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Gepubliceerd in:

01-07-2006 | ORIGINAL PAPER

An MRI Study of Minor Physical Anomalies in Autism

Auteurs: Antonio Y. Hardan, Matcheri S. Keshavan, Sucheta Sreedhar, Mahduri Vemulapalli, Nancy J. Minshew

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2006

Abstract

The objective of this investigation was to examine the existence of minor physical anomalies (MPA) in autism. The interorbital and interlens distances were measured on MRI scans obtained from a sample of 40 non-mentally retarded individuals with autism and 41 healthy controls. No differences were observed between the two groups on any measurements. However, when the analysis was conducted using a split median procedure, individuals with autism and either low FSIQ, PIQ, or VIQ had shorter interorbital distances when compared to controls. Hypotelorism is a MPA that may be present in a subgroup of individuals with autism. Additional research is warranted using large sample sizes with a wide range of intellectual functioning.

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Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., & Yates, K. O. et al. (1999). MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology, 53, 2145–2150. PubMed

Aylward, E. H., Minshew, N. J., Field, K., Sparks, B. F., & Singh, N. (2002). Effects of age on brain volume and head circumference in autism. Neurology, 59, 175–183. PubMed

Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., & Yuzda, E. et al. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychology Medicine, 25, 63–77. CrossRef

Boyes, J., Whalley, H. C., Lawrie, S. M., Johnstone, E. C., & Best, J. J. (2001). A MRI study of ocular hypertelorism in individuals at high risk of developing schizophrenia. Schizophrenia Research, 30, 1–2. CrossRef

Campbell, M., Geller, B., Small, A. M., Petti, T. A., & Ferris, S. H. (1978). Minor physical anomalies in young psychotic children. American Journal of Psychiatry, 135, 573–575. PubMed

Cohen Jr., M. M., Richieri-Costa, A., Guion-Almeida, M. L., & Saavedra, D. (1995). Hypertelorism: Interorbital growth, measurements, and pathogenetic considerations. International Journal of Oral Maxillofacial Surgery, 24, 387–395.

Diewert, V. M., Lozanoff, S., & Choy, V. (1993). Computer reconstructions of human embryonic craniofacial morphology showing changes in relations between the face and brain during primary palate formation. Journal of Craniofacial Genetics and Developmental Biology, 13, 193–201. PubMed

Hardan, A. Y., Minshew, N. J., Mallikarjuhn, M., & Keshavan, M. S. (2001). Brain volume in autism. Journal of Child Neurology, 16, 421–424. PubMed

Hollingshead, A. B. (1975). Four factor index of social status. New Haven, CT: Yale University Department of Sociology.

Jones, K. L. (1997). Smith’s recognizable pattern of human malformation (pp. 727–746). Philadelphia: W.B. Saunders.

Lainhart, J. E., Piven, J., Wzorek, M., Landa, R., Santangelo, S. L., & Coon, H. et al. (1997). Macrocephaly in children and adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 282–290. CrossRefPubMed

Lord, C., Rutter, M., & LeCouteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorder, 24, 659–685. CrossRefPubMed

LeCouteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., & Holdgrafer, M., et al. (1989). Autism diagnostic interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorder, 19, 363–387. CrossRef

Magnotta, V. A., Harris, G., Andreasen, N. C., O’Leary, D. S., Yuh, W. T., & Heckel, D. (2002). Structural MR image processing using the BRAINS2 toolbox. Computerized Medical Imaging and Graphics, 26, 251–264. CrossRefPubMed

Miles, J. H., & Hillman, R. E. (2000). Value of a clinical morphology examination in autism. American Journal of Medical Genetics, 91, 245–253. CrossRefPubMed

Minshew, N. J. (1996). Autism. In B. O. Berg (Ed), Principles of child neurology (pp. 1713–1730). New York: McGraw Hill.

Quinn, P. Q., & Rapoport, J. L. (1974). Minor physical anomalies and neurologic status in hyperactive boys. Pediatrics, 53, 742–747. PubMed

Rodier, P. M., Bryson S. E., & Welch, J. P. (1997). Minor malformations and physical measurements in autism: Data from Nova Scotia. Teratology, 55, 319–325. CrossRefPubMed

Steg, J. P., & Rapoport, J. L. (1975). Minor physical anomalies in normal, neurotic learning disabeled, and severely disturbed children. Journal of Autism and Childhood Schizophrenia, 5, 299–307. CrossRefPubMed

Walker, H. A. (1977). Incidence of minor physical anomaly in autism. Journal of Autism and Childhood Schizophrenia, 7, 165–176. CrossRefPubMed

Titel: An MRI Study of Minor Physical Anomalies in Autism
Auteurs: Antonio Y. Hardan
Matcheri S. Keshavan
Sucheta Sreedhar
Mahduri Vemulapalli
Nancy J. Minshew
Publicatiedatum: 01-07-2006
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-006-0103-4

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