Swipe om te navigeren naar een ander artikel
Variation in the promoter region of the serotonin transporter gene (5-HTTLPR) has been linked to various cognitive-affective indices of stress sensitivity hypothesized to underlie vulnerability to depression. The current study examined the association of 5-HTTLPR with appraisals of naturally occurring acute life stressors in a community sample of 384 youth at elevated risk for depression due to oversampling for maternal depression. Interview measures administered at youth age 20 were used to assess subjective and objective (assigned by an independent rating team) appraisals of the negative impact of recent acute stressful life events. The presence of at least one S allele was associated with elevated subjective appraisals of the negative impact of acute stressors (P = 0.03). Consistent with an endophenotype perspective, support was found for a 5-HTTLPR-stress appraisals-depression mediation model both concurrently and longitudinally. Results indicate that enhanced stress sensitivity may act as an intermediate phenotype through which 5-HTTLPR affects risk for depression.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Beck, A. T., Steer, R. A., & Brown, G. K. (1996). The beck depression inventory (2nd ed.). San Antonio, TX: The Psychological Corporation.
Bedford, A., & Foulds, G. (1978). Delusions-symptoms-states inventory of anxiety and depression. Windsor, England: NFER.
Brown, G. W., & Harris, T. O. (1978). Social origins of depression: A study of psychiatric disorder in women. New York: Free Press.
Collins, L. M., Graham, J. W., & Flaherty, B. P. (1998). An alternative framework for defining mediation. Multivariate Behavioral Research,33, 295–312. CrossRef
Conway, C. C., Hammen, C., Brennan, P. A., Lind, P. A., & Najman, J. M. (2010). Interaction of chronic stress with serotonin transporter and catechol- O-methyltransferase polymorphisms in predicting youth depression. Depression and Anxiety,27, 737–745. PubMed
Espejo, E. P., Ferriter, C. T., Hazel, N. A., Keenan-Miller, D., Hoffmann, L. R., & Hammen, C. (2010). Predictors of subjective ratings of stressor severity: The effects of current mood and neuroticism. Stress and Health Epub ahead of print, doi: 10.1002/smi.1315.
Eysenck, S. B. G., & Barrett, P. (1985). A revised version of the psychoticism scale. Personality and Individual Differences,6, 21–29. CrossRef
Eysenck, H. J., & Eysenck, S. B. G. (1975). Manual of the Eysenck personality questionnaire. London, England: Hodder & Stoughton.
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1995). Structured clinical interview for DSM-IV axis I DISORDERS. Washington, D.C.: American Psychiatric Press.
Gotlib, I., & Hammen, C. (Eds.). (2008). Handbook of depression (2nd ed.). New York: Guilford Press.
Jabbi, M., Korf, J., Kema, I. P., Hartman, C., van der Pompe, G., Minderaa, R. B., et al. (2007). Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA. Molecular Psychiatry,12, 483–490. PubMed
Janssens, A. C., & van Duijin, C. M. (2008). Genome-based prediction of common diseases: Advances and prospects. Human Molecular Genetics,17, 166–173. CrossRef
Keeping, J. D., Najman, J. M., Morrison, J., Western, J. S., Andersen, M. J., & Williams, G. M. (1989). A prospective longitudinal study of social, psychological, and obstetrical factors in pregnancy: Response rates and demographic characteristics of the 8, 556 respondents. British Journal of Obstetrics and Gynaecology,96, 289–297. PubMedCrossRef
MacKinnon, D. P. (2000). Contrasts in multiple mediator models. In J. S. Rose, L. Chassin, C. C. Presson, & S. J. Sherman (Eds.), Multivariate applications in substance use research: New methods for new questions (pp. 141–160). Mahwah, NJ: Erlbaum.
MacKinnon, D. P., & Dwyer, J. H. (1993). Estimation of mediated effects in prevention studies. Evaluation Review, 17, 144–158. CrossRef
MacKinnon, D. P., Fritz, M. S., Williams, J., & Lockwood, C. M. (2007). Distribution of the product confidence limits for the indirect effect: Program PRODCLIN. Behavioral Research Methods,39, 384–389. CrossRef
Wray, N. R., James, M. R., Gordon, S. D., Dumenil, T., Ryan, L., & Coventry, W. L. (2009). Accurate, large-scale genotyping of 5HTTLPR and flanking single nucleotide polyomrphisms in an association study of depression, anxiety, and personality measures. Biological Psychiatry,66, 468–476. PubMedCrossRef
- Appraisals of Stressful Life Events as a Genetically-Linked Mechanism in the Stress–Depression Relationship
Christopher C. Conway
Emmanuel P. Espejo
Naomi R. Wray
Jake M. Najman
Patricia A. Brennan
- Springer US