Skip to main content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Quality of Life Research 9/2017

07-04-2017 | Brief Communication

Assessment of apathy minimising the effect of motor dysfunctions in Parkinson’s disease: a validation study of the dimensional apathy scale

Auteurs: Gabriella Santangelo, Alfonsina D’Iorio, Fausta Piscopo, Sofia Cuoco, Katia Longo, Marianna Amboni, Chiara Baiano, Domenico Tafuri, Maria Teresa Pellecchia, Paolo Barone, Carmine Vitale

Gepubliceerd in: Quality of Life Research | Uitgave 9/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

Apathy is associated with motor symptoms in Parkinson’s disease (PD); therefore, its evaluation could be influenced by motor disability. The Dimensional Apathy Scale (DAS) evaluates apathy excluding confounding effects of motor symptoms. The present study had three major aims: (a) to explore the psychometric properties of the DAS in non-demented PD patients; (b) to determine an optimal cut-off score of the DAS to identify apathetic PD patients; and (c) to determine a specific apathy profile in PD patients as compared to healthy controls (HC).

Methods

One hundred and seven PD patients and 100 HC completed the DAS. To explore convergent and divergent validity of the DAS in PD, patients underwent the Apathy Evaluation Scale and tools for assessing depressive symptoms, anxiety and cognition. Clinical aspects were recorded. Receiver operating characteristic curve analyses were carried out to estimate the optimal cut-off score to identify clinically significant apathy.

Results

The DAS scores showed high internal consistency and good evidence for convergent and discriminant validity. Maximum discrimination between apathetic and non-apathetic patients was obtained with a cut-off score of 28.5 (total score range: 0–72 with higher score indicating more severe apathy). Comparison between PD and HC groups revealed significant differences on total DAS, behavioural/cognitive initiation and emotional subscales.

Conclusions

The DAS is a valid and reliable tool to assess multidimensional apathy in PD, independently of severity of motor symptoms. Reduced initiation of thought and behaviour and emotional blunting characterised PD patients, without confounding effects of motor disability.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
1.
go back to reference Santangelo, G., Trojano, L., Barone, P., Errico, D., Grossi, D., & Vitale, C. (2013). Apathy in Parkinson’s disease: Diagnosis, neuropsychological correlates, pathophysiology and treatment. Behavioral Neurology, 27(4), 501–513. CrossRefPubMedPubMedCentral Santangelo, G., Trojano, L., Barone, P., Errico, D., Grossi, D., & Vitale, C. (2013). Apathy in Parkinson’s disease: Diagnosis, neuropsychological correlates, pathophysiology and treatment. Behavioral Neurology, 27(4), 501–513. CrossRefPubMedPubMedCentral
2.
go back to reference Robert, P., Onyike, C. U., Leentjens, A. F., Dujardin, K., Aalten, P., Starkstein, S., et al. (2009). Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. European Psychiatry, 24, 98–104. CrossRefPubMed Robert, P., Onyike, C. U., Leentjens, A. F., Dujardin, K., Aalten, P., Starkstein, S., et al. (2009). Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. European Psychiatry, 24, 98–104. CrossRefPubMed
3.
go back to reference Robert, P. H., Clairet, S., Benoit, M., Koutaich, J., Bertogliati, C., Tible, O., et al. (2002). The apathy inventory: Assessment of apathy and awareness in Alzheimer’s disease, Parkinson’s disease and mild cognitive impairment. International Journal of Geriatric Psychiatry, 17(12), 1099–1105. CrossRefPubMed Robert, P. H., Clairet, S., Benoit, M., Koutaich, J., Bertogliati, C., Tible, O., et al. (2002). The apathy inventory: Assessment of apathy and awareness in Alzheimer’s disease, Parkinson’s disease and mild cognitive impairment. International Journal of Geriatric Psychiatry, 17(12), 1099–1105. CrossRefPubMed
4.
go back to reference Sockeel, P., Dujardin, K., Devos, D., Denève, C., Destée, A., & Defebvre, L. (2006). The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: Validation in Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 77(5), 579–584. CrossRefPubMedPubMedCentral Sockeel, P., Dujardin, K., Devos, D., Denève, C., Destée, A., & Defebvre, L. (2006). The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: Validation in Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 77(5), 579–584. CrossRefPubMedPubMedCentral
5.
go back to reference Marin, R. S., Biedrzycki, R. C., & Firinciogullari, S. (1991). Reliability and validity of the apathy evaluation scale. Psychiatry Research, 38, 143–162. CrossRefPubMed Marin, R. S., Biedrzycki, R. C., & Firinciogullari, S. (1991). Reliability and validity of the apathy evaluation scale. Psychiatry Research, 38, 143–162. CrossRefPubMed
6.
go back to reference Santangelo, G., Barone, P., Cuoco, S., Raimo, S., Pezzella, D., Picillo, M., et al. (2014). Apathy in untreated, de novo patients with Parkinson’s disease: Validation study of apathy evaluation scale. Journal of Neurology, 261(12), 2319–2328. (Erratum in: J Neurol. 2014;261(12):2329. Franco, Santangelo [corrected to Santangelo, Franco]). CrossRefPubMed Santangelo, G., Barone, P., Cuoco, S., Raimo, S., Pezzella, D., Picillo, M., et al. (2014). Apathy in untreated, de novo patients with Parkinson’s disease: Validation study of apathy evaluation scale. Journal of Neurology, 261(12), 2319–2328. (Erratum in: J Neurol. 2014;261(12):2329. Franco, Santangelo [corrected to Santangelo, Franco]). CrossRefPubMed
7.
go back to reference Radakovic, R., & Abrahams, S. (2014). Developing a new apathy measurement scale: Dimensional apathy scale. Psychiatry Research, 219, 658–663. CrossRefPubMed Radakovic, R., & Abrahams, S. (2014). Developing a new apathy measurement scale: Dimensional apathy scale. Psychiatry Research, 219, 658–663. CrossRefPubMed
8.
go back to reference Radakovic, R., Stephenson, L., Colville, S., Swingler, R., Chandran, S., & Abrahams, S. (2016). Multidimensional apathy in ALS: Validation of the dimensional apathy scale. Journal of Neurology, Neurosurgery and Psychiatry, 87, 663–669. CrossRefPubMed Radakovic, R., Stephenson, L., Colville, S., Swingler, R., Chandran, S., & Abrahams, S. (2016). Multidimensional apathy in ALS: Validation of the dimensional apathy scale. Journal of Neurology, Neurosurgery and Psychiatry, 87, 663–669. CrossRefPubMed
9.
10.
go back to reference Gelb, D. J., Oliver, E., & Gilman, S. (1999). Diagnostic criteria for Parkinson disease. Archives of Neurology, 56, 33–39. CrossRefPubMed Gelb, D. J., Oliver, E., & Gilman, S. (1999). Diagnostic criteria for Parkinson disease. Archives of Neurology, 56, 33–39. CrossRefPubMed
11.
go back to reference Dubois, B., Burn, D., Goetz, C., et al. (2007). Diagnostic procedures for Parkinson’s disease dementia: Recommendations from the movement disorder society task force. Movement Disorder, 22, 2314–2324. CrossRef Dubois, B., Burn, D., Goetz, C., et al. (2007). Diagnostic procedures for Parkinson’s disease dementia: Recommendations from the movement disorder society task force. Movement Disorder, 22, 2314–2324. CrossRef
12.
go back to reference Tomlinson, C. L., Stowe, R., Patel, S., Rick, C., Gray, R., & Clarke, C. E. (2010). Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Movement Disorder, 25, 2649–2653. CrossRef Tomlinson, C. L., Stowe, R., Patel, S., Rick, C., Gray, R., & Clarke, C. E. (2010). Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Movement Disorder, 25, 2649–2653. CrossRef
13.
go back to reference Fahn, S., Elton, R. L., & Members of the UPDRS development committee. (1987). The unified Parkinson’s disease rating scale. In S. Fahn, C. D. Marsden, D. Calne, & M. Goldstein (Eds.), Recent developments in Parkinson’s disease (pp. 153–304). Florham Park, NY: Macmillan Healthcare Information. Fahn, S., Elton, R. L., & Members of the UPDRS development committee. (1987). The unified Parkinson’s disease rating scale. In S. Fahn, C. D. Marsden, D. Calne, & M. Goldstein (Eds.), Recent developments in Parkinson’s disease (pp. 153–304). Florham Park, NY: Macmillan Healthcare Information.
14.
go back to reference Hoehn, M. M., & Yahr, M. D. (1967). Parkinsonism: Onset, progression, and mortality. Neurology, 17, 427–442. CrossRefPubMed Hoehn, M. M., & Yahr, M. D. (1967). Parkinsonism: Onset, progression, and mortality. Neurology, 17, 427–442. CrossRefPubMed
15.
go back to reference Psychiatric, American. (2013). Association diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing. Psychiatric, American. (2013). Association diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
16.
go back to reference Santangelo, G., Raimo, S., Siciliano, M., D’Iorio, A., Piscopo, F., Cuoco, S., et al. (2016). Assessment of apathy independent of physical disability: Validation of the Dimensional Apathy Scale in Italian healthy sample. Neurological Sciences, 38(2), 303–309. doi: 10.​1007/​s10072-016-2766-8. CrossRefPubMed Santangelo, G., Raimo, S., Siciliano, M., D’Iorio, A., Piscopo, F., Cuoco, S., et al. (2016). Assessment of apathy independent of physical disability: Validation of the Dimensional Apathy Scale in Italian healthy sample. Neurological Sciences, 38(2), 303–309. doi: 10.​1007/​s10072-016-2766-8. CrossRefPubMed
17.
go back to reference Santangelo, G., Falco, F., D’Iorio, A., Cuoco, S., Raimo, S., Amboni, M., et al. (2016). Anxiety in early Parkinson’s disease: Validation of the Italian observer-rated version of the Parkinson anxiety scale (OR-PAS). Journal of the Neurological Sciences, 367, 158–161. CrossRefPubMed Santangelo, G., Falco, F., D’Iorio, A., Cuoco, S., Raimo, S., Amboni, M., et al. (2016). Anxiety in early Parkinson’s disease: Validation of the Italian observer-rated version of the Parkinson anxiety scale (OR-PAS). Journal of the Neurological Sciences, 367, 158–161. CrossRefPubMed
18.
go back to reference Isella, V., Mapelli, C., Morielli, N., De Gaspari, D., Siri, C., Pezzoli, G., et al. (2013). Validity and metric of MiniMental Parkinson and MiniMental state examination in Parkinson’s disease. Neurological Sciences, 34(10), 1751–1758. CrossRefPubMed Isella, V., Mapelli, C., Morielli, N., De Gaspari, D., Siri, C., Pezzoli, G., et al. (2013). Validity and metric of MiniMental Parkinson and MiniMental state examination in Parkinson’s disease. Neurological Sciences, 34(10), 1751–1758. CrossRefPubMed
19.
go back to reference McHorney, C. A., & Tarlov, A. R. (1995). Individual-patient monitoring in clinical practice: Are available health status surveys adequate? Quality of Life Research, 4, 293–307. CrossRefPubMed McHorney, C. A., & Tarlov, A. R. (1995). Individual-patient monitoring in clinical practice: Are available health status surveys adequate? Quality of Life Research, 4, 293–307. CrossRefPubMed
20.
go back to reference Gravetter, F., & Wallnau, L. (2014). Essentials of statistics for the behavioral sciences (8th ed.). Belmont, CA: Wadsworth. Gravetter, F., & Wallnau, L. (2014). Essentials of statistics for the behavioral sciences (8th ed.). Belmont, CA: Wadsworth.
21.
go back to reference Cronbach, L. J. (1951). Coefficient alpha and the internal structure of tests. Psychometrika, 16, 297–334. CrossRef Cronbach, L. J. (1951). Coefficient alpha and the internal structure of tests. Psychometrika, 16, 297–334. CrossRef
22.
go back to reference Nunnally, J. C. (1978). Psychometric theory (2d ed.). New York: McGraw-Hill. Nunnally, J. C. (1978). Psychometric theory (2d ed.). New York: McGraw-Hill.
23.
go back to reference Ware, J. E., & Gandek, B. (1998). Methods for testing data quality, scaling assumptions, and reliability: The IQOLA project approach. Inter- national quality of life assessment. Journal of Clinical Epidemiology, 51, 945–952. CrossRefPubMed Ware, J. E., & Gandek, B. (1998). Methods for testing data quality, scaling assumptions, and reliability: The IQOLA project approach. Inter- national quality of life assessment. Journal of Clinical Epidemiology, 51, 945–952. CrossRefPubMed
26.
go back to reference Dujardin, K., Sockeel, P., Devos, D., Delliaux, M., Krystkowiak, P., Destée, A., et al. (2007). Characteristics of apathy in Parkinson’s disease. Movement Disorders, 22, 778–784. CrossRefPubMed Dujardin, K., Sockeel, P., Devos, D., Delliaux, M., Krystkowiak, P., Destée, A., et al. (2007). Characteristics of apathy in Parkinson’s disease. Movement Disorders, 22, 778–784. CrossRefPubMed
27.
go back to reference Haber, S. N., & Knutson, B. (2010). The reward circuit: Linking primate anatomy and human imaging. Neuropsychopharmacology, 35(1), 4–26. CrossRefPubMed Haber, S. N., & Knutson, B. (2010). The reward circuit: Linking primate anatomy and human imaging. Neuropsychopharmacology, 35(1), 4–26. CrossRefPubMed
28.
go back to reference Schultz, W. (2007). Behavioral dopamine signals. Trends in Neuroscience, 30, 203–210. CrossRef Schultz, W. (2007). Behavioral dopamine signals. Trends in Neuroscience, 30, 203–210. CrossRef
29.
go back to reference Martínez-Horta, S., Riba, J., de Bobadilla, R. F., Pagonabarraga, J., Pascual-Sedano, B., Antonijoan, R. M., et al. (2014). Apathy in Parkinson’s disease: Neurophysiological evidence of impaired incentive processing. Journal of Neurosciences, 34(17), 5918–5926. Martínez-Horta, S., Riba, J., de Bobadilla, R. F., Pagonabarraga, J., Pascual-Sedano, B., Antonijoan, R. M., et al. (2014). Apathy in Parkinson’s disease: Neurophysiological evidence of impaired incentive processing. Journal of Neurosciences, 34(17), 5918–5926.
30.
go back to reference Muhammed, K., Manohar, S., Yehuda, M. B., Chong, T. T., Tofaris, G., Lennox, G., et al. (2016). Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson’s disease. Brain, 139(Pt 10), 2706–2721. CrossRefPubMedPubMedCentral Muhammed, K., Manohar, S., Yehuda, M. B., Chong, T. T., Tofaris, G., Lennox, G., et al. (2016). Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson’s disease. Brain, 139(Pt 10), 2706–2721. CrossRefPubMedPubMedCentral
31.
go back to reference Amanzio, M., Torta, D. M., Sacco, K., Cauda, F., D’Agata, F., Duca, S., et al. (2011). Unawareness of deficits in Alzheimer’s disease: Role of the cingulate cortex. Brain, 134(Pt 4), 1061–1076. CrossRefPubMed Amanzio, M., Torta, D. M., Sacco, K., Cauda, F., D’Agata, F., Duca, S., et al. (2011). Unawareness of deficits in Alzheimer’s disease: Role of the cingulate cortex. Brain, 134(Pt 4), 1061–1076. CrossRefPubMed
32.
go back to reference den Brok, M. G., van Dalen, J. W., van Gool, W. A., Moll van Charante, E. P., de Bie, R. M., & Richard, E. (2015). Apathy in Parkinson’s disease: A systematic review and meta-analysis. Movement Disorders, 30, 759–769. CrossRef den Brok, M. G., van Dalen, J. W., van Gool, W. A., Moll van Charante, E. P., de Bie, R. M., & Richard, E. (2015). Apathy in Parkinson’s disease: A systematic review and meta-analysis. Movement Disorders, 30, 759–769. CrossRef
33.
go back to reference Santangelo, G., Vitale, C., Picillo, M., Moccia, M., Cuoco, S., Longo, K., et al. (2015). Mild cognitive impairment in newly diagnosed Parkinson’s disease: A longitudinal prospective study. Parkinsonism and Related Disorders, 21, 1219–1226. CrossRefPubMed Santangelo, G., Vitale, C., Picillo, M., Moccia, M., Cuoco, S., Longo, K., et al. (2015). Mild cognitive impairment in newly diagnosed Parkinson’s disease: A longitudinal prospective study. Parkinsonism and Related Disorders, 21, 1219–1226. CrossRefPubMed
34.
go back to reference Kirsch-Darrow, L., Marsiske, M., Okun, M.S., Bauer, R., Bowers, D. (2011). Apathy and depression: separate factors in Parkinson's disease. Journal of the International Neuropsychological Society, 17(6), 1058–1066 Kirsch-Darrow, L., Marsiske, M., Okun, M.S., Bauer, R., Bowers, D. (2011). Apathy and depression: separate factors in Parkinson's disease. Journal of the International Neuropsychological Society, 17(6), 1058–1066
Metagegevens
Titel
Assessment of apathy minimising the effect of motor dysfunctions in Parkinson’s disease: a validation study of the dimensional apathy scale
Auteurs
Gabriella Santangelo
Alfonsina D’Iorio
Fausta Piscopo
Sofia Cuoco
Katia Longo
Marianna Amboni
Chiara Baiano
Domenico Tafuri
Maria Teresa Pellecchia
Paolo Barone
Carmine Vitale
Publicatiedatum
07-04-2017
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1569-6

Andere artikelen Uitgave 9/2017

Quality of Life Research 9/2017 Naar de uitgave