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Journal of Autism and Developmental Disorders

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01-12-2012 | Original Paper

Are Prenatal Ultrasound Scans Associated with the Autism Phenotype? Follow-up of a Randomised Controlled Trial

Auteurs: Yonit K. Stoch, Cori J. Williams, Joanna Granich, Anna M. Hunt, Lou I. Landau, John P. Newnham, Andrew J. O. Whitehouse

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2012

Abstract

An existing randomised controlled trial was used to investigate whether multiple ultrasound scans may be associated with the autism phenotype. From 2,834 single pregnancies, 1,415 were selected at random to receive ultrasound imaging and continuous wave Doppler flow studies at five points throughout pregnancy (Intensive) and 1,419 to receive a single imaging scan at 18 weeks (Regular), with further scans only as indicated on clinical grounds. There was no significant difference in the rate of Autism Spectrum Disorder between the Regular (9/1,125, 0.8 %) and Intensive (7/1,167, 0.6 %) groups, nor a difference between groups in the level of autistic-like traits in early adulthood. There is no clear link between the frequency and timing of prenatal ultrasound scans and the autism phenotype.

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i.e., (A × B) × (C × D) = 0.30 participants.

A is the number of live-born singleton offspring (n = 2,821); B is the percentage of the current sample who did not provide any diagnostic data at 10 years of age or older (0.171); C is the percentage of individuals with ASD in Australia who are diagnosed beyond 10 years of age (0.10); D = the prevalence of ASD in Australia (0.00625).

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Titel: Are Prenatal Ultrasound Scans Associated with the Autism Phenotype? Follow-up of a Randomised Controlled Trial
Auteurs: Yonit K. Stoch
Cori J. Williams
Joanna Granich
Anna M. Hunt
Lou I. Landau
John P. Newnham
Andrew J. O. Whitehouse
Publicatiedatum: 01-12-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 12/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-012-1526-8

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