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Research on Child and Adolescent Psychopathology

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01-04-2012

Anxiety in Children with Mood Disorders: A Treatment Help or Hindrance?

Auteurs: Colleen M. Cummings, Mary A. Fristad

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 3/2012

Abstract

This study examined the role of comorbid anxiety in treatment outcome for children with mood disorders (N = 165; age 8–11) participating in Multi-Family Psychoeducational Psychotherapy (MF-PEP). Assessments occurred at baseline, 6, 12, and 18 months for two randomly assigned groups: immediate treatment and 1-year wait-list. Most children (69%) had comorbid anxiety disorders. Baseline comorbid anxiety, as reported on the Children’s Interview for Psychiatric Syndromes (ChIPS), was associated with higher Children’s Depression Rating Scale- Revised (CDRS-R) scores but not Young Mania Rating Scale (YMRS) scores. Higher levels of anxiety symptoms were associated with lower Children’s Global Assessment Scale (C-GAS) scores. Participation in MF-PEP did not significantly reduce anxiety symptoms (p = 0.62). However, presence of comorbid anxiety did not impede reduction in depressive (CDRS-R, p = 0.74) or manic (YMRS scores, p = 0.94) symptoms following MF-PEP. More baseline anxiety symptoms were associated with greater improvement in C-GAS scores post-treatment (p = 0.02). Implications are discussed.

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Albano, A. M., & Kendall, P. C. (2002). Cognitive behavioural therapy for children and adolescents with anxiety disorders: clinical research advances. International Review of Psychiatry, 14(2), 129–134.CrossRef

Asarnow, J. R., Emslie, G., Clarke, G., Wagner, K. D., Spirito, A., Vitiello, B., et al. (2009). Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: Predictors and moderators of treatment response. Journal of the American Academy of Child and Adolescent Psychiatry, 48(3), 330–339.PubMed

Aschenbrand, S. G., Kendall, P. C., Webb, A., Safford, S. M., & Flannery-Schroeder, E. (2003). Is childhood separation anxiety disorder a predictor of adult panic disorder and agoraphobia? A seven-year longitudinal study. Journal of the American Academy of Child and Adolescent Psychiatry, 42(12), 1478–1485.PubMedCrossRef

Avenevoli, S., Stollar, M., Li, J., Dierker, L., & Merikangas, K. R. (2001). Comorbidity of depression in children and adolescents: models and evidence from a prospective high-risk family study. Biological Psychiatry, 49, 1071–1081.PubMedCrossRef

Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51(6), 1173–1183.PubMedCrossRef

Berkson, J. (1946). Limitations of the application of fourfold table analysis to hospital data. Biometrics Bulletin, 2(3), 47–53.PubMedCrossRef

Birmaher, B., Brent, D., & the AACAP Work Group on Quality Issues. (2007). Practice parameter for the assessment and treatment of children and adolescents with depressive disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 46(11), 1503–1525.CrossRef

Birmaher, B., Kennah, A., Brent, D., Ehmann, M., Bridge, J., & Axelson, D. (2002). Is bipolar disorder specifically associated with panic disorders in youths? Journal of Clinical Psychiatry, 63(5), 414–419.

Bouchard, S., Mendlowitz, S. L., Coles, M. E., & Franklin, M. (2004). Considerations in the use of exposure with children. Cognitive and Behavioral Practice, 11, 56–64.CrossRef

Brent, D. A., Kolko, D. J., Birmaher, B., Baugher, M., Bridge, J., Roth, C., et al. (1998). Predictors of treatment efficacy in a clinical trial of three psychosocial treatments for adolescent depression. Journal of the American Academy of Child and Adolescent Psychiatry, 37(9), 906–914.PubMedCrossRef

Cerel, J., & Fristad, M. A. (2001). Scaling structure interview data: a comparison of two methods. Journal of the American Academy of Child and Adolescent Psychiatry, 40(3), 341–346.PubMedCrossRef

Cole, D. A., Peeke, L. G., Martin, J. M., Truglio, R., & Seroczynski, A. D. (1998). A longitudinal look at the relationship between depression and anxiety in children and adolescents. Journal of Consulting and Clinical Psychology, 66(3), 451–460.PubMedCrossRef

Cummings, C. M., & Fristad, M. A. (2007). Medications prescribed for children with mood disorders: effects of a family-based psychoeducation program. Experimental and Clinical Psychopharmacology, 15(6), 555–562.PubMedCrossRef

Curry, J., Rohde, P., Simons, A., Silva, S., Vitiello, B., Kratochvil, C., et al. (2006). Predictors and moderators of acute outcome in the Treatment of Adolescents with Depression Study (TADS). Journal of the American Academy of Child and Adolescent Psychiatry, 45(12), 1427–1439.PubMedCrossRef

DelBello, M. P., Hanseman, D., Adler, C. M., Fleck, D. E., & Strakowski, S. M. (2007). Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode. American Journal of Psychiatry, 164, 582–590.PubMedCrossRef

Dickstein, D. P., Rich, B. A., Binstock, A. B., Pradella, A. G., Towbin, K. E., Pine, D. S., et al. (2005). Comorbid anxiety in phenotypes of pediatric bipolar disorder. Journal of Child and Adolescent Psychopharmacology, 15(4), 534–548.PubMedCrossRef

Double, D. B. (1990). The factor structure of manic rating scales. Journal of Affective Disorders, 18(2), 113–119.PubMedCrossRef

Emslie, G. J., Mayes, T. L., Laptook, R. S., & Batt, M. (2003). Predictors of response to treatment in children and adolescents with mood disorders. Psychiatric Clinics of North America, 26, 435–456.PubMedCrossRef

Feske, U., Frank, E., Mallinger, A. G., Houck, P. R., Fagiolini, A., Shear, M. K., et al. (2000). Anxiety as a correlate of response to the acute treatment of bipolar I disorder. American Journal of Psychiatry, 157(6), 956–962.PubMedCrossRef

Fristad, M. A., Weller, E. B., & Weller, R. A. (1992). The mania rating scale: can it be used in children? A preliminary report. Journal of the American Academy of Child & Adolescent Psychiatry, 31(2), 252–257.CrossRef

Fristad, M. A., Weller, R. A., & Weller, E. B. (1995). The Mania Rating Scale (MRS): further reliability and validity studies with children. Annals of Clinical Psychiatry, 7(3), 127–132.PubMedCrossRef

Fristad, M. A., Verducci, J. S., Walters, K., & Young, M. E. (2009). Impact of Multi-Family Psychoeducational Psychotherapy in treating children aged 8 to 12 years with mood disorders. Archives of General Psychiatry, 66(9), 1013–1021.PubMedCrossRef

Fristad, M. A., Goldberg Arnold, J. S., & Leffler, J. M. (2011). Psychotherapy for children with bipolar and depressive disorders. NY: Guilford Press, Inc.

Greco, L., & Morris, T. (2005). Factors influencing the link between social anxiety and peer acceptance: contributions of social skills and close friendships during middle childhood. Behavior Therapy, 36, 197–205.CrossRef

Hale, W. W., Raaijmakers, Q. A., Muris, P., van Hoof, A., & Meeus, W. (2009). One factor or two parallel processes? Comorbidity and development of adolescent anxiety and depressive disorder symptoms. The Journal of Child Psychology and Psychiatry, 50(10), 1218–1226.CrossRef

Harpold, T. L., Wozniak, J., Kwon, A., Gilbert, J., Wood, J., Smith, L., et al. (2005). Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents. Journal of Affective Disorders, 88, 19–26.PubMedCrossRef

Hughes, C. W., Emslie, G., Crismon, M. L., Wagner, K. D., Birmaher, B., Geller, B., et al. (1999). The Texas Children’s Medication Algorithm Project: Report of the Texas Conference Consensus Panel on medication treatment of childhood major depressive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 38(11), 1442–1454.PubMedCrossRef

Hughes, C. W., Emslie, G. J., Crismon, M. L., Posner, K., Birmaher, B., Ryan, N., et al. (2007). Texas children’s medication algorithm project: update from Texas consensus conference panel on medication treatment of childhood major depressive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 46(6), 667–686.PubMedCrossRef

Joshi, G., & Wilens, T. (2009). Comorbidity in pediatric bipolar disorder. Child and Adolescent Psychiatric Clinics of North America, 18, 291–319.PubMedCrossRef

Kendall, P. C., Kortlander, E., Chansky, T. E., & Brady, E. U. (1992). Comorbidity of anxiety and depression in youth: treatment implications. Journal of Consulting and Clinical Psychology, 60(6), 869–880.PubMedCrossRef

Kendall, P. C., Flannery-Schroeder, E., Panichelli-Mindel, S., Southam-Gerow, M., Henin, A., & Warman, M. (1997). Therapy for youth with anxiety disorders: a second randomized clinical trial. Journal of Consulting and Clinical Psychology, 65, 366–380.PubMedCrossRef

Kendall, P. C., Robin, J. A., Hedtke, K. A., Suveg, C., Flannery-Schroeder, E., & Gosch, E. (2005). Considering CBT with anxious youth? Think exposures. Cognitive and Behavioral Practice, 12(1), 136–150.CrossRef

Kolko, D. J., Brent, D. A., Baugher, M., Bridge, J., & Birmaher, B. (2000). Cognitive and family therapies for adolescent depression: treatment specificity, mediation, and moderation. Journal of Consulting and Clinical Psychology, 68(4), 603–614.PubMedCrossRef

Kovacs, M., Gatsonis, C., Paulauskas, S. L., & Richards, C. (1989). Depressive disorders in childhood. IV. A longitudinal study of comorbidity with and risk for anxiety disorders. Archives of General Psychiatry, 46(9), 776–7782.PubMedCrossRef

Kowatch, R. A., Fristad, M., Birmaher, B., Wagner, K. D., Findling, R. L., & Hellander, M. (2005). Treatment guidelines for children and adolescents with bipolar disorder: child psychiatric workgroup on bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 44(3), 213–239.PubMedCrossRef

Lewinsohn, P. M., Zinbarg, R., Seeley, J. R., Lewinsohn, M., & Sack, M. H. (1997). Lifetime comorbidity among anxiety disorders and between anxiety disorders and other mental disorders in adolescents. Journal of Anxiety Disorders, 11(4), 377–394.PubMedCrossRef

March, J., Parker, J., Sullivan, K., Stallings, P., & Conners, C. (1997). The Multidimensional Anxiety Scale for Children (MASC): factor structure, reliability and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 554–565.PubMedCrossRef

Masi, G., Mucci, M., Favilla, L., & Millepiedi, S. (2001a). Anxiety comorbidity in referred children and adolescents with dysthymic disorder. Psychopathology, 34(5), 253–258.CrossRef

Masi, G., Toni, C., Perugi, G., Mucci, M., Millepiedi, S., & Akiskal, H. S. (2001b). Anxiety disorders in children and adolescents with bipolar disorder: a neglected comorbidity. Canadian Journal of Psychiatry, 46, 797–802.

Masi, G., Perugi, G., Millepiedi, S., Mucci, M., Pari, C., Pfanner, C., et al. (2007). Clinical implications of DSM-IV subtyping of bipolar disorder in referred children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 46(10), 1299–1306.PubMedCrossRef

Masi, G., Perugi, G., Millepiedi, S., Mucci, M., Pfanner, C., Berlotta, S., et al. (2010). Pharmacological response in juvenile bipolar disorder subtypes: a naturalistic retrospective examination. Psychiatry Research, 177(1–2), 192–198.PubMedCrossRef

McClellan, J., Kowatch, R., Findling, R. L., & The Work Group on Quality Issues. (2007). Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 46(1), 107–125.PubMedCrossRef

Mendenhall, A. N. (2007). Patterns and predictors of service utilization of children with mood disorders: Effects of a multi-family psychoeducation program. (Doctoral dissertation) Retrieved from http://etd.ohiolink.edu/.

Mendenhall, A. N., Fristad, M. A., & Early, T. J. (2009). Factors influencing service utilization and mood symptom severity in children with mood disorders: Effects of Multi-Family Psychoeducation Groups (MFPG). Journal of Consulting and Clinical Psychology, 77(3), 463–473.PubMedCrossRef

Mendenhall, A. N., Davidson, K. H., & Fristad, M. A. (2010). The service provider and medication usage grids: a new method to measure “treatment as usual” (TAU). Child and Adolescent Social Work, 27(6), 423–434.CrossRef

Mendlowitz, S. L., Manassis, K., Bradley, S., Scapillato, D., Miezitis, S., & Shaw, B. E. (1999). Cognitive-behavioral group treatments in childhood anxiety disorders: the role of parental involvement. Journal of the American Academy of Child and Adolescent Psychiatry, 38(10), 1223–1229.PubMedCrossRef

Poznanski, E. O., Grossman, J. A., Buchsbaum, Y., Banegas, M., Freeman, L., & Gibbons, R. (1984). Preliminary studies of the reliability and validity of the Children’s Depression Rating Scale. Journal of the American Academy of Child Psychiatry, 23(2), 191–197.PubMedCrossRef

Rohde, P., Clarke, G., Lewinsohn, P. M., Seeley, J. R., & Kaufman, N. K. (2001). Impact of comorbidity on a cognitive-behavioral group treatment for adolescent depression. Journal of the American Academy of Child and Adolescent Psychiatry, 40(7), 795–802.PubMedCrossRef

Sachs, G. S., Baldassano, C. F., Truman, C. J., & Guille, C. (2000). Comorbidity of attention deficit hyperactivity disorder with early- and late-onset bipolar disorder. American Journal of Psychiatry, 157, 466–468.

Sala, R., Axelson, D. A., Castro-Fornieles, J., Goldstein, T. R., Ha, W., Fangzi, F., et al. (2010). Comorbid anxiety in children and adolescents with bipolar spectrum disorders: prevalance and clinical correlates. Journal of Clinical Psychiatry, 71(10), 1344–1350.PubMedCrossRef

Seligman, L. D., & Ollendick, T. H. (1998). Comorbidity of anxiety and depression in children and adolescents: an integrative review. Clinical Child and Family Psychology Review, 1(2), 125–144.PubMedCrossRef

Shaffer, D., Gould, M. S., Brasic, J., Ambrosini, P., Fisher, P., Bird, H., et al. (1983). A children’s global assessment scale (CGAS). Archives of General Psychiatry, 40(11), 1228–1231.PubMedCrossRef

Silverman, W., & Albano, A. M. (1996). The anxiety disorders interview schedule for DSM-IV: Child and parent versions. San Antonio: Graywind.

Silverman, W. K., & Hinshaw, S. P. (2008). The second special issue on evidence-based psychosocial treatments for children and adolescents: A 10-year update. Journal of Clinical Child and Adolescent Psychology, 37(1), 1–7.CrossRef

Simon, N. M., Otto, M. W., Wisniewski, S. R., Fossey, M., Sagduyu, K., Frank, E., et al. (2004). Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BP). American Journal of Psychiatry, 161, 2222–2229.PubMedCrossRef

Stark, K. D., Napolitano, S., Swearer, S., Schmidt, K., Jaramillo, D., & Hoyle, J. (1996). Issues in the treatment of depressed children. Applied & Preventive Psychology, 5(2), 59–83.CrossRef

Van Amerigen, M., Manicini, C., & Farvolden, P. (2003). The impact of anxiety disorders on educational achievement. Journal of Anxiety Disorders, 17, 561–571.CrossRef

Verduin, T. L., & Kendall, P. C. (2008). Peer perceptions and liking of children with anxiety disorders. Journal of Abnormal Child Psychology, 36(4), 459–469.PubMedCrossRef

Walkup, J. T., Albano, A. M., Piacentini, J., Birmaher, B., Compton, S. N., Sherrill, J. T., et al. (2008). Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. The New England Journal of Medicine, 359, 2753–2766.PubMedCrossRef

Weckerly, J. (2002). Pediatric bipolar mood disorder. Journal of Developmental and Behavioral Pediatrics, 23(1), 42–56.PubMedCrossRef

Weissman, M. M., Wolk, S., Wickramaratne, P., Goldstein, R. B., Adams, P., Greenwald, S., et al. (1999). Children with prepubertal-onset major depressive disorder and anxiety grown up. Archives of General Psychiatry, 56(9), 794–801.PubMedCrossRef

Weller, E. B., Weller, R. A., Rooney, & Fristad, M. A. (1999a). ChIPS. Washington, DC: American Psychiatric Association.

Weller, E. B., Weller, R. A., Rooney, M., & Fristad, M. A. (1999b). Children’s interview for psychiatric syndromes–parent version (P-ChIPS). Washington, DC: American Psychiatric Association.

Weller, E. B., Weller, R. A., Fristad, M. A., Rooney, M., & Schecter, J. (2000). Children’s interview for psychiatric syndromes (ChIPS). Journal of the American Academy of Child and Adolescent Psychiatry, 39(1), 76–84.PubMedCrossRef

Wilamowska, Z. A., Thompson-Hollands, J., Fairholme, C. P., Ellard, K. K., Farchione, T. J., & Barlow, D. H. (2010). Conceptual background, development, and preliminary data from the Unified Protocol for transdiagnostic treatment of emotional disorders. Depression and Anxiety, 27, 882–890.PubMedCrossRef

Wilens, T. E., Biederman, J., Forkner, P., Ditterline, J., Morris, M., Moore, H., et al. (2003). Patterns of comorbidity and dysfunction in clinical referred preschool and school-age children with bipolar disorder. Journal of Child and Adolescent Psychopharmacology, 13(4), 495–505.PubMedCrossRef

Wilkinson, P., Dubicka, B., Kelvin, R., Roberts, C., & Goodyer, I. (2009). Treated depression in adolescents: predictors of outcome at 28 weeks. The British Journal of Psychiatry, 194, 334–341.PubMedCrossRef

Woodward, L. J., & Fergusson, D. M. (2001). Life course outcomes of young people with anxiety disorders in adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 40(8), 1086–1093.PubMedCrossRef

Wozniak, J., Spencer, T., Biederman, J., Kwon, A., Monuteaux, M., Rettew, J., et al. (2004). The clinical characteristics of unipolar vs. bipolar major depression in ADHD youth. Journal of Affective Disorders, 82S, S59–S69.CrossRef

Yorbik, O., Birmaher, B., Axelson, D., Williamson, D. E., & Ryan, N. D. (2004). Clinical characteristics of depressive symptoms in children and adolescents with major depressive disorder. Journal of Clinical Psychiatry, 65(12), 1654–1659.PubMedCrossRef

Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978). A rating scale for mania: reliability, validity and sensitivity. British Journal of Psychiatry, 133, 429–435.PubMedCrossRef

Young, J. F., Mufson, L., & Davies, M. (2006). Impact of comorbid anxiety in an effectiveness study of interpersonal psychotherapy for depressed adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 45(8), 904–911.PubMedCrossRef

Youngstrom, E. A., Danielson, C. K., Findling, R. L., Gracious, B. L., & Calabrese, J. R. (2002). Factor structure of the Young Mania Rating Scale for use with youths ages 5 to 17 years. Journal of Clinical Child and Adolescent Psychology, 31(4), 567–572.PubMed

Titel: Anxiety in Children with Mood Disorders: A Treatment Help or Hindrance?
Auteurs: Colleen M. Cummings
Mary A. Fristad
Publicatiedatum: 01-04-2012
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 3/2012
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-011-9568-5

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