Skip to main content
Top
Gepubliceerd in:

09-08-2015 | Original Paper

Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis

Auteurs: Ya-Min Li, Jian-Jun Ou, Li Liu, Dan Zhang, Jing-Ping Zhao, Si-Yuan Tang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2016

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

As the link between maternal obesity and risk of autism among offspring is unclear, the present study assessed this association. A systematic search of an electronic database was performed to identify observational studies that examined the association between maternal obesity and autism. The outcome measures were odds ratios comparing offspring autism risk between obese and normal-weight mothers. Five observational studies were included in the meta-analysis. A fixed-effects model was used since low heterogeneity was observed between studies. The pooled adjusted odds ratio was 1.47 (95 % CI 1.24–1.74). The meta-analysis results support an increased risk of autism spectrum disorder in children of women who were obese during pregnancy. However, further study is warranted to confirm these results.
Literatuur
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Association. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Association.
go back to reference Atladóttir, H. Ó., Thorsen, P., Østergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., & Parner, E. T. (2010). Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. Journal of Autism and Developmental Disorders, 40(12), 1423–1430.PubMedCrossRef Atladóttir, H. Ó., Thorsen, P., Østergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., & Parner, E. T. (2010). Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. Journal of Autism and Developmental Disorders, 40(12), 1423–1430.PubMedCrossRef
go back to reference Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., & Charman, T. (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The special needs and autism project (SNAP). Lancet, 368(9531), 210–215.PubMedCrossRef Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., & Charman, T. (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The special needs and autism project (SNAP). Lancet, 368(9531), 210–215.PubMedCrossRef
go back to reference Baron-Cohen, S., Scott, F. J., Allison, C., Williams, J., Bolton, P., Matthews, F. E., & Brayne, C. (2009). Prevalence of autism-spectrum conditions: UK school-based population study. British Journal of Psychiatry, 194(6), 500–509.PubMedCrossRef Baron-Cohen, S., Scott, F. J., Allison, C., Williams, J., Bolton, P., Matthews, F. E., & Brayne, C. (2009). Prevalence of autism-spectrum conditions: UK school-based population study. British Journal of Psychiatry, 194(6), 500–509.PubMedCrossRef
go back to reference Bilder, D. A., Bakian, A. V., Viskochil, J., Clark, E. A., Botts, E. L., Smith, K. R., et al. (2013). Maternal prenatal weight gain and autism spectrum disorders. Pediatrics, 132(5), e1276–e1283.PubMedPubMedCentralCrossRef Bilder, D. A., Bakian, A. V., Viskochil, J., Clark, E. A., Botts, E. L., Smith, K. R., et al. (2013). Maternal prenatal weight gain and autism spectrum disorders. Pediatrics, 132(5), e1276–e1283.PubMedPubMedCentralCrossRef
go back to reference Bolton, P., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective and other psychiatric disorders: patterns of familial aggregation. Psychological Medicine, 28(02), 385–395.PubMedCrossRef Bolton, P., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective and other psychiatric disorders: patterns of familial aggregation. Psychological Medicine, 28(02), 385–395.PubMedCrossRef
go back to reference Buescher, A. V., Cidav, Z., Knapp, M., & Mandell, D. S. (2014). Costs of autism spectrum disorders in the United Kingdom and the United States. JAMA Pediatrics, 168(8), 721–728.PubMedCrossRef Buescher, A. V., Cidav, Z., Knapp, M., & Mandell, D. S. (2014). Costs of autism spectrum disorders in the United Kingdom and the United States. JAMA Pediatrics, 168(8), 721–728.PubMedCrossRef
go back to reference Catalano, P. M., Kirwan, J. P., Haugel-de Mouzon, S., & King, J. (2003). Gestational diabetes and insulin resistance: role in short-and long-term implications for mother and fetus. Journal of Nutrition, 133(5), 1674S–1683S.PubMed Catalano, P. M., Kirwan, J. P., Haugel-de Mouzon, S., & King, J. (2003). Gestational diabetes and insulin resistance: role in short-and long-term implications for mother and fetus. Journal of Nutrition, 133(5), 1674S–1683S.PubMed
go back to reference CDC. (2014). Prevalence of autism spectrum disorders among children aged 8 years: Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63(2), 1–22. CDC. (2014). Prevalence of autism spectrum disorders among children aged 8 years: Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63(2), 1–22.
go back to reference Chen, X., & Scholl, T. O. (2005). Oxidative stress: changes in pregnancy and with gestational diabetes mellitus. Current Diabetes Reports, 5(4), 282–288.PubMedCrossRef Chen, X., & Scholl, T. O. (2005). Oxidative stress: changes in pregnancy and with gestational diabetes mellitus. Current Diabetes Reports, 5(4), 282–288.PubMedCrossRef
go back to reference Dodds, L., Fell, D. B., Shea, S., Armson, B. A., Allen, A. C., & Bryson, S. (2011). The role of prenatal, obstetric and neonatal factors in the development of autism. Journal of Autism and Developmental Disorders, 41(7), 891–902.PubMedCrossRef Dodds, L., Fell, D. B., Shea, S., Armson, B. A., Allen, A. C., & Bryson, S. (2011). The role of prenatal, obstetric and neonatal factors in the development of autism. Journal of Autism and Developmental Disorders, 41(7), 891–902.PubMedCrossRef
go back to reference Eidelman, A. I., & Samueloff, A. (2002) The pathophysiology of the fetus of the diabetic mother. Seminars in perinatology. Elsevier (pp 232–236). Eidelman, A. I., & Samueloff, A. (2002) The pathophysiology of the fetus of the diabetic mother. Seminars in perinatology. Elsevier (pp 232–236).
go back to reference Ervin, R. B. (2009). Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States. National Health Statistics Reports, 13, 1–8.PubMed Ervin, R. B. (2009). Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States. National Health Statistics Reports, 13, 1–8.PubMed
go back to reference Flegal, K. M., Carroll, M. D., Ogden, C. L., & Curtin, L. R. (2010). Prevalence and trends in obesity among US adults, 1999–2008. JAMA, 303(3), 235–241.PubMedCrossRef Flegal, K. M., Carroll, M. D., Ogden, C. L., & Curtin, L. R. (2010). Prevalence and trends in obesity among US adults, 1999–2008. JAMA, 303(3), 235–241.PubMedCrossRef
go back to reference Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. British Journal of Psychiatry, 195(1), 7–14.PubMedPubMedCentralCrossRef Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. British Journal of Psychiatry, 195(1), 7–14.PubMedPubMedCentralCrossRef
go back to reference Georgieff, M. K. (2006). The effect of maternal diabetes during pregnancy on the neurodevelopment of offspring. Minnesota Medicine, 89(3), 44–47.PubMed Georgieff, M. K. (2006). The effect of maternal diabetes during pregnancy on the neurodevelopment of offspring. Minnesota Medicine, 89(3), 44–47.PubMed
go back to reference Georgieff, M. K. (2008). The role of iron in neurodevelopment: Fetal iron deficiency and the developing hippocampus. Biochemical Society Transactions, 36(Pt 6), 1267.PubMedPubMedCentralCrossRef Georgieff, M. K. (2008). The role of iron in neurodevelopment: Fetal iron deficiency and the developing hippocampus. Biochemical Society Transactions, 36(Pt 6), 1267.PubMedPubMedCentralCrossRef
go back to reference Greenland, S. (1987). Quantitative methods in the review of epidemiologic literature. Epidemiologic Reviews, 9(1), 1–30.PubMed Greenland, S. (1987). Quantitative methods in the review of epidemiologic literature. Epidemiologic Reviews, 9(1), 1–30.PubMed
go back to reference Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. British Medical Journal, 327(7414), 557.PubMedPubMedCentralCrossRef Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. British Medical Journal, 327(7414), 557.PubMedPubMedCentralCrossRef
go back to reference Kim, Y. S., Fombonne, E., Koh, Y. J., Kim, S. J., Cheon, K. A., & Leventhal, B. L. (2014). A comparison of DSM-IV pervasive developmental disorder and DSM-5 autism spectrum disorder prevalence in an epidemiologic sample. Journal of the American Academy of Child and Adolescent Psychiatry, 53(5), 500–508.PubMedPubMedCentralCrossRef Kim, Y. S., Fombonne, E., Koh, Y. J., Kim, S. J., Cheon, K. A., & Leventhal, B. L. (2014). A comparison of DSM-IV pervasive developmental disorder and DSM-5 autism spectrum disorder prevalence in an epidemiologic sample. Journal of the American Academy of Child and Adolescent Psychiatry, 53(5), 500–508.PubMedPubMedCentralCrossRef
go back to reference Krakowiak, P., Walker, C. K., Bremer, A. A., Baker, A. S., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2012). Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics, 129(5), e1121–e1128.PubMedPubMedCentralCrossRef Krakowiak, P., Walker, C. K., Bremer, A. A., Baker, A. S., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2012). Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics, 129(5), e1121–e1128.PubMedPubMedCentralCrossRef
go back to reference Kyrou, I., & Tsigos, C. (2009). Stress hormones: Physiological stress and regulation of metabolism. Current Opinion in Pharmacology, 9(6), 787–793.PubMedCrossRef Kyrou, I., & Tsigos, C. (2009). Stress hormones: Physiological stress and regulation of metabolism. Current Opinion in Pharmacology, 9(6), 787–793.PubMedCrossRef
go back to reference Man, K. K., Tong, H. H., Wong, L. Y., Chan, E. W., Simonoff, E., & Wong, I. C. (2015). Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies. Neuroscience and Biobehavioral Reviews, 49C, 82–89.CrossRef Man, K. K., Tong, H. H., Wong, L. Y., Chan, E. W., Simonoff, E., & Wong, I. C. (2015). Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies. Neuroscience and Biobehavioral Reviews, 49C, 82–89.CrossRef
go back to reference Miles, J. H. (2011). Autism spectrum disorders—a genetics review. Genetics in Medicine, 13(4), 278–294.PubMedCrossRef Miles, J. H. (2011). Autism spectrum disorders—a genetics review. Genetics in Medicine, 13(4), 278–294.PubMedCrossRef
go back to reference Moss, B. G., & Chugani, D. C. (2014). Increased risk of very low birth weight, rapid postnatal growth, and autism in underweight and obese mothers. American Journal of Health Promotion, 28(3), 181–188.PubMedCrossRef Moss, B. G., & Chugani, D. C. (2014). Increased risk of very low birth weight, rapid postnatal growth, and autism in underweight and obese mothers. American Journal of Health Promotion, 28(3), 181–188.PubMedCrossRef
go back to reference Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., et al. (2007). The epidemiology of autism spectrum disorders. Annual Reviews in Public Health, 28, 235–258.CrossRef Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., et al. (2007). The epidemiology of autism spectrum disorders. Annual Reviews in Public Health, 28, 235–258.CrossRef
go back to reference Olefsky, J. M., & Glass, C. K. (2010). Macrophages, inflammation, and insulin resistance. Annual Review of Physiology, 72, 219–246.PubMedCrossRef Olefsky, J. M., & Glass, C. K. (2010). Macrophages, inflammation, and insulin resistance. Annual Review of Physiology, 72, 219–246.PubMedCrossRef
go back to reference Pardo, C. A., Vargas, D. L., & Zimmerman, A. W. (2005). Immunity, neuroglia and neuroinflammation in autism. International Review of Psychiatry, 17(6), 485–495.PubMedCrossRef Pardo, C. A., Vargas, D. L., & Zimmerman, A. W. (2005). Immunity, neuroglia and neuroinflammation in autism. International Review of Psychiatry, 17(6), 485–495.PubMedCrossRef
go back to reference Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. (2002). Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. Journal of Clinical Endocrinology and Metabolism, 87(9), 4231–4237.PubMedCrossRef Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. (2002). Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. Journal of Clinical Endocrinology and Metabolism, 87(9), 4231–4237.PubMedCrossRef
go back to reference Reynolds, L. C., Inder, T. E., Neil, J. J., Pineda, R. G., & Rogers, C. E. (2014). Maternal obesity and increased risk for autism and developmental delay among very preterm infants. Journal of Perinatology, 34(9), 688–692.PubMedPubMedCentralCrossRef Reynolds, L. C., Inder, T. E., Neil, J. J., Pineda, R. G., & Rogers, C. E. (2014). Maternal obesity and increased risk for autism and developmental delay among very preterm infants. Journal of Perinatology, 34(9), 688–692.PubMedPubMedCentralCrossRef
go back to reference Rosen, B. N., Lee, B. K., Lee, N. L., Yang, Y., & Burstyn, I. (2014). Maternal smoking and autism spectrum disorder: A meta-analysis. Journal of autism and developmental disorders, 45(6), 1689–1698.CrossRef Rosen, B. N., Lee, B. K., Lee, N. L., Yang, Y., & Burstyn, I. (2014). Maternal smoking and autism spectrum disorder: A meta-analysis. Journal of autism and developmental disorders, 45(6), 1689–1698.CrossRef
go back to reference Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Larsson, H., Hultman, C. M., & Reichenberg, A. (2014). The familial risk of autism. JAMA, 311(17), 1770–1777.PubMedPubMedCentralCrossRef Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Larsson, H., Hultman, C. M., & Reichenberg, A. (2014). The familial risk of autism. JAMA, 311(17), 1770–1777.PubMedPubMedCentralCrossRef
go back to reference Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929.PubMedCrossRef Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929.PubMedCrossRef
go back to reference Suren, P., Gunnes, N., Roth, C., Bresnahan, M., Hornig, M., Hirtz, D., et al. (2014). Parental obesity and risk of autism spectrum disorder. Pediatrics, 133(5), e1128–e1138.PubMedPubMedCentralCrossRef Suren, P., Gunnes, N., Roth, C., Bresnahan, M., Hornig, M., Hirtz, D., et al. (2014). Parental obesity and risk of autism spectrum disorder. Pediatrics, 133(5), e1128–e1138.PubMedPubMedCentralCrossRef
go back to reference Wells, G., Shea, B., O’Connell, D., Peterson, J., Welch, V., & Losos, M. (2013) The Newcastle–Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses 2009. Wells, G., Shea, B., O’Connell, D., Peterson, J., Welch, V., & Losos, M. (2013) The Newcastle–Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses 2009.
go back to reference Xu, G., Jing, J., Bowers, K., Liu, B., & Bao, W. (2014). Maternal diabetes and the risk of autism spectrum disorders in the offspring: A systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 44(4), 766–775.PubMedPubMedCentralCrossRef Xu, G., Jing, J., Bowers, K., Liu, B., & Bao, W. (2014). Maternal diabetes and the risk of autism spectrum disorders in the offspring: A systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 44(4), 766–775.PubMedPubMedCentralCrossRef
go back to reference Zavalza-Gómez, A. B., Anaya-Prado, R., Rincón-Sánchez, A. R., & Mora-Martínez, J. M. (2008). Adipokines and insulin resistance during pregnancy. Diabetes Research and Clinical Practice, 80(1), 8–15.PubMedCrossRef Zavalza-Gómez, A. B., Anaya-Prado, R., Rincón-Sánchez, A. R., & Mora-Martínez, J. M. (2008). Adipokines and insulin resistance during pregnancy. Diabetes Research and Clinical Practice, 80(1), 8–15.PubMedCrossRef
go back to reference Zumoff, B., & Strain, G. W. (1994). A perspective on the hormonal abnormalities of obesity: Are they cause or effect? Obesity Research, 2(1), 56–67.PubMedCrossRef Zumoff, B., & Strain, G. W. (1994). A perspective on the hormonal abnormalities of obesity: Are they cause or effect? Obesity Research, 2(1), 56–67.PubMedCrossRef
Metagegevens
Titel
Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis
Auteurs
Ya-Min Li
Jian-Jun Ou
Li Liu
Dan Zhang
Jing-Ping Zhao
Si-Yuan Tang
Publicatiedatum
09-08-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2549-8