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Gepubliceerd in: Journal of Autism and Developmental Disorders 4/2014

01-04-2014 | Original Paper

Antiepileptic Medications in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Auteurs: Tomoya Hirota, Jeremy Veenstra-VanderWeele, Eric Hollander, Taro Kishi

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2014

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Abstract

Electroencephalogram-recorded epileptiform activity is common in children with autism spectrum disorder (ASD), even without clinical seizures. A systematic literature search identified 7 randomized, placebo-controlled trials of antiepileptic drugs (AEDs) in ASD (total n = 171), including three of valproate, and one each of lamotrigine, levetiracetam, and topiramate. Meta-analysis revealed no significant difference between medication and placebo in four studies targeting irritability/agitation and three studies investigating global improvement, although limitations include lack of power and different medications with diverse actions. Across all seven studies, there was no significant difference in discontinuation rate between two groups. AEDs do not appear to have a large effect size to treat behavioral symptoms in ASD, but further research is needed, particularly in the subgroup of patients with epileptiform abnormalities.
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Metagegevens
Titel
Antiepileptic Medications in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
Auteurs
Tomoya Hirota
Jeremy Veenstra-VanderWeele
Eric Hollander
Taro Kishi
Publicatiedatum
01-04-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1952-2

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