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Gepubliceerd in: Journal of Autism and Developmental Disorders 10/2022

07-10-2021 | Original Paper

Association Between Exposure of Children to General Anesthesia and Autism Spectrum Disorder

Auteurs: Mariana L. Laporta, Juraj Sprung, Caroline A. Fejedelem, Dustin T. Henning, Amy L. Weaver, Andrew C. Hanson, Darrell R. Schroeder, Scott M. Myers, Robert G. Voigt, Toby N. Weingarten, Randall P. Flick, David O. Warner

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2022

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Abstract

This study tested the hypothesis that exposure of children prior to their third birthday to procedures requiring general anesthesia is associated with an increased incidence of autism spectrum disorder (ASD) in later life. This study employed a nested, 1:2 matched-case control study design using ASD cases identified in a population-based birth cohort of children born in Olmsted County, MN from 1976 to 2000. Matching variables included sex, date of birth, and mother’s age in conditional logistic regression including 499 ASD cases and 998 controls. After adjusting for birth weight and health status, there was no significant association between exposure and ASD (OR 1.27 [95% CI 0.92–1.76]), indicating that general anesthesia is not associated with an increased risk of ASD.
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Metagegevens
Titel
Association Between Exposure of Children to General Anesthesia and Autism Spectrum Disorder
Auteurs
Mariana L. Laporta
Juraj Sprung
Caroline A. Fejedelem
Dustin T. Henning
Amy L. Weaver
Andrew C. Hanson
Darrell R. Schroeder
Scott M. Myers
Robert G. Voigt
Toby N. Weingarten
Randall P. Flick
David O. Warner
Publicatiedatum
07-10-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 10/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-05305-0

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