Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

03-03-2016 | Original Paper

Asperger Syndrome and Schizophrenia: A Comparative Neuropsychological Study

Auteurs: Maria Marinopoulou, Tove Lugnegård, Maria Unenge Hallerbäck, Christopher Gillberg, Eva Billstedt

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2016

Abstract

There has been an increasing interest in possible connections between autism spectrum disorder (ASD) and schizophrenia in the last decade. Neuropsychological comparison studies have, however, been few. The present study examined similarities and differences in intellectual and executive functioning between adults with Asperger syndrome (AS) and adults with schizophrenic psychosis (SP). A group with AS and a group with SP were assessed neuropsychologically with WAIS-III and D-KEFS. Similarities were found between groups, as displayed by an uneven cognitive profile, limitations in working memory, processing speed and some aspects of executive functioning. Full Scale IQ was higher in the AS group. These results add to the current research illuminating similarities and differences between ASD and schizophrenia on a cognitive level.

vorige artikel Retrospective Descriptive Study of Cerebral Palsy in Nepal

volgende artikel Pretend Play and Social Engagement in Toddlers at High and Low Genetic Risk for Autism Spectrum Disorder

Ambery, F. Z., Russell, A. J., Perry, K., Morris, R., & Murphy, D. G. (2006). Neuropsychological functioning in adults with Asperger syndrome. Autism, 10(6), 551–564. doi:10.1177/1362361306068507.CrossRefPubMed

APA. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington, DC: American Psychiatric Association.

APA. (2013). Diagnostic and statistical manual of mental disorders: DSM-5. Washington, DC: American Psychiatric Association.

Bolte, S., Rudolf, L., & Poustka, F. (2002). The cognitive structure of higher functioning autism and schizophrenia: A comparative study. Comprehensive Psychiatry, 43(4), 325–330.CrossRefPubMed

Bowie, C. R., & Harvey, P. D. (2005). Cognition in schizophrenia: Impairments, determinants, and functional importance. Psychiatric Clinics of North America, 28(3), 613–633, 626. doi:10.1016/j.psc.2005.05.004.

Bowie, C. R., Leung, W. W., Reichenberg, A., McClure, M. M., Patterson, T. L., Heaton, R. K., & Harvey, P. D. (2008). Predicting schizophrenia patients’ real-world behavior with specific neuropsychological and functional capacity measures. Biological Psychiatry, 63(5), 505–511. doi:10.1016/j.biopsych.2007.05.022.CrossRefPubMed

Brune, M., & Bodenstein, L. (2005). Proverb comprehension reconsidered—’Theory of mind’ and the pragmatic use of language in schizophrenia. Schizophrenia Research, 75(2–3), 233–239. doi:10.1016/j.schres.2004.11.006.CrossRefPubMed

Burbach, J. P., & van der Zwaag, B. (2009). Contact in the genetics of autism and schizophrenia. Trends in Neurosciences, 32(2), 69–72. doi:10.1016/j.tins.2008.11.002.CrossRefPubMed

Bustini, M., Stratta, P., Daneluzzo, E., Pollice, R., Prosperini, P., & Rossi, A. (1999). Tower of Hanoi and WCST performance in schizophrenia: Problem-solving capacity and clinical correlates. Journal of Psychiatric Research, 33(3), 285–290.CrossRefPubMed

CDC. (2014). Prevalence of autism spectrum disorder among children aged 8 years—Autism and developmental disabilities monitoring network, 11 sites, United States, 2010 MMWR. Surveillance Summaries (2014/03/29 ed., Vol. 63, pp. 1–21).

Cath, D. C., Ran, N., Smit, J. H., van Balkom, A. J., & Comijs, H. C. (2008). Symptom overlap between autism spectrum disorder, generalized social anxiety disorder and obsessive compulsive disorder in adults: A preliminary case-controlled study. Psychopathology, 41(2), 101–110.CrossRefPubMed

Cederlund, M. (2007). Boys with Asperger syndrome grown up. A longitudinal follow-up study of 100 cases more than 5 years after original diagnosis. Retrieved from http://hdl.handle.net/2077/3143.

Chan, R. C., Shum, D., Toulopoulou, T., & Chen, E. Y. (2008). Assessment of executive functions: Review of instruments and identification of critical issues. Archives of Clinical Neuropsychology, 23(2), 201–216. doi:10.1016/j.acn.2007.08.010.CrossRefPubMed

Cheung, C., Yu, K., Fung, G., Leung, M., Wong, C., Li, Q., et al. (2010). Autistic disorders and schizophrenia: Related or remote? An anatomical likelihood estimation. PLoS One, 5(8), e12233. doi:10.1371/journal.pone.0012233.CrossRefPubMedPubMedCentral

Chisholm, K., Lin, A., Abu-Akel, A., & Wood, S. J. (2015). The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence. Neuroscience and Biobehavioral Reviews. doi:10.1016/j.neubiorev.2015.04.012.

de Boer, M., Spek, A. A., & Lobbestael, J. (2014). Comparing cognitive functioning in schizophrenia and autism using WAIS-III. Research in Autism Spectrum Disorders, 8(7), 737–745. doi:10.1016/j.rasd.2014.03.001.CrossRef

De Herdt, A., Wampers, M., Vancampfort, D., De Hert, M., Vanhees, L., Demunter, H., et al. (2013). Neurocognition in clinical high risk young adults who did or did not convert to a first schizophrenic psychosis: A meta-analysis. Schizophrenia Research, 149(1–3), 48–55. doi:10.1016/j.schres.2013.06.017.CrossRefPubMed

Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). Delis–Kaplan Executive Function System (D-KEFS)—examiner’s manual. San Antonio, TX: The Psychological Corporation.

Done, D. J., Crow, T. J., Johnstone, E. C., & Sacker, A. (1994). Childhood antecedents of schizophrenia and affective illness: Social adjustment at ages 7 and 11. BMJ, 309, 699–703.CrossRefPubMedPubMedCentral

Eack, S. M., Bahorik, A. L., McKnight, S. A., Hogarty, S. S., Greenwald, D. P., Newhill, C. E., et al. (2013a). Commonalities in social and non-social cognitive impairments in adults with autism spectrum disorder and schizophrenia. Schizophrenia Research, 148(1–3), 24–28. doi:10.1016/j.schres.2013.05.013.CrossRefPubMedPubMedCentral

Eack, S. M., Greenwald, D. P., Hogarty, S. S., Bahorik, A. L., Litschge, M. Y., Mazefsky, C. A., & Minshew, N. J. (2013b). Cognitive enhancement therapy for adults with autism spectrum disorder: Results of an 18-month feasibility study. Journal of Autism and Developmental Disorders, 43(12), 2866–2877. doi:10.1007/s10803-013-1834-7.CrossRefPubMed

Faraone, S. V., & Glatt, S. J. (2010). A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. Journal of Clinical Psychiatry, 71(6), 754–763. doi:10.4088/JCP.08m04902pur.CrossRefPubMed

Fatemi, S. H., & Folsom, T. D. (2009). The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophrenia Bulletin, 35(3), 528–548. doi:10.1093/schbul/sbn187.CrossRefPubMedPubMedCentral

Fatouros-Bergman, H., Cervenka, S., Flyckt, L., Edman, G., & Farde, L. (2014). Meta-analysis of cognitive performance in drug-naive patients with schizophrenia. Schizophrenia Research, 158(1–3), 156–162. doi:10.1016/j.schres.2014.06.034.CrossRefPubMed

First, M. B., & Gibbon, M. (2004). The structured clinical interview for DSM-IV axis I disorders (SCID-I) and the structured clinical interview for DSM-IV axis II disorders (SCID-II). In M. J. Hilsenroth & D. L. Segal (Eds.), Comprehensive handbook of psychological assessment. Personality assessment (Vol. 2, pp. 134–143). Hoboken, NJ: Wiley.

Frazier, T. W., Georgiades, S., Bishop, S. L., & Hardan, A. Y. (2014). Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection. Journal of the American Academy of Child and Adolescent Psychiatry, 53(3), 329–340 e321–323. doi:10.1016/j.jaac.2013.12.004.

Fusar-Poli, P., Deste, G., Smieskova, R., Barlati, S., Yung, A. R., Howes, O., et al. (2012). Cognitive functioning in prodromal psychosis: A meta-analysis. Archives of General Psychiatry, 69(6), 562–571. doi:10.1001/archgenpsychiatry.2011.1592.CrossRefPubMed

Geschwind, D. H. (2011). Genetics of autism spectrum disorders. Trends in Cognitive Sciences, 15(9), 409–416. doi:10.1016/j.tics.2011.07.003.CrossRefPubMedPubMedCentral

Goldstein, G., Minshew, N. J., Allen, D. N., & Seaton, B. E. (2002). High-functioning autism and schizophrenia: A comparison of an early and late onset neurodevelopmental disorder. Archives of Clinical Neuropsychology, 17(5), 461–475.CrossRefPubMed

Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J. (2000). Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the “right stuff”? Schizophrenia Bulletin, 26(1), 119–136.CrossRefPubMed

Haas, M. H., Chance, S. A., Cram, D. F., Crow, T. J., Luc, A., & Hage, S. (2014). Evidence of pragmatic impairments in speech and proverb interpretation in schizophrenia. Journal of Psycholinguistic Research,. doi:10.1007/s10936-014-9298-2.

Hallerbäck, M. U., Lugnegård, T., & Gillberg, C. (2012). Is autism spectrum disorder common in schizophrenia? Psychiatry Research, 198(1), 12–17. doi:10.1016/j.psychres.2012.01.016.CrossRef

Happé, F. G. E. (1995). Understanding minds and metaphors: Insights from the study of figurative language in autism. Metaphor and Symbolic Activity, 10(4), 275–295. doi:10.1207/s15327868ms1004_3.CrossRef

Happé, F., Booth, R., Charlton, R., & Hughes, C. (2006). Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: Examining profiles across domains and ages. Brain and Cognition, 61(1), 25–39. doi:10.1016/j.bandc.2006.03.004.CrossRefPubMed

Hill, E. L. (2004). Executive dysfunction in autism. Trends in Cognitive Sciences, 8(1), 26–32.CrossRefPubMed

Hill, E. L., & Frith, U. (2003). Understanding autism: Insights from mind and brain. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 358(1430), 281–289. doi:10.1098/rstb.2002.1209.CrossRefPubMedPubMedCentral

Hogarty, G. E., Flesher, S., Ulrich, R., Carter, M., Greenwald, D., Pogue-Geile, M., et al. (2004). Cognitive enhancement therapy for schizophrenia: Effects of a 2-year randomized trial on cognition and behavior. Archives of General Psychiatry, 61(9), 866–876. doi:10.1001/archpsyc.61.9.866.

Holdnack, J., Goldstein, G., & Drozdick, L. (2011). Social perception and WAIS-IV performance in adolescents and adults diagnosed with Asperger’s syndrome and autism. Assessment, 18(2), 192–200. doi:10.1177/1073191110394771.CrossRefPubMed

Howlin, P. (2003). Outcome in high-functioning adults with autism with and without early language delays: Implications for the differentiation between autism and Asperger syndrome. Journal of Autism and Developmental Disorders, 33(1), 3–13.CrossRefPubMed

International Schizophrenia Consortium (ISC). (2008). Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature, 455(7210), 237–241.

Jones, P., Rodgers, B., Murray, R., & Marmot, M. (1994). Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet, 344(8934), 1398–1402.CrossRefPubMed

Keefe, R. S., Bilder, R. M., Davis, S. M., Harvey, P. D., Palmer, B. W., Gold, J. M., et al. (2007). Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Archives of General Psychiatry, 64(6), 633–647. doi:10.1001/archpsyc.64.6.633.CrossRefPubMed

King, B. H., & Lord, C. (2011). Is schizophrenia on the autism spectrum? Brain Research, 1380, 34–41. doi:10.1016/j.brainres.2010.11.031.CrossRefPubMed

Kleinhans, N., Akshoomoff, N., & Delis, D. C. (2005). Executive functions in autism and Asperger’s disorder: Flexibility, fluency, and inhibition. Developmental Neuropsychology, 27(3), 379–401. doi:10.1207/s15326942dn2703_5.CrossRefPubMed

Kurtz, M. M. (2006). Symptoms versus neurocognitive skills as correlates of everyday functioning in severe mental illness. Expert Review of Neurotherapeutics, 6(1), 47–56. doi:10.1586/14737175.6.1.47.CrossRefPubMed

Lugnegard, T., Hallerback, M. U., & Gillberg, C. (2015). Asperger syndrome and schizophrenia: Overlap of self-reported autistic traits using the Autism-spectrum Quotient (AQ). Nordic Journal of Psychiatry, 69(4), 268–274. doi:10.3109/08039488.2014.972452.CrossRefPubMed

Lugnegård, T., Hallerbäck, M. U., & Gillberg, C. (2011). Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome. Research in Developmental Disabilities, 32(5), 1910–1917. doi:10.1016/j.ridd.2011.03.025.CrossRefPubMed

Lugnegård, T., Hallerbäck, M. U., & Gillberg, C. (2012). Personality disorders and autism spectrum disorders: What are the connections? Comprehensive Psychiatry, 53(4), 333–340. doi:10.1016/j.comppsych.2011.05.014.CrossRefPubMed

Lugnegård, T., Hallerbäck, M. U., Hjärthag, F., & Gillberg, C. (2013). Social cognition impairments in Asperger syndrome and schizophrenia. Schizophrenia Research, 143(2–3), 277–284. doi:10.1016/j.schres.2012.12.001.CrossRefPubMed

Macintosh, K. E., & Dissanayake, C. (2004). Annotation: The similarities and differences between autistic disorder and Asperger’s disorder: A review of the empirical evidence. Journal of Child Psychology and Psychiatry and Allied Disciplines, 45(3), 421–434.CrossRef

Matsuo, J., Kamio, Y., Takahashi, H., Ota, M., Teraishi, T., Hori, H., et al. (2015). Autistic-like traits in adult patients with mood disorders and schizophrenia. PLoS ONE, 10(4), e0122711. doi:10.1371/journal.pone.0122711.CrossRefPubMedPubMedCentral

Morris, R. G., Rushe, T., Woodruffe, P. W., & Murray, R. M. (1995). Problem solving in schizophrenia: A specific deficit in planning ability. Schizophrenia Research, 14(3), 235–246.CrossRefPubMed

Niemi, L. T., Suvisaari, J. M., Tuulio-Henriksson, A., & Lonnqvist, J. K. (2003). Childhood developmental abnormalities in schizophrenia: Evidence from high-risk studies. Schizophrenia Research, 60(2–3), 239–258.CrossRefPubMed

Nordin, V., & Gillberg, C. (1998). The long-term course of autistic disorders: Update on follow-up studies. Acta Psychiatrica Scandinavica, 97(2), 99–108.CrossRefPubMed

Nygren, G., Hagberg, B., Billstedt, E., Skoglund, A., Gillberg, C., & Johansson, M. (2009). The Swedish version of the diagnostic interview for social and communication disorders (DISCO-10). Psychometric properties. Journal of Autism and Developmental Disorders, 39, 730–741.CrossRefPubMed

Nylander, L., Lugnegård, T., & Hallerbäck, M. U. (2008). Autism spectrum disorders and schizophrenia spectrum disorders in adults—Is there a connection? A literature review and some suggestions for future clinical research. Clinical Neuropsychiatry, 5(1), 43–54.

Orellana, G., & Slachevsky, A. (2013). Executive functioning in schizophrenia. Front Psychiatry, 4, 35. doi:10.3389/fpsyt.2013.00035.CrossRefPubMedPubMedCentral

Ozonoff, S., Cook, I., Coon, H., Dawson, G., Joseph, R. M., Klin, A., et al. (2004). Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: Evidence from the Collaborative Programs of Excellence in Autism network. Journal of Autism and Developmental Disorders, 34(2), 139–150.CrossRefPubMed

Palmer, B. W., Dawes, S. E., & Heaton, R. K. (2009). What do we know about neuropsychological aspects of schizophrenia? Neuropsychology Review, 19(3), 365–384. doi:10.1007/s11065-009-9109-y.CrossRefPubMedPubMedCentral

Pisula, E. (2010). The autistic mind in the light of neuropsychological studies. Acta Neurobiologiae Experimentalis (Wars), 70(2), 119–130.

Rapoport, J., Chavez, A., Greenstein, D., Addington, A., & Gogtay, N. (2009). Autism spectrum disorders and childhood-onset schizophrenia: Clinical and biological contributions to a relation revisited. Journal of the American Academy of Child and Adolescent Psychiatry, 48(1), 10–18. doi:10.1097/CHI.0b013e31818b1c63.CrossRefPubMedPubMedCentral

Rapoport, J. L., Giedd, J. N., & Gogtay, N. (2012). Neurodevelopmental model of schizophrenia: Update 2012. Molecular Psychiatry, 17(12), 1228–1238. doi:10.1038/mp.2012.23.CrossRefPubMedPubMedCentral

Reichenberg, A. (2010). The assessment of neuropsychological functioning in schizophrenia. Dialogues in Clinical Neuroscience, 12(3), 383–392.PubMed

Reiersen, A. M., Constantino, J. N., Volk, H. E., & Todd, R. D. (2007). Autistic traits in a population-based ADHD twin sample. Journal of Child Psychology and Psychiatry and Allied Disciplines, 48(5), 464–472. doi:10.1111/j.1469-7610.2006.01720.x.CrossRef

Spek, A., Scholte, E. M., & van Berckelaer-Onnes, I. A. (2008). Brief report: The use of WAIS-III in adults with HFA and Asperger syndrome. Journal of Autism and Developmental Disorders, 38(4), 782–787. doi:10.1007/s10803-007-0446-5.CrossRefPubMed

Tandon, R., Nasrallah, H. A., & Keshavan, M. S. (2009). Schizophrenia, “just the facts” 4. Clinical features and conceptualization. Schizophrenia Research, 110(1–3), 1–23. doi:10.1016/j.schres.2009.03.005.CrossRefPubMed

Thoma, P., Hennecke, M., Mandok, T., Wahner, A., Brune, M., Juckel, G., & Daum, I. (2009). Proverb comprehension impairments in schizophrenia are related to executive dysfunction. Psychiatry Research, 170(2–3), 132–139. doi:10.1016/j.psychres.2009.01.026.CrossRefPubMed

Treasure, J. (2013). Coherence and other autistic spectrum traits and eating disorders: Building from mechanism to treatment. The Birgit Olsson lecture. Nordic Journal of Psychiatry, 67(1), 38–42. doi:10.3109/08039488.2012.674554.CrossRefPubMed

Tsai, L. Y., & Ghaziuddin, M. (2014). DSM-5 ASD moves forward into the past. Journal of Autism and Developmental Disorders, 44(2), 321–330. doi:10.1007/s10803-013-1870-3.CrossRefPubMed

van Os, J., & Kapur, S. (2009). Schizophrenia. The Lancet, 374(9690), 635–645.CrossRef

Via, E., Radua, J., Cardoner, N., Happe, F., & Mataix-Cols, D. (2011). Meta-analysis of gray matter abnormalities in autism spectrum disorder: Should Asperger disorder be subsumed under a broader umbrella of autistic spectrum disorder? Archives of General Psychiatry, 68(4), 409–418. doi:10.1001/archgenpsychiatry.2011.27.CrossRefPubMed

Volkmar, F. R., Szatmari, P., & Sparrow, S. S. (1993). Sex differences in pervasive developmental disorders. Journal of Autism and Developmental Disorders, 23(4), 579–591.CrossRefPubMed

Waris, P., Lindberg, N., Kettunen, K., & Tani, P. (2013). The relationship between Asperger’s syndrome and schizophrenia in adolescence. European Child and Adolescent Psychiatry, 22(4), 217–223. doi:10.1007/s00787-012-0338-x.CrossRefPubMed

Wechsler, D. (1974). Wechsler Intelligence Scale for Children—Revised: New York: Psychological Corporation.

Wechsler, D. (1981). Wechsler adult intelligence scale-revised. San Antonio: Psychological Corporation Limited.

Wechsler, D. (1997). Wechsler adult scale of intelligence (3rd ed.). San Antonio, TX: The Psychological Corporation.

Wing, L., Leekam, S. R., Libby, S. J., Gould, J., & Larcombe, M. (2002). The diagnostic interview for social and communication disorders: Background, inter-rater reliability and clinical use. Journal of Child Psychology and Psychiatry, 43, 307–325.CrossRefPubMed

Wodka, E. L., Loftis, C., Mostofsky, S. H., Prahme, C., Larson, J. C., Denckla, M. B., & Mahone, E. M. (2008). Prediction of ADHD in boys and girls using the D-KEFS. Archives of Clinical Neuropsychology, 23(3), 283–293. doi:10.1016/j.acn.2007.12.004.CrossRefPubMedPubMedCentral

World Health Organisation. (1992). International statistical classification of diseases and related health problems, 10th Revision (ICD-10). Geneva: WHO.

Wouters, S. G., & Spek, A. A. (2011). The use of the autism-spectrum quotient in differentiating high-functioning adults with autism, adults with schizophrenia and a neurotypical adult control group. Research in Autism Spectrum Disorders, 5, 1169–1175.CrossRef

Titel: Asperger Syndrome and Schizophrenia: A Comparative Neuropsychological Study
Auteurs: Maria Marinopoulou
Tove Lugnegård
Maria Unenge Hallerbäck
Christopher Gillberg
Eva Billstedt
Publicatiedatum: 03-03-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-016-2758-9

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 7/2016

Brief Report: Autism Spectrum Disorder and Substance Use Disorder: A Review and Case Study

The Effect of Parenting Style on Social Smiling in Infants at High and Low Risk for ASD

Service Needs Across the Lifespan for Individuals with Autism

Brief Report: Ages of Language Milestones as Predictors of Developmental Trajectories in Young Children with Autism Spectrum Disorder

The Relationship Between Early Neural Responses to Emotional Faces at Age 3 and Later Autism and Anxiety Symptoms in Adolescents with Autism

Learning with Technology: Video Modeling with Concrete–Representational–Abstract Sequencing for Students with Autism Spectrum Disorder