Skip to main content
Top
Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2018

13-01-2018 | Original Paper

Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study

Auteurs: Dikran Richard Guisso, Fadi S. Saadeh, Dahlia Saab, Joud El Deek, Sarah Chamseddine, Hadi Abou El Hassan, Ghidaa Majari, Rose-Mary Boustany

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2018

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2–18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178 controls selected by systematic digit dialing in the Greater-Beirut area. Male gender (Adjusted Odds Ratio [95% CI]: 3.9 [2.2–7.0]); postpartum feeding difficulties (2.5 [1.2–5.4]); maternal infections/complications during pregnancy (2.9 [1.5–5.5], 2.1 [1.1–3.9]); consanguinity (2.5 [1.0–6.0]); family history of psychiatric disorders (2.2 [1.1–4.4]) were risk factors for ASD. Being born first/second (0.52 [0.28–0.95]) and maternal psychological support during pregnancy (0.49 [0.27–0.89]) were negatively associated with ASD. Identifying ASD correlates is crucial for instigating timely screening and subsequent early intervention.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference American Psychiatric Association. (1993). DSM-IV draft criteria: Amer Psychiatric Pub Incorporated. American Psychiatric Association. (1993). DSM-IV draft criteria: Amer Psychiatric Pub Incorporated.
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub.
go back to reference Blake, N. M., Kirk, R. L., McDermid, E. M., Case, J., & Bashir, H. (1973). The distribution of blood, serum protein and enzyme groups in a series of Lebanese in Australia. The Australian Journal of Experimental Biology and Medical Science, 51(2), 209–220.CrossRefPubMed Blake, N. M., Kirk, R. L., McDermid, E. M., Case, J., & Bashir, H. (1973). The distribution of blood, serum protein and enzyme groups in a series of Lebanese in Australia. The Australian Journal of Experimental Biology and Medical Science, 51(2), 209–220.CrossRefPubMed
go back to reference Burstyn, I., Wang, X., Yasui, Y., Sithole, F., & Zwaigenbaum, L. (2011). Autism spectrum disorders and fetal hypoxia in a population-based cohort: Accounting for missing exposures via estimation-maximization algorithm. BMC Medical Research Methodology, 11(1), 2.CrossRefPubMedPubMedCentral Burstyn, I., Wang, X., Yasui, Y., Sithole, F., & Zwaigenbaum, L. (2011). Autism spectrum disorders and fetal hypoxia in a population-based cohort: Accounting for missing exposures via estimation-maximization algorithm. BMC Medical Research Methodology, 11(1), 2.CrossRefPubMedPubMedCentral
go back to reference Chaste, P., & Leboyer, M. (2012). Autism risk factors: Genes, environment, and gene-environment interactions. Dialogues in Clinical Neuroscience, 14(3), 281.PubMedPubMedCentral Chaste, P., & Leboyer, M. (2012). Autism risk factors: Genes, environment, and gene-environment interactions. Dialogues in Clinical Neuroscience, 14(3), 281.PubMedPubMedCentral
go back to reference Christensen, D. L., Baio, J., Van Naarden Braun, K., Bilder, D., Charles, J., Constantino, J. N., et al. (2016). Prevalence and characteristics of autism spectrum disorder among children aged 8 years–autism and developmental disabilities monitoring Network, 11 Sites, United States, 2012. Morbidity and Mortality Weekly Report. Surveillance Summaries, 65(3), 1–23. https://doi.org/10.15585/mmwr.ss6503a1.PubMed Christensen, D. L., Baio, J., Van Naarden Braun, K., Bilder, D., Charles, J., Constantino, J. N., et al. (2016). Prevalence and characteristics of autism spectrum disorder among children aged 8 years–autism and developmental disabilities monitoring Network, 11 Sites, United States, 2012. Morbidity and Mortality Weekly Report. Surveillance Summaries, 65(3), 1–23. https://​doi.​org/​10.​15585/​mmwr.​ss6503a1.PubMed
go back to reference Collier, S. A., Rasmussen, S. A., Feldkamp, M. L., & Honein, M. A., & National Birth Defects Prevention, S (2009).Prevalence of self-reported infection during pregnancy among control mothers in the National Birth Defects Prevention Study. Birth Defects Research. Part A, Clinical and Molecular Teratology, 85(3), 193–201. https://doi.org/10.1002/bdra.20540.CrossRefPubMed Collier, S. A., Rasmussen, S. A., Feldkamp, M. L., & Honein, M. A., & National Birth Defects Prevention, S (2009).Prevalence of self-reported infection during pregnancy among control mothers in the National Birth Defects Prevention Study. Birth Defects Research. Part A, Clinical and Molecular Teratology, 85(3), 193–201. https://​doi.​org/​10.​1002/​bdra.​20540.CrossRefPubMed
go back to reference Deykin, E. Y., & MacMahon, B. (1979). Viral exposure and autism. American Journal of Epidemiology, 109(6), 628–638.CrossRefPubMed Deykin, E. Y., & MacMahon, B. (1979). Viral exposure and autism. American Journal of Epidemiology, 109(6), 628–638.CrossRefPubMed
go back to reference El Rafei, R., Abbas, H. A., Charafeddine, L., Nakad, P., Al Bizri, A., Hamod, D., et al. (2016). Association of pre-pregnancy body mass index and gestational weight gain with preterm births and fetal size: An observational study from Lebanon. Paediatric and Perinatal Epidemiology, 30(1), 38–45.CrossRefPubMed El Rafei, R., Abbas, H. A., Charafeddine, L., Nakad, P., Al Bizri, A., Hamod, D., et al. (2016). Association of pre-pregnancy body mass index and gestational weight gain with preterm births and fetal size: An observational study from Lebanon. Paediatric and Perinatal Epidemiology, 30(1), 38–45.CrossRefPubMed
go back to reference Frazier, T. W., Georgiades, S., Bishop, S. L., & Hardan, A. Y. (2014). Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection. Journal of the American Academy of Child & Adolescent Psychiatry, 53(3), 329–340.CrossRef Frazier, T. W., Georgiades, S., Bishop, S. L., & Hardan, A. Y. (2014). Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection. Journal of the American Academy of Child & Adolescent Psychiatry, 53(3), 329–340.CrossRef
go back to reference Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. The British Journal of Psychiatry, 195(1), 7–14.CrossRefPubMedPubMedCentral Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. The British Journal of Psychiatry, 195(1), 7–14.CrossRefPubMedPubMedCentral
go back to reference Hamade, A., Salameh, P., Medlej-Hashim, M., Hajj-Moussa, E., Saadallah-Zeidan, N., & Rizk, F. (2013). Autism in children and correlates in Lebanon: A pilot case-control study. Journal of Research in Health Sciences, 13(2), 119–124.PubMed Hamade, A., Salameh, P., Medlej-Hashim, M., Hajj-Moussa, E., Saadallah-Zeidan, N., & Rizk, F. (2013). Autism in children and correlates in Lebanon: A pilot case-control study. Journal of Research in Health Sciences, 13(2), 119–124.PubMed
go back to reference Hiller, R. M., Young, R. L., & Weber, N. (2014). Sex differences in autism spectrum disorder based on DSM-5 criteria: Evidence from clinician and teacher reporting. Journal of Abnormal Child Psychology, 42(8), 1381–1393.CrossRefPubMed Hiller, R. M., Young, R. L., & Weber, N. (2014). Sex differences in autism spectrum disorder based on DSM-5 criteria: Evidence from clinician and teacher reporting. Journal of Abnormal Child Psychology, 42(8), 1381–1393.CrossRefPubMed
go back to reference Hultman, C. M., Sparén, P., & Cnattingius, S. (2002). Perinatal risk factors for infantile autism. Epidemiology, 13(4), 417–423.CrossRefPubMed Hultman, C. M., Sparén, P., & Cnattingius, S. (2002). Perinatal risk factors for infantile autism. Epidemiology, 13(4), 417–423.CrossRefPubMed
go back to reference Kim, Y. S., & Leventhal, B. L. (2015). Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders. Biological Psychiatry, 77(1), 66–74.CrossRefPubMed Kim, Y. S., & Leventhal, B. L. (2015). Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders. Biological Psychiatry, 77(1), 66–74.CrossRefPubMed
go back to reference Kim, Y. S., Leventhal, B. L., Koh, Y.-J., Fombonne, E., Laska, E., Lim, E.-C., et al. (2011). Prevalence of autism spectrum disorders in a total population sample. American Journal of Psychiatry, 168(9), 904–912.CrossRefPubMed Kim, Y. S., Leventhal, B. L., Koh, Y.-J., Fombonne, E., Laska, E., Lim, E.-C., et al. (2011). Prevalence of autism spectrum disorders in a total population sample. American Journal of Psychiatry, 168(9), 904–912.CrossRefPubMed
go back to reference Kolevzon, A., Gross, R., & Reichenberg, A. (2007). Prenatal and perinatal risk factors for autism: A review and integration of findings. Archives of Pediatrics & Adolescent Medicine, 161(4), 326–333.CrossRef Kolevzon, A., Gross, R., & Reichenberg, A. (2007). Prenatal and perinatal risk factors for autism: A review and integration of findings. Archives of Pediatrics & Adolescent Medicine, 161(4), 326–333.CrossRef
go back to reference Kuzniewicz, M. W., Wi, S., Qian, Y., Walsh, E. M., Armstrong, M. A., & Croen, L. A. (2014). Prevalence and neonatal factors associated with autism spectrum disorders in preterm infants. The Journal of Pediatrics, 164(1), 20–25.CrossRefPubMed Kuzniewicz, M. W., Wi, S., Qian, Y., Walsh, E. M., Armstrong, M. A., & Croen, L. A. (2014). Prevalence and neonatal factors associated with autism spectrum disorders in preterm infants. The Journal of Pediatrics, 164(1), 20–25.CrossRefPubMed
go back to reference Lampi, K. M., Lehtonen, L., Tran, P. L., Suominen, A., Lehti, V., Banerjee, P. N., et al. (2012). Risk of autism spectrum disorders in low birth weight and small for gestational age infants. The Journal of Pediatrics, 161(5), 830–836.CrossRefPubMedPubMedCentral Lampi, K. M., Lehtonen, L., Tran, P. L., Suominen, A., Lehti, V., Banerjee, P. N., et al. (2012). Risk of autism spectrum disorders in low birth weight and small for gestational age infants. The Journal of Pediatrics, 161(5), 830–836.CrossRefPubMedPubMedCentral
go back to reference Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., et al. (2005). Risk factors for autism: Perinatal factors, parental psychiatric history, and socioeconomic status. American Journal of Epidemiology, 161(10), 916–925.CrossRefPubMed Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., et al. (2005). Risk factors for autism: Perinatal factors, parental psychiatric history, and socioeconomic status. American Journal of Epidemiology, 161(10), 916–925.CrossRefPubMed
go back to reference McGinnis, W. R., Audhya, T., & Edelson, S. M. (2013). Proposed toxic and hypoxic impairment of a brainstem locus in autism. International Journal of Environmental Research and Public Health, 10(12), 6955–7000.CrossRefPubMedPubMedCentral McGinnis, W. R., Audhya, T., & Edelson, S. M. (2013). Proposed toxic and hypoxic impairment of a brainstem locus in autism. International Journal of Environmental Research and Public Health, 10(12), 6955–7000.CrossRefPubMedPubMedCentral
go back to reference Newschaffer, C. J., Fallin, D., & Lee, N. L. (2002). Heritable and nonheritable risk factors for autism spectrum disorders. Epidemiologic Reviews, 24(2), 137–153.CrossRefPubMed Newschaffer, C. J., Fallin, D., & Lee, N. L. (2002). Heritable and nonheritable risk factors for autism spectrum disorders. Epidemiologic Reviews, 24(2), 137–153.CrossRefPubMed
go back to reference Rizk, F., Salameh, P., & Hamadé, A. (2014). Congenital anomalies: Prevalence and risk factors. Universal Journal of Public Health, 2(2), 58–63. Rizk, F., Salameh, P., & Hamadé, A. (2014). Congenital anomalies: Prevalence and risk factors. Universal Journal of Public Health, 2(2), 58–63.
go back to reference Salhia, H. O., Al-Nasser, L. A., Taher, L. S., Al-Khathaami, A. M., & El-Metwally, A. A. (2014). Systemic review of the epidemiology of autism in Arab Gulf countries. Neurosciences, 19(4), 291–296.PubMedPubMedCentral Salhia, H. O., Al-Nasser, L. A., Taher, L. S., Al-Khathaami, A. M., & El-Metwally, A. A. (2014). Systemic review of the epidemiology of autism in Arab Gulf countries. Neurosciences, 19(4), 291–296.PubMedPubMedCentral
go back to reference Tordjman, S., Somogyi, E., Coulon, N., Kermarrec, S., Cohen, D., Bronsard, G., et al. (2014). Gene × Environment interactions in autism spectrum disorders: Role of epigenetic mechanisms. Frontiers in Psychiatry, 5, e53.CrossRef Tordjman, S., Somogyi, E., Coulon, N., Kermarrec, S., Cohen, D., Bronsard, G., et al. (2014). Gene × Environment interactions in autism spectrum disorders: Role of epigenetic mechanisms. Frontiers in Psychiatry, 5, e53.CrossRef
Metagegevens
Titel
Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study
Auteurs
Dikran Richard Guisso
Fadi S. Saadeh
Dahlia Saab
Joud El Deek
Sarah Chamseddine
Hadi Abou El Hassan
Ghidaa Majari
Rose-Mary Boustany
Publicatiedatum
13-01-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3449-x

Andere artikelen Uitgave 6/2018

Journal of Autism and Developmental Disorders 6/2018 Naar de uitgave