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Gepubliceerd in: Quality of Life Research 7/2008

01-09-2008

Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece

Auteurs: Charitomeni Piperidou, Anna Karlovasitou, Nikolaos Triantafyllou, Evagelia Dimitrakoudi, Aikaterini Terzoudi, Eleni Mavraki, Grigorios Trypsianis, Konstantinos Vadikolias, Ioannis Heliopoulos, Dimitrios Vassilopoulos, Stavros Balogiannis

Gepubliceerd in: Quality of Life Research | Uitgave 7/2008

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Abstract

Purpose

The aim was to study the influence of patients’ age, frequency and type of seizures, disease duration, number of AEDs and use of benzodiazepines on the quality of life of patients with epilepsy.

Patients and methods

We consecutively identified 223 patients with epilepsy who attended the epilepsy outpatient clinics at three university hospitals in Greece. Quality of life was evaluated by QOLIE-31. One-way analysis was used to assess the association of the studied factors and QOLIE-31 subscales. After checking for co-linearity, we performed multivariate stepwise linear regression analysis with all the variables that on univariate analysis showed a statistically significant effect on each subscale of QOLIE-31 to explore which of the studied factors affect independently on QOLIE-31 scores.

Results

Of a total of 223 patients, 118 (52.95%) were men; mean age was 35.18 ± 13.22; mean duration of the disease was 13 years; 58 (26%) patients had generalized seizures, 93 (41.7%) had PS, and 72 (32.3%) of the patients had PsG; 85 (38.1%) were on polytherapy and 38 (17%) were taking benzodiazepines. Independent factors affecting QoL were: seizure frequency (Overall QoL P = 0.0001, Seizure worry and Emotional well-being P < 0.0001, Energy/fatigue and Social functioning P = 0.01); duration of the disease (Overall QoL and Energy/fatigue P = 0.01, Seizure worry P = 0.008, Cognitive functioning P < 0.0001); polytherapy only for the Emotional well-being P < 0.0001; and use of benzodiazepines (Overall QoL, Energy/fatigue, Social functioning P = 0.002, Cognitive functioning P < 0.0001).

Conclusion

Our findings suggest that QoL in epileptic patients might be affected, in addition to the other established factors (high frequency of seizures and polytherapy), by the daily use of benzodiazepines as adjunctive therapy. Change of medical strategy concerning this medication may lead to improving the QoL of these patients.
Literatuur
3.
go back to reference European Declaration on Epilepsy. (2003). Epilepsia, 44(suppl. 6), 2–3. European Declaration on Epilepsy. (2003). Epilepsia, 44(suppl. 6), 2–3.
5.
go back to reference Şenol, V., Soyuer, F., Arman, F., & Öztürk, A. (2007). Influence of fatigue, depression, and demographic, socioeconomic, and clinical variables on quality of life of patients with epilepsy. Epilepsy & Behavior, 10, 96–104. doi:10.1016/j.yebeh.2006.08.006.CrossRef Şenol, V., Soyuer, F., Arman, F., & Öztürk, A. (2007). Influence of fatigue, depression, and demographic, socioeconomic, and clinical variables on quality of life of patients with epilepsy. Epilepsy & Behavior, 10, 96–104. doi:10.​1016/​j.​yebeh.​2006.​08.​006.CrossRef
9.
go back to reference Miller, V., Palermo, T. M., & Grewe, S. D. (2003). Quality of life in pediatric epilepsy: Demographic and disease-related predictors and comparison with health controls. Epilepsy & Behavior, 4, 36–42. doi:10.1016/S1525-5050(02)00601-7.CrossRef Miller, V., Palermo, T. M., & Grewe, S. D. (2003). Quality of life in pediatric epilepsy: Demographic and disease-related predictors and comparison with health controls. Epilepsy & Behavior, 4, 36–42. doi:10.​1016/​S1525-5050(02)00601-7.CrossRef
10.
go back to reference Szaflarski, M., Meckler, J., Privitera, M., & Szaflarski, J. (2006). Quality of life in medication-resistant epilepsy: The effects of patient’s age, age at onset, and disease duration. Epilepsy & Behavior, 8, 547–551. doi:10.1016/j.yebeh.2006.01.001.CrossRef Szaflarski, M., Meckler, J., Privitera, M., & Szaflarski, J. (2006). Quality of life in medication-resistant epilepsy: The effects of patient’s age, age at onset, and disease duration. Epilepsy & Behavior, 8, 547–551. doi:10.​1016/​j.​yebeh.​2006.​01.​001.CrossRef
11.
go back to reference Pirio Richardson, S., Tomaszewski Farias, S., Lima, R. A., III, & Alsaadi, M. T. (2004). Improvement in seizure control and quality of life in medically refractory epilepsy patients converted from polypharmacy to monotherapy. Epilepsy & Behavior, 5, 343–347. doi:10.1016/j.yebeh.2004.01.006.CrossRef Pirio Richardson, S., Tomaszewski Farias, S., Lima, R. A., III, & Alsaadi, M. T. (2004). Improvement in seizure control and quality of life in medically refractory epilepsy patients converted from polypharmacy to monotherapy. Epilepsy & Behavior, 5, 343–347. doi:10.​1016/​j.​yebeh.​2004.​01.​006.CrossRef
14.
go back to reference Sachdeo, R. C., Gates, J. R., Bazil, C. W., Gregory, B. L., et al. (2006). Improved quality of life in patients with partial seizures after conversion to oxcarbazepine monotherapy. Epilepsy & Behavior, 3, 457–463.CrossRef Sachdeo, R. C., Gates, J. R., Bazil, C. W., Gregory, B. L., et al. (2006). Improved quality of life in patients with partial seizures after conversion to oxcarbazepine monotherapy. Epilepsy & Behavior, 3, 457–463.CrossRef
15.
go back to reference Kaminow, L., Schimscock, J. R., Hammer, A. E., & Vuong, A. (2003). Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. Epilepsy & Behavior, 4, 659–666. doi:10.1016/j.yebeh.2003.08.033.CrossRef Kaminow, L., Schimscock, J. R., Hammer, A. E., & Vuong, A. (2003). Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. Epilepsy & Behavior, 4, 659–666. doi:10.​1016/​j.​yebeh.​2003.​08.​033.CrossRef
18.
go back to reference Cramer, J. A., Van Hammé, G., & the N132 Study Group. (2003). Maintenance of improvement in health-related quality of life during long-term treatment with levetiracetam. Epilepsy & Behavior, 4, 118–123. doi:10.1016/S1525-5050(03)00004-0.CrossRef Cramer, J. A., Van Hammé, G., & the N132 Study Group. (2003). Maintenance of improvement in health-related quality of life during long-term treatment with levetiracetam. Epilepsy & Behavior, 4, 118–123. doi:10.​1016/​S1525-5050(03)00004-0.CrossRef
20.
go back to reference Panagotopoulos, P. C. (2002). A clinical guide to epileptic syndromes and their treatment (p. 157). Oxford, UK: Bladon Medical Publishing. Panagotopoulos, P. C. (2002). A clinical guide to epileptic syndromes and their treatment (p. 157). Oxford, UK: Bladon Medical Publishing.
27.
go back to reference Picot, M. C., Crespel, A., Daures, J. P., Baldy-Moulinier, M., & El Hasnaui, A. (2004). Psychometric validation of the French version of the quality of life in epilepsy inventory (QOLIE-31): Comparison with a generic health-related quality of life questionnaire. Epileptic Disorders, 6, 275–285.PubMed Picot, M. C., Crespel, A., Daures, J. P., Baldy-Moulinier, M., & El Hasnaui, A. (2004). Psychometric validation of the French version of the quality of life in epilepsy inventory (QOLIE-31): Comparison with a generic health-related quality of life questionnaire. Epileptic Disorders, 6, 275–285.PubMed
28.
go back to reference De Silva, T. I., Ciconelli, R. M., Alonso, N. B., et al. (2007). Validity and reliability of the Portuguese version of quality of life in epilepsy inventory (QOLIE-31) for Brazil. Epilepsy & Behavior. De Silva, T. I., Ciconelli, R. M., Alonso, N. B., et al. (2007). Validity and reliability of the Portuguese version of quality of life in epilepsy inventory (QOLIE-31) for Brazil. Epilepsy & Behavior.
29.
go back to reference Piperidou, H., Terzoudi, A., Vorvolakos, T., et al. (2006). The Greece version of the quality of life in epilepsy inventory (QOLIE-31). Quality of Life Research, 15, 833–839.PubMed Piperidou, H., Terzoudi, A., Vorvolakos, T., et al. (2006). The Greece version of the quality of life in epilepsy inventory (QOLIE-31). Quality of Life Research, 15, 833–839.PubMed
31.
go back to reference Birbeck, G. L., Kim, S., Hays, R. D., & Vickrey, B. G. (2000). Quality of life measures in epilepsy: How well can they detect change over time? Neurology, 54, 1822–1827.PubMed Birbeck, G. L., Kim, S., Hays, R. D., & Vickrey, B. G. (2000). Quality of life measures in epilepsy: How well can they detect change over time? Neurology, 54, 1822–1827.PubMed
35.
go back to reference Lam, J., Rozsavolgyi, M., Soos, G., et al. (2001). Quality of life of patients with epilepsy (Hungarian survey). Seizure, 10, 100–106.PubMed Lam, J., Rozsavolgyi, M., Soos, G., et al. (2001). Quality of life of patients with epilepsy (Hungarian survey). Seizure, 10, 100–106.PubMed
37.
go back to reference Commission on Classification, Terminology of the International League Against Epilepsy. (1989). Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 30, 389–399.CrossRef Commission on Classification, Terminology of the International League Against Epilepsy. (1989). Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 30, 389–399.CrossRef
39.
go back to reference Vickrey, B. G., Perrine, K., Hays, R. D., et al. (1993). Quality of life in Epilepsy QOLIE-31 (version 1.0): Scoring Manual and Patient Inventory. Santa Monica, CA: RAND. Vickrey, B. G., Perrine, K., Hays, R. D., et al. (1993). Quality of life in Epilepsy QOLIE-31 (version 1.0): Scoring Manual and Patient Inventory. Santa Monica, CA: RAND.
41.
go back to reference Boylan, L. S., Flint, L. A., Labovitz, D. L., et al. (2004). Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology, 62, 258–261.PubMed Boylan, L. S., Flint, L. A., Labovitz, D. L., et al. (2004). Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology, 62, 258–261.PubMed
42.
go back to reference Kellett, M. W., Smith, D. F., & Chadwick, D. W. (1997). Quality of life after epilepsy surgery. Journal of Neurology, Neurosurgery and Psychiatry, 63, 52–58.CrossRef Kellett, M. W., Smith, D. F., & Chadwick, D. W. (1997). Quality of life after epilepsy surgery. Journal of Neurology, Neurosurgery and Psychiatry, 63, 52–58.CrossRef
45.
go back to reference Nubukpo, P., Clément, J. P., Houinato, D., et al. (2004). Psychosocial issues in people with epilepsy in Togo and Benin (West Africa) II. Quality of life measured using the QOLIE-31 scale. Epilepsy & Behavior, 5, 728–734. doi:10.1016/j.yebeh.2004.07.002.CrossRef Nubukpo, P., Clément, J. P., Houinato, D., et al. (2004). Psychosocial issues in people with epilepsy in Togo and Benin (West Africa) II. Quality of life measured using the QOLIE-31 scale. Epilepsy & Behavior, 5, 728–734. doi:10.​1016/​j.​yebeh.​2004.​07.​002.CrossRef
46.
go back to reference Baker, G. A., Jacoby, A., Buck, D., et al. (2001). The quality of life of older people with epilepsy: Findings from a UK community study. Seizure, 42, 1160–1168. Baker, G. A., Jacoby, A., Buck, D., et al. (2001). The quality of life of older people with epilepsy: Findings from a UK community study. Seizure, 42, 1160–1168.
47.
go back to reference Sanjeev, V. T., Samuel, K., Nair, C. R. S., & Sarma, S. (2005). Frequent seizures and polytherapy can impair quality of life in person with epilepsy. Neurology India, 53(1), 46–50.CrossRef Sanjeev, V. T., Samuel, K., Nair, C. R. S., & Sarma, S. (2005). Frequent seizures and polytherapy can impair quality of life in person with epilepsy. Neurology India, 53(1), 46–50.CrossRef
50.
go back to reference Panayiotopoulos, C. P. (2005). THE EPILEPSIES. Seizures, Syndromes and Management (p. 500). UK: Bladon Medical Publishing. Panayiotopoulos, C. P. (2005). THE EPILEPSIES. Seizures, Syndromes and Management (p. 500). UK: Bladon Medical Publishing.
52.
go back to reference Bawden, H. N., Camfield, C. S., Camfield, P. R., et al. (1999). The cognitive and behavioural effects of clobazam and standard monotherapy are comparable. Canadian Study Group for childhood epilepsy. Epilepsy Research, 33(2–3), 133–143. doi:10.1016/S0920-1211(98)00088-6.PubMedCrossRef Bawden, H. N., Camfield, C. S., Camfield, P. R., et al. (1999). The cognitive and behavioural effects of clobazam and standard monotherapy are comparable. Canadian Study Group for childhood epilepsy. Epilepsy Research, 33(2–3), 133–143. doi:10.​1016/​S0920-1211(98)00088-6.PubMedCrossRef
54.
go back to reference Homan, W. R., & Rosenberg, C. H. (1997). Benzodiazepines. In E. Wylle (Ed.), The treatment of epilepsy. Pennsylvania: Williams & Wilkins. Homan, W. R., & Rosenberg, C. H. (1997). Benzodiazepines. In E. Wylle (Ed.), The treatment of epilepsy. Pennsylvania: Williams & Wilkins.
55.
go back to reference Shorvon, S. (1995). Benzodiazepines: Clobazam. In R. H. Levy, R. H. Mattson & B. S. Meldrum (Eds.), Antiepileptic drugs (4th ed., pp. 763–777). New York: Raven Press. Shorvon, S. (1995). Benzodiazepines: Clobazam. In R. H. Levy, R. H. Mattson & B. S. Meldrum (Eds.), Antiepileptic drugs (4th ed., pp. 763–777). New York: Raven Press.
Metagegevens
Titel
Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece
Auteurs
Charitomeni Piperidou
Anna Karlovasitou
Nikolaos Triantafyllou
Evagelia Dimitrakoudi
Aikaterini Terzoudi
Eleni Mavraki
Grigorios Trypsianis
Konstantinos Vadikolias
Ioannis Heliopoulos
Dimitrios Vassilopoulos
Stavros Balogiannis
Publicatiedatum
01-09-2008
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 7/2008
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-008-9375-9

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