Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

07-10-2021 | Original Paper

Association Between Exposure of Children to General Anesthesia and Autism Spectrum Disorder

Auteurs: Mariana L. Laporta, Juraj Sprung, Caroline A. Fejedelem, Dustin T. Henning, Amy L. Weaver, Andrew C. Hanson, Darrell R. Schroeder, Scott M. Myers, Robert G. Voigt, Toby N. Weingarten, Randall P. Flick, David O. Warner

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2022

Abstract

This study tested the hypothesis that exposure of children prior to their third birthday to procedures requiring general anesthesia is associated with an increased incidence of autism spectrum disorder (ASD) in later life. This study employed a nested, 1:2 matched-case control study design using ASD cases identified in a population-based birth cohort of children born in Olmsted County, MN from 1976 to 2000. Matching variables included sex, date of birth, and mother’s age in conditional logistic regression including 499 ASD cases and 998 controls. After adjusting for birth weight and health status, there was no significant association between exposure and ASD (OR 1.27 [95% CI 0.92–1.76]), indicating that general anesthesia is not associated with an increased risk of ASD.

vorige artikel Pilot Randomized Controlled Trial of the WHO Caregiver Skills Training in Public Health Services in Italy

volgende artikel Autism: Comorbidities and Treatment Patterns in the Real World, a Retrospective Cohort Study Among Children, Adolescents and Adults Newly Diagnosed with Autism

Antshel, K. M., & Russo, N. (2019). Autism sectrum disorders and ADHD: Overlapping phenomenology, diagnostic issues, and treatment considerations. Current Psychiatry Reports, 21(5), 34. https://doi.org/10.1007/s11920-019-1020-5CrossRefPubMed

Atladottir, H. O., Thorsen, P., Schendel, D. E., Ostergaard, L., Lemcke, S., & Parner, E. T. (2010). Association of hospitalization for infection in childhood with diagnosis of autism spectrum disorders: A Danish cohort study. Archives of Pediatric and Adolescent Medicine, 164(5), 470–477. https://doi.org/10.1001/archpediatrics.2010.9CrossRef

Baxter, A. J., Brugha, T. S., Erskine, H. E., Scheurer, R. W., Vos, T., & Scott, J. G. (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 45(3), 601–613. https://doi.org/10.1017/S003329171400172XCrossRefPubMed

Chien, L. N., Lin, H. C., Shao, Y. H., Chiou, S. T., & Chiou, H. Y. (2015). Risk of autism associated with general anesthesia during cesarean delivery: A population-based birth-cohort analysis. Journal of Autism and Developmental Disorders, 45(4), 932–942. https://doi.org/10.1007/s10803-014-2247-yCrossRefPubMed

Christensen, D. L., Maenner, M. J., Bilder, D., Constantino, J. N., Daniels, J., Durkin, M. S., Fitzgerald, R. T., Kurzius-Spencer, M., Pettygrove, S. D., Robinson, C., Shenouda, J., White, T., Zahorodny, W., Pazol, K., & Dietz, P. (2019). Prevalence and characteristics of autism spectrumd disorder among children aged 4 years—early autism and developmental disabilities monitoring network, seven sites, United States, 2010, 2012, and 2014. MMWR Surveilancel Summary, 68(2), 1–19. https://doi.org/10.15585/mmwr.ss6802a1CrossRef

Coleman, K., Robertson, N. D., Dissen, G. A., Neuringer, M. D., Martin, L. D., Cuzon Carlson, V. C., Kroenke, C., Fair, D., & Brambrink, A. M. (2016). Isoflurane anesthesia has long-term consequences on motor and behavioral development in infant rhesus macaques. Anesthesiology, 127(1), 74–94. https://doi.org/10.1097/ALN.0000000000001383CrossRef

Creagh, O., Torres, H., Rivera, K., Morales-Franqui, M., Altieri-Acevedo, G., & Warner, D. (2016). Previous exposure to anesthesia and autism spectrum disorder (ASD): A Puerto Rican population-based sibling cohort study. Boletin De La Asociacion Medica De Puerto Rico, 108(2), 73–80.PubMed

Curran, E. A., Dalman, C., Kearney, P. M., Kenny, L. C., Cryan, J. F., Dinan, T. G., & Khashan, A. S. (2015a). Association between obstetric mode of delivery and autism spectrum disorder: A population-based sibling design study. JAMA Psychiatry, 72(9), 935–942. https://doi.org/10.1001/jamapsychiatry.2015.0846CrossRefPubMed

Curran, E. A., O’Neill, S. M., Cryan, J. F., Kenny, L. C., Dinan, T. G., Khashan, A. S., & Kearney, P. M. (2015b). Research review: Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 56(5), 500–508. https://doi.org/10.1111/jcpp.12351CrossRefPubMed

Currenti, S. A. (2010). Understanding and determining the etiology of autism. Cellular and Molecular Neurobiology, 30(2), 161–171. https://doi.org/10.1007/s10571-009-9453-8CrossRefPubMed

Davidson, A. J., Becke, K., de Graaff, J., Giribaldi, G., Habre, W., Hansen, T., Hunt, R. W., Ing, C., Loepke, A., McCann, M. E., Ormond, G. D., Pini Prato, A., Salvo, I., Sun, L., Vutskits, L., Walker, S., & Disma, N. (2015). Anesthesia and the developing brain: A way forward for clinical research. Paediatric Anaesthesia, 25(5), 447–452. https://doi.org/10.1111/pan.12652CrossRefPubMed

de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016). Advancing the understanding of autism disease mechanisms through genetics. Nature Medicine, 22(4), 345–361. https://doi.org/10.1038/nm.4071CrossRefPubMedPubMedCentral

American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders (4th edn., Text Revision). Washington, DC: Author.

DiMaggio, C., Sun, L. S., Kakavouli, A., Byrne, M. W., & Li, G. (2009). A retrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children. Journal of Neurosurgical Anesthesioogyl, 21(4), 286–291. https://doi.org/10.1097/ANA.0b013e3181a71f11CrossRef

DiMaggio, C., Sun, L. S., & Li, G. (2011). Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. Anesthesia and Analgesia, 113(5), 1143–1151. https://doi.org/10.1213/ANE.0b013e3182147f42CrossRefPubMedPubMedCentral

Doja, A., & Roberts, W. (2006). Immunizations and autism: A review of the literature. Canadian Journal of Neurological Science, 33(4), 341–346. https://doi.org/10.1017/s031716710000528xCrossRef

Flick, R. P., Katusic, S. K., Colligan, R. C., Wilder, R. T., Voigt, R. G., Olson, M. D., Sprung, J., Weaver, A. L., Schroeder, D. R., & Warner, D. O. (2012). Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics, 128(5), e1053-1061.CrossRef

Freitag, C. M. (2007). The genetics of autistic disorders and its clinical relevance: A review of the literature. Molecular Psychiatry, 12(1), 2–22. https://doi.org/10.1038/sj.mp.4001896CrossRefPubMed

Gardener, H., Spiegelman, D., & Buka, S. L. (2011). Perinatal and neonatal risk factors for autism: A comprehensive meta-analysis. Pediatrics, 128(2), 344–355. https://doi.org/10.1542/peds.2010-1036CrossRefPubMedPubMedCentral

Gleich, S. J., Flick, R., Hu, D., Zaccariello, M. J., Colligan, R. C., Katusic, S. K., Schroeder, D. R., Hanson, A., Buenvenida, S., Wilder, R. T., Sprung, J., Voigt, R. G., Paule, M. G., Chelonis, J. J., & Warner, D. O. (2014). Neurodevelopment of children exposed to anesthesia: Design of the mayo anesthesia safety in kids (MASK) study. Contemporary Clinical Trials, 41, 45–54. https://doi.org/10.1016/j.cct.2014.12.020CrossRefPubMedPubMedCentral

Gruschow, S. M., Yerys, B. E., Power, T. J., Durbin, D. R., & Curry, A. E. (2019). Validation of the use of electronic health records for classification of ADHD Status. Journal of Attention Disorders, 23(13), 1647–1655. https://doi.org/10.1177/1087054716672337CrossRefPubMed

Hansen, S. N., Schendel, D. E., & Parner, E. T. (2015). Explaining the increase in the prevalence of autism spectrum disorders: The proportion attributable to changes in reporting practices. JAMA Pediatrics, 169(1), 56–62. https://doi.org/10.1001/jamapediatrics.2014.1893CrossRefPubMed

Hansen, T. G. (2015). Anesthesia-related neurotoxicity and the developing animal brain is not a significant problem in children. Paediatric Anaesthesia, 25(1), 65–72. https://doi.org/10.1111/pan.12548CrossRefPubMed

Hu, D., Flick, R. P., Gleich, S. J., Scanlon, M. M., Zaccariello, M. J., Colligan, R. C., Katusic, S. K., Schroeder, D. R., Hanson, A. C., Buenvenida, S. L., Wilder, R. T., Sprung, J., & Warner, D. O. (2016). Construction and characterization of a population-based cohort to study the association of anesthesia exposure with neurodevelopmental outcomes. PLoS ONE, 11(5), e0155288. https://doi.org/10.1371/journal.pone.0155288CrossRefPubMedPubMedCentral

Hu, D., Flick, R. P., Zaccariello, M. J., Colligan, R. C., Katusic, S. K., Schroeder, D. R., Hanson, A. C., Buenvenida, S. L., Gleich, S. J., Wilder, R. T., Sprung, J., & Warner, D. O. (2017). Association between exposure of young children to procedures requiring general anesthesia and learning and behavioral outcomes in a population-based birth cohort. Anesthesiology, 127(2), 227–240. https://doi.org/10.1097/ALN.0000000000001735CrossRefPubMed

Huberman Samuel, M., Meiri, G., Dinstein, I., Flusser, H., Michaelovski, A., Bashiri, A., & Menashe, I. (2019). Exposure to general anesthesia may contribute to the association between Cesarean delivery and autism spectrum disorder. Journal of Autism and Developmental Disorders, 49(8), 3127–3135. https://doi.org/10.1007/s10803-019-04034-9CrossRefPubMed

Ing, C., Sun, M., Olfson, M., DiMaggio, C. J., Sun, L. S., Wall, M. M., & Li, G. (2017). Age at exposure to surgery and anesthesia in children and association with mental disorder diagnosis. Anesthesia and Analgesia. https://doi.org/10.1213/ANE.0000000000002423CrossRefPubMedPubMedCentral

Jevtovic-Todorovic, V., Hartman, R. E., Izumi, Y., Benshoff, N. D., Dikranian, K., Zorumski, C. F., Olney, J. W., & Wozniak, D. F. (2003). Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. Journal of Neuroscience, 23(3), 876–882.CrossRef

Ko, W. R., Huang, J. Y., Chiang, Y. C., Nfor, O. N., Ko, P. C., Jan, S. R., Lung, C. C., Chang, H. C., Lin, L. Y., & Liaw, Y. P. (2015). Risk of autistic disorder after exposure to general anaesthesia and surgery: A nationwide, retrospective matched cohort study. European Journal of Anaesthesiology, 32(5), 303–310. https://doi.org/10.1097/EJA.0000000000000130CrossRefPubMed

Ko, W. R., Liaw, Y. P., Huang, J. Y., Zhao, D. H., Chang, H. C., Ko, P. C., Jan, S. R., Nfor, O. N., Chiang, Y. C., & Lin, L. Y. (2014). Exposure to general anesthesia in early life and the risk of attention deficit/hyperactivity disorder development: A nationwide, retrospective matched-cohort study. Paediatric Anaesthesia, 24(7), 741–748. https://doi.org/10.1111/pan.12371CrossRefPubMed

Kushki, A., Anagnostou, E., Hammill, C., Duez, P., Brian, J., Iaboni, A., Schachar, R., Crosbie, J., Arnold, P., & Lerch, J. P. (2019). Examining overlap and homogeneity in ASD, ADHD, and OCD: A data-driven, diagnosis-agnostic approach. Translational Psychiatry, 9(1), 318. https://doi.org/10.1038/s41398-019-0631-2CrossRefPubMedPubMedCentral

Llanes, E., Blacher, J., Stavropoulos, K., & Eisenhower, A. (2020). Parent and teacher reports of comorbid anxiety and ADHD symptoms in children with ASD. Journal of Autism and Developmental Disorders, 50(5), 1520–1531. https://doi.org/10.1007/s10803-018-3701-zCrossRefPubMed

Lundström, S., Reichenberg, A., Melke, J., Råstam, M., Kerekes, N., Lichtenstein, P., Gillberg, C., & Anckarsäter, H. (2015). Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 56(6), 702–710. https://doi.org/10.1111/jcpp.12329CrossRefPubMed

Lyall, K., Croen, L., Daniels, J., Fallin, M. D., Ladd-Acosta, C., Lee, B. K., Park, B. Y., Snyder, N. W., Schendel, D., Volk, H., Windham, G. C., & Newschaffer, C. (2017). The changing epidemiology of autism spectrum disorders. Annual Review of Public Health, 38, 81–102. https://doi.org/10.1146/annurev-publhealth-031816-044318CrossRefPubMed

Marques, F., Brito, M. J., Conde, M., Pinto, M., & Moreira, A. (2014). Autism spectrum disorder secondary to enterovirsu encephalitis. Journal of Child Neurology, 29(5), 708–714. https://doi.org/10.1177/0883073813508314CrossRefPubMed

Modabbernia, A., Velthorst, E., & Reichenberg, A. (2017). Environmental risk factors for autism: An evidence-based review of systematic reviews and meta-analyses. Molecular Autism, 8, 13. https://doi.org/10.1186/s13229-017-0121-4CrossRefPubMedPubMedCentral

Muhle, R. A., Reed, H. E., Stratigos, K. A., & Veenstra-VanderWeele, J. (2018). The emerging clinical neuroscience of autism spectrum disorder: A review. JAMA Psychiatry, 75(5), 514–523. https://doi.org/10.1001/jamapsychiatry.2017.4685CrossRefPubMed

Myers, S. M., Voigt, R. G., Colligan, R. C., Weaver, A. L., Storlie, C. B., Stoeckel, R. E., Port, J. D., & Katusic, S. K. (2019). Autism spectrum disorder: Incidence and time trends over two decades in a population-based birth cohort. Journal of Autism and Developmental Disorders, 49(4), 1455–1474. https://doi.org/10.1007/s10803-018-3834-0CrossRefPubMedPubMedCentral

Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., Mandell, D. S., Miller, L. A., Pinto-Martin, J., Reaven, J., Reynolds, A. M., Rice, C. E., Schendel, D., & Windham, G. C. (2007). The epidemiology of autism spectrum disorders. Annual Review of Public Health, 28, 235–258. https://doi.org/10.1146/annurev.publhealth.28.021406.144007CrossRefPubMed

Sagi-Dain, L., Kedar, R., Bardicef, M., & Riskin, S. (2020). Numerous confounders affecting the alleged association between cesarean deliveries under general anesthesia and autism spectrum disorder. Journal of Autism and Developmental Disorders, 50(2), 688–690. https://doi.org/10.1007/s10803-019-04247-yCrossRefPubMed

Sedighnejad, A., Soltanipour, S., Saberi, A., Kousha, M., Bidabadi, E., Biazar, G., & Naderi, N. (2020). Risk of attention deficit hyperactivity disorder dfter early exposure to general anesthesia: A case control study. Iranian Journal of Pediatrics, 30(3), e99976.CrossRef

Shi, Y., Hu, D., Rodgers, E. L., Katusic, S. K., Gleich, S. J., Hanson, A. C., Schroeder, D. R., Flick, R. P., & Warner, D. O. (2018). Epidemiology of general anesthesia prior to age 3 in a population-based birth cohort. Paediatric Anaesthesia, 28(6), 513–519. https://doi.org/10.1111/pan.13359CrossRefPubMedPubMedCentral

Shi, Y., Schulte, P. J., Hanson, A. C., Zaccariello, M. J., Hu, D., Crow, S., Flick, R. P., & Warner, D. O. (2020). Utility of medical record diagnostic codes to ascertain attention-deficit/hyperactivity disorder and learning disabilities in populations of children. BMC Pediatrics, 20(1), 510. https://doi.org/10.1186/s12887-020-02411-3CrossRefPubMedPubMedCentral

Sprung, J., Flick, R. P., Katusic, S. K., Colligan, R. C., Barbaresi, W. J., Bojanić, K., Welch, T. L., Olson, M. D., Hanson, A. C., Schroeder, D. R., Wilder, R. T., & Warner, D. O. (2012). Attention-deficit/hyperactivity disorder after early exposure to procedures requiring general anesthesia. Mayo Clinic Proceedings, 87(2), 120–129. https://doi.org/10.1016/j.mayocp.2011.11.008CrossRefPubMedPubMedCentral

St Sauver, J. L., Grossardt, B. R., Yawn, B. P., Melton, L. J., 3rd., Pankratz, J. J., Brue, S. M., & Rocca, W. A. (2012). Data resource profile: The Rochester Epidemiology Project (REP) medical records-linkage system. International Journal of Epidemiology, 41(6), 1614–1624. https://doi.org/10.1093/ije/dys195CrossRefPubMedPubMedCentral

van der Meer, J. M., Oerlemans, A. M., van Steijn, D. J., Lappenschaar, M. G., de Sonneville, L. M., Buitelaar, J. K., & Rommelse, N. N. (2012). Are autism spectrum disorder and attention-deficit/hyperactivity disorder different manifestations of one overarching disorder? Cognitive and symptom evidence from a clinical and population-based sample. Journal of the American Academy of Child and Adolescent Psychiatry, 51(11), 1160-1172.e1163. https://doi.org/10.1016/j.jaac.2012.08.024CrossRefPubMed

Warner, D. O., Zaccariello, M. J., Katusic, S. K., Schroeder, D. R., Hanson, A. C., Schulte, P. J., Buenvenida, S. L., Gleich, S. J., Wilder, R. T., Sprung, J., Hu, D., Voigt, R. G., Paule, M. G., Chelonis, J. J., & Flick, R. P. (2018). Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: The Mayo Anesthesia Safety in Kids (MASK) study. Anesthesiology, 129(1), 89–105. https://doi.org/10.1097/ALN.0000000000002232CrossRefPubMed

Weiner, J. P., Dobson, A., Maxwell, S. L., Coleman, K., Starfield, B., & Anderson, G. F. (1996). Risk-adjusted Medicare capitation rates using ambulatory and inpatient diagnoses. Health Care Financing Review, 17(3), 77–99.PubMedPubMedCentral

Weiner, J. P., Starfield, B. H., Steinwachs, D. M., & Mumford, L. M. (1991). Development and application of a population-oriented measure of ambulatory care case-mix. Medical Care, 29(5), 452–472.CrossRef

Wilder, R. T., Flick, R. P., Sprung, J., Katusic, S. K., Barbaresi, W. J., Mickelson, C., Gleich, S. J., Schroeder, D. R., Weaver, A. L., & Warner, D. O. (2009). Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology, 110(4), 796–804. https://doi.org/10.1097/01.anes.0000344728.34332.5dCrossRefPubMed

Zhang, T., Sidorchuk, A., Sevilla-Cermeño, L., Vilaplana-Pérez, A., Chang, Z., Larsson, H., Mataix-Cols, D., & Fernández de la Cruz, L. (2019). Association of Cesarean delivery with risk of neurodevelopmental and psychiatric disorders in the offspring: A systematic review and meta-analysis. JAMA Network Open, 2(8), e1910236. https://doi.org/10.1001/jamanetworkopen.2019.10236CrossRefPubMedPubMedCentral

Titel: Association Between Exposure of Children to General Anesthesia and Autism Spectrum Disorder
Auteurs: Mariana L. Laporta
Juraj Sprung
Caroline A. Fejedelem
Dustin T. Henning
Amy L. Weaver
Andrew C. Hanson
Darrell R. Schroeder
Scott M. Myers
Robert G. Voigt
Toby N. Weingarten
Randall P. Flick
David O. Warner
Publicatiedatum: 07-10-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05305-0

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 10/2022

Evaluating the Use of Self-reported Measures in Autistic Individuals in the Context of Psychiatric Assessment: A Systematic Review

Brief Report: Perceived Barriers to Physical Activity Among a National Sample of Autistic Adults

Context Modulates Attention to Faces in Dynamic Social Scenes in Children and Adults with Autism Spectrum Disorder

Brief Report: The Broad Autism Phenotype in Swedish Parents of Children With and Without Autism Spectrum Conditions

A Preliminary Examination of the Impact of Working Memory Training on Syntax and Processing Speed in Children with ASD

Identification of a Novel Pathogenic Variant in the NAGLU Gene in a Child with Neurodevelopmental Delay