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Gepubliceerd in: TPO - De Praktijk 5/2013

01-10-2013 | Nascholing

Appels met peren vergelijken bij diabetes type 2

Auteur: Dr. Mattees van Dijk

Gepubliceerd in: TvPO | Uitgave 5/2013

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Extract

  • Vetweefsel speelt een sleutelrol in de energiehuishouding, en daarmee bij obesitas en diabetes type 2.
  • Na de geboorte neemt het aantal adipocyten (vetcellen) toe: bij obese kinderen al vanaf het 2e levensjaar en bij niet-obese kinderen pas vanaf het 6e.
  • Te actieve adipocyten leiden tot de overproductie van ontstekingsfactoren en beschadiging van het vaatendotheel.
  • Te actief vetweefsel kan leiden tot insulineresistentie en hyperinsulinemie.
  • Hyperinsulinemie leidt tot dyslipidemie.
  • Obesitas is het gevolg van een ingewikkeld samenspel van genetica, psychologie en omgevingsfactoren.
  • Mensen met diabetes type 2 hebben van nature minder adipocyten. Maar deze adipocyten hebben een veel groter volume dan die van mensen zonder diabetes type 2.
  • Veel spierweefsel hebben maakt het lichaam gevoeliger voor insuline.
  • Centrale obesitas (‘appeltype’) is geassocieerd met een hoger risico op diabetes type 2 en hart- en vaatziekten.
  • Er zijn op dit moment nog geen goede parameters om hoogrisicogroepen mee op te sporen aangezien BMI, buikomvang en waist-to-hip ratio (taille-heupratio) niet voldoen.
Literatuur
1.
go back to reference Sam S, Haffner S, Davidson MH, D’Agostino RB Sr, Feinstein S, Kondos G, et al. Relation of abdominal fat depots to systemic markers of inflammation in type 2 diabetes. Diabetes Care 2009;32:932–7.PubMedCrossRef Sam S, Haffner S, Davidson MH, D’Agostino RB Sr, Feinstein S, Kondos G, et al. Relation of abdominal fat depots to systemic markers of inflammation in type 2 diabetes. Diabetes Care 2009;32:932–7.PubMedCrossRef
2.
go back to reference D’Adamo E, Cali AMG, Weiss R, Santoro N, Pierpont B, Northrup V, et al. Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents. Diabetes Care 2010;33:1817–22.PubMedCrossRef D’Adamo E, Cali AMG, Weiss R, Santoro N, Pierpont B, Northrup V, et al. Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents. Diabetes Care 2010;33:1817–22.PubMedCrossRef
3.
go back to reference Pou KM, Massaro JM, Hoffmann U, Lieb K, Vasan RS, O’Donnell CJ, et al. Patterns of abdominal fat distribution: The Framingham Heart Study. Diabetes Care 2009;32:481–5.PubMedCrossRef Pou KM, Massaro JM, Hoffmann U, Lieb K, Vasan RS, O’Donnell CJ, et al. Patterns of abdominal fat distribution: The Framingham Heart Study. Diabetes Care 2009;32:481–5.PubMedCrossRef
4.
go back to reference Eckel RH, Kahn SE, Ferrannini E, Goldfine AB, Nathan DM, Schwartz MW, et al. Obesity and type 2 diabetes: What can be unified and what needs to be individualized? Diabetes Care 2011;34:1424–30.PubMedCrossRef Eckel RH, Kahn SE, Ferrannini E, Goldfine AB, Nathan DM, Schwartz MW, et al. Obesity and type 2 diabetes: What can be unified and what needs to be individualized? Diabetes Care 2011;34:1424–30.PubMedCrossRef
5.
go back to reference Wassink AM, Van der Graaf Y, Van Haeften TW, Spiering W, Soedamah-Muthu SS, Visseren FL; SMART Study Group. Waist circumference and metabolic risk factors have separate and additive effects on the risk of future type 2 diabetes in patients with vascular diseases: A cohort study. Diabet Med 2011;28:932–40.PubMedCrossRef Wassink AM, Van der Graaf Y, Van Haeften TW, Spiering W, Soedamah-Muthu SS, Visseren FL; SMART Study Group. Waist circumference and metabolic risk factors have separate and additive effects on the risk of future type 2 diabetes in patients with vascular diseases: A cohort study. Diabet Med 2011;28:932–40.PubMedCrossRef
6.
go back to reference Sam S, Haffner S, Davidson MH, D’Agostino RB Sr, Feinstein S, Kondos G, et al. Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes. Diabetes 2008;57:2022–7.PubMedCrossRef Sam S, Haffner S, Davidson MH, D’Agostino RB Sr, Feinstein S, Kondos G, et al. Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes. Diabetes 2008;57:2022–7.PubMedCrossRef
7.
go back to reference Pasarica M, Xie H, Hymel D, Bray G, Greenway F, Ravussin E, et al. Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes. Diabetes Care 2009;32:900–2.PubMedCrossRef Pasarica M, Xie H, Hymel D, Bray G, Greenway F, Ravussin E, et al. Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes. Diabetes Care 2009;32:900–2.PubMedCrossRef
8.
go back to reference Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, et al. Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age. JAMA 2013;310:280–8.PubMedCrossRef Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, et al. Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age. JAMA 2013;310:280–8.PubMedCrossRef
9.
go back to reference Look AHEAD Research Group, Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013;369:145–54.CrossRef Look AHEAD Research Group, Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013;369:145–54.CrossRef
10.
go back to reference Porter SA, Massaro JM, Hoffmann U, Vasan RS, O’Donnel CJ, Fox CS. Abdominal subcutaneous adipose tissue: A protective fat depot? Diabetes Care 2009;32:1068–75.PubMedCrossRef Porter SA, Massaro JM, Hoffmann U, Vasan RS, O’Donnel CJ, Fox CS. Abdominal subcutaneous adipose tissue: A protective fat depot? Diabetes Care 2009;32:1068–75.PubMedCrossRef
11.
go back to reference Diabetes Prevention Program Outcomes Study Research Group, Orchard TJ, Temprosa M, Barrett-Connor E, Fowler SE, Goldberg RB, et al. Long-term effects of the Diabetes Prevention Program interventions on cardiovascular risk factors: A report from the DPP Outcomes Study. Diabet Med 2013;30:46–55.PubMedCrossRef Diabetes Prevention Program Outcomes Study Research Group, Orchard TJ, Temprosa M, Barrett-Connor E, Fowler SE, Goldberg RB, et al. Long-term effects of the Diabetes Prevention Program interventions on cardiovascular risk factors: A report from the DPP Outcomes Study. Diabet Med 2013;30:46–55.PubMedCrossRef
12.
go back to reference Kursawe R, Eszlinger M, Narayan D, Liu T, Bazuine M, Cali AM, et al. Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: Association with insulin resistance and hepatic steatosis. Diabetes 2010;59:2288–96.PubMedCrossRef Kursawe R, Eszlinger M, Narayan D, Liu T, Bazuine M, Cali AM, et al. Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: Association with insulin resistance and hepatic steatosis. Diabetes 2010;59:2288–96.PubMedCrossRef
Metagegevens
Titel
Appels met peren vergelijken bij diabetes type 2
Auteur
Dr. Mattees van Dijk
Publicatiedatum
01-10-2013
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
TvPO / Uitgave 5/2013
Print ISSN: 2666-9838
Elektronisch ISSN: 2666-9846
DOI
https://doi.org/10.1007/s12503-013-0086-5

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