstructive lung disease (GOLD) 2017. Retrieved October 13, 2017, from http://goldcopd.org.
World Health Organization. Global Recommendations on Physical Activity for Health. Geneva, World Health Organization (2010). Retrieved October 13, 2016, from http://www.who.int/dietphysicalactivity/factsheet_recommendations/en/.
Simon, M. R., Chinchilli, V. M., Phillips, B. R., Sorkness, C. A., Lemanske, R. F., Szefler, S. J., et al. (2010). FEF 25–75 and FEV 1/FVC in relation to clinical and physiologic parameters in asthmatic children with normal FEV 1 values. The Journal of Allergy and Clinical Immunology, 126(3), 527–534.e528. CrossRefPubMedPubMedCentral
Krug, S. J. S., Mensink, G. B. M., Müters, S., Finger, J. D., & Lampert, T. (2013). English version of “Körperliche Aktivität. Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1)”. Bundesgesundheitsbl, 56, 765–771. CrossRef
- Association of generic health-related quality of life (EQ-5D dimensions) and inactivity with lung function in lung-healthy German adults: results from the KORA studies F4L and Age
- Springer International Publishing