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06-04-2020 | Original Article

Antidepressant Use in a 3- to 12-Year Follow-up of Anxious Youth: Results from the CAMELS Trial

Auteurs: Elana R. Kagan, Hannah E. Frank, Lesley A. Norris, Sophie A. Palitz, Erika A. Chiappini, Mark J. Knepley, Margaret E. Crane, Katherine E. Phillips, Golda S. Ginsburg, Courtney Keeton, Anne Marie Albano, John Piacentini, Tara Peris, Scott Compton, Dara Sakolsky, Boris Birmaher, Philip C. Kendall

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 1/2021

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Abstract

The current study explored whether patient characteristics predicted patterns of antidepressant use (i.e., never used, single episode of use, or two or more episodes) in a naturalistic follow-up. Participants in the child/adolescent multimodal (CAMS) extended long-term study. (n = 318) indicated medication use over the course of eight follow-up visits, 3–12 years after receiving treatment in CAMS. 40.6% of participants reported never using an antidepressant during follow-up, 41.4% reported a single episode of antidepressant use, and 18.0% reported multiple episodes of antidepressant use. Greater baseline anxiety severity marginally predicted a single episode of antidepressant use; baseline depression severity predicted multiple episodes of use. Reasons for discontinuing antidepressants included perceived ineffectiveness (31.8%), side effects (25.5%), and improvement in symptoms (18.5%). Exploratory analyses examined predictors of medication use. Findings suggest that antidepressant use is common among anxious youth, as is discontinuation of antidepressant use. Clinical implications and future directions are discussed.
Voetnoten
1
Medications in this category included SSRIs, SNRIs, and related medications, including Sertraline, Fluoxetine, Citalopram, Escitalopram, Paroxetine, Fluvoxamine, Venlafaxine, Desvenlafaxine, Duloxetine, and Bupropion.
 
2
CAMELS participants were more likely to be female, of non-Hispanic ethnicity, and of higher SES than non-participants. Among those who completed less than three visits 12.7% (n = 8) were Hispanic; 49.2% (n = 31) were female, and 28.6% (n = 18) were of lower SES.
 
3
Some participants endorsed both stopping one antidepressant and starting another within the same follow-up interval, but data were not gathered as to whether these occurred concurrently or separately within that period of time. Thus, some participants may have stopped one antidepressant and began another many months later, while others may have switched directly from one to another.
 
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Metagegevens
Titel
Antidepressant Use in a 3- to 12-Year Follow-up of Anxious Youth: Results from the CAMELS Trial
Auteurs
Elana R. Kagan
Hannah E. Frank
Lesley A. Norris
Sophie A. Palitz
Erika A. Chiappini
Mark J. Knepley
Margaret E. Crane
Katherine E. Phillips
Golda S. Ginsburg
Courtney Keeton
Anne Marie Albano
John Piacentini
Tara Peris
Scott Compton
Dara Sakolsky
Boris Birmaher
Philip C. Kendall
Publicatiedatum
06-04-2020
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 1/2021
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-020-00983-w

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