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Journal of Autism and Developmental Disorders

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01-11-2009 | Original Paper

Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder

Auteurs: Kenneth D. Gadow, Jasmin Roohi, Carla J. DeVincent, Sarah Kirsch, Eli Hatchwell

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2009

Abstract

The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp ² = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp ² = 0.10) and teacher-rated tics (p = 0.04; ηp ² = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp ² = 0.09) of BDNF genotype with DAT1 3′ VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.

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Titel: Association of COMT (Val158Met) and BDNF (Val66Met) Gene Polymorphisms with Anxiety, ADHD and Tics in Children with Autism Spectrum Disorder
Auteurs: Kenneth D. Gadow
Jasmin Roohi
Carla J. DeVincent
Sarah Kirsch
Eli Hatchwell
Publicatiedatum: 01-11-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-009-0794-4

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