Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

09-08-2015 | Original Paper

Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis

Auteurs: Ya-Min Li, Jian-Jun Ou, Li Liu, Dan Zhang, Jing-Ping Zhao, Si-Yuan Tang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2016

Abstract

As the link between maternal obesity and risk of autism among offspring is unclear, the present study assessed this association. A systematic search of an electronic database was performed to identify observational studies that examined the association between maternal obesity and autism. The outcome measures were odds ratios comparing offspring autism risk between obese and normal-weight mothers. Five observational studies were included in the meta-analysis. A fixed-effects model was used since low heterogeneity was observed between studies. The pooled adjusted odds ratio was 1.47 (95 % CI 1.24–1.74). The meta-analysis results support an increased risk of autism spectrum disorder in children of women who were obese during pregnancy. However, further study is warranted to confirm these results.

vorige artikel Facial Feedback and Social Input: Effects on Laughter and Enjoyment in Children with Autism Spectrum Disorders

volgende artikel Does Faux Pas Detection in Adult Autism Reflect Differences in Social Cognition or Decision-Making Abilities?

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Association.

Atladóttir, H. Ó., Thorsen, P., Østergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., & Parner, E. T. (2010). Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. Journal of Autism and Developmental Disorders, 40(12), 1423–1430.PubMedCrossRef

Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., & Charman, T. (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The special needs and autism project (SNAP). Lancet, 368(9531), 210–215.PubMedCrossRef

Baron-Cohen, S., Scott, F. J., Allison, C., Williams, J., Bolton, P., Matthews, F. E., & Brayne, C. (2009). Prevalence of autism-spectrum conditions: UK school-based population study. British Journal of Psychiatry, 194(6), 500–509.PubMedCrossRef

Bilder, D. A., Bakian, A. V., Viskochil, J., Clark, E. A., Botts, E. L., Smith, K. R., et al. (2013). Maternal prenatal weight gain and autism spectrum disorders. Pediatrics, 132(5), e1276–e1283.PubMedPubMedCentralCrossRef

Bolton, P., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective and other psychiatric disorders: patterns of familial aggregation. Psychological Medicine, 28(02), 385–395.PubMedCrossRef

Buescher, A. V., Cidav, Z., Knapp, M., & Mandell, D. S. (2014). Costs of autism spectrum disorders in the United Kingdom and the United States. JAMA Pediatrics, 168(8), 721–728.PubMedCrossRef

Catalano, P. M., Kirwan, J. P., Haugel-de Mouzon, S., & King, J. (2003). Gestational diabetes and insulin resistance: role in short-and long-term implications for mother and fetus. Journal of Nutrition, 133(5), 1674S–1683S.PubMed

CDC. (2014). Prevalence of autism spectrum disorders among children aged 8 years: Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63(2), 1–22.

Chen, X., & Scholl, T. O. (2005). Oxidative stress: changes in pregnancy and with gestational diabetes mellitus. Current Diabetes Reports, 5(4), 282–288.PubMedCrossRef

Das, U. (2001). Is obesity an inflammatory condition? Nutrition, 17(11), 953–966.PubMedCrossRef

Dodds, L., Fell, D. B., Shea, S., Armson, B. A., Allen, A. C., & Bryson, S. (2011). The role of prenatal, obstetric and neonatal factors in the development of autism. Journal of Autism and Developmental Disorders, 41(7), 891–902.PubMedCrossRef

Eidelman, A. I., & Samueloff, A. (2002) The pathophysiology of the fetus of the diabetic mother. Seminars in perinatology. Elsevier (pp 232–236).

Ervin, R. B. (2009). Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States. National Health Statistics Reports, 13, 1–8.PubMed

Flegal, K. M., Carroll, M. D., Ogden, C. L., & Curtin, L. R. (2010). Prevalence and trends in obesity among US adults, 1999–2008. JAMA, 303(3), 235–241.PubMedCrossRef

Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. British Journal of Psychiatry, 195(1), 7–14.PubMedPubMedCentralCrossRef

Georgieff, M. K. (2006). The effect of maternal diabetes during pregnancy on the neurodevelopment of offspring. Minnesota Medicine, 89(3), 44–47.PubMed

Georgieff, M. K. (2008). The role of iron in neurodevelopment: Fetal iron deficiency and the developing hippocampus. Biochemical Society Transactions, 36(Pt 6), 1267.PubMedPubMedCentralCrossRef

Greenland, S. (1987). Quantitative methods in the review of epidemiologic literature. Epidemiologic Reviews, 9(1), 1–30.PubMed

Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. British Medical Journal, 327(7414), 557.PubMedPubMedCentralCrossRef

Kim, Y. S., Fombonne, E., Koh, Y. J., Kim, S. J., Cheon, K. A., & Leventhal, B. L. (2014). A comparison of DSM-IV pervasive developmental disorder and DSM-5 autism spectrum disorder prevalence in an epidemiologic sample. Journal of the American Academy of Child and Adolescent Psychiatry, 53(5), 500–508.PubMedPubMedCentralCrossRef

Krakowiak, P., Walker, C. K., Bremer, A. A., Baker, A. S., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2012). Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics, 129(5), e1121–e1128.PubMedPubMedCentralCrossRef

Kyrou, I., & Tsigos, C. (2009). Stress hormones: Physiological stress and regulation of metabolism. Current Opinion in Pharmacology, 9(6), 787–793.PubMedCrossRef

Man, K. K., Tong, H. H., Wong, L. Y., Chan, E. W., Simonoff, E., & Wong, I. C. (2015). Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies. Neuroscience and Biobehavioral Reviews, 49C, 82–89.CrossRef

Miles, J. H. (2011). Autism spectrum disorders—a genetics review. Genetics in Medicine, 13(4), 278–294.PubMedCrossRef

Moss, B. G., & Chugani, D. C. (2014). Increased risk of very low birth weight, rapid postnatal growth, and autism in underweight and obese mothers. American Journal of Health Promotion, 28(3), 181–188.PubMedCrossRef

Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., et al. (2007). The epidemiology of autism spectrum disorders. Annual Reviews in Public Health, 28, 235–258.CrossRef

Olefsky, J. M., & Glass, C. K. (2010). Macrophages, inflammation, and insulin resistance. Annual Review of Physiology, 72, 219–246.PubMedCrossRef

Pardo, C. A., Vargas, D. L., & Zimmerman, A. W. (2005). Immunity, neuroglia and neuroinflammation in autism. International Review of Psychiatry, 17(6), 485–495.PubMedCrossRef

Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. (2002). Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. Journal of Clinical Endocrinology and Metabolism, 87(9), 4231–4237.PubMedCrossRef

Reynolds, L. C., Inder, T. E., Neil, J. J., Pineda, R. G., & Rogers, C. E. (2014). Maternal obesity and increased risk for autism and developmental delay among very preterm infants. Journal of Perinatology, 34(9), 688–692.PubMedPubMedCentralCrossRef

Rosen, B. N., Lee, B. K., Lee, N. L., Yang, Y., & Burstyn, I. (2014). Maternal smoking and autism spectrum disorder: A meta-analysis. Journal of autism and developmental disorders, 45(6), 1689–1698.CrossRef

Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Larsson, H., Hultman, C. M., & Reichenberg, A. (2014). The familial risk of autism. JAMA, 311(17), 1770–1777.PubMedPubMedCentralCrossRef

Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929.PubMedCrossRef

Suren, P., Gunnes, N., Roth, C., Bresnahan, M., Hornig, M., Hirtz, D., et al. (2014). Parental obesity and risk of autism spectrum disorder. Pediatrics, 133(5), e1128–e1138.PubMedPubMedCentralCrossRef

Wells, G., Shea, B., O’Connell, D., Peterson, J., Welch, V., & Losos, M. (2013) The Newcastle–Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses 2009.

Xu, G., Jing, J., Bowers, K., Liu, B., & Bao, W. (2014). Maternal diabetes and the risk of autism spectrum disorders in the offspring: A systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 44(4), 766–775.PubMedPubMedCentralCrossRef

Zavalza-Gómez, A. B., Anaya-Prado, R., Rincón-Sánchez, A. R., & Mora-Martínez, J. M. (2008). Adipokines and insulin resistance during pregnancy. Diabetes Research and Clinical Practice, 80(1), 8–15.PubMedCrossRef

Zumoff, B., & Strain, G. W. (1994). A perspective on the hormonal abnormalities of obesity: Are they cause or effect? Obesity Research, 2(1), 56–67.PubMedCrossRef

Titel: Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis
Auteurs: Ya-Min Li
Jian-Jun Ou
Li Liu
Dan Zhang
Jing-Ping Zhao
Si-Yuan Tang
Publicatiedatum: 09-08-2015
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-015-2549-8

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 1/2016

Brief Report: Patterns of Eye Movements in Face to Face Conversation are Associated with Autistic Traits: Evidence from a Student Sample

Parents’ Translations of Child Gesture Facilitate Word Learning in Children with Autism, Down Syndrome and Typical Development

Elephants in Pyjamas: Testing the Weak Central Coherence Account of Autism Spectrum Disorders Using a Syntactic Disambiguation Task

Additional Evidence is Needed to Recommend Acquiring a Dog to Families of Children with Autism Spectrum Disorder: A Response to Crossman and Kazdin

Sex-Related Cognitive Profile in Autism Spectrum Disorders Diagnosed Late in Life: Implications for the Female Autistic Phenotype

Altered Dynamics of the fMRI Response to Faces in Individuals with Autism