Skip to main content
Top

2019 | OriginalPaper | Hoofdstuk

14. Assisted reproductive technology

Auteurs : Bart C. J. M. Fauser, Didi D. M. Braat

Gepubliceerd in: Textbook of Obstetrics and Gynaecology

Uitgeverij: Bohn Stafleu van Loghum

share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Summary

In vitro fertilization (IVF) – originally developed for the treatment of absolute tubal factor infertility – brings female and male gametes in close proximity in a petri dish outside the human body. Major steps in IVF include ovarian stimulation (aiming to stimulate maturation of multiple follicles), oocyte retrieval via transvaginal puncture to obtain multiple oocytes, fertilization of oocytes and the subsequent development of embryos under strictly controlled circumstances in the laboratory, the transfer of preferably a single, high-quality embryo into the uterine cavity and the freezing of surplus embryos, creating the possibility for additional chances of pregnancy when transferred in subsequent cycles. IVF success rates vary significantly, but current live birth rates are approximately 30 % per started IVF cycle; this represents a cumulative outcome involving the transfer of fresh and frozen embryos harvested from the same oocyte cohort. Intracytoplasmic sperm injection (ICSI) is the mechanical injection of a single sperm into the cytoplasm of an oocyte. This technology is able to generate pregnancies in couples with very poor sperm quality from their own genetic material. Such a sperm may be obtained from the ejaculate, or epididymal or testicular sperm may be obtained by surgical procedures. Currently, more than 60 % of all IVF cycles worldwide make use of the ICSI procedure. IVF can also be applied in many conditions not related to infertility per se, such as preimplantation genetic testing-diagnosis (PGT-D) of embryos in families with known congenital abnormalities, the preservation of fertility (for medical or non-medical reasons) by the cryostorage of ovarian tissue, oocytes or embryos, the use of donor oocytes or embryos, or the transfer of embryos into the uterus of another person allowing her (the ‘surrogate mother’) to carry the pregnancy.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Woordenlijst
PGT-D
Preimplantation genetic testing-diagnosis
NGS
Next generation sequencing
Laparoscopy
A type of surgical procedure in which a small incision is made, usually in the navel, through which a viewing tube (laparoscope) is inserted. This allows the doctor to examine the abdominal and pelvic organs and perform surgical procedures
Endometriosis
A condition in which bits of the tissue similar to the lining of the uterus (endometrium) grow in other parts of the body
GnRH
Gonadotrophin-releasing hormone
FSH
Follicle-stimulating hormone
LH
Luteinizing hormone
GnRH analogue
Modified GnRH molecules with either antagonist or agonist activity
hCG
Human chorionic gonadotrophin
Vitrification
Ultra-rapid freezing technology
Endometrial receptivity
Capacity of the endometrium to allow the embryo to implant
SUZI
Sub-zonal insemination of the oocyte with sperm
OAT
Oligo-astheno-teratozoospermia
Epididymis
Elongated, cordlike structure along the posterior border of the testis, whose coiled duct provides for the storage, transport, and maturation of spermatozoa
PESA
Percutaneous epididymal sperm aspiration
MESA
Retrieval of sperm from the epididymis by using microsurgical techniques
TESE
Testicular sperm extraction
CBAVD
Bilateral occlusion of vasa deference
CFTR
Cystic fibrosis transmembrane regulator
Azoospermia
No sperm present in the ejaculate
vasectomy
A surgical procedure performed on males in which the vas deferens (tubes that carry sperm from the testicles to the seminal vesicles) are cut, tied, cauterized (burned or seared) or otherwise interrupted
POI
Premature or primary ovarian insufficiency
Vitrification
Ultra-rapid freezing technology
IVM
In vitro oocyte maturation
Stem cells
Group of cells that is cultured in vitro and can be propagated indefinitely
Prenatal diagnosis
Any of various diagnostic techniques to determine whether a developing foetus is affected with a genetic disorder or other abnormality
PCOS
Polycystic ovary syndrome
Genomic imprinting
Epigenetic process that leads to inactivation of the paternal or maternal allele of certain genes susceptible to epigenetic regulation
Infertility
Inability to conceive after one year of unprotected intercourse
Literatuur
1.
go back to reference Bastings L, Beerendonk CCM, Westphal JR, et al. Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review. Hum Reprod Update 2013;19:483–506.CrossRef Bastings L, Beerendonk CCM, Westphal JR, et al. Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review. Hum Reprod Update 2013;19:483–506.CrossRef
2.
go back to reference Cohen J, Trounson A, Dawson K, et al. The early days of IVF outside the UK. Hum Reprod Update 2005;11:439–59.CrossRef Cohen J, Trounson A, Dawson K, et al. The early days of IVF outside the UK. Hum Reprod Update 2005;11:439–59.CrossRef
3.
go back to reference Dyer S, Chambers GM, de Mouzon J, et al. International committee for monitoring assisted reproductive technologies world report: assisted reproductive technology 2008, 2009 and 2010. Hum Reprod. 2016;31:1588–609.CrossRef Dyer S, Chambers GM, de Mouzon J, et al. International committee for monitoring assisted reproductive technologies world report: assisted reproductive technology 2008, 2009 and 2010. Hum Reprod. 2016;31:1588–609.CrossRef
4.
go back to reference European IVF monitoring consortium (EIM). Assisted reproductive technology in Europe, 2012. Hum Reprod. 2016;31:1638–52.CrossRef European IVF monitoring consortium (EIM). Assisted reproductive technology in Europe, 2012. Hum Reprod. 2016;31:1638–52.CrossRef
5.
go back to reference Fauser BC, Devroey P, Macklon NS. Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet 2005;365:1807–16.CrossRef Fauser BC, Devroey P, Macklon NS. Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet 2005;365:1807–16.CrossRef
6.
go back to reference Golombok S. Modern Families. Cambridge: Cambridge University Press; 2015. ISBN 9781107650251 Golombok S. Modern Families. Cambridge: Cambridge University Press; 2015. ISBN 9781107650251
7.
go back to reference Jeruss JS, Woodruff TK. Preservation of fertility in patients with cancer. N Engl J Med. 2009;360:902–11.CrossRef Jeruss JS, Woodruff TK. Preservation of fertility in patients with cancer. N Engl J Med. 2009;360:902–11.CrossRef
8.
go back to reference Macklon NS, Stouffer RL, Giudice LC, Fauser BC. The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocr Rev. 2006;27:170–207.CrossRef Macklon NS, Stouffer RL, Giudice LC, Fauser BC. The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocr Rev. 2006;27:170–207.CrossRef
9.
go back to reference Wilkinson J, Roberts SA, Vail A. Developments in IVF warrant the adoption of new performance indicators for ART clinics, but do not justify the abandonment of patient-centred measures. Hum Reprod. 2017;24:1–5. Wilkinson J, Roberts SA, Vail A. Developments in IVF warrant the adoption of new performance indicators for ART clinics, but do not justify the abandonment of patient-centred measures. Hum Reprod. 2017;24:1–5.
Metagegevens
Titel
Assisted reproductive technology
Auteurs
Bart C. J. M. Fauser
Didi D. M. Braat
Copyright
2019
Uitgeverij
Bohn Stafleu van Loghum
DOI
https://doi.org/10.1007/978-90-368-2131-5_14