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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2008

01-02-2008 | Original Paper

Are There Enhanced MBP Autoantibodies in Autism?

Auteurs: Jane E. Libbey, Hilary H. Coon, Nikki J. Kirkman, Thayne L. Sweeten, Judith N. Miller, Edward K. Stevenson, Janet E. Lainhart, William M. McMahon, Robert S. Fujinami

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2008

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Abstract

Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism.
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Metagegevens
Titel
Are There Enhanced MBP Autoantibodies in Autism?
Auteurs
Jane E. Libbey
Hilary H. Coon
Nikki J. Kirkman
Thayne L. Sweeten
Judith N. Miller
Edward K. Stevenson
Janet E. Lainhart
William M. McMahon
Robert S. Fujinami
Publicatiedatum
01-02-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0400-6

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